Effect of glycine on pH changes and protein stability during freeze-thawing in phosphate buffer systems

Journal of Pharmaceutical Sciences

Volumn 91, Issue 9, 2002, Pages 1969-1979

  Pikal Cleland, Katherine A ^a,c   Cleland, Jeffrey L ^b   Anchordoquy, Thomas J ^a   Carpenter, John F ^a  

^a UNIVERSITY OF COLORADO   (United States)

^b GENENTECH INC   (United States)

^c NEKTAR THERAPEUTICS   (United States)

Author keywords

Crystallization; Freeze thaw; Glycine; PH changes; Phosphate buffers; Protein inactivation

Indexed keywords

AMINO ACID; AMMONIUM SULFATE; GLYCINE; LACTATE DEHYDROGENASE; RECOMBINANT GAMMA INTERFERON; SUCCINIC ACID;

ARTICLE; CRYSTALLIZATION; DIFFERENTIAL SCANNING CALORIMETRY; FREEZING; GEL PERMEATION CHROMATOGRAPHY; PH; PROTEIN STABILITY; THAWING;

EID: 0036771258     PISSN: 00223549     EISSN: None     Source Type: Journal    
DOI: 10.1002/jps.10184     Document Type: Article

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