Mechanism of G551D-CFTR (cystic fibrosis transmembrane conductance regulator) potentiation by a high affinity ATP analog

Journal of Biological Chemistry

Volumn 283, Issue 9, 2008, Pages 5364-5369

  Bompadre, Silvia G ^a   Li, Min ^a   Hwang, Tzyh Chang ^a,b  

^a UNIVERSITY OF MISSOURI   (United States)

^b University of Missouri   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BINDING ENERGY; CELL MEMBRANES; NUCLEIC ACIDS; NUCLEOTIDES;

ATP ANALOGS; ATP BINDING POCKETS; ATP BINDINGS; CHANNEL ACTIVITIES; CHLORIDE CHANNELS; CYSTIC FIBROSES; CYSTIC FIBROSIS (CF) TRANSMEMBRANE CONDUCTANCE REGULATOR (CFTR); CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATORS; DIMER INTERFACES; HIGH AFFINITIES; NUCLEOTIDE BINDINGS; OPEN CHANNELS; SIGNATURE SEQUENCES; TAIL CONFIGURATIONS;

BINDING SITES;

ADENOSINE TRIPHOSPHATE; ADENOSINE TRIPHOSPHATE DERIVATIVE; ASPARTIC ACID; CHLORIDE CHANNEL; GLYCINE; N6 (2 PHENYLETHYL) ADENOSINE TRIPHOSPHATE; NUCLEOTIDE; TRANSMEMBRANE CONDUCTANCE REGULATOR; UNCLASSIFIED DRUG; CFTR PROTEIN, HUMAN; DRUG DERIVATIVE; N6 (2 PHENYLETHYL) ATP; N6-(2-PHENYLETHYL)-ATP;

ANIMAL CELL; ARTICLE; BINDING AFFINITY; CHANNEL GATING; CHO CELL; CONTROLLED STUDY; DIMERIZATION; GENE MUTATION; NONHUMAN; NUCLEOTIDE BINDING SITE; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; AMINO ACID SUBSTITUTION; ANIMAL; BINDING SITE; CELL MEMBRANE POTENTIAL; CRICETULUS; CYSTIC FIBROSIS; DRUG EFFECT; GENETICS; HAMSTER; HUMAN; HYDROLYSIS; METABOLISM; MISSENSE MUTATION; PROTEIN MOTIF; PROTEIN TERTIARY STRUCTURE;

ADENOSINE TRIPHOSPHATE; AMINO ACID MOTIFS; AMINO ACID SUBSTITUTION; ANIMALS; BINDING SITES; CHO CELLS; CRICETINAE; CRICETULUS; CYSTIC FIBROSIS; CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR; DIMERIZATION; HUMANS; HYDROLYSIS; MEMBRANE POTENTIALS; MUTATION, MISSENSE; PROTEIN STRUCTURE, TERTIARY;

EID: 41949115564     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M709417200     Document Type: Article

References (29)

1. Riordan, J. R., Rommens, J. M., Kerem, B., Alon, N., Rozmahel, R., Grzelczak, Z., Zielenski, J., Lok, S., Plavsic, N., Chou, J.-L., Drumm, M. L., Iannuzzi, M. C., Collins, F. S., and Tsui, L.-C. (1989) Science 245, 1066-1073
2. Welsh, M. J., and Smith, A. E. (1993) Cell 73. 7, 1251-1254
3. Quinton, P. M. (1990) FASEB J. 4, 2709-2717
4. Vergani, P., Lockless, S. W., Nairn, A. C., and Gadsby, D. C. (2005) Nature 433, 876-880
5. Mense, M., Vergani, P., White, D. M., Altberg, G., Nairn, A. C., and Gadsby, D. C. (2006) EMBO 25, 4728-4739
6. Zhou, Z., Wang, X., Liu, H.-Y., Zou, X., Li, M., and Hwang, J. H. (2006) J. Gen. Physiol. 128, 413-422
7. Bompadre, S. G., Sohma, Y., Li, M., and Hwang, T.-C. (2007) J. Gen. Physiol. 129, 285-298
8. Drumm, M. L., Wilkinson, D. J., Smit, L. S., Worrell, R. T., Strong, T. V., Frizzell, R. A., Dawson, D. C., and Collins, F. S. (1991) Science 254, 1797-1799
9. Cai, Z., Taddei, A., and Sheppard, D. N. (2006) J. Biol. Chem. 281, 1970-1977
10. Cutting, G. R., Kasch, L. M., Rosenstein, B. J., Zielenski, J., Tsui, L. C., Antonarakis, S. E., and Kazazian, H. H. (1990) Nature 346, 366-369
11. Kerem, B.-S., Zielenski, J., Markiewicz, D., Bozon, D., Gazit, E., Yahav, J., Kennedy, D., Riordan, J. R., Collins, F. S., Rommens, J. M., and Tsui, L.-C. (1990) Proc. Natl. Acad. Sci. U. S. A. 87, 8447-8451
12. Illek, B., Zhang, L., Lewis, N. C., Moss, R. B., Dong, J. Y., and Fischer, H. (1999) Am. J. Physiol. 277, C833-C839
13. Galietta, L. J., Springsteel, M. F., Eda, M., Niedzinski, E. J., By, K., Haddadin, M. J., Kurth, M. J., Nantz, M. H., and Verkman, A. S. (2001) J. Biol. Chem. 276, 19723-19728
14. Moran, O., Galietta, L. J., and Zegarra-Moran, O. (2005) CMLS Cell. Mol. Life Sci. 62, 446-460
15. Pedemonte, N., Sonawane, N. D., Taddei, A., Hu, J., Zegarra-Moran, O., Suen, Y. F., Robins, L. I., Dicus, C. W., Willenbring, D., Nantz, M. H., Kurth, M. J., Galietta, L. J., and Verkman, A. S. (2005) Mol. Pharmacol. 67, 1797-1807
16. Bompadre, S. G., Ai, T., Cho, J. H., Wang, X., Sohma, Y., Li, M., and Hwang, T.-C. (2005) J. Gen. Physiol. 125, 361-375
17. Zhou, Z., Wang, X., Li, M., Sohma, Y., Zou, X., and Hwang, T.-C. (2005) J. Physiol. (Lond.) 569, 447-457
18. Csanady, L. (2000) Biophys. J. 78, 785-799
19. Lewis, H. A., Zhao, X., Wang, C., Sauder, J. M., Rooney, I., Noland, B. W., Lorimer, D., Kearins, M. C., Conners, K., Condon, B., Maloney, P. C., Guggino, W. B., Hunt, J. F., and Emtage, S. (2005) J. Biol. Chem. 280, 1346-1353
20. Bompadre, S. G., Cho, J. H., Wang, X., Zou, X., Sohma, Y., Li, M., and Hwang, T.-C. (2005) J. Gen. Physiol. 125, 377-394
21. Powe, A. C., Nakkash, L. A., Li, M., and Hwang, T.-C. (2002) J. Physiol. (Lond.) 539, 333-346
22. Wang, W., Bernard, K., Li, G., and Kirk, K. L. (2007) J. Biol. Chem. 282, 4533-4544
23. Lewis, H. A., Buchanan, S. G., Burley, S. K., Conners, K., Dickey, M., Dorwart, M., Fowler, R., Gao, X., Gruggino, W. B., Hendrickson, W. A., Hunt, J. F., Kearins, M. C., Lorimer, D., Maloney, P. C., Post, K. W., Rajashankar, K. R., Rutter, M. E., Sauder, J. M., Shriver, S., Thibodeau, P. H., Thomas, P. J., Zhang, M., Zhao, X., and Emtage, S. (2004) EMBO J. 23, 282-293
24. Colquhoun, D. (1998) Br. J. Pharmacol. 125, 924-947
25. Gregory, R. J., Rich, D. P., Cheng, S. H., Souza, D. W., Paul, S., Manavalan, P., Anderson, M. P., Welsh, M. J., and Smith, A. E. (1991) Mol. Biol. Cell 11, 3886-3893
26. Ai, T., Bompadre, S. G., Wang, X., Hu, S., Li, M., and Hwang, T.-C. (2004) Mol. Pharmacol. 65, 1415-1426
27. Zegarra-Moran, O., Monteverde, M., Galietta, L. J., and Moran, O. (2007) J. Biol. Chem. 282, 9098-9104
28. Basso, C., Vergani, P., Nairn, A. C., and Gadsby, D. C. (2003) J. Gen. Physiol. 122, 333-348
29. Aleksandrov, L., Aleksandrov, A. A., Chang, X. B., and Riordan, J. R. (2002) J. Biol. Chem. 277, 15419-15425