Insights into substrate specificity of geranylgeranyl reductases revealed by the structure of digeranylgeranylglycerophospholipid reductase, an essential enzyme in the biosynthesis of archaeal membrane lipids

Journal of Molecular Biology

Volumn 404, Issue 3, 2010, Pages 403-417

  Xu, Qingping ^a,b   Eguchi, Tadashi ^c   Mathews, Irimpan I ^a   Rife, Christopher L ^a,b   Chiu, Hsiu Ju ^a,b   Farr, Carol L ^b,d   Feuerhelm, Julie ^b,e   Jaroszewski, Lukasz ^b,f,g   Klock, Heath E ^b,e   Knuth, Mark W ^b,e   Miller, Mitchell D ^a,b   Weekes, Dana ^b,g   Elsliger, Marc André ^b,d   Deacon, Ashley M ^a,b   Godzik, Adam ^b,f,g   Lesley, Scott A ^b,d,e   Wilson, Ian A ^b,d  

^a SLAC NATIONAL ACCELERATOR LABORATORY   (United States)

^b Joint Center for Structural Genomics   (United States)

^c TOKYO INSTITUTE OF TECHNOLOGY   (Japan)

^d SCRIPPS RESEARCH INSTITUTE   (United States)

^e GENOMICS INSTITUTE OF THE NOVARTIS RESEARCH FOUNDATION   (United States)

^f UNIVERSITY OF CALIFORNIA   (United States)

^g BURNHAM INSTITUTE   (United States)

Author keywords

Archaeal membrane lipids biosynthesis; Digeranylgeranylglycerophospholipid reductase; FAD; Geranylgeranyl reductase; Substrate recycling

Indexed keywords

DIGERANYLGERANYLGLYCEROPHOSPHOLIPID REDUCTASE; FLAVINE ADENINE NUCLEOTIDE; GERANYLGERANYL REDUCTASE; OXIDOREDUCTASE; UNCLASSIFIED DRUG;

ARTICLE; BINDING SITE; CONFORMATIONAL TRANSITION; CRYSTAL STRUCTURE; ENZYME SPECIFICITY; ENZYME STRUCTURE; LIPOGENESIS; NONHUMAN; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN MOTIF; STRUCTURE ANALYSIS; THERMOPLASMA ACIDOPHILUM;

ARCHAEA; BACTERIA (MICROORGANISMS); EUKARYOTA; THERMOPLASMA ACIDOPHILUM;

EID: 78349312271     PISSN: 00222836     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jmb.2010.09.032     Document Type: Article

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