Control by signaling modulators of the sorting of canalicular transporters in rat hepatocyte couplets: Role of the cytoskeleton

Hepatology

Volumn 32, Issue 6, 2000, Pages 1342-1356

  Roma, Marcelo G ^a   Milkiewicz, Piotr ^b,c   Elias, Elwyn ^c   Coleman, Roger ^b  

^a Facultad de Ciencias Naturales e Instituto M Lillo   (Argentina)

^b UNIVERSITY OF BIRMINGHAM   (United Kingdom)

^c QUEEN ELIZABETH HOSPITAL   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

12 (2 CYANOETHYL) 6,7,12,13 TETRAHYDRO 13 METHYL 5 OXOINDOLO[2,3 A]PYRROLO[3,4 C]CARBAZOLE; BILE ACID; BILE ACID DERIVATIVE; BREFELDIN A; BUCLADESINE; CHOLYLLYSYL FLUORESCEIN; COLCHICINE; CYTOCHALASIN D; ETHYLENE GLYCOL 1,2 BIS(2 AMINOPHENYL) ETHER N,N,N',N' TETRAACETIC ACID TETRA(ACETOMETHYL)ESTER; F ACTIN; KT 5720; N (6 AMINOHEXYL) 5 CHLORO 1 NAPHTHALENESULFONAMIDE; N [2 (4 BROMOCINNAMYLAMINO)ETHYL] 5 ISOQUINOLINESULFONAMIDE; PHORBOL DIBUTYRATE; PROTEIN KINASE (CALCIUM,CALMODULIN); STAUROSPORINE; THAPSIGARGIN; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CELL ISOLATION; CELL MEMBRANE TRANSPORT; CELL POLARITY; CELL VACUOLE; CYTOSKELETON; INTRAHEPATIC BILE DUCT; LIVER CELL CULTURE; MALE; MEMBRANE VESICLE; MICROFILAMENT; MICROTUBULE; NONHUMAN; PRIORITY JOURNAL; RAT;

EID: 0033652585     PISSN: 02709139     EISSN: None     Source Type: Journal    
DOI: 10.1053/jhep.2000.20519     Document Type: Article

References (58)

1. Hepatocyte surface polarity
2. Membrane traffic at the hepatocyte's sinusoidal and canalicular surface domains
3. 3H]fucose to plasma membrane and Golgi apparatus glycoproteins
4. 5'Nucleotidase is sorted to the apical domain of hepatocytes via an indirect route
5. Biogenesis of the rat hepatocyte plasma membrane in vivo: Comparison of the pathway taken by apical and basolateral proteins using subcellular fractionation
6. Priority targeting of glycosyl-phosphatidylinositol-anchored proteins to the bile canalicular (apical) plasma membrane of hepatocytes
7. Mechanisms and functional features of polarized membrane traffic in epithelial and hepatic cells
8. -) exchanger in rat hepatocytes
9. Cyclic AMP stimulates sorting of the canalicular organic anion transporter (Mrp2/cMoat) to the apical domain in hepatocyte couplets
10. The role of phosphoinositide 3-kinase in taurocholate-induced trafficking of ATP-dependent canalicular transporters in rat liver
11. Vesicle targeting to the apical domain regulates bile excretory function in isolated rat hepatocyte couplets
12. Isolated rat hepatocyte couplets in short-term culture: Structural characteristics and plasma membrane reorganization
13. Redistribution of canalicular cell membrane enzyme in hepatocytes following their isolation and during early cell culture
14. Changes in the localization of the rat canalicular conjugate export pump Mrp2 in phalloidin-induced cholestasis
15. Cholyl lysyl fluorescein synthesis, biliary excretion in vivo and during single pass perfusion in isolated rat liver
16. Stability and optimization of canalicular function in hepatocyte couplets
17. Quantitative assessment of canalicular bile formation in isolated hepatocyte couplets using microscopic optical planimetry
18. Purification of hepatocyte couplets by centrifugal elutriation
19. Periportal and perivenous-enriched hepatocyte couplets: Differences in canalicular activity and in response to oxidative stress
20. Fluorescent choleretic and cholestatic bile salts take different paths across the hepatocyte: Transcytosis of glycolithocholate leads to an extensive redistribution of annexin II
21. Vasopressin-induced disruption of actin cytoskeleton organization and canalicular function in isolated rat hepatocyte couplets: Possible involvement of protein kinase C
22. cDNA cloning of the hepatocyte canalicular isoform of the multidrug resistance protein, cMrp, reveals a novel conjugate export pump deficient in hyperbilirubinemic mutant rats
23. Actin accumulation at sites of bacterial adhesion to tissue culture cells: Basis of a new diagnostic test for enteropathogenic and enterohemorrhagic Escherichia coli
24. cAMP-dependent protein kinase: Framework for a diverse family of regulatory enzymes
25. Role of phosphoinositides in the regulation of liver function
26. 2+ concentration in isolated rat hepatocytes
27. Selective inhibition of protein kinase C isozymes by the indolocarbazole Go 6976
28. Bleb formation in hepatocytes during drug metabolism is caused by disturbances in thiol and calcium ion homeostasis
29. 2+ homeostasis on hepatocyte canalicular function in vitro
30. 2+ is mediated by the activation of a non-lysosomal proteolytic system
31. Bile canaliculus formation in cultured HEPG2 cells
32. Targeting of aminopeptidase N to bile canaliculi correlates with secretory activities of the developing canalicular domain
33. Actin microfilaments play a critical role in endocytosis at the apical membrane but not the basolateral surface of polarized epithelial cells
34. Actin filament disassembly is a sufficient trigger for exocytosis in nonexitable cells
35. Actin filaments and microtubules are involved in different membrane traffic pathways that transport sphingolipids to the apical surface of polarized HepG2 cells
36. Golgi-derived vesicles from developing epithelial cells bind actin filaments and possess myosinas a cytoplasmically oriented peripheral membrane protein
37. Novel 130-kDa rat liver myosin-will translocate actin filaments
38. Brefeldin A causes disassembly of the Golgi complex and accumulation of secretory proteins in the endoplasmic reticulum
39. Brefeldin A causes a microtubule-mediated fusion of the trans-Golgi network and early endosomes
40. Effect of Brefeldin A on transcytotic vesicular pathway and bile secretion: A study on the isolated perfused rat liver and isolated rat hepatocyte couplets
41. Redistribution of canalicular organic anion transport activity in isolated and cultured rat hepatocytes
42. Remodeling of a rat hepatocyte plasma membrane glycoprotein
43. Microtubule-dependent vesicle transport: Modulation of channel and transporter activity in liver and kidney
44. Taurocholate stimulates transcytic vesicular pathways labeled by horseradish peroxidase in isolated perfused rat liver
45. Segregation of glucosylceramide and sphingomyelin occurs in the apical to basolateral transcytotic route in HepG2 cells
46. DBcAMP stimulates vesicle transport and HRP excretion in isolated perfused rat liver
47. +/taurocholate cotransport by cyclic AMP
48. Density-dependent proliferation of adult rat hepatocytes in primary culture induced by epidermal growth factor is potentiated by cAMP-elevating agents
49. 2+ transport ATPase by thapsigargin at subnanomolar concentrations
50. The calcium ionophore A233187 increases the tight-junctional permeability in rat liver
51. Vasopressin reduces taurochenodeoxycholate-induced hepatotoxicity by lowering the hepatocyte taurochenodeoxycholate content
52. Endothelin-1 stimulates bile acid secretion and vesicular transport in the isolated perfused rat liver
53. 2+ on exocytosis in the isolated perfused rat liver
54. The calmodulin antagonist W-7 affects transcytosis, lysosomal transport, and recycling
55. 2+-regulated exocytosis
56. Differential expression of five protein kinase C isoenzymes in FAO and HepG2 hepatoma cell lines compared with normal rat hepatocytes
57. Sphingolipid transport to the apical plasma membrane domain in human hepatoma cells is controlled by PKC and PKA activity: A correlation with cell polarity in HepG2 cells
58. Phosphorylation of myosin-1 from rat liver by protein kinase C reduces calmodulin binding