Endothelial lipase enhances low density lipoprotein binding and cell association in THP-1 macrophages

Cardiovascular Research

Volumn 76, Issue 3, 2007, Pages 528-538

  Qiu, Guosong ^a   Hill, John S ^a  

^a ST PAUL S HOSPITAL   (Canada)

Author keywords

Atherosclerosis; Endothelial lipase; Lipid metabolism; Lipoproteins; Macrophages

Indexed keywords

ANTIBODY; CD36 ANTIGEN; COMPLEMENTARY DNA; HEPARAN SULFATE; HEPARIN LYASE; LENTIVIRUS VECTOR; LIPID; LOW DENSITY LIPOPROTEIN; LOW DENSITY LIPOPROTEIN RECEPTOR; MUTANT PROTEIN; OXIDIZED LOW DENSITY LIPOPROTEIN; PROTEOHEPARAN SULFATE; SHORT HAIRPIN RNA; TRIACYLGLYCEROL LIPASE;

ARTICLE; BINDING ASSAY; CATALYSIS; CELL FUNCTION; CONTROLLED STUDY; EMBRYO; ENDOTHELIUM; ENZYME INACTIVATION; GENE EXPRESSION REGULATION; GENE OVEREXPRESSION; HUMAN; HUMAN CELL; LIPID STORAGE; LIPID TRANSPORT; MACROPHAGE; PRIORITY JOURNAL; PROTEIN BINDING; RECEPTOR BLOCKING; WILD TYPE;

CELL ADHESION; CELL LINE, TUMOR; CELLS, CULTURED; HEPARAN SULFATE PROTEOGLYCANS; HUMANS; LEUKEMIA, MONOCYTIC, ACUTE; LIPASE; LIPID METABOLISM; LIPOPROTEINS, LDL; MACROPHAGES;

EID: 35548970798     PISSN: 00086363     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.cardiores.2007.08.002     Document Type: Article

References (42)

1. Wong H., and Schotz M.C. The lipase gene family. J Lipid Res 43 (2002) 993-999
2. Jaye M., Lynch K.J., Krawiec J., Marchadier D., Maugeais C., Doan K., et al. A novel endothelial-derived lipase that modulates HDL metabolism. Nat Genet 21 (1999) 424-428
3. Hirata K., Dichek H.L., Cioffi J.A., Choi S.Y., Leeper N.J., Quintana L., et al. Cloning of a unique lipase from endothelial cells extends the lipase gene family. J Biol Chem 274 (1999) 14170-14175
4. Jin W., Millar J.S., Broedl U., Glick J.M., and Rader D.J. Inhibition of endothelial lipase causes increased HDL cholesterol levels in vivo. J Clin Invest 111 (2003) 357-362
5. Ishida T., Choi S., Kundu R.K., Hirata K., Rubin E.M., Cooper A.D., et al. Endothelial lipase is a major determinant of HDL level. J Clin Invest 111 (2003) 347-355
6. Ma K., Cilingiroglu M., Otvos J.D., Ballantyne C.M., Marian A.J., and Chan L. Endothelial lipase is a major genetic determinant for high-density lipoprotein concentration, structure, and metabolism. Proc Natl Acad Sci U S A 100 (2003) 2748-2753
7. Paradis M.E., Badellino K.O., Rader D.J., Deshaies Y., Couture P., Archer W.R., et al. Endothelial lipase is associated with inflammation in humans. J Lipid Res 47 (2006) 2808-2813
8. Badellino K.O., Wolfe M.L., Reilly M.P., and Rader D.J. Endothelial lipase concentrations are increased in metabolic syndrome and associated with coronary atherosclerosis. PLoS Med 3 (2006) e22
9. Azumi H., Hirata K., Ishida T., Kojima Y., Rikitake Y., Takeuchi S., et al. Immunohistochemical localization of endothelial cell-derived lipase in atherosclerotic human coronary arteries. Cardiovasc Res 58 (2003) 647-654
10. Ishida T., Choi S.Y., Kundu R.K., Spin J., Yamashita T., Hirata K., et al. Endothelial lipase modulates susceptibility to atherosclerosis in apolipoprotein-E-deficient mice. J Biol Chem 279 (2004) 45085-45092
11. Ko K.W., Paul A., Ma K., Li L., and Chan L. Endothelial lipase modulates HDL but has no effect on atherosclerosis development in apoE-/- and LDLR-/- mice. J Lipid Res 46 (2005) 2586-2594
12. Broedl U.C., Maugeais C., Millar J.S., Jin W., Moore R.E., Fuki I.V., et al. Endothelial lipase promotes the catabolism of ApoB-containing lipoproteins. Circ Res 94 (2004) 1554-1561
13. Fuki I.V., Blanchard N., Jin W., Marchadier D.H., Millar J.S., Glick J.M., et al. Endogenously produced endothelial lipase enhances binding and cellular processing of plasma lipoproteins via heparan sulfate proteoglycan-mediated pathway. J Biol Chem 278 (2003) 34331-34338
14. Fan J., Unoki H., Kojima N., Sun H., Shimoyamada H., Deng H., et al. Overexpression of lipoprotein lipase in transgenic rabbits inhibits diet-induced hypercholesterolemia and atherosclerosis. J Biol Chem 276 (2001) 40071-40079
15. Koike T., Liang J., Wang X., Ichikawa T., Shiomi M., Sun H., et al. Enhanced aortic atherosclerosis in transgenic Watanabe heritable hyperlipidemic rabbits expressing lipoprotein lipase. Cardiovasc Res 65 (2005) 524-534
16. Semenkovich C.F., Coleman T., and Daugherty A. Effects of heterozygous lipoprotein lipase deficiency on diet-induced atherosclerosis in mice. J Lipid Res 39 (1998) 1141-1151
17. Wilson K., Fry G.L., Chappell D.A., Sigmund C.D., and Medh J.D. Macrophage-specific expression of human lipoprotein lipase accelerates atherosclerosis in transgenic apolipoprotein e knockout mice but not in C57BL/6 mice. Arterioscler Thromb Vasc Biol 21 (2001) 1809-1815
18. Yagyu H., Ishibashi S., Chen Z., Osuga J., Okazaki M., Perrey S., et al. Overexpressed lipoprotein lipase protects against atherosclerosis in apolipoprotein E knockout mice. J Lipid Res 40 (1999) 1677-1685
19. Babaev V.R., Fazio S., Gleaves L.A., Carter K.J., Semenkovich C.F., and Linton M.F. Macrophage lipoprotein lipase promotes foam cell formation and atherosclerosis in vivo. J Clin Invest 103 (1999) 1697-1705
20. Babaev V.R., Patel M.B., Semenkovich C.F., Fazio S., and Linton M.F. Macrophage lipoprotein lipase promotes foam cell formation and atherosclerosis in low density lipoprotein receptor-deficient mice. J Biol Chem 275 (2000) 26293-26299
21. Van Eck M., Zimmermann R., Groot P.H., Zechner R., and Van Berkel T.J. Role of macrophage-derived lipoprotein lipase in lipoprotein metabolism and atherosclerosis. Arterioscler Thromb Vasc Biol 20 (2000) E53-E62
22. Qiu G., Ho A.C., Yu W., and Hill J.S. Suppression of endothelial lipase or lipoprotein lipase expression in THP-1 macrophages attenuates pro-inflammatory cytokine secretion. J Lipid Res 48 (2007) 385-394
23. Hoff H.F., Whitaker T.E., and O'Neil J. Oxidation of low density lipoprotein leads to particle aggregation and altered macrophage recognition. J Biol Chem 267 (1992) 602-609
24. Ishikawa Y., Inadera H., Shirai K., Hashimoto H., Fukamachi I., Saito Y., et al. Moderate oxidation of hypertriglyceridemic low-density lipoprotein causes apolipoprotein B epitope change and enhances its uptake by macrophages. Biochim Biophys Acta 1126 (1992) 60-64
25. Hazell L.J., and Stocker R. Oxidation of low-density lipoprotein with hypochlorite causes transformation of the lipoprotein into a high-uptake form for macrophages. Biochem J 290 Pt 1 (1993) 165-172
26. Ji Z.S., Brecht W.J., Miranda R.D., Hussain M.M., Innerarity T.L., and Mahley R.W. Role of heparan sulfate proteoglycans in the binding and uptake of apolipoprotein E-enriched remnant lipoproteins by cultured cells. J Biol Chem 268 (1993) 10160-10167
27. Seo T., and St Clair R.W. Heparan sulfate proteoglycans mediate internalization and degradation of beta-VLDL and promote cholesterol accumulation by pigeon macrophages. J Lipid Res 38 (1997) 765-779
28. Bartels ED, Nielsen JE, Lindegaard ML, Hulten LM, Schroeder TV, Nielsen LB. Endothelial lipase is highly expressed in macrophages in advanced human atherosclerotic lesions. Atherosclerosis in press.
29. Campos H., Arnold K.S., Balestra M.E., Innerarity T.L., and Krauss R.M. Differences in receptor binding of LDL subfractions. Arterioscler Thromb Vasc Biol 16 (1996) 794-801
30. Merkel M., Heeren J., Dudeck W., Rinninger F., Radner H., Breslow J.L., et al. Inactive lipoprotein lipase (LPL) alone increases selective cholesterol ester uptake in vivo, whereas in the presence of active LPL it also increases triglyceride hydrolysis and whole particle lipoprotein uptake. J Biol Chem 277 (2002) 7405-7411
31. Merkel M., Kako Y., Radner H., Cho I.S., Ramasamy R., Brunzell J.D., et al. Catalytically inactive lipoprotein lipase expression in muscle of transgenic mice increases very low density lipoprotein uptake: direct evidence that lipoprotein lipase bridging occurs in vivo. Proc Natl Acad Sci U S A 95 (1998) 13841-13846
32. Lutz E.P., Merkel M., Kako Y., Melford K., Radner H., Breslow J.L., et al. Heparin-binding defective lipoprotein lipase is unstable and causes abnormalities in lipid delivery to tissues. J Clin Invest 107 (2001) 1183-1192
33. Chappell D.A., Fry G.L., Waknitz M.A., Muhonen L.E., Pladet M.W., Iverius P.H., et al. Lipoprotein lipase induces catabolism of normal triglyceride-rich lipoproteins via the low density lipoprotein receptor-related protein/alpha 2-macroglobulin receptor in vitro. A process facilitated by cell-surface proteoglycans. J Biol Chem 268 (1993) 14168-14175
34. Mulder M., Lombardi P., Jansen H., van Berkel T.J., Frants R.R., and Havekes L.M. Heparan sulphate proteoglycans are involved in the lipoprotein lipase-mediated enhancement of the cellular binding of very low density and low density lipoproteins. Biochem Biophys Res Commun 185 (1992) 582-587
35. Loeffler B., Heeren J., Blaeser M., Radner H., Kayser D., Aydin B., et al. Lipoprotein lipase facilitated uptake of LDL is mediated by the LDL receptor. J Lipid Res 48 (2007) 288-298
36. Mulder M., Lombardi P., Jansen H., van Berkel T.J., Frants R.R., and Havekes L.M. Low density lipoprotein receptor internalizes low density and very low density lipoproteins that are bound to heparan sulfate proteoglycans via lipoprotein lipase. J Biol Chem 268 (1993) 9369-9375
37. Obunike J.C., Sivaram P., Paka L., Low M.G., and Goldberg I.J. Lipoprotein lipase degradation by adipocytes: receptor-associated protein (RAP)-sensitive and proteoglycan-mediated pathways. J Lipid Res 37 (1996) 2439-2449
38. Sehayek E., Wang X.X., Vlodavsky I., Avner R., Levkovitz H., Olivecrona T., et al. Heparan sulfate-dependent and low density lipoprotein receptor-related protein-dependent catabolic pathways for lipoprotein lipase in mouse embryonic fibroblasts. Isr J Med Sci 32 (1996) 449-454
39. Beisiegel U., Weber W., and Bengtsson-Olivecrona G. Lipoprotein lipase enhances the binding of chylomicrons to low density lipoprotein receptor-related protein. Proc Natl Acad Sci U S A 88 (1991) 8342-8346
40. Chappell D.A., Fry G.L., Waknitz M.A., Iverius P.H., Williams S.E., and Strickland D.K. The low density lipoprotein receptor-related protein/alpha 2-macroglobulin receptor binds and mediates catabolism of bovine milk lipoprotein lipase. J Biol Chem 267 (1992) 25764-25767
41. Saxena U., Klein M.G., and Goldberg I.J. Metabolism of endothelial cell-bound lipoprotein lipase. Evidence for heparan sulfate proteoglycan-mediated internalization and recycling. J Biol Chem 265 (1990) 12880-12886
42. Williams K.J., Fless G.M., Petrie K.A., Snyder M.L., Brocia R.W., and Swenson T.L. Mechanisms by which lipoprotein lipase alters cellular metabolism of lipoprotein(a), low density lipoprotein, and nascent lipoproteins. Roles for low density lipoprotein receptors and heparan sulfate proteoglycans. J Biol Chem 267 (1992) 13284-13292