The synthesis of 18β-glycyrrhetinic acid derivatives which have increased antiproliferative and apoptotic effects in leukemia cells

Bioorganic and Medicinal Chemistry

Volumn 15, Issue 16, 2007, Pages 5432-5439

  Liu, Dan ^a   Song, Dandan ^a   Guo, Gang ^a   Wang, Rui ^a   Lv, Jinling ^a   Jing, Yongkui ^b   Zhao, Linxiang ^a  

^a SHENYANG PHARMACEUTICAL UNIVERSITY   (China)

^b MOUNT SINAI SCHOOL OF MEDICINE   (United States)

Author keywords

18 Glycyrrhetinic acid; Apoptosis; Structure activity relationship; Synthesis

Indexed keywords

3 (ETHOXYIMINO) 11 OXOOLEAN 12 EN 29 OIC ACID; 3 (METHOXYIMINO) 11 OXOOLEAN 12 EN 29 OIC ACID; 3 (N ACETOXYIMINO) 11 OXOOLEAN 12 EN 29 OIC ACID; 3 (N PROPIONYLOXYIMINO) 11 OXOOLEAN 12 EN 29 OIC ACID; 3 (N PROPOXYOXYIMINO) 11 OXOOLEAN 12 EN 29 OIC ACID; 3 HYDROXYIMINO 11 OXOOLEAN 12 EN 29 OIC ACID; 3,11 DIOXOOLEAN 12 EN 29 OIC ACID; ANTILEUKEMIC AGENT; CARBONYL DERIVATIVE; ETHYL 3 (ETHOXYIMINO) 11 OXOOLEAN 12 EN 29 OIC ACID; ETHYL 3 OXYIMINO 11 OXOOLEAN 12 EN 29 OIC ACID; FUNCTIONAL GROUP; GLYCYRRHETINIC ACID; GLYCYRRHETINIC ACID DERIVATIVE; HYDROXYL GROUP; METHYL 3 (ETHOXYIMINO) 11 OXOOLEAN 12 EN 29 OIC ACID; METHYL 3 (METHOXYIMINO) 11 OXOOLEAN 12 EN 29 OIC ACID; METHYL 3 (PROPOXYIMINO) 11 OXOOLEAN 12 EN 29 OIC ACID; METHYL 3 OXYIMINO 11 OXOOLEAN 12 EN 29 OIC ACID; METHYL 3,11 DIOXOOLEAN 12 EN 29 OIC ACID; N PROPYL 3 (N PROPOXYIMINO) 11 OXOOLEAN 12 EN 29 OIC ACID; N PROPYL 3 OXYIMINO 11 OXOOLEAN 12 EN 29 OIC ACID; OXIME; UNCLASSIFIED DRUG; DRUG DERIVATIVE;

ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CANCER INHIBITION; CHEMICAL MODIFICATION; CONTROLLED STUDY; DRUG EFFECT; DRUG STRUCTURE; DRUG SYNTHESIS; HUMAN; HUMAN CELL; LEUKEMIA CELL; STRUCTURE ACTIVITY RELATION; CELL PROLIFERATION; CELL STRAIN HL 60; CHEMICAL STRUCTURE; CHEMISTRY; LEUKEMIA; PATHOLOGY; SYNTHESIS;

APOPTOSIS; CELL PROLIFERATION; GLYCYRRHETINIC ACID; HL-60 CELLS; HUMANS; LEUKEMIA; MOLECULAR STRUCTURE;

EID: 34250712966     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2007.05.057     Document Type: Article

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