Current recommendations for treatment of severe toxic alcohol poisonings

Intensive Care Medicine

Volumn 31, Issue 2, 2005, Pages 189-195

  Mégarbane, Bruno ^a   Borron, Stephen W ^b   Baud, Frédéric J ^a  

^a HÔPITAL LARIBOISIÈRE   (France)

^b GEORGE WASHINGTON UNIVERSITY SCHOOL OF MEDICINE AND HEALTH SCIENCES   (United States)

Author keywords

Acute poisoning; Ethylene glycol; Fomepizole; Hemodialysis; Methanol

Indexed keywords

2 PROPANOL; 4 METHYLPYRAZOLE; ALCOHOL; DISULFIRAM; ETHYLENE GLYCOL;

ABDOMINAL PAIN; ACIDOSIS; ALCOHOL INTOXICATION; CLINICAL TRIAL; CONFERENCE PAPER; DIALYSIS; DIARRHEA; DIZZINESS; DOSE RESPONSE; DRUG CLEARANCE; DRUG COST; DRUG EFFICACY; DRUG ELIMINATION; DRUG HALF LIFE; DRUG METABOLISM; DRUG SAFETY; DRUNKENNESS; EOSINOPHILIA; EYE DISEASE; FEVER; FLUSHING; HEADACHE; HEMODIALYSIS; HUMAN; HYPOTENSION; INJECTION SITE REACTION; KIDNEY FAILURE; LYMPHANGITIS; METHANOL POISONING; NAUSEA; NEUROLOGIC DISEASE; RASH; SIDE EFFECT; SLURRED SPEECH; STATISTICAL SIGNIFICANCE; TACHYCARDIA; VASODILATATION; VERTIGO; VOMITING;

ALCOHOL DEHYDROGENASE; ALCOHOLIC INTOXICATION; ANTIDOTES; CLINICAL TRIALS; ETHYLENE GLYCOL; HUMANS; METHANOL; PYRAZOLES; RENAL DIALYSIS;

EID: 14944341595     PISSN: 03424642     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00134-004-2521-0     Document Type: Conference Paper

References (39)

1. Watson WA, Litovitz TL, Rodgers GC Jr, Klein-Schwartz W, Youniss J, Rose SR, Borys D, May ME (2003) 2002 annual report of the American Association of poison control centers toxic exposure surveillance system. Am J Emerg Med 21:353-421
2. Hylander B, Kjellstrand CM (1996) Prognostic factors and treatment of severe ethylene glycol intoxication. Intensive Care Med 22:546-552
3. Liu JJ, Daya MR, Carrasquillo O, Kales SN (1998) Prognostic factors in patients with methanol poisoning. J Toxicol Clin Toxicol 36:175-181
4. Jacobsen D, McMartin KE (1997) Antidotes for methanol and ethylene glycol poisoning. J Toxicol Clin Toxicol 35:127-143
5. Mégarbane B, Baud F (2003) Is there a remaining place for hemodialysis in toxic alcohol poisonings treated with fomepizole? J Toxicol Clin Toxicol 41:396-397 [abstr]
6. Baud FJ, Galliot M, Astier A, Bien DV, Garnier R, Likforman J, Bismuth C (1988) Treatment of ethylene glycol poisoning with intravenous 4-methylpyrazole. N Engl J Med 319:97-100
7. Borron SW, Mégarbane B, Baud FJ (1999) Fomepizole in treatment of uncomplicated ethylene glycol poisoning. Lancet 354:831
8. Mégarbane B, Borron SW, Trout H, Hantson P, Jaeger A, Krencker E, Bismuth C, Baud FJ (2001) Treatment of acute methanol poisoning with fomepizole. Intensive Care Med 27:1370-1378
9. Brent J, McMartin K, Phillips S, Burkhart KK, Donovan JW, Wells M, Kulig K (1999) Fomepizole for the treatment of ethylene glycol poisoning. Methylpyrazole for Toxic Alcohols Study Group. N Engl J Med 340:832-838
10. Brent J, McMartin K, Philipps S, Aaron C, Kulig K, Methylpyrazole for Toxic Alcohols Study Group (2001) Fomepizole for the treatment of methanol poisoning. N Engl J Med 344:424-429
11. McMartin KE, Hedström KG, Tolf BR, Ostling-Wintzell H, Blomstrand R (1980) Studies on the meatbolic interactions between 4-methylpyrazole and methanol using the monkey as an animal model. Arch Biochem Biophys 199:606-614
12. Jacobsen D, Barron SK, Sebastian CS, Blomstrand R, McMartin KE (1989) Non-linear kinetics of 4-methylpyrazole in healthy human subjects. Eur J Clin Pharmacol 37:599-604
13. Jacobsen D, Sebastian CS, Dies DF, Breau RL, Spann EG, Barron SK, McMartin KE (1996) Kinetic interactions between 4-methylpyrazole and ethanol in healthy humans. Alcohol Clin Exp Res 20:804-809
14. Barceloux DG, Krenzelok EO, Olson K, Watson W (1999) American Academy of Clinical Toxicology practice guidelines on the treatment of ethylene glycol poisoning. J Toxicol Clin Toxicol 37:537-560
15. Barceloux DG, Bong GR, Krenzelok EP, Cooper H, Vale JA, American Academy of Clinical Toxicology ad Hoc Committee on the Treatment Guidelines for Methanol Poisoning (2002) American Academy of Clinical Toxicology practice guidelines on the treatment of methanol poisoning. J Toxicol Clin Toxicol 40:415-446
16. Faissel H, Houze P, Baud FJ, Scherrmann JM (1995) 4-methylpyrazole monitoring during hemodialysis of ethylene glycol intoxicated patients. Eur J Clin Pharmacol 49:211-213
17. Jobard E, Harry P, Turcant A, Roy PM, Allain P (1996) 4-methylpyrazole and hemodialysis in ethylene glycol poisoning. J Toxicol Clin Toxicol 34:379-381
18. Sivilotti MLA, Burns MJ, McMartin KE, Brent J (2001) Toxicokinetics of ethylene glycol during fomepizole therapy: implications for management. Ann Emerg Med 36:114-125
19. Martin Caravati E, Heileson HL, Jones M (2004) Treatment of severe pediatric ethylene glycol intoxication without hemodialysis. J Toxicol Clin Toxicol 42:255-259
20. Brown MJ, Shannon MW, Woolf A, Boyer EW (2001) Childhood methanol ingestion treated with fomepizole and hemodialysis. Pediatrics 108:77-79
21. Benitez JG, Swanson-Biearman B, Krenzelok EP (2000) Nystagmus secondary to fomepizole administration in a pediatric patient. J Toxicol Clin Toxicol 38:795-798
22. Roy M, Bailey B, Chalut D, Senécal PE, Gandreault P (2003) What are the adverse effects of ethanol used as an antidote in the treatment of suspected methanol poisoning in children. J Toxicol Clin Toxicol 41:155-161
23. Hirsch DJ, Jindal KK, Wong P, Fraser AD (2001) A simple method to estimate the required dialysis time for cases of alcohol poisoning. Kidney Int 60:2021-2024
24. Moreau CL, Kerns W II, Tomaszewski CA, McMartin KE, Rose SR, Ford MD, Brent J (1998) Glycolate kinetics and hemodialysis in ethylene glycol poisoining. J Toxicol Clin Toxicol 36:659-666
25. Watson WA (2000) Ethylene glycol toxicity: closing in on rational, evidence-based treatment. Ann Emerg Med 36:139-141
26. Porter WH, Rutter PW, Bush BA, Papas AA, Dunnington JE (2001) Ethylene glycol toxicity: the role of serum glycolic acid in hemodialysis. J Toxicol Clin Toxicol 39:607-615
27. Hantson P, Wallemacq P, Brau M, Vanbinst R, Haufroid V, Mahieu P (1999) Two cases of acute methanol poisoning partially treated by oral 4-methylpyrazole. Intensive Care Med 25:528-531
28. Burns MJ, Graudins A, Aaron CK, McMartin K, Brent J (1997) Treatment of methanol poisoning with intravenous 4-methylpyrazole. Ann Emerg Med 30:829-832
29. Kerns W 2nd, Tomaszewski C, McMartin K, Ford M, Brent J, META Study Group (2003) Methylpyrazole for toxic alcohols: formate kinetics in methanol poisoning. J Toxicol Clin Toxicol 41:257-258
30. Yip L, Jacobsen D (2002) Endogenous formate elimination and total body clearance during hemodialysis. J Toxicol Clin Toxciol 40:137-143
31. Bekka R, Borron SW, Astier A, Sandouk P, Bismuth C, Baud FJ (2001) Treatment of methanol and isopropanol poisoning with intravenous fomepizole. J Toxicol Clin Toxicol 39:59-67
32. Sivilotti ML, Burns MJ, Aaron CK, McMartin KE, Brent J (2001) Reversal of severe methanol-induced visual impairment: no evidence of retinal toxicity due to fomepizole. J Toxicol Clin Toxicol 39:627-631
33. Essama Mbia JJ, Guerit JM, Haufroid V, Hantson P (2002) Fomepizole therapy for reversal of visual impairment after methanol poisoning: a case documented by visual evoked potentials investigation. Am J Ophtalmol 134:914-916
34. Hantson P, Mahieu P (2000) Pancreatic injury following acute methanol poisoning. J Toxicol Clin Toxicol 38:297-303
35. Borron SW, Baud FJ, Garnier R (1997) Intravenous 4-methylpyrazole as an antidote for diethylene glycol and triethylene glycol poisoning: a case report. Vet Hum Tox 39:26-28
36. Osterhoudt KC (2002) Fomepizole therapy for pediatric butoxyethanol intoxication. J Toxicol Clin Toxicol 40:929-930
37. Mégarbane B, Fompeydie D, Garnier R, Baud FJ (2002) Treatment of a 1,4-butanediol poisoning with fomepizole. J Toxicol Clin Toxicol 40:77-80
38. Brophy PD, Tenenbein M, Gardner J, Bunchman TE, Smoyer WE (2000) Childhood diethylene glycol poisoning treated with alcohol dehydrogenase inhibitor fomepizole and hemodialysis. Am J Kidney Dis 35:958-962
39. Lindros KO, Stowell A, Pikkarainen P, Salaspuro M (1981) The disulfiram (antabuse) - alcohol reaction in male alcoholics: its efficient management by 4-methylpyrazole. Alcohol Clin Exp Res 5:528-530