Structure-cytotoxicity relationship in a series of N-phosphorus substituted E,E-3,5-bis(3-pyridinylmethylene)- and E,E-3,5-bis(4-pyridinylmethylene) piperid-4-ones

European Journal of Medicinal Chemistry

Volumn 45, Issue 12, 2010, Pages 5926-5934

  Leonova, Evgeniya S ^a   Makarov, Michael V ^a   Rybalkina, Ekaterina Yu ^b   Nayani, Shravana L ^c   Tongwa, Paul ^c   Fonari, Alexander ^c   Timofeeva, Tatiana V ^c   Odinets, Irina L ^a  

^a A N NESMEYANOV INSTITUTE OF ORGANOELEMENT COMPOUNDS   (Russian Federation)

^b N N BLOKHIN RUSSIAN CANCER RESEARCH CENTER   (Russian Federation)

^c NEW MEXICO HIGHLANDS UNIVERSITY   (United States)

Author keywords

3,5 bis((hetero)arylidene)piperid 4 ones; 4 Piperidones; Cytotoxicity structure relationship; N Phosphoryl 3,5 bis(pyridinylmethylene)piperid 4 ones; N Phosphorylalkylene 3,5 bis(pyridinylmethylene)piperid 4 ones; Synthesis; X ray structure

Indexed keywords

1 METHYL 4 OXO 3,5 BIS(3 PYRIDINYLMETHYLENE)PIPERIDINONE; 1 METHYL 4 OXO 3,5 BIS(4 PYRIDINYLMETHYLENE)PIPERIDINONE; 4 OXO 3,5 BIS(3 PYRIDINYLMETHYLENE)PIPERIDINE; 4 OXO 3,5 BIS(4 PYRIDINYLMETHYLENE)PIPERIDINE; ANTINEOPLASTIC AGENT; DIETHYL 2 [4 OXO 3,5 BIS(3 PYRIDINYLMETHYLENE)PIPERIDIN 1 YL]ETHYLPHOSPHONATE; DIETHYL 4 OXO 3,5 BIS(3 PYRIDINYLMETHYLENE) 1 PIPERIDINYLPHOSPHONATE; DIETHYL 4 OXO 3,5 BIS(4 PYRIDINYLMETHYLENE) 1 PIPERIDINYLPHOSPHONATE; DOXORUBICIN; ETHYLMETHYL[4 OXO 3,5 BIS(3 PYRIDINYLMETHYLENE) 1 PIPERIDINYL]PHOSPHONATE; MELPHALAN; N (4 PHOSPHORYLBUTYL) 3,5 BIS(PYRIDINYLMETHYLENE)PIPERID 4 ONE; PHENYLMETHYL[4 OXO 3,5 BIS(3 PYRIDINYLMETHYLENE) 1 PIPERIDINYL]PHOSPHINATE; PHENYLMETHYL[4 OXO 3,5 BIS(4 PYRIDINYLMETHYLENE) 1 PIPERIDINYL]PHOSPHINATE; PYRIDINE DERIVATIVE; UNCLASSIFIED DRUG;

ALDOL REACTION; ANTINEOPLASTIC ACTIVITY; ARTICLE; CANCER CELL CULTURE; CONTROLLED STUDY; CRYSTAL STRUCTURE; CYTOTOXICITY; DRUG SCREENING; DRUG SYNTHESIS; HUMAN; HUMAN CELL; IC 50; PHOSPHORYLATION; STRUCTURE ACTIVITY RELATION; X RAY CRYSTALLOGRAPHY;

ANTINEOPLASTIC AGENTS; CELL LINE, TUMOR; CELL PROLIFERATION; CRYSTALLOGRAPHY, X-RAY; DRUG SCREENING ASSAYS, ANTITUMOR; HUMANS; MODELS, MOLECULAR; MOLECULAR STRUCTURE; PHOSPHORUS; PIPERIDINES; PYRIDINES; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 78649322402     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2010.09.058     Document Type: Article

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