Glycine crystallization in frozen and freeze-dried systems: Effect of pH and buffer concentration

Pharmaceutical Research

Volumn 24, Issue 3, 2007, Pages 593-604

  Varshney, Dushyant B ^a,b   Kumar, Satyendra ^c   Shalaev, Evgenyi Y ^d   Sundaramurthi, Prakash ^a   Kang, Shin Woong ^e   Gatlin, Larry A ^d   Suryanarayanan, Raj ^a  

^a UNIVERSITY OF MINNESOTA   (United States)

^b ELI LILLY AND COMPANY   (United States)

^c NATIONAL SCIENCE FOUNDATION   (United States)

^d PFIZER GLOBAL RESEARCH AND DEVELOPMENT   (United States)

^e KENT STATE UNIVERSITY   (United States)

Author keywords

Freeze drying; Glycine; Lyophiles; Phosphate buffer; Polymorphs and salts; Synchrotron XRD

Indexed keywords

GLYCINE; PHOSPHATE BUFFERED SALINE;

ADDITION REACTION; ARTICLE; CONCENTRATION (PARAMETERS); CRYSTALLIZATION; DRUG IDENTIFICATION; FREEZE DRYING; LABORATORY; LYOPHILISATE; PH; PRIORITY JOURNAL; SYNCHROTRON; X RAY DIFFRACTION;

BUFFERS; CRYSTALLIZATION; FREEZE DRYING; FREEZING; GLYCINE; HYDROGEN-ION CONCENTRATION; PHOSPHATES; REPRODUCIBILITY OF RESULTS; SYNCHROTRONS; TECHNOLOGY, PHARMACEUTICAL; X-RAY DIFFRACTION;

EID: 33847164966     PISSN: 07248741     EISSN: 1573904X     Source Type: Journal    
DOI: 10.1007/s11095-006-9178-z     Document Type: Article

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