Oral fomepizole administration to treat ethylene glycol and methanol poisonings: Advantages and limitations

Clinical Toxicology

Volumn 46, Issue 10, 2008, Pages 1097-

  Mégarbane, Bruno ^a   Houzé, Pascal ^b   Baud, Frédéric J ^a  

^a HÔPITAL LARIBOISIÈRE   (France)

^b SAINT LOUIS HOSPITAL   (France)

Author keywords

[No Author keywords available]

Indexed keywords

4 METHYLPYRAZOLE; CHLORIDE; ETHYLENE GLYCOL; METHANOL; SULFATE;

ADULT; ALCOHOL BLOOD LEVEL; ALCOHOL INTOXICATION; BLINDNESS; CLINICAL ARTICLE; CONTROLLED STUDY; DRUG ABSORPTION; DRUG EFFICACY; DRUG SAFETY; DRUG SYNTHESIS; EOSINOPHILIA; FEMALE; HUMAN; INJECTION SITE INFLAMMATION; KIDNEY FAILURE; LETTER; MALE; PRURITUS; RETROSPECTIVE STUDY; SIDE EFFECT; TASTE AVERSION; TREATMENT OUTCOME;

ADMINISTRATION, ORAL; ADULT; ANTIDOTES; ETHYLENE GLYCOL; FEMALE; HUMANS; INJECTIONS, INTRAVENOUS; MALE; METHANOL; MIDDLE AGED; POISONING; PYRAZOLES; RETROSPECTIVE STUDIES;

EID: 57449094253     PISSN: 15563650     EISSN: 15569519     Source Type: Journal    
DOI: 10.1080/15563650802310911     Document Type: Letter

References (5)

1. Marraffa J, Forrest A, Grant W, Stork C, McMartin K, Howland MA. Oral administration of fomepizole produces similar blood levels as identical intravenous dose. Clin Toxicol (Phila) 2008; 46:181-186.
2. Baud FJ, Bismuth C, Garnier R, Galliot M, Astier A, Maistre G, Soffer M. 4-Methylpyrazole may be an alternative to ethanol therapy for ethylene glycol intoxication in man. J Toxicol Clin Toxicol 1986-1987; 24:463-483.
3. Borron SW, Mégarbane B, Baud FJ. Fomepizole in treatment of uncomplicated ethylene glycol poisoning. Lancet 1999; 354:831.
4. Hantson P, Wallemacq P, Brau M, Vanbinst R, Haufroid V, Mahieu P. Two cases of acute methanol poisoning partially treated by oral 4-methylpyrazole. Intensive Care Med 1999; 25:528-531.
5. Caravati EM, Erdman AR, Christianson G, Manoguerra AS, Booze LL, Woolf AD, Olson KR, Chyka PA, Scharman EJ, Wax PM, Keyes DC, Troutman WG. American Association of Poison Control Centers. Ethylene glycol exposure: an evidence-based consensus guideline for out-of-hospital management. Clin Toxicol (Phila) 2005; 43:327-345.