Maltodextrins as lyoprotectants in the lyophilization of a model protein, LDH

Pharmaceutical Research

Volumn 13, Issue 1, 1996, Pages 146-150

  Corveleyn, Sam ^a   Remon, Jean Paul ^a  

^a GHENT UNIVERSITY   (Belgium)

Author keywords

Freeze drying; Maltodextrins; PEG; Protein

Indexed keywords

LACTATE DEHYDROGENASE; MACROGOL 8000; MALTODEXTRIN;

ARTICLE; DIFFERENTIAL SCANNING CALORIMETRY; ENZYME ACTIVITY; FREEZE DRYING; PRIORITY JOURNAL; PROTECTION; X RAY DIFFRACTION;

ANIMALS; FREEZE DRYING; L-LACTATE DEHYDROGENASE; POLYETHYLENE GLYCOLS; POLYSACCHARIDES; RABBITS; SOLUTIONS;

EID: 0029963110     PISSN: 07248741     EISSN: None     Source Type: Journal    
DOI: 10.1023/A:1016006106821     Document Type: Article

References (11)

1. C. Manning, Kamlesh Patel and Ronald T. Borchardt. Stability of Protein Pharmaceutical. Pharm. Res., 6, 903-918 (1989).
2. Michael J. Pikal. Freeze-Drying of Proteins. Part II: Formulation Selection. Pharmaceutical Technology International, 1991, pp.40-43.
3. Arno T.P. Skrabanja, A.L.J. De Meere, R.A. De Ruiter and P.J.M. Van den Oetelaar. Lyophilization of Biotechnology Products. J.Parent. Sci. Technol., 48, 311-317 (1994).
4. Sandeep Nema and Kenneth E. Avis. Freeze-thaw studies of a model protein, lactate dehydrogenase, in the presence of cryoprotectants. J.Parent. Sci.Technol., 47, 76-83(1993).
5. J.F. Carpenter, S.J. Prestrelski and T. Arakawa. Separation of freezing- and drying-induced denaturation of lyophilized proteins using stress-specific stabilization. I. Enzyme Activity and Calorimetric Studies. Arch. Biochem. Biophys., 303, 456-464 (1993).
6. J.F. Carpenter, T. Arakawa and J.H. Crowe. Interactions of stabilizing additives with proteins during freeze-thawing and freeze-drying. Develop. Biol. Standard., 74, 225-239 (1991).
7. J.F. Carpenter L.M. Crowe and J.H. Crowe. Stabilization of phosphofructokinase with sugars duhng freeze-drying: characterization of enhanced protection in the presence of divalent cations. Biochim.Biophys.Acta. 923, 109-115 (1987).
8. J.F. Carpenter and J.H. Crowe. An infrared spectroscopic study of the interactions of carbohydrates with dried proteins. Biochemistry, 28, 3916-3922 (1989).
9. Michael W. Townsend and Patrick P. DeLuca. Use of lyoprotectants in the freeze-drying of a model protein, Ribonuclease A. J. Parent. Sci.Technol., 42, 190-199 (1988).
10. Ken-ichi Izutsu, Sumie Yoshioka and Tadao Terao. Decreased protein-stabilizing effects of cryoprotectants due to crystallisation. Pharm. Res. 10, 1232-1237, 1993.
11. Michael J. Pikal. Freeze-Drying of Proteins. Part I: Process Design. Pharmaceutical Technology International, 1991, pp.37-40.