Correlation between apical localization of Abcc2/Mrp2 and phosphorylation status of ezrin in rat intestine

Drug Metabolism and Disposition

Volumn 37, Issue 7, 2009, Pages 1521-1527

  Nakano, Takafumi ^a   Sekine, Shuichi ^a   Ito, Kousei ^b   Horie, Toshiharu ^a  

^a CHIBA UNIVERSITY   (Japan)

^b UNIVERSITY OF TOKYO HOSPITAL   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

EZRIN; GLUTATHIONE; GLUTATHIONE S BIMANE; MULTIDRUG RESISTANCE PROTEIN 1; MULTIDRUG RESISTANCE PROTEIN 2; PROTEIN KINASE C; PROTEIN KINASE C ACTIVATOR; RHODAMINE 123; UNCLASSIFIED DRUG;

ANIMAL TISSUE; APICAL MEMBRANE; ARTICLE; BRUSH BORDER; CARBOXY TERMINAL SEQUENCE; CONTROLLED STUDY; DOWN REGULATION; ENZYME ACTIVATION; INTESTINE EPITHELIUM; MALE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN LOCALIZATION; PROTEIN PHOSPHORYLATION; PROTEIN PROTEIN INTERACTION; PROTEIN TRANSPORT; RAT; SMALL INTESTINE; TISSUE DISTRIBUTION; TISSUE HOMOGENATE;

ANIMALS; ATP-BINDING CASSETTE TRANSPORTERS; CYTOSKELETAL PROTEINS; HEPATOCYTES; INTESTINES; MALE; MULTIDRUG RESISTANCE-ASSOCIATED PROTEINS; P-GLYCOPROTEINS; PHORBOL ESTERS; PHOSPHORYLATION; PROTEIN KINASE C; RATS; RATS, SPRAGUE-DAWLEY; STATISTICS AS TOPIC;

RATTUS;

EID: 67649400445     PISSN: 00909556     EISSN: 1521009X     Source Type: Journal    
DOI: 10.1124/dmd.108.024836     Document Type: Article

References (40)

1. Ahmad S, Safa AR, and Glazer RI (1994) Modulation of P-glycoprotein by protein kinase C alpha in a baculovirus expression system. Biochemistry 33:10313-10318. (Pubitemid 24281796)
2. Chan LM, Lowes S, and Hirst BH (2004) The ABCs of drug transport in intestine and liver: efflux proteins limiting drug absorption and bioavailability. Eur J Pharm Sci 21:25-51. (Pubitemid 38050202)
3. Chaudhary PM and Roninson IB (1992) Activation of MDR1 (P-glycoprotein) gene expression in human cells by protein kinase C agonists. Oncol Res 4:281-290. (Pubitemid 23164727)
4. Dietrich CG, de Waart DR, Ottenhoff R, Schoots IG, and Elferink RP (2001) Increased bioavailability of the food-derived carcinogen 2-amino-1-methyl-6- phenylimidazo[4,5-b]pyridine in MRP2-deficient rats. Mol Pharmacol 59:974-980. (Pubitemid 32381575)
5. Dietrich CG, Geier A, Salein N, Lammert F, Roeb E, Oude Elferink RP, Matern S, and Gartung C (2004) Consequences of bile duct obstruction on intestinal expression and function of multidrug resistance-associated protein 2. Gastroenterology 126:1044-1053. (Pubitemid 38451176)
6. Goodfellow HR, Sardini A, Ruetz S, Callaghan R, Gros P, McNaughton PA, and Higgins CF (1996) Protein kinase C-mediated phosphorylation does not regulate drug transport by the human multidrug resistance P-glycoprotein. J Biol Chem 271:13668-13674. (Pubitemid 26185417)
7. Hakata T, Ito K, and Horie T (2005) Enhanced absorption of 3-O-methyl glucose following gastrointestinal injury induced by repeated oral administration of 5-FU in mice. J Pharm Sci 94:1713-1722. (Pubitemid 41360866)
8. Hanzel D, Reggio H, Bretscher A, Forte JG, and Mangeat P (1991) The secretion-stimulated 80K phosphoprotein of parietal cells is ezrin, and has properties of a membrane cytoskeletal linker in the induced apical microvilli. EMBO J 10:2363-2373. (Pubitemid 21905709)
9. Hayashi K, Yonemura S, Matsui T and Tsukita S (1999) Immunofluorescence detection of ezrin/radixin/moesin (ERM) proteins with their carboxyl-terminal threonine phosphorylated in cultured cells and tissues. J Cell Sci 112 (Pt 8):1149-1158.
10. Hofmann J (2004) Protein kinase C isozymes as potential targets for anticancer therapy. Curr Cancer Drug Targets 4:125-146. (Pubitemid 38332552)
11. Ito K, Wakabayashi T, and Horie T (2005) Mrp2/Abcc2 transport activity is stimulated by protein kinase Calpha in a baculovirus co-expression system. Life Sci 77:539-550. (Pubitemid 40719886)
12. Janecki AJ, Montrose MH, Zimniak P, Zweibaum A, Tse CM, Khurana S, and Donowitz M (1998) Subcellular redistribution is involved in acute regulation of the brush border Na+/H+ exchanger isoform 3 in human colon adenocarcinoma cell line Caco-2. Protein kinase C-mediated inhibition of the exchanger. J Biol Chem 273:8790-8798. (Pubitemid 28176158)
13. Ji B, Ito K, Sekine S, Tajima A, and Horie T (2004) Ethacrynic-acid- induced glutathione depletion and oxidative stress in normal and Mrp2-deficient rat liver. Free Radic Biol Med 37:1718-1729. (Pubitemid 39441056)
14. Jones BR, Li W, Cao J, Hoffman TA, Gerk PM, and Vore M (2005) The role of protein synthesis and degradation in the post-transcriptional regulation of rat multidrug resistance-associated protein 2 (Mrp2, Abcc2). Mol Pharmacol 68:701-710. (Pubitemid 41206023)
15. Kameyama N, Arisawa S, Ueyama J, Kagota S, Shinozuka K, Hattori A, Tatsumi Y, Hayashi H, Takagi K, and Wakusawa S (2008) Increase in P-glycoprotein accompanied by activation of protein kinase Calpha and NF-kappaB p65 in the livers of rats with streptozotocin-induced diabetes. Biochim Biophys Acta 1782:355-360.
16. Kellett GL (2001) The facilitated component of intestinal glucose absorption. J Physiol 531:585-595. (Pubitemid 32243741)
17. Kessler M, Acuto O, Storelli C, Murer H, Müller M, and Semenza G (1978) A modified procedure for the rapid preparation of efficiently transporting vesicles from small intestinal brush border membranes. Their use in investigating some properties of D-glucose and choline transport systems. Biochim Biophys Acta 506:136-154. (Pubitemid 8237850)
18. Kikuchi S, Hata M, Fukumoto K, Yamane Y, Matsui T, Tamura A, Yonemura S, Yamagishi H, Keppler D, Tsukita S, et al. (2002) Radixin deficiency causes conjugated hyperbilirubinemia with loss of Mrp2 from bile canalicular membranes. Nat Genet 31:320-325. (Pubitemid 34887601)
19. Kojima H, Nies AT, König J, Hagmann W, Spring H, Uemura M, Fukui H, and Keppler D (2003) Changes in the expression and localization of hepatocellular transporters and radixin in primary biliary cirrhosis. J Hepatol 39:693-702. (Pubitemid 37372176)
20. Kubitz R, D'urso D, Keppler D, and Häussinger D (1997) Osmodependent dynamic localization of the multidrug resistance protein 2 in the rat hepatocyte canalicular membrane. Gastroenterology 113:1438-1442.
21. Kubitz R, Huth C, Schmitt M, Horbach A, Kullak-Ublick G, and Häussinger D (2001) Protein kinase C-dependent distribution of the multidrug resistance protein 2 from the canalicular to the basolateral membrane in human HepG2 cells. Hepatology 34:340-350. (Pubitemid 32702347)
22. Li T, Tomimatsu T, Ito K, and Horie T (2003) Fluorescein-methotrexate transport in brush border membrane vesicles from rat small intestine. Life Sci 73:2631-2639. (Pubitemid 37088212)
23. Luciani F, Molinari A, Lozupone F, Calcabrini A, Lugini L, Stringaro A, Puddu P, Arancia G, Cianfriglia M, and Fais S (2002) P-glycoprotein-actin association through ERM family proteins: a role in P-glycoprotein function in human cells of lymphoid origin. Blood 99:641-648. (Pubitemid 34533103)
24. Matsui T, Maeda M, Doi Y, Yonemura S, Amano M, Kaibuchi K, Tsukita S, and Tsukita S (1998) Rho-kinase phosphorylates COOH-terminal threonines of ezrin/radixin/moesin (ERM) proteins and regulates their head-to-tail association. J Cell Biol 140:647-657. (Pubitemid 28134067)
25. Mottino AD, Cao J, Veggi LM, Crocenzi F, Roma MG, and Vore M (2002) Altered localization and activity of canalicular Mrp2 in estradiol-17beta-D- glucuronide-induced cholestasis. Hepatology 35:1409-1419. (Pubitemid 34966895)
26. Naud J, Michaud J, Boisvert C, Desbiens K, Leblond FA, Mitchell A, Jones C, Bonnardeaux A, and Pichette V (2007) Down-regulation of intestinal drug transporters in chronic renal failure in rats. J Pharmacol Exp Ther 320:978-985. (Pubitemid 46294060)
27. Newton AC (1995) Protein kinase C: structure, function, and regulation. J Biol Chem 270:28495-28498.
28. Ng T, Parsons M, Hughes WE, Monypenny J, Zicha D, Gautreau A, Arpin M, Gschmeissner S, Verveer PJ, Bastiaens PI, et al. (2001) Ezrin is a downstream effector of trafficking PKC-integrin complexes involved in the control of cell motility. EMBO J 20:2723-2741. (Pubitemid 32938557)
29. Oude Elferink RP, Bakker CT, Roelofsen H, Middelkoop E, Ottenhoff R, Heijn M, and Jansen PL (1993) Accumulation of organic anion in intracellular vesicles of cultured rat hepatocytes is mediated by the canalicular multispecific organic anion transporter. Hepatology 17:434-444. (Pubitemid 23072819)
30. Prince LS, Workman RB Jr, and Marchase RB (1994) Rapid endocytosis of the cystic fibrosis transmembrane conductance regulator chloride channel. Proc Natl Acad Sci U S A 91:5192-5196. (Pubitemid 24177819)
31. Saotome I, Curto M, and McClatchey AI (2004) Ezrin is essential for epithelial organization and villus morphogenesis in the developing intestine. Dev Cell 6:855-864. (Pubitemid 38745419)
32. Saxon ML, Zhao X, and Black JD (1994) Activation of protein kinase C isozymes is associated with post-mitotic events in intestinal epithelial cells in situ. J Cell Biol 126:747-763. (Pubitemid 24241387)
33. Sekine S, Ito K, and Horie T (2006) Oxidative stress and Mrp2 internalization. Free Radic Biol Med 40:2166-2174. (Pubitemid 43903103)
34. Takano M, Yumoto R, and Murakami T (2006) Expression and function of efflux drug transporters in the intestine. Pharmacol Ther 109:137-161. (Pubitemid 41740818)
35. Wald FA, Oriolo AS, Mashukova A, Fregien NL, Langshaw AH, and Salas PJ (2008) Atypical protein kinase C (iota) activates ezrin in the apical domain of intestinal epithelial cells. J Cell Sci 121:644-654.
36. Wang W, Soroka CJ, Mennone A, Rahner C, Harry K, Pypaert M, and Boyer JL (2006) Radixin is required to maintain apical canalicular membrane structure and function in rat hepatocytes. Gastroenterology 131:878-884. (Pubitemid 44307066)
37. Wimmer R, Hohenester S, Pusl T, Denk GU, Rust C, and Beuers U (2008) Tauroursodeoxycholic acid exerts anticholestatic effects by a cooperative cPKCalpha-/PKA-dependent mechanism in rat liver. Gut 57:1448-1454.
38. Yamaguchi H, Yano I, Saito H, and Inui K (2002) Pharmacokinetic role of P-glycoprotein in oral bioavailability and intestinal secretion of grepafloxacin in vivo. J Pharmacol Exp Ther 300:1063-1069. (Pubitemid 34165013)
39. Yang Q, Onuki R, Nakai C, and Sugiyama Y (2007) Ezrin and radixin both regulate the apical membrane localization of ABCC2 (MRP2) in human intestinal epithelial Caco-2 cells. Exp Cell Res 313:3517-3525. (Pubitemid 47404555)
40. Zhu L, Zhou R, Mettler S, Wu T, Abbas A, Delaney J, and Forte JG (2007) High turnover of ezrin T567 phosphorylation: conformation, activity, and cellular function. Am J Physiol Cell Physiol 293:C874-C884. (Pubitemid 47437395)