Optimization of the degenerated interfacial ATP binding site improves the function of disease-related mutant Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) channels

Journal of Biological Chemistry

Volumn 285, Issue 48, 2010, Pages 37663-37671

  Tsai, Ming Feng ^a,b   Jih, Kang Yang ^a,b   Shimizu, Hiroyasu ^c   Li, Min ^b   Hwang, Tzyh Chang ^a,b  

^a University of Missouri   (United States)

^b UNIVERSITY OF MISSOURI   (United States)

^c OSAKA MEDICAL COLLEGE   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACID RESIDUES; ATP BINDING; ATP-BINDING CASSETTE; ATP-BINDING SITE; CHLORIDE CHANNELS; CYSTIC FIBROSIS; CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATORS; EXPERIMENTAL EVIDENCE; GENETIC DISEASE; NUCLEOTIDE-BINDING DOMAIN; SIDE CHAINS;

AMINO ACIDS; BINDING ENERGY; BIOCHEMISTRY; CHLORINE COMPOUNDS; OPTIMIZATION;

BINDING SITES;

ADENOSINE TRIPHOSPHATE; MUTANT PROTEIN; NUCLEOTIDE BINDING DOMAIN 1; NUCLEOTIDE BINDING DOMAIN 2; NUCLEOTIDE BINDING PROTEIN; TRANSMEMBRANE CONDUCTANCE REGULATOR; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; BINDING AFFINITY; BINDING SITE; CONTROLLED STUDY; ELECTROPHYSIOLOGY; ENZYME ACTIVITY; ENZYME KINETICS; FEMALE; HYDROLYSIS; MOLECULAR DYNAMICS; MOLECULAR INTERACTION; NONHUMAN; PRIORITY JOURNAL; PROCESS OPTIMIZATION; PROTEIN BINDING; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN PROTEIN INTERACTION; WILD TYPE;

ADENOSINE TRIPHOSPHATE; AMINO ACID MOTIFS; AMINO ACID SUBSTITUTION; BINDING SITES; CYSTIC FIBROSIS; CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR; HUMANS; MUTATION, MISSENSE; PROTEIN BINDING; PROTEIN STRUCTURE, TERTIARY;

EID: 78549242002     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M110.172817     Document Type: Article

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