Mycophenolic acid increases apoptosis, lysosomes and lipid droplets in human lymphoid and monocytic cell lines

Transplantation

Volumn 68, Issue 3, 1999, Pages 411-418

  Cohn, Ronald G ^a   Mirkovich, Anna ^a   Dunlap, Bonnie ^a   Burton, Pamela ^a   Chiu, Shu Hui ^a   Eugui, Elsie ^a   Caulfield, John P ^a  

^a ROCHE BIOSCIENCE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

GUANOSINE; INOSINATE DEHYDROGENASE; MYCOPHENOLIC ACID; TRIACYLGLYCEROL;

ANTIINFLAMMATORY ACTIVITY; APOPTOSIS; ARTICLE; CELL PROLIFERATION; CELL VIABILITY; CONTROLLED STUDY; DNA SYNTHESIS INHIBITION; DRUG EFFICACY; ENZYME INHIBITION; HUMAN; HUMAN CELL; IMMUNOSUPPRESSIVE TREATMENT; PRIORITY JOURNAL;

APOPTOSIS; CELL LINE; CELL SIZE; DOSE-RESPONSE RELATIONSHIP, DRUG; GUANOSINE; HUMANS; LIPIDS; LYMPHOCYTES; LYSOSOMES; MONOCYTES; MYCOPHENOLIC ACID; TUMOR CELLS, CULTURED; U937 CELLS;

EID: 0033567353     PISSN: 00411337     EISSN: None     Source Type: Journal    
DOI: 10.1097/00007890-199908150-00014     Document Type: Article

References (44)

1. Wu JC. Mycophenolate mofetil: molecular mechanisms of action. Perspect Drug Disc Design 1994; 2: 185.
2. Allison AC, Eugui EM. Immunosuppressive and other effects of mycophenolic acid and an ester prodrug, mycophenolate mofetil. Immunol Rev 1993; 136: 5.
3. Allison AC, Kowalski WJ, Muller CD, Eugui EM. Mechanisms of action of mycophenolic acid. Ann NY Acad Sci 1993; 696: 63.
4. Natsumeda Y, Carr SF. Human type I and type II IMPDH as drug targets. Ann NY Acad Sci 1993; 696: 88.
5. Eugui EM, Almquist SJ, Muller CD, Allison AC. Lymphocyte-selective cytostatic and immunosuppressive effects of mycophenolic acid in vitro: role of guanosine nucleotide depletion. Scand. J Immunol 1991; 33: 161.
6. Eugui EM, Mirkovich A, Allison AC. Lymphocyte-selective antiproliferative and immunosuppressive effects of mycophenolic acid in mice. Scand J Immunol 1991; 33: 175.
7. Squier MK, Sehnert AJ, Cohen JJ. Apoptosis in leukocytes. J Leukocyte Biol 1995; 57: 2.
8. Goldblum R. Therapy of rheumatoid arthritis with mycophenolate mofetil. Clin Exp Rheum 1993; 11 (suppl. 8): S117.
9. Waters R, Webster D, Allison AC. Mycophenolic acid and some antioxidants induce differentiation of monocytic lineage cells and augment production of IL-1 receptor antagonist. Ann NY Acad Sci 1993; 696: 185.
10. Allison AC, Waters RV. Long-acting antirheumatic drugs induce differentiation of cells of the monocyte-macrophage lineage and alter the expression of cytokines and IL-1 receptor antagonist. Agents Actions (Suppl) 1993; 44: 113.
11. Minowada J, Onuma T, Moore GE. Rosette-forming human lymphoid cell lines. I. Establishment and evidence for origin of thymus-derived lymphocytes. J Natl Cancer Inst 1972; 49: 891.
12. Sundstrom C, Nilsson K. Establishment and characterization of a human histiocytic lymphoma cell line (U-937). Int J Cancer 1976; 17: 565.
13. Tsuchiya S, Yamabe M, Yamaguchi Y, Kobayashi Y, Konno T, Tada K. Establishment and characterization of a human acute monocytic leukemia cell line (THP-1). Int J Cancer 1980; 26: 171.
14. Knight DP. Cytological staining methods in electron microscopy. In: Lewis PR, Knight DP, eds. Staining methods for sectioned material. New York: North-Holland Publishing Company, 1982: 25.
15. Humphrey CD, Pittman FE. A simple methylene blue - azure II - basic fuchsin stain for epoxy embedded tissue sections. Stain Technol 1974; 49: 9.
16. Robinson JP, Darzynkiewicz Z, Dean PN, et al. Basic protocol 1: DNA content analysis of fixed cells with propidium iodide. In: Current protocols in cytometry on CD-ROM. New York: John Wiley & Sons, 1998.
17. Greenspan P, Mayer EP, Fowler SD. Nile red: a selective fluorescent stain for intracellular lipid droplets. J Cell Biol 1985; 100: 965.
18. Cianflone K, Dahan S, Monge JC, Sniderman AD. Pathogenesis of carbohydrate-induced hypertriglyceridemia using HepG2 cells as a model system. Arteriosclerosis Thrombosis 1992; 12: 271.
19. Cohen JJ. Apoptosis. Immunol Today 1993; 14: 126.
20. Allison AC, Mallucci L. Uptake of hydrocarbon carcinogens by lysosomes. Nature 1964; 203: 1024.
21. Yamaji Y, Natsumeda Y, Yamada Y, Irino S, Weber G. Synergistic action of tiazofurin and retinoic acid on differentiation and colony formation of HL-60 leukemia cells. Life Sci 1990; 46: 435.
22. Knight RD, Mangum J, Lucas DL, Cooney DA, Khan EC, Wright DG. Inosine monophosphate dehydrogenase and myeloid cell maturation. Blood 1987; 69: 634.
23. Lucas DL, Robins RK, Knight RD, Wright DG. Induced maturation of the human promyelocytic leukemia cell line, HL-60, by 2-b-D-ribofuranosylselenazole-4-carboxamide. Biochem Biophys Res Commun 1983; 115: 971.
24. Lucas DL, Webster K, Wright DG. Purine metabolism in myeloid precursor cells during maturation: studies with the HL-60 cell line. J Clin Invest 1983; 72: 1889.
25. Stet EH, DeAbreu RA, Bokkerink JPM, et al. Inhibition of IMP dehydrogenase by mycophenolic acid in Molt F4 human malignant lymphoblasts. Ann Clin Biochem 1994; 31: 174.
26. Catapano CV, Dayton JS, Mitchell BS, Fernandes DJ. GTP depletion induced by IMP dehydrogenase inhibitors blocks RNA-primed DNA synthesis. Molec Pharm 1995; 47: 948.
27. Cherwinski HM, Cohn RG, Cheung P, et al. The immunosuppressant leflunomide inhibits lymphocyte proliferation by inhibiting pyrimidine biosynthesis. J Pharm Exp Ther 1995; 275: 1043.
28. Kiguchi K, Collart FR, Henning-Chubb C, Huberman E. Cell differentiation and altered IMP dehydrogenase expression in human T-lymphoblastoid leukemic cells by mycophenolic acid and tiazofurin. Exp Cell Res 1990; 187: 47.
29. Collart FR, Huberman E. Expression of IMP dehydrogenase in differentiating HL-60 cells. Blood 1990; 75: 570.
30. Banka CL, Black AS, Dyer CA, Curtiss LK. THP-1 cells form foam cells in response to coculture with lipoproteins but not platelets. J Lipid Res 1991; 32: 35.
31. Miyazaki A, Rahim AT, Ohta T, Morino Y, Horiuchi S. High density lipoprotein mediates selective reduction in cholesteryl esters from macrophage foam cells. Biochim Biophys Acta 1992; 1126: 73.
32. Tangirala RK, Jerome WG, Jones NL, et al. Formation of cholesterol monohydrate crystals in macrophage-derived foam cells. J Lipid Res 1994; 35: 93.
33. Dodd RC, Cohen MS, Newman SL, Gray TK. Vitamin D metabolites change the phenotype of monoblastic U937 cells. Proc Natl Acad Sci USA 1983; 80: 7538.
34. Olsson I, Gullberg U, Ivhed I, Nilsson K. Induction of differentiation of the human histiocytic lymphoma cell line U937 by 1-a,25-dihydroxycholecalciferol. Cancer Res 1983; 43: 5862.
35. 3-induced alterations of lipid metabolism in human monocyte-macrophages. Am J Physiol 1989; 257: E290.
36. Costlow ME. Differentiation-inducing agents decrease cryptic prolactin receptors in cultured rat mammary tumor cells. Exp Cell Res 1984; 155: 17.
37. Freitas I, Pontiggia P, Barni S, et al. Histochemical probes for the detection of hypoxic tumour cells. Anticancer Res 1990; 10: 613.
38. Greve G, Rotevatn S, Svendby K, Grong K. Early morphologic changes in cat heart muscle cells after acute coronary artery occlusion. Am J Pathol 1990; 136: 273.
39. Johnson JA, Willis WT, Dallman PR, Brooks GA. Muscle mitochondrial ultrastructure in exercise-trained iron-deficient rats. J Appl Physiol 1990; 68: 113.
40. Schaper J, Froede R, St.Hein MD, et al. Impairment of the myocardial ultrastructure and changes of the cytoskeleton in dilated cardiomyopathy. Circulation 199; 83: 504.
41. Roux-Lombard P, Modoux C, Dayer JM. Production of interleukin-1 (IL-1) and a specific IL-1 inhibitor during human monocyte-macrophage differentiation: Influence of GM-CSF. Cytokine 1989; 1: 45.
42. Azuma H, Binder J, Heeman U, Schmid C, Tullius SG, Tilney NL. Effects of RS61443 on functional and morphological changes in chronically rejecting rat kidney allografts. Transplantation 1995; 59: 460.
43. Platz KP, Bechstein WO, Eckhoff DE, Suzuki Y, Sollinger HW. RS-61443 reverses acute allograft rejection in dogs. Surgery 1991; 110: 736.
44. Sollinger HW, Belzer FO, Deierhoi MH, et al. RS-61443 (Mycophenolate Mofetil). A multicenter study for refractory kidney transplant rejection. Ann Surg 1992; 216: 513.