Update on the role of endothelial lipase in high-density lipoprotein metabolism, reverse cholesterol transport, and atherosclerosis

Circulation Journal

Volumn 74, Issue 11, 2010, Pages 2263-2270

  Yasuda, Tomoyuki ^a,b   Ishida, Tatsuro ^b   Rader, Daniel J ^a  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

^b KOBE UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

Author keywords

Apolipoprotein; Atherosclerosis; High density lipoprotein; Lipids; Lipoprotein

Indexed keywords

APOLIPOPROTEIN A1; APOLIPOPROTEIN A2; APOLIPOPROTEIN E; C REACTIVE PROTEIN; CHOLESTEROL; ENDOTHELIAL LIPASE; HIGH DENSITY LIPOPROTEIN; HIGH DENSITY LIPOPROTEIN CHOLESTEROL; INTERLEUKIN 6; LIPOPROTEIN LIPASE; LOW DENSITY LIPOPROTEIN RECEPTOR; PHOSPHOLIPASE; PHOSPHOLIPASE A2; PROTEOHEPARAN SULFATE; SCAVENGER RECEPTOR BI; TRIACYLGLYCEROL LIPASE; UNCLASSIFIED DRUG;

ATHEROGENESIS; ATHEROSCLEROSIS; CHOLESTEROL BLOOD LEVEL; CHOLESTEROL TRANSPORT; ENZYME ACTIVITY; ENZYME INHIBITION; HUMAN; INFLAMMATION; LIPOPROTEIN METABOLISM; NONHUMAN; PROTEIN EXPRESSION; PROTEIN FUNCTION; REVIEW; SINGLE NUCLEOTIDE POLYMORPHISM;

ANIMALS; ATHEROSCLEROSIS; BIOLOGICAL TRANSPORT; CARDIOVASCULAR AGENTS; CHOLESTEROL; ENDOTHELIUM, VASCULAR; ENZYME INHIBITORS; HUMANS; LIPASE; LIPOPROTEINS, HDL; MICE; POLYMORPHISM, SINGLE NUCLEOTIDE;

EID: 78349287329     PISSN: 13469843     EISSN: 13474820     Source Type: Journal    
DOI: 10.1253/circj.CJ-10-0934     Document Type: Review

References (64)

1. Ishikawa T, Mizuno K, Nakaya N, Ohashi Y, Tajima N, Kushiro T, et al. The relationship between the effect of pravastatin and risk factors for coronary heart disease in Japanese patients with hypercholesterolemia. Circ J 2008; 72: 1576-1582.
2. Heart Protection Study Collaborative Group. MRC/BHF Heart Protection Study of cholesterol lowering with simvastatin in 20,536 high-risk individuals: A randomised placebo-controlled trial. Lancet 2002; 360: 7-22.
3. Rader DJ. High-density lipoproteins and atherosclerosis. Am J Cardiol 2002; 90: 62i-70i.
4. Rader DJ, Alexander ET, Weibel GL, Billheimer J, Rothblat GH. The role of reverse cholesterol transport in animals and humans and relationship to atherosclerosis. J Lipid Res 2009; 50(Suppl): S189-S194.
5. Barter PJ, Nicholls S, Rye KA, Anantharamaiah GM, Navab M, Fogelman AM. Antiinflammatory properties of HDL. Circ Res 2004; 95: 764-772.
6. Keech A, Simes RJ, Barter P, Best J, Scott R, Taskinen MR, et al. Effects of long-term fenofibrate therapy on cardiovascular events in 9795 people with type 2 diabetes mellitus (the FIELD study): Randomised controlled trial. Lancet 2005; 366: 1849-1861.
7. Nissen SE, Tsunoda T, Tuzcu EM, Schoenhagen P, Cooper CJ, Yasin M, et al. Effect of recombinant ApoA-I Milano on coronary atherosclerosis in patients with acute coronary syndromes: A randomized controlled trial. JAMA 2003; 290: 2292-2300.
8. Barter PJ, Caulfield M, Eriksson M, Grundy SM, Kastelein JJ, Komajda M, et al. Effects of torcetrapib in patients at high risk for coronary events. N Engl J Med 2007; 357: 2109-2122.
9. Miller GC, Long CJ, Bojilova ED, Marchadier D, Badellino KO, Blanchard N, et al. Role of N-linked glycosylation in the secretion and activity of endothelial lipase. J Lipid Res 2004; 45: 2080-2087.
10. Hirata K, Dichek HL, Cioffi JA, Choi SY, Leeper NJ, Quintana L, et al. Cloning of a unique lipase from endothelial cells extends the lipase gene family. J Biol Chem 1999; 274: 14170-14175.
11. Strauss JG, Hayn M, Zechner R, Levak-Frank S, Frank S. Fatty acids liberated from high-density lipoprotein phospholipids by endothelial- derived lipase are incorporated into lipids in HepG2 cells. Biochem J 2003; 371: 981-988.
12. Jahangiri A, Rader DJ, Marchadier D, Curtiss LK, Bonnet DJ, Rye KA. Evidence that endothelial lipase remodels high density lipoproteins without mediating the dissociation of apolipoprotein A-I. J Lipid Res 2005; 46: 896-903.
13. Maugeais C, Tietge UJ, Broedl UC, Marchadier D, Cain W, McCoy MG, et al. Dose-dependent acceleration of high-density lipoprotein catabolism by endothelial lipase. Circulation 2003; 108: 2121-2126.
14. Nijstad N, Wiersma H, Gautier T, van der Giet M, Maugeais C, Tietge UJ. Scavenger receptor BI-mediated selective uptake is required for the remodeling of high density lipoprotein by endothelial lipase. J Biol Chem 2009; 284: 6093-6100.
15. Ishida T, Choi S, Kundu RK, Hirata K, Rubin EM, Cooper AD, et al. Endothelial lipase is a major determinant of HDL level. J Clin Invest 2003; 111: 347-355.
16. Ma K, Cilingiroglu M, Otvos JD, Ballantyne CM, Marian AJ, Chan L. Endothelial lipase is a major genetic determinant for highdensity lipoprotein concentration, structure, and metabolism. Proc Natl Acad Sci USA 2003; 100: 2748-2753.
17. Badellino KO, Wolfe ML, Reilly MP, Rader DJ. Endothelial lipase concentrations are increased in metabolic syndrome and associated with coronary atherosclerosis. PLoS Med 2006; 3: e22.
18. Jaye M, Lynch KJ, Krawiec J, Marchadier D, Maugeais C, Doan K, et al. A novel endothelial-derived lipase that modulates HDL metabolism. Nat Genet 1999; 21: 424-428.
19. Fuki IV, Blanchard N, Jin W, Marchadier DH, Millar JS, Glick JM, et al. Endogenously produced endothelial lipase enhances binding and cellular processing of plasma lipoproteins via heparan sulfate proteoglycan-mediated pathway. J Biol Chem 2003; 278: 34331-34338.
20. Broedl UC, Maugeais C, Marchadier D, Glick JM, Rader DJ. Effects of nonlipolytic ligand function of endothelial lipase on high density lipoprotein metabolism in vivo. J Biol Chem 2003; 278: 40688-40693.
21. Strauss JG, Zimmermann R, Hrzenjak A, Zhou Y, Kratky D, Levak-Frank S, et al. Endothelial cell-derived lipase mediates uptake and binding of high-density lipoprotein (HDL) particles and the selective uptake of HDL-associated cholesterol esters independent of its enzymic activity. Biochem J 2002; 368: 69-79.
22. Tanaka H, Ishida T, Johnston TP, Yasuda T, Ueyama T, Kojima Y, et al. Role of endothelial lipase in plasma HDL levels in a murine model of hypertriglyceridemia. J Atheroscler Thromb 2009; 16: 327-338.
23. Hirata K, Ishida T, Matsushita H, Tsao PS, Quertermous T. Regulated expression of endothelial cell-derived lipase. Biochem Biophys Res Commun 2000; 272: 90-93.
24. Jin W, Sun GS, Marchadier D, Octtaviani E, Glick JM, Rader DJ. Endothelial cells secrete triglyceride lipase and phospholipase activities in response to cytokines as a result of endothelial lipase. Circ Res 2003; 92: 644-650.
25. Yasuda T, Hirata K, Ishida T, Kojima Y, Tanaka H, Okada T, et al. Endothelial lipase is increased by inflammation and promotes LDL uptake in macrophages. J Atheroscler Thromb 2007; 14: 192-201.
26. Wang X, Jin W, Rader DJ. Upregulation of macrophage endothelial lipase by toll-like receptors 4 and 3 modulates macrophage interleukin-10 and -12 production. Circ Res 2007; 100: 1008-1015.
27. Shimokawa Y, Hirata K, Ishida T, Kojima Y, Inoue N, Quertermous T, et al. Increased expression of endothelial lipase in rat models of hypertension. Cardiovasc Res 2005; 66: 594-600.
28. Paradis ME, Badellino KO, Rader DJ, Deshaies Y, Couture P, Archer WR, et al. Endothelial lipase is associated with inflammation in humans. J Lipid Res 2006; 47: 2808-2813.
29. Badellino KO, Wolfe ML, Reilly MP, Rader DJ. Endothelial lipase is increased in vivo by inflammation in humans. Circulation 2008; 117: 678-685.
30. Kojima Y, Ishida T, Sun L, Yasuda T, Toh R, Rikitake Y, et al. Pitavastatin decreases the expression of endothelial lipase both in vitro and in vivo. Cardiovasc Res 2010; 87: 385-393.
31. Qiu G, Hill JS. Atorvastatin decreases lipoprotein lipase and endothelial lipase expression in human THP-1 macrophages. J Lipid Res 2007; 48: 2112-2122.
32. Matsuo Y, Hashizume T, Shioji S, Akasaka T. Metabolic syndrome is strongly associated with chronic subclinical inflammation in patients achieving optimal low-density lipoprotein-cholesterol levels in secondary prevention of cardiovascular disease. Circ J 2008; 72: 2046-2050.
33. Yu KC, David C, Kadambi S, Stahl A, Hirata K, Ishida T, et al. Endothelial lipase is synthesized by hepatic and aorta endothelial cells and its expression is altered in apoE-deficient mice. J Lipid Res 2004; 45: 1614-1623.
34. Griffon N, Jin W, Petty TJ, Millar J, Badellino KO, Saven JG, et al. Identification of the active form of endothelial lipase, a homodimer in a head-to-tail conformation. J Biol Chem 2009; 284: 23322-23330.
35. Jin W, Fuki IV, Seidah NG, Benjannet S, Glick JM, Rader DJ. Proprotein convertases [corrected] are responsible for proteolysis and inactivation of endothelial lipase. J Biol Chem 2005; 280: 36551-36559.
36. Shimamura M, Matsuda M, Yasumo H, Okazaki M, Fujimoto K, Kono K, et al. Angiopoietin-like protein3 regulates plasma HDL cholesterol through suppression of endothelial lipase. Arterioscler Thromb Vasc Biol 2007; 27: 366-372.
37. Jin W, Wang X, Millar JS, Quertermous T, Rothblat GH, Glick JM, et al. Hepatic proprotein convertases modulate HDL metabolism. Cell Metab 2007; 6: 129-136.
38. McCoy MG, Sun GS, Marchadier D, Maugeais C, Glick JM, Rader DJ. Characterization of the lipolytic activity of endothelial lipase. J Lipid Res 2002; 43: 921-929.
39. Broedl UC, Jin W, Fuki IV, Millar JS, Rader DJ. Endothelial lipase is less effective at influencing HDL metabolism in vivo in mice expressing apoA-II. J Lipid Res 2006; 47: 2191-2197.
40. Brown RJ, Miller GC, Griffon N, Long CJ, Rader DJ. Glycosylation of endothelial lipase at asparagine-116 reduces activity and the hydrolysis of native lipoproteins in vitro and in vivo. J Lipid Res 2007; 48: 1132-1139.
41. Skropeta D, Settasatian C, McMahon MR, Shearston K, Caiazza D, McGrath KC, et al. N-Glycosylation regulates endothelial lipasemediated phospholipid hydrolysis in apoE- and apoA-I-containing high density lipoproteins. J Lipid Res 2007; 48: 2047-2057.
42. Edmondson AC, Brown RJ, Kathiresan S, Cupples LA, Demissie S, Manning AK, et al. Loss-of-function variants in endothelial lipase are a cause of elevated HDL cholesterol in humans. J Clin Invest 2009; 119: 1042-1050.
43. Vergeer M, Cohn DM, Boekholdt SM, Sandhu MS, Prins HM, Ricketts SL, et al. Lack of association between common genetic variation in endothelial lipase (LIPG) and the risk for CAD and DVT. Atherosclerosis 2010; 211: 558-564.
44. Shimizu M, Kanazawa K, Hirata K, Ishida T, Hiraoka E, Matsuda Y, et al. Endothelial lipase gene polymorphism is associated with acute myocardial infarction, independently of high-density lipoprotein- cholesterol levels. Circ J 2007; 71: 842-846.
45. Tang NP, Wang LS, Yang L, Zhou B, Gu HJ, Sun QM, et al. Protective effect of an endothelial lipase gene variant on coronary artery disease in a Chinese population. J Lipid Res 2008; 49: 369-375.
46. Brown RJ, Edmondson AC, Griffon N, Hill TB, Fuki IV, Badellino KO, et al. A naturally occurring variant of endothelial lipase associated with elevated HDL exhibits impaired synthesis. J Lipid Res 2009; 50: 1910-1916.
47. Teslovich TM, Musunuru K, Smith AV, Edmondson AC, Stylianou IM, Koseki M, et al. Biological, clinical and population relevance of 95 loci for blood lipids. Nature 2010; 466: 707-713.
48. Yancey PG, Kawashiri MA, Moore R, Glick JM, Williams DL, Connelly MA, et al. In vivo modulation of HDL phospholipid has opposing effects on SR-BI- and ABCA1-mediated cholesterol efflux. J Lipid Res 2004; 45: 337-346.
49. Brown RJ, Lagor WR, Sankaranaravanan S, Yasuda T, Quertermous T, Rothblat GH, et al. Impact of combined deficiency of hepatic lipase and endothelial lipase on the metabolism of both high-density lipoproteins and apolipoprotein B-containing lipoproteins. Circ Res 2010; 107: 357-364.
50. Qiu G, Hill JS. Endothelial lipase promotes apolipoprotein AImediated cholesterol efflux in THP-1 macrophages. Arterioscler Thromb Vasc Biol 2009; 29: 84-91.
51. Wiersma H, Gatti A, Nijstad N, Kuipers F, Tietge UJ. Hepatic SRBI, not endothelial lipase, expression determines biliary cholesterol secretion in mice. J Lipid Res 2009; 50: 1571-1580.
52. Zhang X, Qi R, Xian X, Yang F, Blackstein M, Deng X, et al. Spontaneous atherosclerosis in aged lipoprotein lipase-deficient mice with severe hypertriglyceridemia on a normal chow diet. Circ Res 2008; 102: 250-256.
53. Shimada M, Ishibashi S, Inaba T, Yagyu H, Harada K, Osuga JI, et al. Suppression of diet-induced atherosclerosis in low density lipoprotein receptor knockout mice overexpressing lipoprotein lipase. Proc Natl Acad Sci USA 1996; 93: 7242-7246.
54. Ichikawa T, Kitajima S, Liang J, Koike T, Wang X, Sun H, et al. Overexpression of lipoprotein lipase in transgenic rabbits leads to increased small dense LDL in plasma and promotes atherosclerosis. Lab Invest 2004; 84: 715-726.
55. Mezdour H, Jones R, Dengremont C, Castro G, Maeda N. Hepatic lipase deficiency increases plasma cholesterol but reduces susceptibility to atherosclerosis in apolipoprotein E-deficient mice. J Biol Chem 1997; 272: 13570-13575.
56. Freeman L, Amar MJ, Shamburek R, Paigen B, Brewer HB Jr, Santamarina-Fojo S, et al. Lipolytic and ligand-binding functions of hepatic lipase protect against atherosclerosis in LDL receptordeficient mice. J Lipid Res 2007; 48: 104-113.
57. Ishida T, Choi SY, Kundu RK, Spin J, Yamashita T, Hirata K, et al. Endothelial lipase modulates susceptibility to atherosclerosis in apolipoprotein-E-deficient mice. J Biol Chem 2004; 279: 45085-45092.
58. Ko KW, Paul A, Ma K, Li L, Chan L. Endothelial lipase modulates HDL but has no effect on atherosclerosis development in apoE-/- and LDLR-/- mice. J Lipid Res 2005; 46: 2586-2594.
59. Broedl UC, Maugeais C, Millar JS, Jin W, Moore RE, Fuki IV, et al. Endothelial lipase promotes the catabolism of ApoB-containing lipoproteins. Circ Res 2004; 94: 1554-1561.
60. Ahmed W, Orasanu G, Nehra V, Asatryan L, Rader DJ, Ziouzenkova O, et al. High-density lipoprotein hydrolysis by endothelial lipase activates PPARalpha: A candidate mechanism for high-density lipoprotein-mediated repression of leukocyte adhesion. Circ Res 2006; 98: 490-498.
61. Kojma Y, Hirata K, Ishida T, Shimokawa Y, Inoue N, Kawashima S, et al. Endothelial lipase modulates monocyte adhesion to the vessel wall: A potential role in inflammation. J Biol Chem 2004; 279: 54032-54038.
62. Qiu G, Hill JS. Endothelial lipase enhances low density lipoprotein binding and cell association in THP-1 macrophages. Cardiovasc Res 2007; 76: 528-538.
63. Azumi H, Hirata K, Ishida T, Kojima Y, Rikitake Y, Takeuchi S, et al. Immunohistochemical localization of endothelial cell-derived lipase in atherosclerotic human coronary arteries. Cardiovasc Res 2003; 58: 647-654.
64. VanderLaan PA, Reardon CA, Thisted RA, Getz GS. VLDL best predicts aortic root atherosclerosis in LDL receptor deficient mice. J Lipid Res 2009; 50: 376-385.