메뉴 건너뛰기




Volumn 103, Issue 8-9, 2010, Pages 469-476

Update on gene therapy for myocardial ischaemia and left ventricular systolic dysfunction or heart failure

Author keywords

Gene therapy; Heart failure; Left ventricular dysfunction

Indexed keywords

ADENOVIRUS VECTOR; CALCIUM; FIBROBLAST GROWTH FACTOR; FIBROBLAST GROWTH FACTOR 1; FIBROBLAST GROWTH FACTOR 2; FIBROBLAST GROWTH FACTOR 4; GROWTH FACTOR; HYPOXIA INDUCIBLE FACTOR; HYPOXIA INDUCIBLE FACTOR 1ALPHA; PLACEBO; SARCOPLASMIC RETICULUM CALCIUM TRANSPORTING ADENOSINE TRIPHOSPHATASE; SONIC HEDGEHOG PROTEIN; STROMAL CELL DERIVED FACTOR 1; UNCLASSIFIED DRUG; VASCULOTROPIN; VASCULOTROPIN 121; VASCULOTROPIN 165; VASCULOTROPIN 189; VASCULOTROPIN 206; VASCULOTROPIN A;

EID: 78449274379     PISSN: 18752136     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.acvd.2010.04.006     Document Type: Review
Times cited : (7)

References (45)
  • 1
    • 60449094498 scopus 로고    scopus 로고
    • Heart disease and stroke statistics - 2009 update: A report from the American Heart Association Statistics Committee and Stroke Statistics Subcommittee
    • D. Lloyd-Jones, R. Adams, and M. Carnethon Heart disease and stroke statistics - 2009 update: a report from the American Heart Association Statistics Committee and Stroke Statistics Subcommittee Circulation 119 2009 480 486
    • (2009) Circulation , vol.119 , pp. 480-486
    • Lloyd-Jones, D.1    Adams, R.2    Carnethon, M.3
  • 2
    • 34250772826 scopus 로고    scopus 로고
    • Current status of cardiovascular gene therapy
    • T.T. Rissanen, and S. Yla-Herttuala Current status of cardiovascular gene therapy Mol Ther 15 2007 1233 1247
    • (2007) Mol Ther , vol.15 , pp. 1233-1247
    • Rissanen, T.T.1    Yla-Herttuala, S.2
  • 3
    • 0036622139 scopus 로고    scopus 로고
    • Gene therapy with adenovirus-mediated myocardial transfer of vascular endothelial growth factor 121 improves cardiac performance in a pacing model of congestive heart failure
    • E. Leotta, G. Patejunas, and G. Murphy Gene therapy with adenovirus-mediated myocardial transfer of vascular endothelial growth factor 121 improves cardiac performance in a pacing model of congestive heart failure J Thorac Cardiovasc Surg 123 2002 1101 1113
    • (2002) J Thorac Cardiovasc Surg , vol.123 , pp. 1101-1113
    • Leotta, E.1    Patejunas, G.2    Murphy, G.3
  • 4
    • 0024818355 scopus 로고
    • Vascular endothelial growth factor is a secreted angiogenic mitogen
    • D.W. Leung, G. Cachianes, and W.J. Kuang Vascular endothelial growth factor is a secreted angiogenic mitogen Science 246 1989 1306 1309
    • (1989) Science , vol.246 , pp. 1306-1309
    • Leung, D.W.1    Cachianes, G.2    Kuang, W.J.3
  • 5
    • 0036105785 scopus 로고    scopus 로고
    • Expression of vascular endothelial growth factor and vascular endothelial growth factor receptor-2 (KDR/Flk-1) in ischemic skeletal muscle and its regeneration
    • T.T. Rissanen, I. Vajanto, and M.O. Hiltunen Expression of vascular endothelial growth factor and vascular endothelial growth factor receptor-2 (KDR/Flk-1) in ischemic skeletal muscle and its regeneration Am J Pathol 160 2002 1393 1403
    • (2002) Am J Pathol , vol.160 , pp. 1393-1403
    • Rissanen, T.T.1    Vajanto, I.2    Hiltunen, M.O.3
  • 6
    • 0030583587 scopus 로고    scopus 로고
    • Therapeutic angiogenesis following arterial gene transfer of vascular endothelial growth factor in a rabbit model of hindlimb ischemia
    • S. Takeshita, L. Weir, and D. Chen Therapeutic angiogenesis following arterial gene transfer of vascular endothelial growth factor in a rabbit model of hindlimb ischemia Biochem Biophys Res Commun 227 1996 628 635
    • (1996) Biochem Biophys Res Commun , vol.227 , pp. 628-635
    • Takeshita, S.1    Weir, L.2    Chen, D.3
  • 7
    • 33847421319 scopus 로고    scopus 로고
    • Vascular endothelial growth factors: Biology and current status of clinical applications in cardiovascular medicine
    • S. Yla-Herttuala, T.T. Rissanen, and I. Vajanto Vascular endothelial growth factors: biology and current status of clinical applications in cardiovascular medicine J Am Coll Cardiol 49 2007 1015 1026
    • (2007) J Am Coll Cardiol , vol.49 , pp. 1015-1026
    • Yla-Herttuala, S.1    Rissanen, T.T.2    Vajanto, I.3
  • 8
    • 0031439523 scopus 로고    scopus 로고
    • Adenovirus-mediated expression of the secreted form of basic fibroblast growth factor (FGF-2) induces cellular proliferation and angiogenesis in vivo
    • H. Ueno, J.J. Li, and S. Masuda Adenovirus-mediated expression of the secreted form of basic fibroblast growth factor (FGF-2) induces cellular proliferation and angiogenesis in vivo Arterioscler Thromb Vasc Biol 17 1997 2453 2460
    • (1997) Arterioscler Thromb Vasc Biol , vol.17 , pp. 2453-2460
    • Ueno, H.1    Li, J.J.2    Masuda, S.3
  • 9
    • 4043184065 scopus 로고    scopus 로고
    • Progenitor cell trafficking is regulated by hypoxic gradients through HIF-1 induction of SDF-1
    • D.J. Ceradini, A.R. Kulkarni, and M.J. Callaghan Progenitor cell trafficking is regulated by hypoxic gradients through HIF-1 induction of SDF-1 Nat Med 10 2004 858 864
    • (2004) Nat Med , vol.10 , pp. 858-864
    • Ceradini, D.J.1    Kulkarni, A.R.2    Callaghan, M.J.3
  • 10
    • 0032581277 scopus 로고    scopus 로고
    • Role of HIF-1 alpha in hypoxia-mediated apoptosis, cell proliferation and tumour angiogenesis
    • P. Carmeliet, Y. Dor, and J.M. Herbert Role of HIF-1 alpha in hypoxia-mediated apoptosis, cell proliferation and tumour angiogenesis Nature 394 1998 485 490
    • (1998) Nature , vol.394 , pp. 485-490
    • Carmeliet, P.1    Dor, Y.2    Herbert, J.M.3
  • 11
    • 0034960583 scopus 로고    scopus 로고
    • The morphogen sonic hedgehog is an indirect angiogenic agent upregulating two families of angiogenic growth factors
    • R. Pola, L.E. Ling, and M. Silver The morphogen sonic hedgehog is an indirect angiogenic agent upregulating two families of angiogenic growth factors Nat Med 7 2001 706 711
    • (2001) Nat Med , vol.7 , pp. 706-711
    • Pola, R.1    Ling, L.E.2    Silver, M.3
  • 12
    • 30744466891 scopus 로고    scopus 로고
    • Sonic hedgehog myocardial gene therapy: Tissue repair through transient reconstitution of embryonic signalling
    • K.F. Kusano, R. Pola, and T. Murayama Sonic hedgehog myocardial gene therapy: tissue repair through transient reconstitution of embryonic signalling Nat Med 11 2005 1197 1204
    • (2005) Nat Med , vol.11 , pp. 1197-1204
    • Kusano, K.F.1    Pola, R.2    Murayama, T.3
  • 13
    • 70350129066 scopus 로고    scopus 로고
    • The hedgehog transcription factor Gli3 modulates angiogenesis
    • M.A. Renault, J. Roncalli, and J. Tongers The hedgehog transcription factor Gli3 modulates angiogenesis Circ Res 105 2009 818 826
    • (2009) Circ Res , vol.105 , pp. 818-826
    • Renault, M.A.1    Roncalli, J.2    Tongers, J.3
  • 14
    • 0027165675 scopus 로고
    • Signal sequence trap: A cloning strategy for secreted proteins and type i membrane proteins
    • K. Tashiro, H. Tada, and R. Heilker Signal sequence trap: a cloning strategy for secreted proteins and type I membrane proteins Science 261 1993 600 603
    • (1993) Science , vol.261 , pp. 600-603
    • Tashiro, K.1    Tada, H.2    Heilker, R.3
  • 15
    • 9344255481 scopus 로고    scopus 로고
    • Stromal cell-derived factor-1 alpha plays a critical role in stem cell recruitment to the heart after myocardial infarction but is not sufficient to induce homing in the absence of injury
    • J.D. Abbott, Y. Huang, and D. Liu Stromal cell-derived factor-1 alpha plays a critical role in stem cell recruitment to the heart after myocardial infarction but is not sufficient to induce homing in the absence of injury Circulation 110 2004 3300 3305
    • (2004) Circulation , vol.110 , pp. 3300-3305
    • Abbott, J.D.1    Huang, Y.2    Liu, D.3
  • 16
    • 0033538344 scopus 로고    scopus 로고
    • Ca2+ handling and sarcoplasmic reticulum Ca2+ content in isolated failing and nonfailing human myocardium
    • B. Pieske, L.S. Maier, and D.M. Bers Ca2+ handling and sarcoplasmic reticulum Ca2+ content in isolated failing and nonfailing human myocardium Circ Res 85 1999 38 46
    • (1999) Circ Res , vol.85 , pp. 38-46
    • Pieske, B.1    Maier, L.S.2    Bers, D.M.3
  • 17
    • 0028101383 scopus 로고
    • Relation between myocardial function and expression of sarcoplasmic reticulum Ca(2+)-ATPase in failing and nonfailing human myocardium
    • G. Hasenfuss, H. Reinecke, and R. Studer Relation between myocardial function and expression of sarcoplasmic reticulum Ca(2+)-ATPase in failing and nonfailing human myocardium Circ Res 75 1994 434 442
    • (1994) Circ Res , vol.75 , pp. 434-442
    • Hasenfuss, G.1    Reinecke, H.2    Studer, R.3
  • 18
    • 0028882650 scopus 로고
    • Unchanged protein levels of SERCA II and phospholamban but reduced Ca2+ uptake and Ca(2+)-ATPase activity of cardiac sarcoplasmic reticulum from dilated cardiomyopathy patients compared with patients with nonfailing hearts
    • R.H. Schwinger, M. Bohm, and U. Schmidt Unchanged protein levels of SERCA II and phospholamban but reduced Ca2+ uptake and Ca(2+)-ATPase activity of cardiac sarcoplasmic reticulum from dilated cardiomyopathy patients compared with patients with nonfailing hearts Circulation 92 1995 3220 3228
    • (1995) Circulation , vol.92 , pp. 3220-3228
    • Schwinger, R.H.1    Bohm, M.2    Schmidt, U.3
  • 19
    • 0036341380 scopus 로고    scopus 로고
    • Chronic suppression of heart-failure progression by a pseudophosphorylated mutant of phospholamban via in vivo cardiac rAAV gene delivery
    • M. Hoshijima, Y. Ikeda, and Y. Iwanaga Chronic suppression of heart-failure progression by a pseudophosphorylated mutant of phospholamban via in vivo cardiac rAAV gene delivery Nat Med 8 2002 864 871
    • (2002) Nat Med , vol.8 , pp. 864-871
    • Hoshijima, M.1    Ikeda, Y.2    Iwanaga, Y.3
  • 20
    • 85047689989 scopus 로고    scopus 로고
    • Chronic phospholamban inhibition prevents progressive cardiac dysfunction and pathological remodeling after infarction in rats
    • Y. Iwanaga, M. Hoshijima, and Y. Gu Chronic phospholamban inhibition prevents progressive cardiac dysfunction and pathological remodeling after infarction in rats J Clin Invest 113 2004 727 736
    • (2004) J Clin Invest , vol.113 , pp. 727-736
    • Iwanaga, Y.1    Hoshijima, M.2    Gu, Y.3
  • 21
    • 3242660757 scopus 로고    scopus 로고
    • Intracoronary adenovirus encoding adenylyl cyclase VI increases left ventricular function in heart failure
    • N.C. Lai, D.M. Roth, and M.H. Gao Intracoronary adenovirus encoding adenylyl cyclase VI increases left ventricular function in heart failure Circulation 110 2004 330 336
    • (2004) Circulation , vol.110 , pp. 330-336
    • Lai, N.C.1    Roth, D.M.2    Gao, M.H.3
  • 22
    • 0038210219 scopus 로고    scopus 로고
    • Safety and feasibility of catheter-based local intracoronary vascular endothelial growth factor gene transfer in the prevention of postangioplasty and in-stent restenosis and in the treatment of chronic myocardial ischemia: Phase II results of the Kuopio Angiogenesis Trial (KAT)
    • M. Hedman, J. Hartikainen, and M. Syvanne Safety and feasibility of catheter-based local intracoronary vascular endothelial growth factor gene transfer in the prevention of postangioplasty and in-stent restenosis and in the treatment of chronic myocardial ischemia: phase II results of the Kuopio Angiogenesis Trial (KAT) Circulation 107 2003 2677 2683
    • (2003) Circulation , vol.107 , pp. 2677-2683
    • Hedman, M.1    Hartikainen, J.2    Syvanne, M.3
  • 23
    • 20144386684 scopus 로고    scopus 로고
    • Direct intramyocardial plasmid vascular endothelial growth factor-A165 gene therapy in patients with stable severe angina pectoris. A randomized double-blind placebo-controlled study: The Euroinject One trial
    • J. Kastrup, E. Jorgensen, and A. Ruck Direct intramyocardial plasmid vascular endothelial growth factor-A165 gene therapy in patients with stable severe angina pectoris. A randomized double-blind placebo-controlled study: the Euroinject One trial J Am Coll Cardiol 45 2005 982 988
    • (2005) J Am Coll Cardiol , vol.45 , pp. 982-988
    • Kastrup, J.1    Jorgensen, E.2    Ruck, A.3
  • 24
    • 0035040977 scopus 로고    scopus 로고
    • In vivo myocardial gene transfer: Optimization, evaluation and direct comparison of gene transfer vectors
    • M.J. Wright, L.M. Wightman, and C. Lilley In vivo myocardial gene transfer: optimization, evaluation and direct comparison of gene transfer vectors Basic Res Cardiol 96 2001 227 236
    • (2001) Basic Res Cardiol , vol.96 , pp. 227-236
    • Wright, M.J.1    Wightman, L.M.2    Lilley, C.3
  • 25
    • 0033541587 scopus 로고    scopus 로고
    • Expression of the primary coxsackie and adenovirus receptor is downregulated during skeletal muscle maturation and limits the efficacy of adenovirus-mediated gene delivery to muscle cells
    • J. Nalbantoglu, G. Pari, and G. Karpati Expression of the primary coxsackie and adenovirus receptor is downregulated during skeletal muscle maturation and limits the efficacy of adenovirus-mediated gene delivery to muscle cells Hum Gene Ther 10 1999 1009 1019
    • (1999) Hum Gene Ther , vol.10 , pp. 1009-1019
    • Nalbantoglu, J.1    Pari, G.2    Karpati, G.3
  • 26
    • 0036665610 scopus 로고    scopus 로고
    • Increased vascularity detected by digital subtraction angiography after VEGF gene transfer to human lower limb artery: A randomized, placebo-controlled, double-blinded phase II study
    • K. Makinen, H. Manninen, and M. Hedman Increased vascularity detected by digital subtraction angiography after VEGF gene transfer to human lower limb artery: a randomized, placebo-controlled, double-blinded phase II study Mol Ther 6 2002 127 133
    • (2002) Mol Ther , vol.6 , pp. 127-133
    • Makinen, K.1    Manninen, H.2    Hedman, M.3
  • 27
    • 10744232374 scopus 로고    scopus 로고
    • Adenoviral catheter-mediated intramyocardial gene transfer using the mature form of vascular endothelial growth factor-D induces transmural angiogenesis in porcine heart
    • J. Rutanen, T.T. Rissanen, and J.E. Markkanen Adenoviral catheter-mediated intramyocardial gene transfer using the mature form of vascular endothelial growth factor-D induces transmural angiogenesis in porcine heart Circulation 109 2004 1029 1035
    • (2004) Circulation , vol.109 , pp. 1029-1035
    • Rutanen, J.1    Rissanen, T.T.2    Markkanen, J.E.3
  • 28
    • 0037968240 scopus 로고    scopus 로고
    • Gene transfer as a tool to induce therapeutic vascular growth
    • S. Yla-Herttuala, and K. Alitalo Gene transfer as a tool to induce therapeutic vascular growth Nat Med 9 2003 694 701
    • (2003) Nat Med , vol.9 , pp. 694-701
    • Yla-Herttuala, S.1    Alitalo, K.2
  • 29
    • 0032570267 scopus 로고    scopus 로고
    • Chronic heart failure in the United States: A manifestation of coronary artery disease
    • M. Gheorghiade, and R.O. Bonow Chronic heart failure in the United States: a manifestation of coronary artery disease Circulation 97 1998 282 289 (Pubitemid 28067315)
    • (1998) Circulation , vol.97 , Issue.3 , pp. 282-289
    • Gheorghiade, M.1    Bonow, R.O.2
  • 30
    • 34248155707 scopus 로고    scopus 로고
    • Gene therapy progress and prospects: Therapeutic angiogenesis for ischemic cardiovascular disease
    • K.A. Vincent, C. Jiang, and I. Boltje Gene therapy progress and prospects: therapeutic angiogenesis for ischemic cardiovascular disease Gene Ther 14 2007 781 789
    • (2007) Gene Ther , vol.14 , pp. 781-789
    • Vincent, K.A.1    Jiang, C.2    Boltje, I.3
  • 31
    • 33748155036 scopus 로고    scopus 로고
    • Angiogenic gene therapy in patients with nonrevascularizable ischemic heart disease: A phase 2 randomized, controlled trial of AdVEGF(121) (AdVEGF-121) versus maximum medical treatment
    • D.J. Stewart, J.D. Hilton, and J.M. Arnold Angiogenic gene therapy in patients with nonrevascularizable ischemic heart disease: a phase 2 randomized, controlled trial of AdVEGF(121) (AdVEGF-121) versus maximum medical treatment Gene Ther 13 2006 1503 1511
    • (2006) Gene Ther , vol.13 , pp. 1503-1511
    • Stewart, D.J.1    Hilton, J.D.2    Arnold, J.M.3
  • 32
    • 0032578961 scopus 로고    scopus 로고
    • Gene therapy for myocardial angiogenesis: Initial clinical results with direct myocardial injection of phVEGF165 as sole therapy for myocardial ischemia
    • D.W. Losordo, P.R. Vale, and J.F. Symes Gene therapy for myocardial angiogenesis: initial clinical results with direct myocardial injection of phVEGF165 as sole therapy for myocardial ischemia Circulation 98 1998 2800 2804
    • (1998) Circulation , vol.98 , pp. 2800-2804
    • Losordo, D.W.1    Vale, P.R.2    Symes, J.F.3
  • 33
    • 0034730094 scopus 로고    scopus 로고
    • Left ventricular electromechanical mapping to assess efficacy of phVEGF(165) gene transfer for therapeutic angiogenesis in chronic myocardial ischemia
    • P.R. Vale, D.W. Losordo, and C.E. Milliken Left ventricular electromechanical mapping to assess efficacy of phVEGF(165) gene transfer for therapeutic angiogenesis in chronic myocardial ischemia Circulation 102 2000 965 974
    • (2000) Circulation , vol.102 , pp. 965-974
    • Vale, P.R.1    Losordo, D.W.2    Milliken, C.E.3
  • 34
    • 6644223710 scopus 로고    scopus 로고
    • Randomized, single-blind, placebo-controlled pilot study of catheter-based myocardial gene transfer for therapeutic angiogenesis using left ventricular electromechanical mapping in patients with chronic myocardial ischemia
    • P.R. Vale, D.W. Losordo, and C.E. Milliken Randomized, single-blind, placebo-controlled pilot study of catheter-based myocardial gene transfer for therapeutic angiogenesis using left ventricular electromechanical mapping in patients with chronic myocardial ischemia Circulation 103 2001 2138 2143
    • (2001) Circulation , vol.103 , pp. 2138-2143
    • Vale, P.R.1    Losordo, D.W.2    Milliken, C.E.3
  • 35
    • 0037133624 scopus 로고    scopus 로고
    • Angiogenic Gene Therapy (AGENT) trial in patients with stable angina pectoris
    • C.L. Grines, M.W. Watkins, and G. Helmer Angiogenic Gene Therapy (AGENT) trial in patients with stable angina pectoris Circulation 105 2002 1291 1297
    • (2002) Circulation , vol.105 , pp. 1291-1297
    • Grines, C.L.1    Watkins, M.W.2    Helmer, G.3
  • 36
    • 0142107372 scopus 로고    scopus 로고
    • A randomized, double-blind, placebo-controlled trial of Ad5FGF-4 gene therapy and its effect on myocardial perfusion in patients with stable angina
    • C.L. Grines, M.W. Watkins, and J.J. Mahmarian A randomized, double-blind, placebo-controlled trial of Ad5FGF-4 gene therapy and its effect on myocardial perfusion in patients with stable angina J Am Coll Cardiol 42 2003 1339 1347
    • (2003) J Am Coll Cardiol , vol.42 , pp. 1339-1347
    • Grines, C.L.1    Watkins, M.W.2    Mahmarian, J.J.3
  • 37
    • 34548446034 scopus 로고    scopus 로고
    • Effects of Ad5FGF-4 in patients with angina: An analysis of pooled data from the AGENT 3 and AGENT 4 trials
    • T.D. Henry, C.L. Grines, and M.W. Watkins Effects of Ad5FGF-4 in patients with angina: an analysis of pooled data from the AGENT 3 and AGENT 4 trials J Am Coll Cardiol 50 2007 1038 1046
    • (2007) J Am Coll Cardiol , vol.50 , pp. 1038-1046
    • Henry, T.D.1    Grines, C.L.2    Watkins, M.W.3
  • 38
    • 62649133817 scopus 로고    scopus 로고
    • Calcium upregulation by percutaneous administration of gene therapy in cardiac disease (CUPID Trial), a first-in-human phase 1/2 clinical trial
    • B.E. Jaski, M.L. Jessup, and D.M. Mancini Calcium upregulation by percutaneous administration of gene therapy in cardiac disease (CUPID Trial), a first-in-human phase 1/2 clinical trial J Card Fail 15 2009 171 181
    • (2009) J Card Fail , vol.15 , pp. 171-181
    • Jaski, B.E.1    Jessup, M.L.2    Mancini, D.M.3
  • 39
    • 33845629751 scopus 로고    scopus 로고
    • Adenylyl cyclase gene transfer in heart failure
    • H.K. Hammond Adenylyl cyclase gene transfer in heart failure Ann N Y Acad Sci 1080 2006 426 436
    • (2006) Ann N y Acad Sci , vol.1080 , pp. 426-436
    • Hammond, H.K.1
  • 40
    • 38049112584 scopus 로고    scopus 로고
    • Long-term expression of bicistronic vector driven by the FGF-1 IRES in mouse muscle
    • C. Allera-Moreau, A. Delluc-Clavieres, and C. Castano Long-term expression of bicistronic vector driven by the FGF-1 IRES in mouse muscle BMC Biotechnol 7 2007 74
    • (2007) BMC Biotechnol , vol.7 , pp. 74
    • Allera-Moreau, C.1    Delluc-Clavieres, A.2    Castano, C.3
  • 41
    • 73849098996 scopus 로고    scopus 로고
    • IRES-based vector co-expressing FGF-2 and Cyr61 provides synergistic and safe therapeutics of lower limb ischemia
    • A. Rayssac, C. Neveu, and M. Pucelle IRES-based vector co-expressing FGF-2 and Cyr61 provides synergistic and safe therapeutics of lower limb ischemia Mol Ther 17 2009 2010 2019
    • (2009) Mol Ther , vol.17 , pp. 2010-2019
    • Rayssac, A.1    Neveu, C.2    Pucelle, M.3
  • 42
    • 34748833540 scopus 로고    scopus 로고
    • Arteriogenesis: Basic mechanisms and therapeutic stimulation
    • S. Grundmann, J.J. Piek, and G. Pasterkamp Arteriogenesis: basic mechanisms and therapeutic stimulation Eur J Clin Invest 37 2007 755 766
    • (2007) Eur J Clin Invest , vol.37 , pp. 755-766
    • Grundmann, S.1    Piek, J.J.2    Pasterkamp, G.3
  • 43
    • 4544384667 scopus 로고    scopus 로고
    • Synergistic effect of bone marrow mobilization and vascular endothelial growth factor-2 gene therapy in myocardial ischemia
    • A. Kawamoto, T. Murayama, and K. Kusano Synergistic effect of bone marrow mobilization and vascular endothelial growth factor-2 gene therapy in myocardial ischemia Circulation 110 2004 1398 1405
    • (2004) Circulation , vol.110 , pp. 1398-1405
    • Kawamoto, A.1    Murayama, T.2    Kusano, K.3
  • 44
    • 33748044611 scopus 로고    scopus 로고
    • Intramyocardial injection of vascular endothelial growth factor-A165 plasmid followed by granulocyte-colony stimulating factor to induce angiogenesis in patients with severe chronic ischaemic heart disease
    • R.S. Ripa, Y. Wang, and E. Jorgensen Intramyocardial injection of vascular endothelial growth factor-A165 plasmid followed by granulocyte-colony stimulating factor to induce angiogenesis in patients with severe chronic ischaemic heart disease Eur Heart J 27 2006 1785 1792
    • (2006) Eur Heart J , vol.27 , pp. 1785-1792
    • Ripa, R.S.1    Wang, Y.2    Jorgensen, E.3
  • 45
    • 0033017213 scopus 로고    scopus 로고
    • DNA delivery from polymer matrices for tissue engineering
    • L.D. Shea, E. Smiley, and J. Bonadio DNA delivery from polymer matrices for tissue engineering Nat Biotechnol 17 1999 551 554
    • (1999) Nat Biotechnol , vol.17 , pp. 551-554
    • Shea, L.D.1    Smiley, E.2    Bonadio, J.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.