Therapeutic review: Fomepizole: A critical assessment of current dosing recommendations

Journal of Clinical Pharmacology

Volumn 49, Issue 2, 2009, Pages 130-137

  Bestic, Michelle ^a   Blackford, Martha ^b   Reed, Michael ^b  

^a CASE WESTERN RESERVE UNIVERSITY   (United States)

^b AKRON CHILDREN'S HOSPITAL   (United States)

Author keywords

CYP2E1 induction; Ethanol ingestion; Fomepizole; Methanol ingestion

Indexed keywords

2 BUTANOL; 4 BROMOPYRAZOLE; 4 CARBOXYPYRAZOLE; 4 HYDROXYMETHYLPYRAZOLE; 4 IODOPYRAZOLE; 4 METHYLPYRAZOLE; ALCOHOL; ALCOHOL DEHYDROGENASE; ANTIDOTE; BICARBONATE; CARBAMAZEPINE; CYTOCHROME P450 2E1; DIMETHYLNITROSAMINE; DRUG METABOLITE; DRUG METABOLIZING ENZYME; ETHYLENE GLYCOL; FORMALDEHYDE; METHANOL; PHENOBARBITAL; PLACEBO; PYRAZOLE; PYRAZOLE DERIVATIVE; RIFAMPICIN; UNCLASSIFIED DRUG;

ABDOMINAL PAIN; ACUTE KIDNEY FAILURE; ALCOHOL INTOXICATION; ALCOHOL METABOLISM; ANURIA; BINDING AFFINITY; BRADYCARDIA; CENTRAL NERVOUS SYSTEM DEPRESSION; CLINICAL FEATURE; DIARRHEA; DRUG ABSORPTION; DRUG APPROVAL; DRUG BIOAVAILABILITY; DRUG BLOOD LEVEL; DRUG CLEARANCE; DRUG DISPOSITION; DRUG DISTRIBUTION; DRUG DOSE ESCALATION; DRUG EFFICACY; DRUG INDICATION; DRUG METABOLISM; DRUG SAFETY; DRUG TOLERABILITY; DRUG URINE LEVEL; DRUNKENNESS; DYSGEUSIA; ELECTRORETINOGRAM; ENZYME INDUCTION; ENZYME INHIBITION; EOSINOPHILIA; EYE TOXICITY; FOOD AND DRUG ADMINISTRATION; HEADACHE; HEART ARRHYTHMIA; HUMAN; HYPOCALCEMIA; HYPOGLYCEMIA; IN VITRO STUDY; LOADING DRUG DOSE; METABOLIC ACIDOSIS; METHANOL POISONING; MICHAELIS CONSTANT; MICROSOME; MONKEY; NAUSEA; NONHUMAN; PERITONEAL DIALYSIS; RECOMMENDED DRUG DOSE; REVIEW; SEIZURE; SHOCK; SIDE EFFECT; SINGLE DRUG DOSE; SYMPTOMATOLOGY; TACHYCARDIA; VOLUNTEER; VOMITING; ADULT; ANIMAL; DOSE RESPONSE; DRUG ANTAGONISM; DRUG EFFECT; METABOLISM; PRACTICE GUIDELINE;

ADULT; ALCOHOL DEHYDROGENASE; ANIMALS; ANTIDOTES; CYTOCHROME P-450 CYP2E1; DOSE-RESPONSE RELATIONSHIP, DRUG; ENZYME INDUCTION; ETHYLENE GLYCOL; HUMANS; METHANOL; PRACTICE GUIDELINES AS TOPIC; PYRAZOLES;

EID: 58849120885     PISSN: 00912700     EISSN: 15524604     Source Type: Journal    
DOI: 10.1177/0091270008327142     Document Type: Review

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