Halogenation of 4-hydroxy/amino-3-methoxyphenyl acetamide TRPV1 agonists showed enhanced antagonism to capsaicin

Bioorganic and Medicinal Chemistry

Volumn 18, Issue 22, 2010, Pages 8092-8105

  Kang, Dong Wook ^a   Kim, Yong Soo ^a   Lim, Kwang Su ^a   Kim, Myeong Seop ^a   Pearce, Larry V ^b   Pavlyukovets, Vladimir A ^b   Tao, Andy K ^b   Lang Kuhs, Krystle A ^b   Blumberg, Peter M ^b   Lee, Jeewoo ^a  

^a Seoul National University   (South Korea)

^b NATIONAL CANCER INSTITUTE   (United States)

Author keywords

Capsaicin; Capsaicinoid; Halogenation; Resiniferatoxin; TRPV1 agonist; TRPV1 antagonist

Indexed keywords

2 (4 TERT BUTYLBENZYL) 3 [2 (4 AMINO 3 BROMO 5 METHOXYPHENYL)ACETAMIDO]PROPYLPIVALATE; 2 (4 TERT BUTYLBENZYL) 3 [2 (4 HYDROXY 3 IODO 5 METHOXYPHENYL)ACETAMIDO]PROPYLPIVALATE; 6' IODONONIVAMIDE; CAPSAICIN; THIOUREA; UNCLASSIFIED DRUG; VANILLOID RECEPTOR AGONIST;

ANIMAL CELL; ARTICLE; BINDING AFFINITY; CHEMICAL MODIFICATION; CHO CELL; DRUG EFFICACY; DRUG RECEPTOR BINDING; DRUG STRUCTURE; DRUG SYNTHESIS; HALOGENATION; NONHUMAN; STRUCTURE ACTIVITY RELATION;

ACETAMIDES; ANIMALS; BENZAMIDES; CAPSAICIN; CHO CELLS; CRICETINAE; CRICETULUS; HALOGENATION; RATS; STRUCTURE-ACTIVITY RELATIONSHIP; THIOUREA; TRPV CATION CHANNELS;

CRICETULUS GRISEUS;

EID: 78449263017     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2010.09.001     Document Type: Article

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