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Volumn 47, Issue 4, 2010, Pages 331-339

Fatty acids inhibit insulin-mediated glucose transport associated with actin remodeling in rat L6 muscle cells

Author keywords

Actin; Fatty acid; Glucose transporter GLUT4; Insulin; Skeletal muscle cell

Indexed keywords

ACTIN; DEOXYGLUCOSE; GLUCOSE; GLUCOSE TRANSPORTER 4; INSULIN; LINOLEIC ACID; MYC PROTEIN; OLEIC ACID; PALMITIC ACID;

EID: 78549278037     PISSN: 09405429     EISSN: 14325233     Source Type: Journal    
DOI: 10.1007/s00592-010-0225-1     Document Type: Article
Times cited : (4)

References (48)
  • 1
    • 0033927667 scopus 로고    scopus 로고
    • Cellular mechanisms of insulin resistance
    • 1:CAS:528:DC%2BD3cXkvFWhu7k%3D 10.1172/JCI10583 10903330
    • GI Shulman 2000 Cellular mechanisms of insulin resistance J Clin Invest 106 171 176 1:CAS:528:DC%2BD3cXkvFWhu7k%3D 10.1172/JCI10583 10903330
    • (2000) J Clin Invest , vol.106 , pp. 171-176
    • Shulman, G.I.1
  • 2
    • 0028904053 scopus 로고
    • Insulin action and the insulin signaling network
    • 1:CAS:528:DyaK2MXmtFWisrw%3D 7781591
    • B Cheatham CR Kahn 1995 Insulin action and the insulin signaling network Endocr Rev 16 117 142 1:CAS:528:DyaK2MXmtFWisrw%3D 7781591
    • (1995) Endocr Rev , vol.16 , pp. 117-142
    • Cheatham, B.1    Kahn, C.R.2
  • 3
    • 0033913213 scopus 로고    scopus 로고
    • Signaling pathways in insulin action: Molecular targets of insulin resistance
    • 1:CAS:528:DC%2BD3cXkvFWhu7g%3D 10.1172/JCI10582 10903329
    • JE Pessin AR Saltiel 2000 Signaling pathways in insulin action: molecular targets of insulin resistance J Clin Invest 106 165 169 1:CAS:528: DC%2BD3cXkvFWhu7g%3D 10.1172/JCI10582 10903329
    • (2000) J Clin Invest , vol.106 , pp. 165-169
    • Pessin, J.E.1    Saltiel, A.R.2
  • 4
    • 0036723740 scopus 로고    scopus 로고
    • Need for GLUT4 activation to reach maximum effect of insulin-mediated glucose uptake in brown adipocytes isolated from GLUT4myc-expressing mice
    • 1:CAS:528:DC%2BD38Xmslerur8%3D 10.2337/diabetes.51.9.2719 12196464
    • D Konrad PJ Bilan Z Nawaz G Sweeney W Niu Z Liu CN Antonescu A Rudich A Klip 2002 Need for GLUT4 activation to reach maximum effect of insulin-mediated glucose uptake in brown adipocytes isolated from GLUT4myc-expressing mice Diabetes 51 2719 2726 1:CAS:528:DC%2BD38Xmslerur8%3D 10.2337/diabetes.51.9.2719 12196464
    • (2002) Diabetes , vol.51 , pp. 2719-2726
    • Konrad, D.1    Bilan, P.J.2    Nawaz, Z.3    Sweeney, G.4    Niu, W.5    Liu, Z.6    Antonescu, C.N.7    Rudich, A.8    Klip, A.9
  • 5
    • 3543017307 scopus 로고    scopus 로고
    • Intracellular delivery of phosphatidylinositol (3,4,5)-trisphosphate causes incorporation of glucose transporter 4 into the plasma membrane of muscle and fat cells without increasing glucose uptake
    • DOI 10.1074/jbc.M402897200
    • G Sweeney RR Garg RB Ceddia D Li M Ishiki R Somwar LJ Foster PO Neilsen GD Prestwich A Rudich A Klip 2004 Intracellular delivery of phosphatidylinositol (3,4,5)-trisphosphate causes incorporation of glucose transporter 4 into the plasma membrane of muscle and fat cells without increasing glucose uptake J Biol Chem 279 32233 32242 1:CAS:528:DC%2BD2cXmtVChsrY%3D 10.1074/jbc.M402897200 15166230 (Pubitemid 39014672)
    • (2004) Journal of Biological Chemistry , vol.279 , Issue.31 , pp. 32233-32242
    • Sweeney, G.1    Garg, R.R.2    Ceddia, R.B.3    Li, D.4    Ishiki, M.5    Somwar, R.6    Foster, L.J.7    Neilsen, P.O.8    Prestwich, G.D.9    Rudich, A.10    Klip, A.11
  • 6
    • 0036968480 scopus 로고    scopus 로고
    • Activation of the glucose transporter GLUT4 by insulin
    • DOI 10.1139/o02-156
    • LM Furtado R Somwar G Sweeney W Niu A Klip 2002 Activation of the glucose transporter GLUT4 by insulin Biochem Cell Biol 80 569 578 1:CAS:528: DC%2BD38Xos1ais78%3D 10.1139/o02-156 12440698 (Pubitemid 36124818)
    • (2002) Biochemistry and Cell Biology , vol.80 , Issue.5 , pp. 569-578
    • Furtado, L.M.1    Somwar, R.2    Sweeney, G.3    Niu, W.4    Klip, A.5
  • 7
    • 0041413142 scopus 로고    scopus 로고
    • The AMP-activated protein kinase activator AICAR does not induce GLUT4 translocation to transverse tubules but stimulates glucose uptake and p38 mitogen-activated protein kinases α and β in skeletal muscle
    • DOI 10.1096/fj.02-1125com
    • K Lemieux D Konrad A Klip A Marette 2003 The AMP-activated protein kinase activator AICAR does not induce GLUT4 translocation to transverse tubules but stimulates glucose uptake and p38 mitogen-activated protein kinases alpha and beta in skeletal muscle FASEB J 17 1658 1665 10.1096/fj.02-1125com 12958172 (Pubitemid 37100067)
    • (2003) FASEB Journal , vol.17 , Issue.12 , pp. 1658-1665
    • Lemieux, K.1    Konrad, D.2    Klip, A.3    Marette, A.4
  • 8
    • 0038381442 scopus 로고    scopus 로고
    • Maturation of the regulation of GLUT4 activity by p38 MAPK during L6 cell myogenesis
    • DOI 10.1074/jbc.M211136200
    • W Niu C Huang Z Nawaz M Levy R Somwar D Li PJ Bilan A Klip 2003 Maturation of the regulation of GLUT4 activity by p38 MAPK during L6 cell myogenesis J Biol Chem 278 17953 17962 1:CAS:528:DC%2BD3sXjs1Kitbo%3D 10.1074/jbc.M211136200 12637564 (Pubitemid 36799402)
    • (2003) Journal of Biological Chemistry , vol.278 , Issue.20 , pp. 17953-17962
    • Niu, W.1    Huang, C.2    Nawaz, Z.3    Levy, M.4    Somwar, R.5    Li, D.6    Bilan, P.J.7    Klip, A.8
  • 9
    • 0347721775 scopus 로고    scopus 로고
    • A dominant-negative p38 MAPK mutant and novel selective inhibitors of p38 MAPK reduce insulin-stimulated glucose uptake in 3T3-L1 adipocytes without affecting GLUT4 translocation
    • DOI 10.1074/jbc.M205277200
    • R Somwar S Koterski G Sweeney R Sciotti S Djuric C Berg J Trevillyan PE Scherer CM Rondinone A Klip 2002 A dominant-negative p38 MAPK mutant and novel selective inhibitors of p38 MAPK reduce insulin-stimulated glucose uptake in 3T3-L1 adipocytes without affecting GLUT4 translocation J Biol Chem 277 50386 50395 1:CAS:528:DC%2BD38Xps12ns7o%3D 10.1074/jbc.M205277200 12393894 (Pubitemid 36042189)
    • (2002) Journal of Biological Chemistry , vol.277 , Issue.52 , pp. 50386-50395
    • Somwar, R.1    Koterski, S.2    Sweeney, G.3    Sciotti, R.4    Djuric, S.5    Berg, C.6    Trevillyan, J.7    Scherer, P.E.8    Rondinone, C.M.9    Klip, A.10
  • 10
    • 0041659271 scopus 로고    scopus 로고
    • Push/pull mechanisms of GLUT4 traffic in muscle cells
    • DOI 10.1046/j.1365-201X.2003.01163.x
    • A Rudich A Klip 2003 Push/pull mechanisms of GLUT4 traffic in muscle cells Acta Physiol Scand 178 297 308 1:CAS:528:DC%2BD3sXmt1Crtr0%3D 10.1046/j.1365-201X.2003.01163.x 12864734 (Pubitemid 36960420)
    • (2003) Acta Physiologica Scandinavica , vol.178 , Issue.4 , pp. 297-308
    • Rudich, A.1    Klip, A.2
  • 11
    • 0033569673 scopus 로고    scopus 로고
    • Role of the actin cytoskeleton in insulin action
    • DOI 10.1002/(SICI)1097-0029(19991015)47:2<79::AID-JEMT1>3.0.CO;2-S
    • T Tsakiridis P Tong B Matthews E Tsiani PJ Bilan A Klip GP Downey 1999 Role of the actin cytoskeleton in insulin action Microsc Res Tech 47 79 92 1:STN:280:DyaK1MvlsVOltg%3D%3D 10.1002/(SICI)1097-0029(19991015)47:2<79::AID- JEMT1>3.0.CO;2-S 10523787 (Pubitemid 29519817)
    • (1999) Microscopy Research and Technique , vol.47 , Issue.2 , pp. 79-92
    • Tsakiridis, T.1    Tong, P.2    Matthews, B.3    Tsiani, E.4    Bilan, P.J.5    Klip, A.6    Downey, G.P.7
  • 12
    • 0033962410 scopus 로고    scopus 로고
    • Insulin-induced actin filament remodeling colocalizes actin with phosphatidylinositol 3-kinase and GLUT4 in L6 myotubes
    • 1:CAS:528:DC%2BD3cXht1yntLs%3D 10633079
    • ZA Khayat P Tong K Yaworsky RJ Bloch A Klip 2000 Insulin-induced actin filament remodeling colocalizes actin with phosphatidylinositol 3-kinase and GLUT4 in L6 myotubes J Cell Sci 113 279 290 1:CAS:528:DC%2BD3cXht1yntLs%3D 10633079
    • (2000) J Cell Sci , vol.113 , pp. 279-290
    • Khayat, Z.A.1    Tong, P.2    Yaworsky, K.3    Bloch, R.J.4    Klip, A.5
  • 13
    • 0037706869 scopus 로고    scopus 로고
    • Intracellular segregation of phosphatidylinositol-3,4,5-trisphosphate by insulin-dependent actin remodeling in L6 skeletal muscle cells
    • DOI 10.1128/MCB.23.13.4611-4626.2003
    • N Patel A Rudich ZA Khayat R Garg A Klip 2003 Intracellular segregation of phosphatidylinositol-3,4,5-trisphosphate by insulin-dependent actin remodeling in L6 skeletal muscle cells Mol Cell Biol 23 4611 4626 1:CAS:528:DC%2BD3sXltVSit7Y%3D 10.1128/MCB.23.13.4611-4626.2003 12808101 (Pubitemid 36734750)
    • (2003) Molecular and Cellular Biology , vol.23 , Issue.13 , pp. 4611-4626
    • Patel, N.1    Rudich, A.2    Khayat, Z.A.3    Garg, R.4    Klip, A.5
  • 14
    • 0034907579 scopus 로고    scopus 로고
    • Insulin-induced cortical actin remodeling promotes GLUT4 insertion at muscle cell membrane ruffles
    • 1:CAS:528:DC%2BD3MXlvVGltL4%3D 11489930
    • P Tong ZA Khayat C Huang N Patel A Ueyama A Klip 2001 Insulin-induced cortical actin remodeling promotes GLUT4 insertion at muscle cell membrane ruffles J Clin Invest 108 371 381 1:CAS:528:DC%2BD3MXlvVGltL4%3D 11489930
    • (2001) J Clin Invest , vol.108 , pp. 371-381
    • Tong, P.1    Khayat, Z.A.2    Huang, C.3    Patel, N.4    Ueyama, A.5    Klip, A.6
  • 15
    • 0029948212 scopus 로고    scopus 로고
    • Mechanism of free fatty acid-induced insulin resistance in humans
    • 1:CAS:528:DyaK28XjvVWksLw%3D 10.1172/JCI118742 8675698
    • M Roden TB Price G Perseghin KF Petersen DL Rothman GW Cline GI Shulman 1996 Mechanism of free fatty acid-induced insulin resistance in humans J Clin Invest 97 2859 2865 1:CAS:528:DyaK28XjvVWksLw%3D 10.1172/JCI118742 8675698
    • (1996) J Clin Invest , vol.97 , pp. 2859-2865
    • Roden, M.1    Price, T.B.2    Perseghin, G.3    Petersen, K.F.4    Rothman, D.L.5    Cline, G.W.6    Shulman, G.I.7
  • 16
    • 0024392514 scopus 로고
    • Glucose and free fatty acid metabolism in non-insulin-dependent diabetes mellitus. Evidence for multiple sites of insulin resistance
    • 1:CAS:528:DyaL1MXkslGkurc%3D 10.1172/JCI114142 2661589
    • LC Groop RC Bonadonna S DelPrato K Ratheiser K Zyck E Ferrannini RA DeFronzo 1989 Glucose and free fatty acid metabolism in non-insulin-dependent diabetes mellitus. Evidence for multiple sites of insulin resistance J Clin Invest 84 205 213 1:CAS:528:DyaL1MXkslGkurc%3D 10.1172/JCI114142 2661589
    • (1989) J Clin Invest , vol.84 , pp. 205-213
    • Groop, L.C.1    Bonadonna, R.C.2    Delprato, S.3    Ratheiser, K.4    Zyck, K.5    Ferrannini, E.6    Defronzo, R.A.7
  • 17
    • 0027218865 scopus 로고
    • Interaction between glucose and free fatty acid metabolism in human skeletal muscle
    • 1:CAS:528:DyaK3sXlslCnurk%3D 10.1172/JCI116603 8326021
    • DE Kelley M Mokan JA Simoneau LJ Mandarino 1993 Interaction between glucose and free fatty acid metabolism in human skeletal muscle J Clin Invest 92 91 98 1:CAS:528:DyaK3sXlslCnurk%3D 10.1172/JCI116603 8326021
    • (1993) J Clin Invest , vol.92 , pp. 91-98
    • Kelley, D.E.1    Mokan, M.2    Simoneau, J.A.3    Mandarino, L.J.4
  • 19
  • 20
    • 14644435061 scopus 로고    scopus 로고
    • Differential utilization of saturated palmitate and unsaturated oleate: Evidence from cultured myotubes
    • DOI 10.2337/diabetes.54.3.648
    • M Gaster AC Rustan H Beck-Nielsen 2005 Differential utilization of saturated palmitate and unsaturated oleate: evidence from cultured myotubes Diabetes 54 648 656 1:CAS:528:DC%2BD2MXitlegsr8%3D 10.2337/diabetes.54.3.648 15734839 (Pubitemid 40322066)
    • (2005) Diabetes , vol.54 , Issue.3 , pp. 648-656
    • Gaster, M.1    Rustan, A.C.2    Beck-Nielsen, H.3
  • 21
    • 0033952722 scopus 로고    scopus 로고
    • Insulin resistance directly correlates with increased saturated fatty acids in skeletal muscle triglycerides
    • 1:CAS:528:DC%2BD3cXht1yht7s%3D 10.1016/S0026-0495(00)91377-5 10690948
    • M Manco G Mingrone AV Greco E Capristo D Gniuli A De Gaetano G Gasbarrini 2000 Insulin resistance directly correlates with increased saturated fatty acids in skeletal muscle triglycerides Metabolism 49 220 224 1:CAS:528:DC%2BD3cXht1yht7s%3D 10.1016/S0026-0495(00)91377-5 10690948
    • (2000) Metabolism , vol.49 , pp. 220-224
    • Manco, M.1    Mingrone, G.2    Greco, A.V.3    Capristo, E.4    Gniuli, D.5    De Gaetano, A.6    Gasbarrini, G.7
  • 22
    • 0028071690 scopus 로고
    • Insulin sensitivity is related to the fatty acid composition of serum lipids and skeletal muscle phospholipids in 70-year-old men
    • 1:CAS:528:DyaK2cXmvFeht7o%3D 10.1007/BF00400468 7851683
    • B Vessby S Tengblad H Lithell 1994 Insulin sensitivity is related to the fatty acid composition of serum lipids and skeletal muscle phospholipids in 70-year-old men Diabetologia 37 1044 1050 1:CAS:528:DyaK2cXmvFeht7o%3D 10.1007/BF00400468 7851683
    • (1994) Diabetologia , vol.37 , pp. 1044-1050
    • Vessby, B.1    Tengblad, S.2    Lithell, H.3
  • 24
    • 0032496396 scopus 로고    scopus 로고
    • GLUT4 translocation by insulin in intact muscle cells: Detection by a fast and quantitative assay
    • DOI 10.1016/S0014-5793(98)00423-2, PII S0014579398004232
    • Q Wang Z Khayat K Kishi Y Ebina A Klip 1998 GLUT4 translocation by insulin in intact muscle cells: detection by a fast and quantitative assay FEBS Lett 427 193 197 1:CAS:528:DyaK1cXjtVKjtLc%3D 10.1016/S0014-5793(98)00423-2 9607310 (Pubitemid 28225056)
    • (1998) FEBS Letters , vol.427 , Issue.2 , pp. 193-197
    • Wang, Q.1    Khayat, Z.2    Kishi, K.3    Ebina, Y.4    Klip, A.5
  • 25
    • 0020476679 scopus 로고
    • Hexose transport in L6 muscle cells. Kinetic properties and the number of [3H]cytochalasin B binding sites
    • 1:CAS:528:DyaL38XhvFOju74%3D 10.1016/0005-2736(82)90555-7 7093257
    • A Klip WJ Logan G Li 1982 Hexose transport in L6 muscle cells. Kinetic properties and the number of [3H]cytochalasin B binding sites Biochim Biophys Acta 687 265 280 1:CAS:528:DyaL38XhvFOju74%3D 10.1016/0005-2736(82)90555-7 7093257
    • (1982) Biochim Biophys Acta , vol.687 , pp. 265-280
    • Klip, A.1    Logan, W.J.2    Li, G.3
  • 26
    • 13544272049 scopus 로고    scopus 로고
    • Evidence for a role of the exocyst in insulin-stimulated Glut4 trafficking in 3T3-L1 adipocytes
    • DOI 10.1074/jbc.M409928200
    • MA Ewart M Clarke S Kane LH Chamberlain GW Gould 2005 Evidence for a role of the exocyst in insulin-stimulated Glut4 trafficking in 3T3-L1 adipocytes J Biol Chem 280 3812 3816 1:CAS:528:DC%2BD2MXovVGmug%3D%3D 10.1074/jbc.M409928200 15550383 (Pubitemid 40223850)
    • (2005) Journal of Biological Chemistry , vol.280 , Issue.5 , pp. 3812-3816
    • Ewart, M.-A.1    Clarke, M.2    Kane, S.3    Chamberlain, L.H.4    Gould, G.W.5
  • 27
    • 0025766692 scopus 로고
    • Palmitate stimulates glucose transport in rat adipocytes by a mechanism involving translocation of the insulin sensitive glucose transporter (GLUT4)
    • 1:CAS:528:DyaK3MXkvV2rsLo%3D 10.1016/0006-291X(91)91989-P 1710451
    • RW Hardy JH Ladenson EJ Henriksen JO Holloszy JM McDonald 1991 Palmitate stimulates glucose transport in rat adipocytes by a mechanism involving translocation of the insulin sensitive glucose transporter (GLUT4) Biochem Biophys Res Commun 177 343 349 1:CAS:528:DyaK3MXkvV2rsLo%3D 10.1016/0006- 291X(91)91989-P 1710451
    • (1991) Biochem Biophys Res Commun , vol.177 , pp. 343-349
    • Hardy, R.W.1    Ladenson, J.H.2    Henriksen, E.J.3    Holloszy, J.O.4    McDonald, J.M.5
  • 28
    • 0021806545 scopus 로고
    • Insulin-like stimulation of glucose transport in isolated adipocytes by fatty acids
    • 1:CAS:528:DyaL2MXkt1Sntrk%3D 10.1016/0006-291X(85)91090-3 3890851
    • HG Joost HJ Steinfelder 1985 Insulin-like stimulation of glucose transport in isolated adipocytes by fatty acids Biochem Biophys Res Commun 128 1358 1363 1:CAS:528:DyaL2MXkt1Sntrk%3D 10.1016/0006-291X(85)91090-3 3890851
    • (1985) Biochem Biophys Res Commun , vol.128 , pp. 1358-1363
    • Joost, H.G.1    Steinfelder, H.J.2
  • 29
    • 4744344777 scopus 로고    scopus 로고
    • Fatty acid-induced insulin resistance in L6 myotubes is prevented by inhibition of activation and nuclear localization of nuclear factor κB
    • DOI 10.1074/jbc.M406514200
    • S Sinha G Perdomo NF Brown RM O'Doherty 2004 Fatty acid-induced insulin resistance in L6 myotubes is prevented by inhibition of activation and nuclear localization of nuclear factor kappa B J Biol Chem 279 41294 41301 1:CAS:528:DC%2BD2cXnvFWhsb4%3D 10.1074/jbc.M406514200 15252018 (Pubitemid 39313568)
    • (2004) Journal of Biological Chemistry , vol.279 , Issue.40 , pp. 41294-41301
    • Sinha, S.1    Perdomo, G.2    Brown, N.F.3    O'Doherty, R.M.4
  • 30
    • 0038755467 scopus 로고    scopus 로고
    • High levels of palmitic acid lead to insulin resistance due to changes in the level of phosphorylation of the insulin receptor and insulin receptor substrate-1
    • DOI 10.1023/A:1023423005187
    • R Reynoso LM Salgado V Calderon 2003 High levels of palmitic acid lead to insulin resistance due to changes in the level of phosphorylation of the insulin receptor and insulin receptor substrate-1 Mol Cell Biochem 246 155 162 1:CAS:528:DC%2BD3sXjtFKmsbg%3D 10.1023/A:1023423005187 12841357 (Pubitemid 36798736)
    • (2003) Molecular and Cellular Biochemistry , vol.246 , Issue.1-2 , pp. 155-162
    • Reynoso, R.1    Salgado, L.M.2    Calderon, V.3
  • 31
    • 2642561229 scopus 로고    scopus 로고
    • Palmitate, but not unsaturated fatty acids, induces the expression of interleukin-6 in human myotubes through proteasome-dependent activation of nuclear factor-κB
    • DOI 10.1074/jbc.M312692200
    • C Weigert K Brodbeck H Staiger C Kausch F Machicao HU Haring ED Schleicher 2004 Palmitate, but not unsaturated fatty acids, induces the expression of interleukin-6 in human myotubes through proteasome-dependent activation of nuclear factor-kappaB J Biol Chem 279 23942 23952 1:CAS:528:DC%2BD2cXksV2isrw%3D 10.1074/jbc.M312692200 15028733 (Pubitemid 38725252)
    • (2004) Journal of Biological Chemistry , vol.279 , Issue.23 , pp. 23942-23952
    • Weigert, C.1    Brodbeck, K.2    Staiger, H.3    Kausch, C.4    Machicao, F.5    Haring, H.U.6    Schleicher, E.D.7
  • 33
    • 0033588253 scopus 로고    scopus 로고
    • Ceramide generation is sufficient to account for the inhibition of the insulin-stimulated PKB pathway in C2C12 skeletal muscle cells pretreated with palmitate
    • DOI 10.1074/jbc.274.34.24202
    • C Schmitz-Peiffer DL Craig TJ Biden 1999 Ceramide generation is sufficient to account for the inhibition of the insulin-stimulated PKB pathway in C2C12 skeletal muscle cells pretreated with palmitate J Biol Chem 274 24202 24210 1:CAS:528:DyaK1MXlsVOnurw%3D 10.1074/jbc.274.34.24202 10446195 (Pubitemid 29390356)
    • (1999) Journal of Biological Chemistry , vol.274 , Issue.34 , pp. 24202-24210
    • Schmitz-Peiffer, C.1    Craig, D.L.2    Biden, T.J.3
  • 34
    • 0034804625 scopus 로고    scopus 로고
    • Conjugated linoleic acid supplementation in humans-metabolic effects
    • 1:CAS:528:DC%2BD3MXnsVyrurc%3D 10.1007/s11745-001-0784-7 11592727
    • A Smedman B Vessby 2001 Conjugated linoleic acid supplementation in humans-metabolic effects Lipids 36 773 781 1:CAS:528:DC%2BD3MXnsVyrurc%3D 10.1007/s11745-001-0784-7 11592727
    • (2001) Lipids , vol.36 , pp. 773-781
    • Smedman, A.1    Vessby, B.2
  • 35
    • 0031594368 scopus 로고    scopus 로고
    • 31P NMR studies on the mechanism of insulin resistance in obesity
    • DOI 10.2337/diabetes.47.3.381
    • KF Petersen R Hendler T Price G Perseghin DL Rothman N Held JM Amatruda GI Shulman 1998 13C/31P NMR studies on the mechanism of insulin resistance in obesity Diabetes 47 381 386 1:CAS:528:DyaK1cXhs1aqtbo%3D 10.2337/diabetes.47.3. 381 9519743 (Pubitemid 28104199)
    • (1998) Diabetes , vol.47 , Issue.3 , pp. 381-386
    • Petersen, K.F.1    Hendler, R.2    Price, T.3    Perseghin, G.4    Rothman, D.L.5    Held, N.6    Amatruda, J.M.7    Shulman, G.I.8
  • 36
    • 0026611962 scopus 로고
    • 31P nuclear magnetic resonance measurements of muscle glucose-6-phosphate. Evidence for reduced insulin-dependent muscle glucose transport or phosphorylation activity in non-insulin-dependent diabetes mellitus
    • 1:CAS:528:DyaK38XitFahtrs%3D 10.1172/JCI115686 1556176
    • DL Rothman RG Shulman GI Shulman 1992 31P nuclear magnetic resonance measurements of muscle glucose-6-phosphate. Evidence for reduced insulin-dependent muscle glucose transport or phosphorylation activity in non-insulin-dependent diabetes mellitus J Clin Invest 89 1069 1075 1:CAS:528:DyaK38XitFahtrs%3D 10.1172/JCI115686 1556176
    • (1992) J Clin Invest , vol.89 , pp. 1069-1075
    • Rothman, D.L.1    Shulman, R.G.2    Shulman, G.I.3
  • 37
    • 0028809238 scopus 로고
    • Decreased muscle glucose transport/phosphorylation is an early defect in the pathogenesis of non-insulin-dependent diabetes mellitus
    • 1:CAS:528:DyaK2MXjslehurY%3D 10.1073/pnas.92.4.983 7862678
    • DL Rothman I Magnusson G Cline D Gerard CR Kahn RG Shulman GI Shulman 1995 Decreased muscle glucose transport/phosphorylation is an early defect in the pathogenesis of non-insulin-dependent diabetes mellitus Proc Natl Acad Sci USA 92 983 987 1:CAS:528:DyaK2MXjslehurY%3D 10.1073/pnas.92.4.983 7862678
    • (1995) Proc Natl Acad Sci USA , vol.92 , pp. 983-987
    • Rothman, D.L.1    Magnusson, I.2    Cline, G.3    Gerard, D.4    Kahn, C.R.5    Shulman, R.G.6    Shulman, G.I.7
  • 38
    • 48549086608 scopus 로고    scopus 로고
    • Adipocytes in subjects with impaired fasting glucose and impaired glucose tolerance are resistant to the anti-lipolytic effect of insulin
    • 1:CAS:528:DC%2BD1cXpt1Smsr0%3D 10.1007/s00592-008-0033-z 18357404
    • MA Abdul-Ghani M Molina-Carrion R Jani C Jenkinson RA Defronzo 2008 Adipocytes in subjects with impaired fasting glucose and impaired glucose tolerance are resistant to the anti-lipolytic effect of insulin Acta Diabetol 45 147 150 1:CAS:528:DC%2BD1cXpt1Smsr0%3D 10.1007/s00592-008-0033-z 18357404
    • (2008) Acta Diabetol , vol.45 , pp. 147-150
    • Abdul-Ghani, M.A.1    Molina-Carrion, M.2    Jani, R.3    Jenkinson, C.4    Defronzo, R.A.5
  • 39
    • 78751588732 scopus 로고    scopus 로고
    • Analysis of the membrane fluidity of erythrocyte ghosts in diabetic, spontaneously hypertensive rats
    • doi: 10.1007/s00592-009-0120-9
    • Perez-Hernandez IH, Avendano-Flores YS, Mejia-Zepeda R (2009) Analysis of the membrane fluidity of erythrocyte ghosts in diabetic, spontaneously hypertensive rats. Acta Diabetol. doi: 10.1007/s00592-009-0120-9
    • (2009) Acta Diabetol
    • Perez-Hernandez, I.H.1    Avendano-Flores, Y.S.2    Mejia-Zepeda, R.3
  • 40
    • 0023240831 scopus 로고
    • Fish oil prevents insulin resistance induced by high-fat feeding in rats
    • 1:STN:280:DyaL2s3pt1WitQ%3D%3D 10.1126/science.3303333 3303333
    • LH Storlien EW Kraegen DJ Chisholm GL Ford DG Bruce WS Pascoe 1987 Fish oil prevents insulin resistance induced by high-fat feeding in rats Science 237 885 888 1:STN:280:DyaL2s3pt1WitQ%3D%3D 10.1126/science.3303333 3303333
    • (1987) Science , vol.237 , pp. 885-888
    • Storlien, L.H.1    Kraegen, E.W.2    Chisholm, D.J.3    Ford, G.L.4    Bruce, D.G.5    Pascoe, W.S.6
  • 41
    • 0035002369 scopus 로고    scopus 로고
    • Insulin resistance and the disruption of Glut4 trafficking in skeletal muscle
    • 1:CAS:528:DC%2BD3MXjsl2nsbk%3D 10.1172/JCI13020 11375407
    • M Mueckler 2001 Insulin resistance and the disruption of Glut4 trafficking in skeletal muscle J Clin Invest 107 1211 1213 1:CAS:528: DC%2BD3MXjsl2nsbk%3D 10.1172/JCI13020 11375407
    • (2001) J Clin Invest , vol.107 , pp. 1211-1213
    • Mueckler, M.1
  • 42
    • 0029057886 scopus 로고
    • Regulation of cell surface GLUT1, GLUT3, and GLUT4 by insulin and IGF-I in L6 myotubes
    • 1:CAS:528:DyaK2MXmvVemsrk%3D 10.1016/0014-5793(95)00589-2 7615080
    • CM Wilson Y Mitsumoto F Maher A Klip 1995 Regulation of cell surface GLUT1, GLUT3, and GLUT4 by insulin and IGF-I in L6 myotubes FEBS Lett 368 19 22 1:CAS:528:DyaK2MXmvVemsrk%3D 10.1016/0014-5793(95)00589-2 7615080
    • (1995) FEBS Lett , vol.368 , pp. 19-22
    • Wilson, C.M.1    Mitsumoto, Y.2    Maher, F.3    Klip, A.4
  • 43
    • 0031046769 scopus 로고    scopus 로고
    • Insulin regulation and selective segregation with glucose transporter-4 of the membrane aminopeptidase vp165 in rat skeletal muscle cells
    • DOI 10.1210/en.138.3.1029
    • S Sumitani T Ramlal R Somwar SR Keller A Klip 1997 Insulin regulation and selective segregation with glucose transporter-4 of the membrane aminopeptidase vp165 in rat skeletal muscle cells Endocrinology 138 1029 1034 1:CAS:528:DyaK2sXht1Orurg%3D 10.1210/en.138.3.1029 9048605 (Pubitemid 27089756)
    • (1997) Endocrinology , vol.138 , Issue.3 , pp. 1029-1034
    • Sumitani, S.1    Ramlal, T.2    Somwar, R.3    Keller, S.R.4    Klip, A.5
  • 44
    • 0035824626 scopus 로고    scopus 로고
    • Differential effects of phosphatidylinositol 3-kinase inhibition on intracellular signals regulating GLUT4 translocation and glucose transport
    • 1:CAS:528:DC%2BD3MXptVymsbY%3D 10.1074/jbc.M109093200 11598141
    • R Somwar W Niu DY Kim G Sweeney VK Randhawa C Huang T Ramlal A Klip 2001 Differential effects of phosphatidylinositol 3-kinase inhibition on intracellular signals regulating GLUT4 translocation and glucose transport J Biol Chem 276 46079 46087 1:CAS:528:DC%2BD3MXptVymsbY%3D 10.1074/jbc.M109093200 11598141
    • (2001) J Biol Chem , vol.276 , pp. 46079-46087
    • Somwar, R.1    Niu, W.2    Kim, D.Y.3    Sweeney, G.4    Randhawa, V.K.5    Huang, C.6    Ramlal, T.7    Klip, A.8
  • 45
    • 0035504158 scopus 로고    scopus 로고
    • GLUT4 translocation precedes the stimulation of glucose uptake by insulin in muscle cells: Potential activation of GLUT4 via p38 mitogen-activated protein kinase
    • DOI 10.1042/0264-6021:3590639
    • R Somwar DY Kim G Sweeney C Huang W Niu C Lador T Ramlal A Klip 2001 GLUT4 translocation precedes the stimulation of glucose uptake by insulin in muscle cells: potential activation of GLUT4 via p38 mitogen-activated protein kinase Biochem J 359 639 649 1:CAS:528:DC%2BD3MXovVSisbw%3D 10.1042/0264-6021: 3590639 11672439 (Pubitemid 33063389)
    • (2001) Biochemical Journal , vol.359 , Issue.3 , pp. 639-649
    • Somwar, R.1    Kim, D.Y.2    Sweeney, G.3    Huang, C.4    Niu, W.5    Lador, C.6    Ramlal, T.7    Klip, A.8
  • 46
    • 0035827642 scopus 로고    scopus 로고
    • MKK6/3 and p38 MAPK pathway activation is not necessary for insulin-induced glucose uptake but regulates glucose transporter expression
    • 1:CAS:528:DC%2BD3MXktlKgtbY%3D 10.1074/jbc.M101087200 11279172
    • M Fujishiro Y Gotoh H Katagiri H Sakoda T Ogihara M Anai Y Onishi H Ono M Funaki K Inukai Y Fukushima M Kikuchi Y Oka T Asano 2001 MKK6/3 and p38 MAPK pathway activation is not necessary for insulin-induced glucose uptake but regulates glucose transporter expression J Biol Chem 276 19800 19806 1:CAS:528:DC%2BD3MXktlKgtbY%3D 10.1074/jbc.M101087200 11279172
    • (2001) J Biol Chem , vol.276 , pp. 19800-19806
    • Fujishiro, M.1    Gotoh, Y.2    Katagiri, H.3    Sakoda, H.4    Ogihara, T.5    Anai, M.6    Onishi, Y.7    Ono, H.8    Funaki, M.9    Inukai, K.10    Fukushima, Y.11    Kikuchi, M.12    Oka, Y.13    Asano, T.14
  • 47
    • 0942298232 scopus 로고    scopus 로고
    • P38gamma MAPK regulation of glucose transporter expression and glucose uptake in L6 myotubes and mouse skeletal muscle
    • 1:CAS:528:DC%2BD2cXhsFKru7g%3D 14592936
    • RC Ho O Alcazar N Fujii MF Hirshman LJ Goodyear 2004 p38gamma MAPK regulation of glucose transporter expression and glucose uptake in L6 myotubes and mouse skeletal muscle Am J Physiol Regul Integr Comp Physiol 286 R342 R349 1:CAS:528:DC%2BD2cXhsFKru7g%3D 14592936
    • (2004) Am J Physiol Regul Integr Comp Physiol , vol.286
    • Ho, R.C.1    Alcazar, O.2    Fujii, N.3    Hirshman, M.F.4    Goodyear, L.J.5
  • 48
    • 0033537853 scopus 로고    scopus 로고
    • An inhibitor of p38 mitogen-activated protein kinase prevents insulin- stimulated glucose transport but not glucose transporter translocation in 3T3-L1 adipocytes and L6 myotubes
    • DOI 10.1074/jbc.274.15.10071
    • G Sweeney R Somwar T Ramlal A Volchuk A Ueyama A Klip 1999 An inhibitor of p38 mitogen-activated protein kinase prevents insulin-stimulated glucose transport but not glucose transporter translocation in 3T3-L1 adipocytes and L6 myotubes J Biol Chem 274 10071 10078 1:CAS:528:DyaK1MXis1Gjtrs%3D 10.1074/jbc.274.15.10071 10187787 (Pubitemid 29180874)
    • (1999) Journal of Biological Chemistry , vol.274 , Issue.15 , pp. 10071-10078
    • Sweeney, G.1    Somwar, R.2    Ramlal, T.3    Volchuk, A.4    Ueyama, A.5    Klip, A.6


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