Incorporation of therapeutic interventions in physiologically based pharmacokinetic modeling of human clinical case reports of accidental or intentional overdosing with ethylene glycol

Toxicological Sciences

Volumn 85, Issue 1, 2005, Pages 491-501

  Corley, Rick A ^a,c   McMartin, K E ^b  

^a PACIFIC NORTHWEST NATIONAL LABORATORY   (United States)

^b LOUISIANA STATE UNIVERSITY HEALTH SCIENCES CENTER   (United States)

^c Biological Monitoring and Modeling   (United States)

Author keywords

Ethanol; Ethylene glycol; Fomepizole; Glycolic acid; Hemodialysis; PBPK modeling

Indexed keywords

4 METHYLPYRAZOLE; ALCOHOL; ALTHESIN; BICARBONATE; CHARCOAL; CLONAZEPAM; DIAZEPAM; ETHYLENE GLYCOL; GLYCOLIC ACID; MAGNESIUM CITRATE; MANNITOL; METHYLPREDNISOLONE; PHENOBARBITAL; PHENYTOIN; THIAMINE;

ADULT; ADULT RESPIRATORY DISTRESS SYNDROME; AGED; ALCOHOL INTOXICATION; ARTICLE; BLOOD SAMPLING; CENTRAL NERVOUS SYSTEM DEPRESSION; CLINICAL ARTICLE; CONTROLLED STUDY; FEMALE; GAS CHROMATOGRAPHY; HEMODIALYSIS; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; MALE; MASS SPECTROMETRY; METABOLIC ACIDOSIS; NEPHROTOXICITY; PRESCHOOL CHILD; SEIZURE; STOMACH LAVAGE; TOXICOKINETICS; URINARY EXCRETION;

ANTIDOTES; ENVIRONMENTAL EXPOSURE; ETHYLENE GLYCOL; EVIDENCE-BASED MEDICINE; HUMANS; INTESTINAL ABSORPTION; METABOLIC DETOXICATION, DRUG; MODELS, BIOLOGICAL; POISONING; RENAL DIALYSIS; RISK ASSESSMENT;

EID: 18144395824     PISSN: 10966080     EISSN: None     Source Type: Journal    
DOI: 10.1093/toxsci/kfi120     Document Type: Article

References (34)

1. Andersen, M. E., Clewell, H. J., III, Gargas, M. L., Smith, E A., and Reitz, R. H. (1987). Physiologically based pharmacokinetics and the risk assessment process for methylene chloride. Toxicol. Appl. Pharmacol. 87, 185-205.
2. Barceloux, D. G., Krenzelok, E. P., Olson, K., and Watson, W. (1999). American Academy of Clinical Toxicology practice guidelines on the treatment of ethylene glycol poisoning. J. Toxicol. Clin. Toxicol. 37, 537-560.
3. Baud, F. J., Bismuth, C., Garnier, R., Galliot, M., Astier, A., Maistre, G., and Soffer, M. (1987). 4-Methylpyrazole may be an alternative to ethanol therapy for ethylene glycol intoxication in man. Clin. Toxicol. 24, 463-483.
4. Baud, F. J., Galliot, M., Astier, A., Bien, D. V., Garnier, R., Likforman, J., and Bismuth, C. (1988). Treatment of ethylene glycol poisoning with intravenous 4-methylpyrazole. N. Engl. J. Med. 319, 97-100.
5. Borron, S. W., Megarbane B., and Baud F. J. (1999). Fomepizole in treatment of uncomplicated ethylene glycol poisoning. Lancet 354, 831.
6. Bowen, D. A. L., Minty, P. S. B., and Sengupta, A. (1978). Two fatal cases of ethylene glycol poisoning. Med. Sci. Law 18, 102-107.
7. Brent, J., McMartin, K., Phillips, S., Burkhart, K. K., Donavon, J. W., Wells, M., and Kulig, K. (1999). Fomepizole for the treatment of ethylene glycol poisoning. N. Engl. J. Med. 340, 832-838.
8. Carney, E. W. (1994). An integrated perspective on the developmental toxicity of ethylene glycol. Reprod. Toxicol. 8, 99-113.
9. Center for the Evaluation of Risks to Human Reproduction (CERHR) (2004). NTP-CERHR monograph on the potential human reproductive and developmental effects of ethylene colycol. NIH Publication No. 04-4481. January, 2004.
10. Cheng, J. T., Beysolow, T. D., Kaul, B., Weisman, R., and Feinfeld, D. A. (1987). Clearance of ethylene glycol by kidneys and hemodialysis. Clin. Toxicol. 25, 95-108.
11. Connally, H. E., Hamar, D. W., and Thrall, M. A. (2000). Inhibition of canine and feline alcohol dehydrogenase activity by fomepizole. Am. J. Vet. Res. 61, 450-455.
12. Corley, R. A., Bartels, M. J., Carney, E. W., Weitz, K. K., Soelberg, J. J., Gies, R. A., and Thrall, K. D. (2005). Development of a physiologically based pharmacokinetic model for ethylene glycol and its developmentally toxic metabolite, glycolic acid, in rats and humans. Toxicol. Sci., in press.
13. Cruzan, G., Corley, R. A., Hard, G. C., Mertens, J. W. M., McMartin, K. E., Snellings, W. B., Gingell, R., and Deyo, J. A. (2004). Subchronic toxicity of ethylene glycol in male Wistar and F344 rats is related to metabolism and clearance of metabolites. Toxicol. Sci. 81, 502-511.
14. Curtain, L., Kraner, J., Wine, H., Savitt, D., and Abuelo, G. (1992). Complete recovery after massive ethylene glycol ingestion. Arch. Intern. Med. 152, 1311-1313.
15. DePass, L. R., Garman, R. H., Woodside, M. D., Giddens, W. E., Maronpot, R. R., and Weil, C. S. (1986). Chronic toxicity and oncogenicity studies of ethylene glycol in rats and mice. Fundam. Appl. Toxicol. 7, 547-565.
16. Eder, A. F., McGrath, C. M., Dowdy, Y. G., Tomaszewski, J. E., Rosenberg, F. M., Wilson, R. B., Wolf, B. A., and Shaw, L. M. (1998). Ethylene glycol poisoning: Toxicokinetic and analytical factors affecting laboratory diagnosis. Clin. Chem. 44, 168-177.
17. Gaunt, I. F., Hardy, J., Gangolli, S. D., Butterworth, K. R., and Lloyd, A. G. (1974). Short-term Toxicity of Monoethylene Glycol in the Rat. BIBRA International, Carshalton, Surrey, U.K. Research Report 4/1974.
18. Gordon, H. L., and Hunter, J. M. (1982). Ethylene glycol poisoning. A case report. Anesthesiologist 37, 332-338.
19. Grauer, G. F., Thrall, M. A. H., Henre, B. A., and Hjelle, J. J. (1987). Comparison of the effects of ethanol and 4-methylpyrazole on the pharmacokinetics and toxicity of ethylene glycol in the dog. Toxicol. Lett. 35, 307-314.
20. Harry, P., Jobard, E., Briand, M., Caubet, A., and Turcant, A. (1998). Ethylene glycol poisoning in a child treated with 4-methylpyrazole. Pediatrics 102, E31.
21. Harry, P., Turcant, A., Bouachour, G., Houze, R, Alquier, P., and Allain, P. (1994). Efficacy of 4-methylpyrazole in ethylene glycol poisoning: Clinical and toxicokinetic aspects. Hum. Exper. Toxicol. 13, 61-64.
22. Hewlett, T. P., and McMartin, K. E. (1986). Ethylene glycol poisoning. The value of glycolic acid determinations for diagnosis and treatment. Clin. Toxicol. 24, 389-402.
23. International Commission on Radiation Protection (ICRP). (1975). Reference Man: Anatomical, Physiological and Metabolic Characteristics. Report of the task group on Reference Man (Snyder, W. S., Cook, M. J., Nasset, E. S., Karhausen, L. R., Howells, G. P., and Tipton, I. H., Eds.). ICRP Publication 23, Elsevier, New York, pp. 354.
24. Jacobsen, D., Hewlett, T. P., Webb, R., Brown, S. T., Ordinario, A. T., and McMartin, K. E. (1988). Ethylene glycol intoxication: Evaluation of kinetics and crystalluria. Am. J. Med. 84, 145-152.
25. Jacobsen, D., Ovrebo, S., Ostborg, J., and Sejersted, O. M. (1984). Glycolate causes the acidosis in ethylene glycol poisoning and is effectively removed by haemodialysis. Acta Med. Scand. 216, 409-416.
26. Li, T. K., and Theorell, H. (1969). Human liver alcohol dehydrogenase: Inhibtion by pyrazole and pyrazole analogs. Acta Chem. Scand. 23, 892-902.
27. Malmlund, H. O., Berg, A., Karlman, G., Magnusson, A., and Ullman, B. (1991). Considerations for the treatment of ethylene glycol poisoning based on analysis of two cases. Clin. Toxicol. 29, 231-240.
28. NTP (National Toxicology Program). (1993). NTP technical report on the toxicology and carcinogenesis studies of ethylene glycol (CAS Nos. 107-21-1) in B6C3F1 mice (feed studies). National Toxicology Program, US Department of Health and Human Services. NIH Publication 93-3144.
29. Pastino, G. M., Asgharian, B., Roberts, K., Medinsky, M. A., and Bond, J. A. (1997). A comparison of physiologically based pharmacokinetic model predictions and experimental data for inhaled ethanol in male and female B6C3F1 mice, F344 rats, and humans. Toxicol. Appl. Pharmacol. 145, 147-157.
30. Pastino, G. M., Flynn, E. J., and Sultatos, L. G. (2000). Genetic polymorphisms in ethanol metabolism: Issues and goals for physiologically based pharmacokinetic modeling. Drug Chem. Toxicol. 23, 179-201.
31. Reynier, M. (1969). Pyrazole inhibition and kinetic studies of ethanol and retinal oxidation catalyzed by rat liver alcohol dehydrogenase. Acta Chem. Scand. 23, 1119-1129.
32. Tardif, R., Lapare, S., Krishnan, K., and Brodeur, J. (1993). Physiologically baesd modeling of the interaction between toluene and m-xylene in the rat. Toxicol. Appl. Pharmacol. 120, 266-273.
33. Tornesi, B., and Carney, E. W. (2003). Changes in pH gradients, protein and osmolarity of the rabbit conceptus during gestation (GD) 9-12. Birth Defects Res. 68, 262.
34. Walder, A. D., and Tyler, C. K. G. (1994). Ethylene glycol antifreeze poisoning. Three case reports and a review of treatment. Anaesthesiologist 49, 964-967.