Synthesis and biological activity of some antitumor active derivatives from glycyrrhetinic acid

European Journal of Medicinal Chemistry

Volumn 45, Issue 12, 2010, Pages 5718-5723

  Csuk, René ^a   Schwarz, Stefan ^a   Kluge, Ralph ^a   Ströhl, Dieter ^a  

^a MARTIN LUTHER UNIVERSITY HALLE WITTENBERG   (Germany)

Author keywords

Antitumor activity; Apoptosis; Glycyrrhetinic acid

Indexed keywords

3 BETA (CHLOROACETYL) 11 OXO OLEAN 12 EN 30 OIC ACID; ANTINEOPLASTIC AGENT; GLYCYRRHETINIC ACID DERIVATIVE; METHYL 3 BETA (CHLOROACETYL) 11 OXO OLEAN 12 EN 30 OATE; METHYL 3 BETA 3 [[N (10 AMINODECL)GLYCYL]OXY] 11 OXO OLEAN 12 EN 30 OATE; METHYL 3 BETA 3 [[N (3 AMINOPROPYL)GLYCYL]OXY] 11 OXO OLEAN 12 EN 30 OATE; METHYL 3 BETA 3 [[N (4 AMINOBUTYL)GLYCYL]OXY] 11 OXO OLEAN 12 EN 30 OATE; METHYL 3 BETA 3 [[N (5 AMINOPENTYL)GLYCYL]OXY] 11 OXO OLEAN 12 EN 30 OATE; METHYL 3 BETA 3 [[N (6 AMINOHEXYL)GLYCYL]OXY] 11 OXO OLEAN 12 EN 30 OATE; METHYL 3 BETA 3 [[N (7 AMINOHEPTYL)GLYCYL]OXY] 11 OXO OLEAN 12 EN 30 OATE; METHYL 3 BETA 3 [[N (8 AMINOOCTYL)GLYCYL]OXY] 11 OXO OLEAN 12 EN 30 OATE; METHYL 3 BETA 3 [[N (9 AMINONONYL)GLYCYL]OXY] 11 OXO OLEAN 12 EN 30 OATE; METHYL 3 BETA HYDROXY 11 OXO OLEAN 12 EN 30 OATE; UNCLASSIFIED DRUG;

ANTINEOPLASTIC ACTIVITY; ARTICLE; CANCER CELL CULTURE; CONTROLLED STUDY; DRUG SCREENING; DRUG SYNTHESIS; HUMAN; HUMAN CELL; IC 50;

ANTINEOPLASTIC AGENTS; APOPTOSIS; CELL PROLIFERATION; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG SCREENING ASSAYS, ANTITUMOR; GLYCYRRHETINIC ACID; HUMANS; MOLECULAR CONFORMATION; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP; TUMOR CELLS, CULTURED;

EID: 78649323960     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2010.09.028     Document Type: Article

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