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Bioorganic and Medicinal Chemistry Letters

Volumn 20, Issue 24, 2010, Pages 7212-7215

Discovery of new azaindole-based PI3Kα inhibitors: Apoptotic and antiangiogenic effect on cancer cells

(6) Hong, Seunghee a Lee, Soyoung a Kim, Bomi a Lee, Hyunseung b Hong, Soon Sun b Hong, Sungwoo a

a Korea Advanced Institute of Science and Technology (KAIST) (South Korea)

b Inha University School of Medicine (South Korea)

Author keywords

Antiangiogenesis; Azaindole; Fragment growing strategy; Phosphatidylinositol 3 kinase

Indexed keywords

ANGIOGENESIS INHIBITOR; ANTINEOPLASTIC AGENT; INDOLE DERIVATIVE; PHOSPHATIDYLINOSITOL 3 KINASE; PHOSPHATIDYLINOSITOL 3 KINASE ALPHA; PHOSPHATIDYLINOSITOL 3 KINASE INHIBITOR; UNCLASSIFIED DRUG;

ANTIANGIOGENIC ACTIVITY; APOPTOSIS; ARTICLE; BINDING AFFINITY; CANCER CELL; CELL PROLIFERATION; CONTROLLED STUDY; DRUG DESIGN; DRUG PROTEIN BINDING; HUMAN; HUMAN CELL; IC 50; STRUCTURE ACTIVITY RELATION;

ANGIOGENESIS INHIBITORS; APOPTOSIS; BREAST NEOPLASMS; CELL LINE, TUMOR; CELL MOVEMENT; DRUG EVALUATION, PRECLINICAL; ENZYME INHIBITORS; FEMALE; HUMANS; INDOLES; PHOSPHATIDYLINOSITOL 3-KINASES; STRUCTURE-ACTIVITY RELATIONSHIP; SULFONAMIDES;

EID: 78449274341 PISSN: 0960894X EISSN: None Source Type: Journal
DOI: 10.1016/j.bmcl.2010.10.108 Document Type: Article

Times cited : (42)

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