Overexpression of lipoprotein lipase in transgenic rabbits leads to increased small dense LDL in plasma and promotes atherosclerosis

Laboratory Investigation

Volumn 84, Issue 6, 2004, Pages 715-726

  Ichikawa, Tomonaga ^a   Kitajima, Shuji ^b   Liang, Jingyan ^a   Koike, Tomonari ^a   Wang, Xiaofei ^a   Sun, Huijun ^a,c   Okazaki, Mitsuyo ^d   Morimoto, Masatoshi ^b   Shikama, Hisataka ^e   Watanabe, Teruo ^b   Yamada, Nobuhiro ^a   Fan, Jianglin ^a  

^a UNIVERSITY OF TSUKUBA   (Japan)

^b SAGA UNIVERSITY   (Japan)

^c DALIAN MEDICAL UNIVERSITY   (China)

^d TOKYO MEDICAL AND DENTAL UNIVERSITY   (Japan)

^e ASTELLAS PHARMA INC   (Japan)

Author keywords

Atherosclerosis; Hypercholesterolemia; Lipoprotein lipase; Macrophage; Remnant lipoprotein; Small dense LDL; Transgenic rabbit

Indexed keywords

APOLIPOPROTEIN B; CHOLESTEROL; COPPER; LIPOPROTEIN LIPASE; LOW DENSITY LIPOPROTEIN; TRIACYLGLYCEROL; VERY LOW DENSITY LIPOPROTEIN;

ADIPOSE TISSUE; ANIMAL EXPERIMENT; ANIMAL TISSUE; AORTA ATHEROSCLEROSIS; ARTICLE; ATHEROSCLEROSIS; CHOLESTEROL BLOOD LEVEL; CONTROLLED STUDY; DIET; ENZYME ACTIVITY; GENE OVEREXPRESSION; HUMAN; HYPERCHOLESTEROLEMIA; LIPOPROTEIN METABOLISM; MALE; NONHUMAN; OXIDATION; PRIORITY JOURNAL; RABBIT; SKELETAL MUSCLE; TRANSGENIC ANIMAL; TRANSGENIC MOUSE;

ANIMALS; ANIMALS, GENETICALLY MODIFIED; AORTA; APOLIPOPROTEINS B; ARTERIOSCLEROSIS; GENE EXPRESSION; HUMANS; LIPOPROTEIN LIPASE; LIPOPROTEINS, LDL; LIPOPROTEINS, VLDL; MALE; MICROSCOPY, ELECTRON; RABBITS; RECOMBINANT PROTEINS;

EID: 2642581722     PISSN: 00236837     EISSN: None     Source Type: Journal    
DOI: 10.1038/labinvest.3700102     Document Type: Article

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