Adverse Drug Events Associated With the Antidotes for Methanol and Ethylene Glycol Poisoning: A Comparison of Ethanol and Fomepizole

Annals of Emergency Medicine

Volumn 53, Issue 4, 2009, Pages

  Lepik, Katherine J ^a   Levy, Adrian R ^b,c   Sobolev, Boris G ^b,d   Purssell, Roy A ^a,d   DeWitt, Christopher R ^a,c   Erhardt, Gunnar D ^a,f   Kennedy, James R ^a,e   Daws, Derek E ^a   Brignall, Jane L ^a  

^a British Columbia Drug and Poison Information Centre   (Canada)

^b UNIVERSITY OF BRITISH COLUMBIA   (Canada)

^c ST PAUL S HOSPITAL   (Canada)

^d VANCOUVER GENERAL HOSPITAL   (Canada)

^e Department of Emergency Medicine ^*  (Canada)

^f ROYAL COLUMBIAN HOSPITAL   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

4 METHYLPYRAZOLE; ALCOHOL; ANTIDOTE; ETHYLENE GLYCOL; METHANOL;

ABDOMINAL PAIN; ADOLESCENT; ADULT; AGITATION; ALCOHOL INTOXICATION; ARTICLE; BRADYCARDIA; COMA; CONTROLLED STUDY; DROWSINESS; DRUG INDUCED DISEASE; DRUG SUBSTITUTION; DRUG SURVEILLANCE PROGRAM; FEMALE; HEADACHE; HEART ARREST; HEART ARRHYTHMIA; HEART MUSCLE CONDUCTION DISTURBANCE; HUMAN; HYPOGLYCEMIA; HYPOTENSION; MAJOR CLINICAL STUDY; MALE; MEDICAL RECORD REVIEW; METABOLIC ACIDOSIS; NAUSEA; PAPILLEDEMA; PHLEBITIS; POLYURIA; PRIORITY JOURNAL; RESPIRATION DEPRESSION; RESTLESSNESS; SEIZURE; SIDE EFFECT; STUPOR; TREATMENT DURATION; VIOLENCE; VISUAL IMPAIRMENT; VOMITING;

EID: 62349105974     PISSN: 01960644     EISSN: 10976760     Source Type: Journal    
DOI: 10.1016/j.annemergmed.2008.05.008     Document Type: Article

References (34)

1. Weiner S.W. Toxic alcohols. In: Flomenbaum N.E., Goldfrank L.R., Hoffman R.S., et al. (Eds). Goldfrank's Toxicologic Emergencies. 8th ed. (2006), McGraw-Hill, New York, NY 1447-1459
2. Barceloux D.G., Bond G.R., Krenzelok E.P., et al. American Academy of Clinical Toxicology practice guidelines on the treatment of methanol poisoning. J Toxicol Clin Toxicol 40 (2002) 415-446
3. Barceloux D.G., Krenzelok E.P., Olson K., et al. American Academy of Clinical Toxicology practice guidelines on the treatment of ethylene glycol poisoning. J Toxicol Clin Toxicol 37 (1999) 537-560
4. Bronstein A.C., Spyker D.A., Cantilena J.R., et al. 2006 Annual report of the American Association of Poison Control Centers' National Poison Data System (NPDS). Clin Toxicol 45 (2007) 815-917
5. Brent J. Antidotes and alcohols: has fomepizole made ethanol an obsolete therapy? Internet J Med Toxicol. Available at: http://www.ijmt.net/ijmt/1_1/1_1_2.html. Accessed June 12, 2008.
6. Howland M.A. Antidotes in depth: fomepizole. In: Flomenbaum N.E., Goldfrank L.R., Hoffman R.S., et al. (Eds). Goldfrank's Toxicologic Emergencies. 8th ed. (2006), McGraw-Hill, New York, NY 1460-1464
7. Mycyk M.B., Des Lauriers C., Metz J., et al. Compliance with poison center fomepizole recommendations is suboptimal in cases of toxic alcohol poisoning. Am J Ther 13 (2006) 485-489
8. Green R. The management of severe toxic alcohol ingestion at a tertiary care centre after the introduction of fomepizole. Am J Emerg Med 25 (2007) 799-803
9. Nebeker J.R., Barach P., and Samore M.H. Clarifying adverse drug events: a clinician's guide to terminology, documentation and reporting. Ann Intern Med 140 (2004) 795-801
10. Gordis L. Chort studies. Epidemiology. 2nd ed. (2000), WB Saunders Co, Philadelphia, PA 131-139
11. Knaus W., Draper E., Wagner D., et al. APACHE II: a severity of disease classification system. Crit Care Med 13 (1985) 818-829
12. Persson H.E., Sjoberg G.K., Haines J.A., et al. Poisoning Severity Score. Grading of acute poisoning. J Toxicol Clin Toxicol 36 (1998) 205-209
13. WHO-UMC. Definitions: Serious adverse reaction. World Health Organization Collaborating Centre for International Drug Monitoring: Uppsala Monitoring Centre. April 13, 2006. http://www.who-umc.org/DynPage.aspx?id=22680 Accessed January 11, 2007
14. Jazz Pharmaceuticals. Antizol (fomepizole) injection product monograph. http://antizol.info/monograph.htm Accessed March 2, 2007
15. Kramer M.S. Assessing causality of adverse drug reactions: global introspection and its limitations. Drug Inf J 20 (1986) 433-437
16. WHO-UMC. Causality assessment of suspected adverse reactions. World Health Organization Collaborating Centre for International Drug Monitoring: Uppsala Monitoring Centre. http://www.who-umc.org/DynPage.aspx?id=22682 Accessed February 16, 2007
17. Cox D.R. Regression models and life tables. J R Stat Soc B 34 (1972) 187-220
18. Selvin S. Practical Biostatistical Methods (1995), Duxbury Press, Belmont, CA
19. Peduzzi P., Concato J., Feinstein A.R., et al. Importance of events per independent variable in proportional hazards regression analysis II. Accuracy and precision of regression estimates. J Clin Epidemiol 48 (1995) 1503-1510
20. Landis J.R., and Koch G.G. The measurement of observer agreement for categorical data. Biometrics 33 (1977) 159-174
21. Lepik K.J., Brubacher J.R., DeWitt C.R., et al. Bradycardia and hypotension associated with fomepizole infusion during hemodialysis. Clin Toxicol 46 (2008) 570-573
22. Smithline N., and Gardner K. Gaps: anionic and osmolal. JAMA 236 (1976) 1594-1597
23. Macedo A.F., Marques F.B., Ribeiro C.F., et al. Causality assessment of adverse drug reactions: comparison of the results obtained from published decisional algorithms and from the evaluations of an expert panel, according to different levels of imputability. J Clin Pharm Ther 28 (2003) 137-143
24. Roe O. Clinical investigations of methyl alcohol poisoning with special reference to the pathogenesis and treatment of amblyopia. Acta Med Scand 113 (1943) 558-608
25. Seifert S.A. Ethanol. In: Dart R.C. (Ed). Medical Toxicology. 3rd ed. (2004), Lippincott Williams & Wilkins, Philadelphia, PA 196-199
26. Sivilotti M.L. Ethanol, isopropanol and methanol. In: Dart R.C. (Ed). Medical Toxicology. 3rd ed. (2004), Lippincott Williams & Wilkins, Philadelphia, PA 1211-1230
27. Kowalczyk M., Halvorsen S., Ovrebo S., et al. Ethanol treatment in ethylene glycol poisoned patients. Vet Hum Toxicol 40 (1998) 225-228
28. Meyer R.J., Beard M.E., Ardagh M.W., et al. Methanol poisoning. N Z Med J 113 (2000) 11-13
29. Roy M., Bailey B., Chalut D., et al. What are the adverse effects of ethanol used as an antidote in the treatment of suspected methanol poisoning in children?. J Toxicol Clin Toxicol 41 (2003) 155-161
30. Lister D., Tierney M., and Dickinson G. Effectiveness of IV ethanol therapy combined with hemodialysis in the treatment of methanol and ethylene glycol poisoning. Can J Hosp Pharm 58 (2005) 142-147
31. Paasma R., Hovda K.E., Tikkerberi A., et al. Methanol mass poisoning in Estonia: outbreak in 154 patients. Clin Toxicol 45 (2007) 152-157
32. Brent J., McMartin K., Phillips S., et al. Fomepizole for the treatment of ethylene glycol poisoning. N Engl J Med 340 (1999) 832-838
33. Brent J., McMartin K., Phillips S., et al. Fomepizole for the treatment of methanol poisoning. N Engl J Med 344 (2001) 424-429
34. Jacobsen D., Sebastian C.S., Blomstrand R., et al. 4-Methylpyrazole: a controlled study of safety in healthy human subjects after single, ascending doses. Alcohol Clin Exp Res 12 (1988) 516-522