LPS-induced dissociation of multidrug resistance-associated protein 2 (Mrp2) and radixin is associated with Mrp2 selective internalization in rats

Biochemical Pharmacology

Volumn 81, Issue 1, 2011, Pages 178-184

  Saeki, Junjiro ^a   Sekine, Shuichi ^a   Horie, Toshiharu ^a  

^a CHIBA UNIVERSITY   (Japan)

Author keywords

Biliary transporter; Cholestasis; Internalization; LPS; Radixin

Indexed keywords

LIPOPOLYSACCHARIDE; MULTIDRUG RESISTANCE PROTEIN 2; RADIXIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CHOLESTASIS; CONTROLLED STUDY; DISSOCIATION; IMMUNOPRECIPITATION; INTERNALIZATION; LIVER FAILURE; MALE; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; PROTEIN PHOSPHORYLATION; PROTEIN PROTEIN INTERACTION; RAT;

ANIMALS; ATP-BINDING CASSETTE TRANSPORTERS; CHOLESTASIS; CYTOSKELETAL PROTEINS; LIPOPOLYSACCHARIDES; LIVER; MEMBRANE PROTEINS; MULTIDRUG RESISTANCE-ASSOCIATED PROTEINS; P-GLYCOPROTEIN; PHOSPHORYLATION; RATS; RNA PROCESSING, POST-TRANSCRIPTIONAL;

EID: 78549258081     PISSN: 00062952     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bcp.2010.09.016     Document Type: Article

References (36)

1. Jedlitschky G., Leier I., Buchholz U., Hummel-Eisenbeiss J., Burchell B., Keppler D. ATP-dependent transport of bilirubin glucuronides by the multidrug resistance protein MRP1 and its hepatocyte canalicular isoform MRP2. Biochem J 1997, 327(Pt 1):305-310.
2. Aboutwerat A., Pemberton P.W., Smith A., Burrows P.C., McMahon R.F., Jain S.K., et al. Oxidant stress is a significant feature of primary biliary cirrhosis. Biochim Biophys Acta 2003, 1637(2):142-150.
3. Maki A., Kono H., Gupta M., Asakawa M., Suzuki T., Matsuda M., et al. Predictive power of biomarkers of oxidative stress and inflammation in patients with hepatitis C virus-associated hepatocellular carcinoma. Ann Surg Oncol 2007, 14(3):1182-1190.
4. Kojima H., Nies A.T., Konig J., Hagmann W., Spring H., Uemura M., et al. Changes in the expression and localization of hepatocellular transporters and radixin in primary biliary cirrhosis. J Hepatol 2003, 39(5):693-702.
5. Paulusma C.C., Kothe M.J., Bakker C.T., Bosma P.J., van Bokhoven I., van Marle J., et al. Zonal down-regulation and redistribution of the multidrug resistance protein 2 during bile duct ligation in rat liver. Hepatology 2000, 31(3):684-693.
6. Beuers U., Bilzer M., Chittattu A., Kullak-Ublick G.A., Keppler D., Paumgartner G., et al. Tauroursodeoxycholic acid inserts the apical conjugate export pump, Mrp2, into canalicular membranes and stimulates organic anion secretion by protein kinase C-dependent mechanisms in cholestatic rat liver. Hepatology 2001, 33(5):1206-1216.
7. Mottino A.D., Cao J., Veggi L.M., Crocenzi F., Roma M.G., Vore M. Altered localization and activity of canalicular Mrp2 in estradiol-17beta-d-glucuronide-induced cholestasis. Hepatology 2002, 35(6):1409-1419.
8. Rost D., Kartenbeck J., Keppler D. Changes in the localization of the rat canalicular conjugate export pump Mrp2 in phalloidin-induced cholestasis. Hepatology 1999, 29(3):814-821.
9. Ji B., Ito K., Sekine S., Tajima A., Horie T. Ethacrynic-acid-induced glutathione depletion and oxidative stress in normal and Mrp2-deficient rat liver. Free Radic Biol Med 2004, 37(11):1718-1729.
10. Sekine S., Ito K., Horie T. Oxidative stress and Mrp2 internalization. Free Radic Biol Med 2006, 40(12):2166-2174.
11. Sekine S., Ito K., Horie T. Canalicular Mrp2 localization is reversibly regulated by the intracellular redox status. Am J Physiol Gastrointest Liver Physiol 2008, 295(5):G1035-G1041.
12. Kubitz R., Wettstein M., Warskulat U., Haussinger D. Regulation of the multidrug resistance protein 2 in the rat liver by lipopolysaccharide and dexamethasone. Gastroenterology 1999, 116(2):401-410.
13. Yano K., Sekine S., Nemoto K., Fuwa T., Horie T. The effect of dimerumic acid on LPS-induced downregulation of Mrp2 in the rat. Biochem Pharmacol 2010, 80(4):533-539.
14. Ishikawa H., Tamura A., Matsui T., Sasaki H., Hakoshima T., Tsukita S., et al. Structural conversion between open and closed forms of radixin: low-angle shadowing electron microscopy. J Mol Biol 2001, 310(5):973-978.
15. Kikuchi S., Hata M., Fukumoto K., Yamane Y., Matsui T., Tamura A., et al. Radixin deficiency causes conjugated hyperbilirubinemia with loss of Mrp2 from bile canalicular membranes. Nat Genet 2002, 31(3):320-325.
16. Kojima H., Sakurai S., Uemura M., Kitamura K., Kanno H., Nakai Y., et al. Disturbed colocalization of multidrug resistance protein 2 and radixin in human cholestatic liver diseases. J Gastroenterol Hepatol 2008, 23(7 Pt 2):e120-e128.
17. Kojima H., Sakurai S., Yoshiji H., Uemura M., Yoshikawa M., Fukui H. The role of radixin in altered localization of canalicular conjugate export pump Mrp2 in cholestatic rat liver. Hepatol Res 2008, 38(2):202-210.
18. Rost D., Kloeters-Plachky P., Stiehl A. Retrieval of the rat canalicular conjugate export pump Mrp2 is associated with a rearrangement of actin filaments and radixin in bile salt-induced cholestasis. Eur J Med Res 2008, 13(7):314-318.
19. Nakano T., Sekine S., Ito K., Horie T. Correlation between apical localization of Abcc2/Mrp2 and phosphorylation status of ezrin in rat intestine. Drug Metab Dispos 2009, 37(7):1521-1527.
20. Akita H., Suzuki H., Ito K., Kinoshita S., Sato N., Takikawa H., et al. Characterization of bile acid transport mediated by multidrug resistance associated protein 2 and bile salt export pump. Biochim Biophys Acta 2001, 1511(1):7-16.
21. Doi Y., Itoh M., Yonemura S., Ishihara S., Takano H., Noda T., et al. Normal development of mice and unimpaired cell adhesion/cell motility/actin-based cytoskeleton without compensatory up-regulation of ezrin or radixin in moesin gene knockout. J Biol Chem 1999, 274(4):2315-2321.
22. Vos T.A., Hooiveld G.J., Koning H., Childs S., Meijer D.K., Moshage H., et al. Up-regulation of the multidrug resistance genes, Mrp1 and Mdr1b, and down-regulation of the organic anion transporter, Mrp2, and the bile salt transporter, Spgp, in endotoxemic rat liver. Hepatology 1998, 28(6):1637-1644.
23. Yang Q., Onuki R., Nakai C., Sugiyama Y. Ezrin and radixin both regulate the apical membrane localization of ABCC2 (MRP2) in human intestinal epithelial Caco-2 cells. Exp Cell Res 2007, 313(16):3517-3525.
24. Roma M.G., Milkiewicz P., Elias E., Coleman R. Control by signaling modulators of the sorting of canalicular transporters in rat hepatocyte couplets: role of the cytoskeleton. Hepatology 2000, 32(6):1342-1356.
25. 2+-dependent protein kinase C isoforms induce cholestasis in rat liver. J Biol Chem 2004, 279(11):10323-10330.
26. Kubitz R., Sutfels G., Kuhlkamp T., Kolling R., Haussinger D. Trafficking of the bile salt export pump from the Golgi to the canalicular membrane is regulated by the p38 MAP kinase. Gastroenterology 2004, 126(2):541-553.
27. Shoda J., Miura T., Utsunomiya H., Oda K., Yamamoto M., Kano M., et al. Genipin enhances Mrp2 (Abcc2)-mediated bile formation and organic anion transport in rat liver. Hepatology 2004, 39(1):167-178.
28. Crocenzi F.A., Mottino A.D., Roma M.G. Regulation of synthesis and trafficking of canalicular transporters and its alteration in acquired hepatocellular cholestasis. Experimental therapeutic strategies for its prevention. Curr Med Chem 2004, 11(4):501-524.
29. Harris M.J., Kuwano M., Webb M., Board P.G. Identification of the apical membrane-targeting signal of the multidrug resistance-associated protein 2 (MRP2/MOAT). J Biol Chem 2001, 276(24):20876-20881.
30. Kocher O., Comella N., Gilchrist A., Pal R., Tognazzi K., Brown L.F., et al. PDZK1, a novel PDZ domain-containing protein up-regulated in carcinomas and mapped to chromosome 1q21, interacts with cMOAT (MRP2), the multidrug resistance-associated protein. Lab Invest 1999, 79(9):1161-1170.
31. Luciani F., Molinari A., Lozupone F., Calcabrini A., Lugini L., Stringaro A., et al. P-glycoprotein-actin association through ERM family proteins: a role in P-glycoprotein function in human cells of lymphoid origin. Blood 2002, 99(2):641-648.
32. Lee J.H., Katakai T., Hara T., Gonda H., Sugai M., Shimizu A. Roles of p-ERM and Rho-ROCK signaling in lymphocyte polarity and uropod formation. J Cell Biol 2004, 167(2):327-337.
33. Belkina N.V., Liu Y., Hao J.J., Karasuyama H., Shaw S. LOK is a major ERM kinase in resting lymphocytes and regulates cytoskeletal rearrangement through ERM phosphorylation. Proc Natl Acad Sci U S A 2009, 106(12):4707-4712.
34. Hebert M., Potin S., Sebbagh M., Bertoglio J., Breard J., Hamelin J. Rho-ROCK-dependent ezrin-radixin-moesin phosphorylation regulates Fas-mediated apoptosis in Jurkat cells. J Immunol 2008, 181(9):5963-5973.
35. Jeon S., Kim N.H., Kim J.Y., Lee A.Y. Stem cell factor induces ERM proteins phosphorylation through PI3K activation to mediate melanocyte proliferation and migration. Pigment Cell Melanoma Res 2009, 22(1):77-85.
36. Zhu L., Zhou R., Mettler S., Wu T., Abbas A., Delaney J., et al. High turnover of ezrin T567 phosphorylation: conformation, activity, and cellular function. Am J Physiol Cell Physiol 2007, 293(3):C874-C884.