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Volumn 36, Issue 7, 2010, Pages 598-611

Inhibition of microglial and astrocytic inflammatory responses by the immunosuppressant mycophenolate mofetil

Author keywords

Astrocytes; Inflammation; Microglia; Mycophenolate mofetil; Nitric oxide; Proinflammatory cytokines

Indexed keywords

GUANOSINE; IMMUNOSUPPRESSIVE AGENT; INOSINE PHOSPHATE; INTERLEUKIN 1BETA; LIPOPOLYSACCHARIDE; MYCOPHENOLIC ACID 2 MORPHOLINOETHYL ESTER; NITRIC OXIDE; TUMOR NECROSIS FACTOR ALPHA;

EID: 78349278062     PISSN: 03051846     EISSN: 13652990     Source Type: Journal    
DOI: 10.1111/j.1365-2990.2010.01104.x     Document Type: Article
Times cited : (12)

References (45)
  • 1
    • 0026575478 scopus 로고
    • Macrophages and inflammatory damage in spinal cord injury
    • Blight AR. Macrophages and inflammatory damage in spinal cord injury. J Neurotrauma 1992; 9 (Suppl. 1): S83-91
    • (1992) J Neurotrauma , vol.9 , Issue.1 SUPPL.
    • Blight, A.R.1
  • 2
    • 0025786684 scopus 로고
    • Glial changes following an excitotoxic lesion in the CNS - I. Microglia/macrophages
    • Marty S, Dusart I, Peschanski M. Glial changes following an excitotoxic lesion in the CNS - I. Microglia/macrophages. Neuroscience 1991; 45: 529-39
    • (1991) Neuroscience , vol.45 , pp. 529-539
    • Marty, S.1    Dusart, I.2    Peschanski, M.3
  • 3
    • 0029346926 scopus 로고
    • Resident microglia and hematogenous macrophages as phagocytes in adoptively transferred experimental autoimmune encephalomyelitis: an investigation using rat radiation bone marrow chimeras
    • Rinner WA, Bauer J, Schmidts M, Lassmann H, Hickey WF. Resident microglia and hematogenous macrophages as phagocytes in adoptively transferred experimental autoimmune encephalomyelitis: an investigation using rat radiation bone marrow chimeras. Glia 1995; 14: 257-66
    • (1995) Glia , vol.14 , pp. 257-266
    • Rinner, W.A.1    Bauer, J.2    Schmidts, M.3    Lassmann, H.4    Hickey, W.F.5
  • 5
    • 33646790870 scopus 로고    scopus 로고
    • Strategies of medical intervention in the management of acute spinal cord injury
    • Hurlbert RJ. Strategies of medical intervention in the management of acute spinal cord injury. Spine 2006; 31 (Suppl. 11): S16-21
    • (2006) Spine , vol.31 , Issue.11 SUPPL.
    • Hurlbert, R.J.1
  • 8
    • 0032816454 scopus 로고    scopus 로고
    • The effects of FK506 on dorsal column axons following spinal cord injury in adult rats: neuroprotection and local regeneration
    • Bavetta S, Hamlyn PJ, Burnstock G, Lieberman AR, Anderson PN. The effects of FK506 on dorsal column axons following spinal cord injury in adult rats: neuroprotection and local regeneration. Exp Neurol 1999; 158: 382-93
    • (1999) Exp Neurol , vol.158 , pp. 382-393
    • Bavetta, S.1    Hamlyn, P.J.2    Burnstock, G.3    Lieberman, A.R.4    Anderson, P.N.5
  • 9
    • 0028262480 scopus 로고
    • Suppressive effect of FK-506, a novel immunosuppressant, against MPTP-induced dopamine depletion in the striatum of young C57BL/6 mice
    • Kitamura Y, Itano Y, Kubo T, Nomura Y. Suppressive effect of FK-506, a novel immunosuppressant, against MPTP-induced dopamine depletion in the striatum of young C57BL/6 mice. J Neuroimmunol 1994; 50: 221-4
    • (1994) J Neuroimmunol , vol.50 , pp. 221-224
    • Kitamura, Y.1    Itano, Y.2    Kubo, T.3    Nomura, Y.4
  • 11
    • 0027240533 scopus 로고
    • Macrolide antibiotics protect neurons in culture against the N-methyl-D-aspartate (NMDA) receptor-mediated toxicity of glutamate
    • Manev H, Favaron M, Candeo P, Fadda E, Lipartiti M, Milani D. Macrolide antibiotics protect neurons in culture against the N-methyl-D-aspartate (NMDA) receptor-mediated toxicity of glutamate. Brain Res 1993; 624: 331-5
    • (1993) Brain Res , vol.624 , pp. 331-335
    • Manev, H.1    Favaron, M.2    Candeo, P.3    Fadda, E.4    Lipartiti, M.5    Milani, D.6
  • 12
    • 0042970735 scopus 로고    scopus 로고
    • FK506 and its analogs - therapeutic potential for neurological disorders
    • Klettner A, Herdegen T. FK506 and its analogs - therapeutic potential for neurological disorders. Curr Drug Targets CNS Neurol Disord 2003; 2: 153-62
    • (2003) Curr Drug Targets CNS Neurol Disord , vol.2 , pp. 153-162
    • Klettner, A.1    Herdegen, T.2
  • 13
    • 20444441180 scopus 로고    scopus 로고
    • Interleukin-1beta exacerbates and interleukin-1 receptor antagonist attenuates neuronal injury and microglial activation after excitotoxic damage in organotypic hippocampal slice cultures
    • Hailer NP, Vogt C, Korf HW, Dehghani F. Interleukin-1beta exacerbates and interleukin-1 receptor antagonist attenuates neuronal injury and microglial activation after excitotoxic damage in organotypic hippocampal slice cultures. Eur J Neurosci 2005; 21: 2347-60
    • (2005) Eur J Neurosci , vol.21 , pp. 2347-2360
    • Hailer, N.P.1    Vogt, C.2    Korf, H.W.3    Dehghani, F.4
  • 14
    • 0031595870 scopus 로고    scopus 로고
    • Interleukin-1beta and the interleukin-1 receptor antagonist act in the striatum to modify excitotoxic brain damage in the rat
    • Lawrence CB, Allan SM, Rothwell NJ. Interleukin-1beta and the interleukin-1 receptor antagonist act in the striatum to modify excitotoxic brain damage in the rat. Eur J Neurosci 1998; 10: 1188-95
    • (1998) Eur J Neurosci , vol.10 , pp. 1188-1195
    • Lawrence, C.B.1    Allan, S.M.2    Rothwell, N.J.3
  • 15
    • 57049150620 scopus 로고    scopus 로고
    • Successful inhibition of excitotoxic neuronal damage and microglial activation after delayed application of interleukin-1 receptor antagonist
    • Vogt C, Hailer NP, Ghadban C, Korf HW, Dehghani F. Successful inhibition of excitotoxic neuronal damage and microglial activation after delayed application of interleukin-1 receptor antagonist. J Neurosci Res 2008; 86: 3314-21
    • (2008) J Neurosci Res , vol.86 , pp. 3314-3321
    • Vogt, C.1    Hailer, N.P.2    Ghadban, C.3    Korf, H.W.4    Dehghani, F.5
  • 16
    • 0034045586 scopus 로고    scopus 로고
    • Mycophenolate mofetil and its mechanisms of action
    • Allison AC, Eugui EM. Mycophenolate mofetil and its mechanisms of action. Immunopharmacology 2000; 47: 85-118
    • (2000) Immunopharmacology , vol.47 , pp. 85-118
    • Allison, A.C.1    Eugui, E.M.2
  • 17
    • 0026081633 scopus 로고
    • Lymphocyte-selective antiproliferative and immunosuppressive effects of mycophenolic acid in mice
    • Eugui EM, Mirkovich A, Allison AC. Lymphocyte-selective antiproliferative and immunosuppressive effects of mycophenolic acid in mice. Scand J Immunol 1991; 33: 175-83
    • (1991) Scand J Immunol , vol.33 , pp. 175-183
    • Eugui, E.M.1    Mirkovich, A.2    Allison, A.C.3
  • 18
    • 0141836933 scopus 로고    scopus 로고
    • The immunosuppressant mycophenolate mofetil attenuates neuronal damage after excitotoxic injury in hippocampal slice cultures
    • Dehghani F, Hischebeth GT, Wirjatijasa F, Kohl A, Korf HW, Hailer NP. The immunosuppressant mycophenolate mofetil attenuates neuronal damage after excitotoxic injury in hippocampal slice cultures. Eur J Neurosci 2003; 18: 1061-72
    • (2003) Eur J Neurosci , vol.18 , pp. 1061-1072
    • Dehghani, F.1    Hischebeth, G.T.2    Wirjatijasa, F.3    Kohl, A.4    Korf, H.W.5    Hailer, N.P.6
  • 19
    • 33745119046 scopus 로고    scopus 로고
    • The immunosuppressant mycophenolate mofetil improves preservation of the perforant path in organotypic hippocampal slice cultures: a retrograde tracing study
    • Oest TM, Dehghani F, Korf HW, Hailer NP. The immunosuppressant mycophenolate mofetil improves preservation of the perforant path in organotypic hippocampal slice cultures: a retrograde tracing study. Hippocampus 2006; 16: 437-42
    • (2006) Hippocampus , vol.16 , pp. 437-442
    • Oest, T.M.1    Dehghani, F.2    Korf, H.W.3    Hailer, N.P.4
  • 20
    • 0034883429 scopus 로고    scopus 로고
    • Astrocytic factors protect neuronal integrity and reduce microglial activation in an in vitro model of N-methyl-D-aspartate-induced excitotoxic injury in organotypic hippocampal slice cultures
    • Hailer NP, Wirjatijasa F, Roser N, Hischebeth GT, Korf HW, Dehghani F. Astrocytic factors protect neuronal integrity and reduce microglial activation in an in vitro model of N-methyl-D-aspartate-induced excitotoxic injury in organotypic hippocampal slice cultures. Eur J Neurosci 2001; 14: 315-26
    • (2001) Eur J Neurosci , vol.14 , pp. 315-326
    • Hailer, N.P.1    Wirjatijasa, F.2    Roser, N.3    Hischebeth, G.T.4    Korf, H.W.5    Dehghani, F.6
  • 21
    • 4544382302 scopus 로고    scopus 로고
    • Clodronate inhibits the secretion of proinflammatory cytokines and NO by isolated microglial cells and reduces the number of proliferating glial cells in excitotoxically injured organotypic hippocampal slice cultures
    • Dehghani F, Conrad A, Kohl A, Korf HW, Hailer NP. Clodronate inhibits the secretion of proinflammatory cytokines and NO by isolated microglial cells and reduces the number of proliferating glial cells in excitotoxically injured organotypic hippocampal slice cultures. Exp Neurol 2004; 189: 241-51
    • (2004) Exp Neurol , vol.189 , pp. 241-251
    • Dehghani, F.1    Conrad, A.2    Kohl, A.3    Korf, H.W.4    Hailer, N.P.5
  • 22
    • 0019423594 scopus 로고
    • Use of avidin-biotin-peroxidase complex (ABC) in immunoperoxidase techniques: a comparison between ABC and unlabeled antibody (PAP) procedures
    • Hsu SM, Raine L, Fanger H. Use of avidin-biotin-peroxidase complex (ABC) in immunoperoxidase techniques: a comparison between ABC and unlabeled antibody (PAP) procedures. J Histochem Cytochem 1981; 29: 577-80
    • (1981) J Histochem Cytochem , vol.29 , pp. 577-580
    • Hsu, S.M.1    Raine, L.2    Fanger, H.3
  • 23
    • 0036605571 scopus 로고    scopus 로고
    • Interleukin-4, interleukin-10, and interleukin-1-receptor antagonist but not transforming growth factor-beta induce ramification and reduce adhesion molecule expression of rat microglial cells
    • Wirjatijasa F, Dehghani F, Blaheta RA, Korf HW, Hailer NP. Interleukin-4, interleukin-10, and interleukin-1-receptor antagonist but not transforming growth factor-beta induce ramification and reduce adhesion molecule expression of rat microglial cells. J Neurosci Res 2002; 68: 579-87
    • (2002) J Neurosci Res , vol.68 , pp. 579-587
    • Wirjatijasa, F.1    Dehghani, F.2    Blaheta, R.A.3    Korf, H.W.4    Hailer, N.P.5
  • 24
    • 0037238362 scopus 로고    scopus 로고
    • Mycophenolic acid inhibits inosine 5'-monophosphate dehydrogenase and suppresses immunoglobulin and cytokine production of B cells
    • Jonsson CA, Carlsten H. Mycophenolic acid inhibits inosine 5'-monophosphate dehydrogenase and suppresses immunoglobulin and cytokine production of B cells. Int Immunopharmacol 2003; 3: 31-7
    • (2003) Int Immunopharmacol , vol.3 , pp. 31-37
    • Jonsson, C.A.1    Carlsten, H.2
  • 25
    • 0028026864 scopus 로고
    • Interleukin-4 induces proliferation and activation of microglia but suppresses their induction of class II major histocompatibility complex antigen expression
    • Suzumura A, Sawada M, Itoh Y, Marunouchi T. Interleukin-4 induces proliferation and activation of microglia but suppresses their induction of class II major histocompatibility complex antigen expression. J Neuroimmunol 1994; 53: 209-18
    • (1994) J Neuroimmunol , vol.53 , pp. 209-218
    • Suzumura, A.1    Sawada, M.2    Itoh, Y.3    Marunouchi, T.4
  • 26
    • 0032823758 scopus 로고    scopus 로고
    • Proliferation of microglia and astrocytes in the dentate gyrus following entorhinal cortex lesion: a quantitative bromodeoxyuridine-labelling study
    • Hailer NP, Grampp A, Nitsch R. Proliferation of microglia and astrocytes in the dentate gyrus following entorhinal cortex lesion: a quantitative bromodeoxyuridine-labelling study. Eur J Neurosci 1999; 11: 3359-64
    • (1999) Eur J Neurosci , vol.11 , pp. 3359-3364
    • Hailer, N.P.1    Grampp, A.2    Nitsch, R.3
  • 27
    • 0034672185 scopus 로고    scopus 로고
    • Corticotropin releasing factor induces proliferation of cerebellar astrocytes
    • Ha BK, Bishop GA, King JS, Burry RW. Corticotropin releasing factor induces proliferation of cerebellar astrocytes. J Neurosci Res 2000; 62: 789-98
    • (2000) J Neurosci Res , vol.62 , pp. 789-798
    • Ha, B.K.1    Bishop, G.A.2    King, J.S.3    Burry, R.W.4
  • 28
    • 0032006643 scopus 로고    scopus 로고
    • Vitamin E induces ramification and downregulation of adhesion molecules in cultured microglial cells
    • Heppner FL, Roth K, Nitsch R, Hailer NP. Vitamin E induces ramification and downregulation of adhesion molecules in cultured microglial cells. Glia 1998; 22: 180-8
    • (1998) Glia , vol.22 , pp. 180-188
    • Heppner, F.L.1    Roth, K.2    Nitsch, R.3    Hailer, N.P.4
  • 29
    • 0345305740 scopus 로고    scopus 로고
    • Mycophenolate mofetil inhibits human Tenon fibroblast proliferation by guanosine depletion
    • Heinz C, Heise K, Hudde T, Steuhl KP. Mycophenolate mofetil inhibits human Tenon fibroblast proliferation by guanosine depletion. Br J Ophthalmol 2003; 87: 1397-8
    • (2003) Br J Ophthalmol , vol.87 , pp. 1397-1398
    • Heinz, C.1    Heise, K.2    Hudde, T.3    Steuhl, K.P.4
  • 30
    • 0029609949 scopus 로고
    • Mycophenolate mofetil (MMF, RS-61443) inhibits inflammation and smooth muscle cell proliferation in rat aortic allografts
    • Raisanen-Sokolowski A, Vuoristo P, Myllarniemi M, Yilmaz S, Kallio E, Hayry P. Mycophenolate mofetil (MMF, RS-61443) inhibits inflammation and smooth muscle cell proliferation in rat aortic allografts. Transpl Immunol 1995; 3: 342-51
    • (1995) Transpl Immunol , vol.3 , pp. 342-351
    • Raisanen-Sokolowski, A.1    Vuoristo, P.2    Myllarniemi, M.3    Yilmaz, S.4    Kallio, E.5    Hayry, P.6
  • 31
    • 0038011246 scopus 로고    scopus 로고
    • Cardiac allograft vasculopathy: current concepts and treatment
    • Waller J, Brook NR, Nicholson ML. Cardiac allograft vasculopathy: current concepts and treatment. Transpl Int 2003; 16: 367-75
    • (2003) Transpl Int , vol.16 , pp. 367-375
    • Waller, J.1    Brook, N.R.2    Nicholson, M.L.3
  • 32
    • 0031759148 scopus 로고    scopus 로고
    • Mycophenolic acid: a new approach to the therapy of experimental mesangial proliferative glomerulonephritis
    • Ziswiler R, Steinmann-Niggli K, Kappeler A, Daniel C, Marti HP. Mycophenolic acid: a new approach to the therapy of experimental mesangial proliferative glomerulonephritis. J Am Soc Nephrol 1998; 9: 2055-66
    • (1998) J Am Soc Nephrol , vol.9 , pp. 2055-2066
    • Ziswiler, R.1    Steinmann-Niggli, K.2    Kappeler, A.3    Daniel, C.4    Marti, H.P.5
  • 33
    • 0033567353 scopus 로고    scopus 로고
    • Mycophenolic acid increases apoptosis, lysosomes and lipid droplets in human lymphoid and monocytic cell lines
    • Cohn RG, Mirkovich A, Dunlap B, Burton P, Chiu SH, Eugui E, Caulfield JP. Mycophenolic acid increases apoptosis, lysosomes and lipid droplets in human lymphoid and monocytic cell lines. Transplantation 1999; 68: 411-18
    • (1999) Transplantation , vol.68 , pp. 411-418
    • Cohn, R.G.1    Mirkovich, A.2    Dunlap, B.3    Burton, P.4    Chiu, S.H.5    Eugui, E.6    Caulfield, J.P.7
  • 34
    • 0025782723 scopus 로고
    • Purinergic stimulation of astroblast proliferation: guanosine and its nucleotides stimulate cell division in chick astroblasts
    • Kim JK, Rathbone MP, Middlemiss PJ, Hughes DW, Smith RW. Purinergic stimulation of astroblast proliferation: guanosine and its nucleotides stimulate cell division in chick astroblasts. J Neurosci Res 1991; 28: 442-55
    • (1991) J Neurosci Res , vol.28 , pp. 442-455
    • Kim, J.K.1    Rathbone, M.P.2    Middlemiss, P.J.3    Hughes, D.W.4    Smith, R.W.5
  • 36
    • 0028953023 scopus 로고
    • Extracellular guanosine and guanosine-5'-triphosphate increase: NGF synthesis and release from cultured mouse neopallial astrocytes
    • Middlemiss PJ, Gysbers JW, Rathbone MP. Extracellular guanosine and guanosine-5'-triphosphate increase: NGF synthesis and release from cultured mouse neopallial astrocytes. Brain Res 1995; 677: 152-6
    • (1995) Brain Res , vol.677 , pp. 152-156
    • Middlemiss, P.J.1    Gysbers, J.W.2    Rathbone, M.P.3
  • 38
    • 0026468615 scopus 로고
    • Guanosine enhances NGF-stimulated neurite outgrowth in PC12 cells
    • Gysbers JW, Rathbone MP. Guanosine enhances NGF-stimulated neurite outgrowth in PC12 cells. Neuroreport 1992; 3: 997-1000
    • (1992) Neuroreport , vol.3 , pp. 997-1000
    • Gysbers, J.W.1    Rathbone, M.P.2
  • 39
    • 0035958192 scopus 로고    scopus 로고
    • Effects of immunosuppressive treatment on host responses against intracerebral porcine neural tissue xenografts in rats
    • Wennberg L, Czech KA, Larsson LC, Mirza B, Bennet W, Song Z, Widner H. Effects of immunosuppressive treatment on host responses against intracerebral porcine neural tissue xenografts in rats. Transplantation 2001; 71: 1797-806
    • (2001) Transplantation , vol.71 , pp. 1797-1806
    • Wennberg, L.1    Czech, K.A.2    Larsson, L.C.3    Mirza, B.4    Bennet, W.5    Song, Z.6    Widner, H.7
  • 40
    • 33749075049 scopus 로고    scopus 로고
    • Combined immunosuppressive agents or CD4 antibodies prolong survival of human neural stem cell grafts and improve disease outcomes in amyotrophic lateral sclerosis transgenic mice
    • Yan J, Xu L, Welsh AM, Chen D, Hazel T, Johe K, Koliatsos VE. Combined immunosuppressive agents or CD4 antibodies prolong survival of human neural stem cell grafts and improve disease outcomes in amyotrophic lateral sclerosis transgenic mice. Stem Cells 2006; 24: 1976-85
    • (2006) Stem Cells , vol.24 , pp. 1976-1985
    • Yan, J.1    Xu, L.2    Welsh, A.M.3    Chen, D.4    Hazel, T.5    Johe, K.6    Koliatsos, V.E.7
  • 42
    • 0034935149 scopus 로고    scopus 로고
    • Mycophenolate-mofetil in the treatment of refractory multiple sclerosis
    • Ahrens N, Salama A, Haas J. Mycophenolate-mofetil in the treatment of refractory multiple sclerosis. J Neurol 2001; 248: 713-14
    • (2001) J Neurol , vol.248 , pp. 713-714
    • Ahrens, N.1    Salama, A.2    Haas, J.3
  • 44
    • 0035310730 scopus 로고    scopus 로고
    • Mycophenolate (CellCept) treatment of myasthenia gravis, chronic inflammatory polyneuropathy and inclusion body myositis
    • Mowzoon N, Sussman A, Bradley WG. Mycophenolate (CellCept) treatment of myasthenia gravis, chronic inflammatory polyneuropathy and inclusion body myositis. J Neurol Sci 2001; 185: 119-22
    • (2001) J Neurol Sci , vol.185 , pp. 119-122
    • Mowzoon, N.1    Sussman, A.2    Bradley, W.G.3


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