Bradycardia and hypotension associated with fomepizole infusion during hemodialysis

Clinical Toxicology

Volumn 46, Issue 6, 2008, Pages 570-573

  Lepik, Katherine J ^a   Brubacher, Jeffrey R ^a,b   DeWitt, Christopher R ^a,c   Lam, George S S ^d   Lawson, Edward J ^d   Erhardt, Gunnar D ^a,e   Purssell, Roy A ^a,b   Kennedy, James R ^a,c   Brignall, Jane L ^a  

^a Drug and Poison Information Centre   (Canada)

^b VANCOUVER GENERAL HOSPITAL   (Canada)

^c ST PAUL S HOSPITAL   (Canada)

^d SURREY MEMORIAL HOSPITAL   (Canada)

^e ROYAL COLUMBIAN HOSPITAL   (Canada)

Author keywords

Adverse effects; Bradycardia; Ethylene glycol; Fomepizole; Hypotension

Indexed keywords

4 METHYLPYRAZOLE; ALCOHOL; ATROPINE; ETHYLENE GLYCOL; LORAZEPAM; MORPHINE; PLASMA SUBSTITUTE;

ADULT; ARTICLE; ATAXIA; BLOOD EXAMINATION; BLOOD PRESSURE MEASUREMENT; BRADYCARDIA; CASE REPORT; CLINICAL FEATURE; COMPUTER ASSISTED TOMOGRAPHY; GLASGOW COMA SCALE; HEMODIALYSIS; HUMAN; HYPOTENSION; INTOXICATION; MALE; METABOLIC ACIDOSIS; SLURRED SPEECH; TREATMENT OUTCOME;

ACIDOSIS; ANTIDOTES; BLOOD PRESSURE; BRADYCARDIA; DOSE-RESPONSE RELATIONSHIP, DRUG; ETHYLENE GLYCOL; HEART RATE; HUMANS; HYPOTENSION; INFUSIONS, INTRAVENOUS; MALE; MIDDLE AGED; PYRAZOLES; RENAL DIALYSIS;

EID: 46249107389     PISSN: 15563650     EISSN: 15569519     Source Type: Journal    
DOI: 10.1080/15563650701725128     Document Type: Article

References (28)

1. Antizol® (fomepizole) injection product monograph. Jazz Pharmaceuticals. Available at: http://antizol.info/monograph.htm. Accessed March 2, 2007.
2. Smithline N, Gardner K. Gaps-anionic and osmolal. The Journal of the American Medical Association. 1976; 236(14):1594-1597.
3. Voyce S, McCaffree D. Pulmonary artery catheters. In: Irwin R, Rippe R, eds. Irwin & Rippe's Intensive Care Medicine (electronic version). 5 ed. Philadelphia: Lippincott Williams & Wilkins; 2003:56.
4. Davenport A. Intradialytic complications during hemodialysis. Hemodialysis International. 2006; 10:162-167.
5. Zoccali C, Tripepi G, Mallamaci F, Panuccio V. The heart rate response pattern to dialysis hypotension in hemodialysis. Nephrology Dialysis Transplantation. 1997; 12:519-523.
6. Magnusson G, Nyberg J, Bodin N, Hansson E. Toxicity of pyrazole and 4- methylpyrazole in mice and rats. Experientia. 1972; 28:1198-1200.
7. Blomstrand R, Ellin A, Lof A, Ostling-Wintzell H. Biological effects and metabolic interactions after chronic and acute administration of 4-methylpyrazole and ethanol to rats. Archives of Biochemistry & Biophysics. Feb 1980; 199(2):591-605.
8. Jacobsen D, Sebastian CS, Barron SK, Carriere EW, McMartin KE. Effects of 4-methylpyrazole, methanol/ethylene glycol antidote, in healthy humans. Journal of Emergency Medicine. 1990; 8(4):455-461.
9. Jacobsen D, Sebastian CS, Blomstrand R, McMartin KE. 4-Methylpyrazole: a controlled study of safety in healthy human subjects after single, ascending doses. Alcoholism: Clinical & Experimental Research. 1988; 12(4):516-522.
10. Brent J, McMartin K, Phillips S, et al. Fomepizole for the treatment of ethylene glycol poisoning. New England Journal of Medicine. 1999; 340(11):832-838.
11. Brent J, McMartin K, Phillips S, Aaron C, Kulig K. Fomepizole for the treatment of methanol poisoning. New England Journal of Medicine. 2001; 344(6):424-429.
12. Baud FJ, Bismuth C, Garnier R, et al. 4-Methylpyrazole may be an alternative to ethanol therapy for ethylene glycol intoxication in man. Journal of Toxicology - Clinical Toxicology. 1986; 24(6):463-483.
13. Baud FJ, Galliot M, Astier A, et al. Treatment of ethylene glycol poisoning with intravenous 4-methylpyrazole. New England Journal of Medicine. 1988; 319(2):97-100.
14. Hantson P, Wallemacq P, Brau M, Vanbinst R, Haufroid V, Mahieu P. Two cases of acute methanol poisoning partially treated by oral 4-methylpyrazole. Intensive Care Medicine. 1999; 25(5):528-531.
15. Megarbane B, Borron SW, Trout H, et al. Treatment of acute methanol poisoning with fomepizole. Intensive Care Medicine. 2001; 27(8):1370-1378.
16. Borron SW, Megarbane B, Baud FJ. Fomepizole in treatment of uncomplicated ethylene glycol poisoning. Lancet. 1999; 354(9181):831.
17. Orth RE. Biologically active pyrazoles. Journal of Pharmaceutical Sciences. 1968; 57(4):537-556.
18. Lieber C, Rubin E, DeCarli L, Misra P, Gang H. Effects of pyrazole on hepatic function and structure. Laboratory Investigation. 1970; 22(6):615-621.
19. Wilson W, Bottiglieri N. Phase I studies with pyrazole. Cancer Chemotherapy Reports. 1962; 21:137-141.
20. Foley H, Shnider B, Gold G, Uzer Y. Phase I studies of pyrazole (NSC-45410). Cancer Chemotherapy Reports. 1965; 44:45-48.
21. Eckle T, Ghanayim N, Trick M, Unertl K, Eltzschig H. Intraoperative metamizol as a cause for acute anaphylactic collapse. European Journal of Anaesthesiology. 2005; 22:810-812.
22. Janke C, Schmeck J, Passani D, Dodidou P, Struck B, Kerger H. Anaphylaktisches herzkreislauf-versagen nach intraoperativer metamizolapplikation. (German, English abstract). Anaesthesist. 2003; 52:321-325.
23. Avellaneda C, Gomez A, Martos F, Rubio M, Sarmiento J, de la Cuesta F. The effect of a single intravenous dose of metamizol 2 g, ketorolac 30 mg and propacetamol 1 g on haemodynamic parameters and postoperative pain after heart surgery. European Journal of Anaesthesiology. 2000; 17:85-90.
24. Gozzoli V, Treggiari M, Kleger G, et al. Randomized trial of the effect of antipyresis by metamizol, propacetamol or external cooling on metabolism, hemodynamics and inflammatory response. Intensive Care Medicine. 2004; 30:401-407.
25. Poblete B, Romand J, Pichard C, Konig P, Suter P. Metabolic effects of i.v. propacetamol, metamizol or external cooling in critically ill febrile sedated patients. British Journal of Anaesthesia. 1997; 78:123-127.
26. Braun R, Buche I, Maier P, Thiele H. Perioperative analgesia with intraoperatively started infusion of high-dose dipyrone in orthopaedic and trauma surgery. Acute Pain. 1999; 2(4):167-171.
27. Kampe S, Warm M, Landwehr S, et al. Clinical equivalence of IV paracetamol compared to IV dipyrone for postoperative analgesia after surgery for breast cancer. Current Medical Research and Opinion. 2006; 22(10):1949-1954.
28. Cruz P, Garutti I, Diaz S, Fernandez-Quero L. Metamizol frente a propacetamol: estudio comparativo de los efectos hemodinámicos y antipiréticos en pacientes críticamente enfermos. (Spanish, English abstract). Revista Española de Anestesiología y Reanimación. 2002; 49:391-396.