Multivariate SAR/QSAR of 3-aryl-4-hydroxyquinolin-2(1H)-one derivatives as type i fatty acid synthase (FAS) inhibitors

European Journal of Medicinal Chemistry

Volumn 45, Issue 12, 2010, Pages 5817-5826

  De Melo, Eduardo Borges ^a  

^a UNIVERSIDADE ESTADUAL DO OESTE DO PARANÁ   (Brazil)

Author keywords

3 aryl 4 hydroxyquinolin 2(1H) one; FAS; OPS; PCA; PLS; QSAR

Indexed keywords

3 4 HYDROXYQUINOLIN 2(1H) ONE DERIVATIVE; FATTY ACID SYNTHASE INHIBITOR; UNCLASSIFIED DRUG;

ALGORITHM; ARTICLE; CORRELATION ANALYSIS; DRUG SYNTHESIS; MULTIVARIATE ANALYSIS; QUANTITATIVE STRUCTURE ACTIVITY RELATION; RANDOMIZATION; STRUCTURE ACTIVITY RELATION;

ENZYME INHIBITORS; FATTY ACID SYNTHETASE COMPLEX, TYPE I; HUMANS; HYDROXYQUINOLINES; MODELS, MOLECULAR; MOLECULAR STRUCTURE; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 78649332944     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2010.09.044     Document Type: Article

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