Second generation analogs of rigid 6,7-spiro scaffolds targeting the bacterial ribosome

Bioorganic and Medicinal Chemistry Letters

Volumn 20, Issue 24, 2010, Pages 7488-7492

  Stathakis, Christos I ^a   Mavridis, Ioannis ^a   Kythreoti, Georgia ^a   Papakyriakou, Athanasios ^a   Katsoulis, Ioannis A ^a   Cottin, Thomas ^a   Anastasopoulou, Panoula ^a   Vourloumis, Dionisios ^a  

^a Institute of Physical Chemistry   (Greece)

Author keywords

Aminoglycosides; Antibiotics; Ribosomal RNA; Spiro compounds

Indexed keywords

ANTIBIOTIC AGENT; FRAMYCETIN; NEAMINE; SPIRO COMPOUND;

ARTICLE; BACTERIAL CELL; DRUG ACTIVITY; DRUG SYNTHESIS; DRUG TARGETING; IC 50; RIBOSOME;

AMINOGLYCOSIDES; ANTI-BACTERIAL AGENTS; BACTERIA; BINDING SITES; COMPUTER SIMULATION; RNA, RIBOSOMAL, 16S; SPIRO COMPOUNDS;

BACTERIA (MICROORGANISMS);

EID: 78449293048     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2010.10.001     Document Type: Article

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