Caenorhabditis elegans generates biologically relevant levels of genotoxic metabolites from aflatoxin B1 but not benzo[a]pyrene in vivo

Toxicological Sciences

Volumn 118, Issue 2, 2010, Pages 444-453

  Leung, Maxwell C K ^a   Goldstone, Jared V ^b   Boyd, Windy A ^c   Freedman, Jonathan H ^c   Meyer, Joel N ^a  

^a DUKE UNIVERSITY   (United States)

^b WOODS HOLE OCEANOGRAPHIC INSTITUTION   (United States)

^c NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES   (United States)

Author keywords

Aflatoxin B1; Benzo a pyrene; Caenorhabditis elegans; Cytochrome P450; Genotoxicity; Nucleotide excision repair

Indexed keywords

AFLATOXIN B1; BENZO[A]PYRENE; CHLORPYRIFOS; CYTOCHROME P450; PROMUTAGEN; XENOBIOTIC AGENT;

ARTICLE; BACTERIAL STRAIN; CAENORHABDITIS ELEGANS; DNA DAMAGE; ENZYME METABOLISM; EXCISION REPAIR; GENE SEQUENCE; GENOTOXICITY; GROWTH INHIBITION; IN VIVO STUDY; NONHUMAN; PHYLOGENY; XENOBIOTIC METABOLISM;

AFLATOXIN B1; ANIMAL TESTING ALTERNATIVES; ANIMALS; BENZO(A)PYRENE; BIOTRANSFORMATION; CAENORHABDITIS ELEGANS; CYTOCHROME P-450 ENZYME SYSTEM; DNA; DNA DAMAGE; DNA REPAIR; MUTAGENS; PHYLOGENY; SPECIES SPECIFICITY;

CAENORHABDITIS ELEGANS; MAMMALIA; NEMATODA;

EID: 78549294219     PISSN: 10966080     EISSN: 10960929     Source Type: Journal    
DOI: 10.1093/toxsci/kfq295     Document Type: Article

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