Treatment of patients with ethylene glycol or methanol poisoning: Focus on fomepizole

Open Access Emergency Medicine

Volumn 2, Issue , 2010, Pages 67-75

  Mégarbane, Bruno ^a  

^a HÔPITAL LARIBOISIÈRE   (France)

Author keywords

Ethanol; Hemodialysis; Metabolic acidosis

Indexed keywords

4 METHYLPYRAZOLE; ALCOHOL; ANTIDOTE; BICARBONATE; CALCIUM SALT; ETHYLENE GLYCOL; FOLINIC ACID; METHANOL; PYRIDOXINE;

ABDOMINAL PAIN; ALCOHOL BLOOD LEVEL; AMINOTRANSFERASE BLOOD LEVEL; ANION GAP; BRADYCARDIA; CLINICAL EFFECTIVENESS; CLINICAL FEATURE; CLINICAL TRIAL; CONTINUOUS INFUSION; COST EFFECTIVENESS ANALYSIS; DIARRHEA; DIZZINESS; DRUG BLOOD LEVEL; DRUG CLEARANCE; DRUG CONTRAINDICATION; DRUG COST; DRUG DOSE INCREASE; DRUG DOSE REDUCTION; DRUG EFFICACY; DRUG ELIMINATION; DRUG ERUPTION; DRUG FEVER; DRUG HALF LIFE; DRUG INDICATION; DRUG INDUCED HEADACHE; DRUG INTERMITTENT THERAPY; DRUG MECHANISM; DRUG SAFETY; DRUG WITHDRAWAL; DRUNKENNESS; EOSINOPHILIA; HEALTH CARE COST; HEMODIALYSIS; HUMAN; HYPOCALCEMIA; HYPOGLYCEMIA; HYPOTENSION; INJECTION SITE IRRITATION; INTOXICATION; KIDNEY FAILURE; LIVER TOXICITY; LOADING DRUG DOSE; LYMPHANGITIS; METABOLIC ACIDOSIS; METHANOL POISONING; NAUSEA; NEUROLOGIC DISEASE; NEUROTOXICITY; NONHUMAN; NYSTAGMUS; ORGAN INJURY; PANCREATITIS; PATIENT SAFETY; RECOMMENDED DRUG DOSE; REVIEW; SIDE EFFECT; SINGLE DRUG DOSE; SLURRED SPEECH; TACHYCARDIA; TREATMENT INDICATION; VERTIGO; VISUAL IMPAIRMENT; VOMITING;

EID: 78649247346     PISSN: None     EISSN: 11791500     Source Type: Journal    
DOI: 10.2147/OAEM.S5346     Document Type: Review

References (65)

1. Bronstein AC, Spyker DA, Cantilena LR Jr, Green JL, Rumack BH, Heard SE. American Association of Poison Control Centers. 2007 Annual Report of the American Association of Poison Control Centers' National Poison Data System (NPDS): 25th Annual Report. Clin Toxicol (Phila). 2008;46(10):927-1057.
2. Hovda KE, Hunderi OH, Tafjord AB, Dunlop O, Rudberg N, Jacobsen D. Methanol outbreak in Norway 2002-2004: epidemiology, clinical features and prognostic signs. J Intern Med. 2005;258(2):181-190.
3. Brahmi N, Blel Y, Abidi N, et al. Methanol poisoning in Tunisia: report of 16 cases. Clin Toxicol (Phila). 2007;45(6):717-720. (Pubitemid 47394416)
4. Paasma R, Hovda KE, Tikkerberi A, Jacobsen D. Methanol mass poisoning in Estonia: outbreak in 154 patients. Clin Toxicol (Phila). 2007;45(2):152-157. (Pubitemid 46280024)
5. Brent J. Fomepizole for ethylene glycol and methanol poisoning. N Engl J Med. 2009;360(21):2216-2223.
6. Froberg K, Dorion RP, McMartin KE. The role of calcium oxalate crystal deposition in cerebral vessels during ethylene glycol poisoning. Clin Toxicol (Phila). 2006;44(3):315-318.
7. Paasma R, Hovda KE, Jacobsen D. Methanol poisoning and long term sequelae - a six years follow-up after a large methanol outbreak. BMC Clin Pharmacol. 2009;9:5.
8. Jacobsen D, McMartin KE. Antidotes for methanol and ethylene glycol poisoning. J Toxicol Clin Toxicol. 1997;35(2):127-143.
9. Mégarbane B, Borron SW, Baud FJ. Current recommendations for treatment of severe toxic alcohol poisonings. Intensive Care Med. 2005;31(2):189-195. (Pubitemid 40362266)
10. Kraut JA, Kurtz I. Toxic alcohol ingestions: clinical features, diagnosis, and management. Clin J Am Soc Nephrol. 2008;3(1):208-225.
11. Hylander B, Kjellstrand CM. Prognostic factors and treatment of severe ethylene glycol intoxication. Intensive Care Med. 1996;22(6):546-552. (Pubitemid 26202596)
12. Liu JJ, Daya MR, Carrasquillo O, Kales SN. Prognostic factors in patients with methanol poisoning. J Toxicol Clin Toxicol. 1998(3);36:175-181.
13. Hassanian-Moghaddam H, Pajoumand A, Dadgar SM, Shadnia SH. Prognostic factors in methanol poisoning. Hum Exp Toxicol. 2007;26(7):583-586.
14. Hovda KE, Hunderi OH, Rudberg N, Froyshov S, Jacobsen D. Anion and osmolal gaps in the diagnosis of methanol poisoning: clinical study in 28 patients. Intensive Care Med. 2004;30(9):1842-1846.
15. Soghoian S, Sinert R, Wiener SW, Hoffman RS. Ethylene glycol toxicity presenting with non-anion gap metabolic acidosis. Basic Clin Pharmacol Toxicol. 2009;104(1):22-26.
16. Morgan TJ, Clark C, Clague A. Artifactual elevation of measured plasma L-lactate concentration in the presence of glycolate. Crit Care Med. 1999;27(10):2177-2179. (Pubitemid 29508333)
17. Hvoda KE, Urdal P, Jacobsen D. Increased serum formate in the diagnosis of methanol poisoning. J Anal Toxicol. 2005;29(6):586-588.
18. Porter WH, Rutter PW, Bush BA, Papas AA, Dunnington JE. Ethylene glycol toxicity: the role of serum glycolic acid in hemodialysis. J Toxicol Clin Toxicol. 2001;39(6):607-615.
19. Caravati EM, Erdman AR, Christianson G, et al. Ethylene glycol exposure: an evidence-based consensus guideline for out-of-hospital management. Clin Toxicol (Phila). 2005;43(5):327-345. (Pubitemid 41428766)
20. Wallace EA, Green AS. Methanol toxicity secondary to inhalant abuse in adult men. Clin Toxicol (Phila). 2009;47(3):239-242.
21. Bebarta VS, Heard K, Dart RC. Inhalational abuse of methanol products: elevated methanol and formate levels without vision loss. Am J Emerg Med. 2006;24(6):725-728.
22. Hovda KE, Jacobsen D. Expert opinion: fomepizole may ameliorate the need for hemodialysis in methanol poisoning. Hum Exp Toxicol. 2008;27(7):539-546.
23. Bestic M, Blackford M, Reed M. Fomepizole: a critical assessment of current dosing recommendations. J Clin Pharmacol. 2009;49(2):130-137.
24. Barceloux DG, Krenzelok EO, Olson K, Watson W. American Academy of Clinical Toxicology practice guidelines on the treatment of ethylene glycol poisoning. J Toxicol Clin Toxicol. 1999;37(5):537-560.
25. Barceloux DG, Bong GR, Krenzelok EP, Cooper H, Vale JA. American Academy of Clinical Toxicology ad Hoc Committee on the Treatment Guidelines for Methanol Poisoning. American Academy of Clinical Toxicology practice guidelines on the treatment of methanol poisoning. J Toxicol Clin Toxicol. 2002;40(4):415-446.
26. Baud FJ, Galliot M, Astier A, et al. Treatment of ethylene glycol poisoning with intravenous 4-methylpyrazole. N Engl J Med. 1988;319:97-100.
27. Borron SW, Mégarbane B, Baud FJ. Fomepizole in treatment of uncomplicated ethylene glycol poisoning. Lancet. 1999;354(9181):831.
28. Mégarbane B, Borron SW, Trout H, et al. Treatment of acute methanol poisoning with fomepizole. Intensive Care Med. 2001;27(8):1370-1378. (Pubitemid 32758936)
29. Brent J, McMartin K, Phillips S, et al. Fomepizole for the treatment of ethylene glycol poisoning. Methylpyrazole for Toxic Alcohols Study Group. N Engl J Med. 1999;(11);340:832-838.
30. Brent J, McMartin K, Philipps S, Aaron C, Kulig K, Methylpyrazole for Toxic Alcohols Study Group. Fomepizole for the treatment of methanol poisoning. N Engl J Med. 2001;344(6):424-429.
31. McMartin KE, Hedström KG, Tolf BR, Ostling-Wintzell H, Blomstrand R. Studies on the metabolic interactions between 4-methylpyrazole and methanol using the monkey as an animal model. Arch Biochem Biophys. 1980;199(2):606-614.
32. Jacobsen D, Barron SK, Sebastian CS, Blomstrand R, McMartin KE. Non-linear kinetics of 4-methylpyrazole in healthy human subjects. Eur J Clin Pharmacol. 1989;37(6):599-604. (Pubitemid 20025776)
33. Marraffa J, Forrest A, Grant W, Stork C, McMartin K, Howland MA. Oral administration of fomepizole produces similar blood levels as identical intravenous dose. Clin Toxicol (Phila). 2008;46(3):181-186.
34. Jacobsen D, Sebastian CS, Dies DF, et al. Kinetic interactions between 4-methylpyrazole and ethanol in healthy humans. Alcohol Clin Exp Res. 1996;20(5):804-809.
35. Páez AM, Shannon M, Maher T, Quang L. Effects of 4-methylpyrazole on ethanol neurobehavioral toxicity in CD-1 mice. Acad Emerg Med. 2004;11(8):820-826. (Pubitemid 38951089)
36. Sivilotti ML, Burns MJ, McMartin KE, Brent J. Toxicokinetics of ethylene glycol during fomepizole therapy : implications for management. Ann Emerg Med. 2001;36(2):114-125.
37. Kerns W 2nd, Tomaszewski C, McMartin K, Ford M, Brent J; META Study Group. Methylpyrazole for Toxic Alcohols: Formate kinetics in methanol poisoning. J Toxicol Clin Toxicol. 2002;40(2):137-143.
38. Hovda KE, Andersson KS, Urdal P, Jacobsen D. Methanol and formate kinetics during treatment with fomepizole. Clin Toxicol (Phila). 2005;43(4):221-227.
39. Hantson P, Haufroid V, Wallemacq P. Formate kinetics in methanol poisoning. Hum Exp Toxicol. 2005;24(2):55-59.
40. Lepik KJ, Brubacher JR, DeWitt CR, et al. Bradycardia and hypotension associated with fomepizole infusion during hemodialysis. Clin Toxicol (Phila). 2008;46(6):570-573.
41. Harry P, Jobard E, Briand M, Caubet A, Turcant A. Ethylene glycol poisoning in a child treated with 4-methylpyrazole. Pediatrics. 1998;102(3):E31.
42. Baum CR, Langman CB, Oker EE, Goldstein CA, Aviles SR, Makar JK. Fomepizole treatment of ethylene glycol poisoning in an infant. Pediatrics. 2000;106(6):1489-1491.
43. Benitez JG, Swanson-Biearman B, Krenzelok EP. Nystagmus secondary to fomepizole administration in a pediatric patient. J Toxicol Clin Toxicol. 2000;38(7):795-798. (Pubitemid 32047308)
44. Boyer EW, Mejia M, Woolf A, Shannon M. Severe ethylene glycol ingestion treated without hemodialysis. Pediatrics. 2001;107(1):172-173.
45. Brown MJ, Shannon MW, Woolf A, Boyer EW. Childhood methanol ingestion treated with fomepizole and hemodialysis. Pediatrics. 2001;108(4):77-79.
46. Roy M, Bailey B, Chalut D, Senécal PE, Gandreault P. What are the adverse effects of ethanol used as an antidote in the treatment of suspected methanol poisoning in children. J Toxicol Clin Toxicol. 2003;41(1):155-161. (Pubitemid 36520465)
47. Caravati EM, Heileson HL, Jones M. Treatment of severe pediatric ethylene glycol intoxication without hemodialysis. J Toxicol Clin Toxicol. 2004;42(3):255-259.
48. Detaille T, Wallemacq P, Clément de Cléty S, et al. Fomepizole alone for severe infant ethylene glycol poisoning. Pediatr Crit Care Med. 2004;5(5):490-491.
49. Faissel H, Houze P, Baud FJ, Scherrmann JM. 4-methylpyrazole monitoring during hemodialysis of ethylene glycol intoxicated patients. Eur J Clin Pharmacol. 1995;49(3):211-213.
50. Jobard E, Harry P, Turcant A, Roy PM, Allain P. 4-methylpyrazole and hemodialysis in ethylene glycol poisoning. J Toxicol Clin Toxicol. 1996;34(4):379-381.
51. Moreau CL, Kerns II W, Tomaszewski CA, et al. Glycolate kinetics and hemodialysis in ethylene glycol poisoining. J Toxicol Clin Toxicol. 1998;36(7):659-666. (Pubitemid 28564206)
52. Hovda KE, Mundal H, Urdal P, McMartin K, Jacobsen D. Extremely slow formate elimination in severe methanol poisoning: a fatal case report. Clin Toxicol (Phila). 2007;45(5):516-521. (Pubitemid 46763672)
53. Watson WA. Ethylene glycol toxicity: closing in on rational, evidence-based treatment. Ann Emerg Med. 2000;36(2):139-141.
54. Pizon AF, Brooks DE. Hyperosmolality: another indication for hemodialysis following acute ethylene glycol poisoning. Clin Toxicol (Phila). 2006;44(2):181-183.
55. Sivilotti ML, Burns MJ, Aaron CK, McMartin KE, Brent J. Reversal of severe methanol-induced visual impairment: no evidence of retinal toxicity due to fomepizole. J Toxicol Clin Toxicol. 2001;39(6):627-631. (Pubitemid 33117063)
56. Essama Mbia JJ, Guerit JM, Haufroid V, Hantson P. Fomepizole therapy for reversal of visual impairment after methanol poisoning: a case documented by visual evoked potentials investigation. Am J Ophtalmol. 2002;134(6):914-916. (Pubitemid 35425467)
57. Hirsch DJ, Jindal KK, Wong P, Fraser AD. A simple method to estimate the required dialysis time for cases of alcohol poisoning. Kidney Int. 2001;60(5):2021-2024.
58. Corley RA, McMartin KE. Incorporation of therapeutic interventions in physiologically based pharmacokinetic modeling of human clinical case reports of accidental or intentional overdosing with ethylene glycol. Toxicol Sci. 2005;85(1):491-501.
59. Lepik KJ, Levy AR, Sobolev BG, et al. Adverse drug events associated with the antidotes for methanol and ethylene glycol poisoning: a comparison of ethanol and fomepizole. Ann Emerg Med. 2009;53(4):439-450.
60. Hantson P, Mahieu P. Pancreatic injury following acute methanol poisoning. J Toxicol Clin Toxicol. 2000;38(3):297-303.
61. Mégarbane B, Houzé P, Baud FJ. Oral fomepizole administration to treat ethylene glycol and methanol poisonings: advantages and limitations. Clin Toxicol (Phila). 2008;46(10):1097.
62. Amathieu R, Merouani M, Borron SW, Lapostolle F, Smail N, Adnet F. Prehospital diagnosis of massive ethylene glycol poisoning and use of an early antidote. Resuscitation. 2006;70(2):285-286. (Pubitemid 44189005)
63. Anseeuw K, Sabbe MB, Legrand A. Methanol poisoning: the duality between 'fast and cheap' and 'slow and expensive'. Eur J Emerg Med. 2008;15(2):107-109.
64. Mycyk MB, DesLauriers C, Metz J, Wills B, Mazor SS. Compliance with poison center fomepizole recommendations is suboptimal in cases of toxic alcohol poisoning. Am J Ther. 2006;13(6):485-489.
65. Sivilotti ML. Ethanol: tastes great! Fomepizole: less filling! Ann Emerg Med. 2009;53(4):451-453.