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Volumn 76, Issue 16, 2010, Pages 1794-1801

Molecular targets of natural drug substances: Idiosyncrasies and preferences

Author keywords

drug substances; molecular mechanisms; natural products; target classes

Indexed keywords

ALKALOID; ANSAMYCIN DERIVATIVE; ANTIINFECTIVE AGENT; ANTIINFLAMMATORY AGENT; ANTINEOPLASTIC AGENT; CARRIER PROTEIN; CELL NUCLEUS RECEPTOR; CHLORAMPHENICOL; CYTOKINE RECEPTOR; DIHYDROFOLATE REDUCTASE INHIBITOR; G PROTEIN COUPLED RECEPTOR; HORMONE; HYDROLASE; IMMUNOSUPPRESSIVE AGENT; INTEGRIN RECEPTOR; ION CHANNEL; ISOMERASE; LIGASE; LYASE; NATURAL PRODUCT; NUCLEIC ACID; NUTRACEUTICAL; OXIDOREDUCTASE; PHOSPHODIESTERASE INHIBITOR; POTASSIUM CHANNEL; RIBOSOME PROTEIN; THIAZIDE DIURETIC AGENT; TRANSFERASE; UNINDEXED DRUG; VOLTAGE GATED CALCIUM CHANNEL;

EID: 78349275387     PISSN: 00320943     EISSN: 14390221     Source Type: Journal    
DOI: 10.1055/s-0030-1250236     Document Type: Review
Times cited : (3)

References (51)
  • 3
    • 67650436176 scopus 로고    scopus 로고
    • Drug discovery and natural products: End of an era or an endless frontier?
    • Li J W. H., Vederas J C. Drug discovery and natural products: end of an era or an endless frontier? Science 2009 325 161-165
    • (2009) Science , vol.325 , pp. 161-165
    • Li, J.W.H.1    Vederas, J.C.2
  • 4
    • 0037208308 scopus 로고    scopus 로고
    • Property distributions: Differences between drugs, natural products, and molecules from combinatorial chemistry
    • Feher M, Schmidt J M. Property distributions: differences between drugs, natural products, and molecules from combinatorial chemistry. J Chem Inf Comput Sci 2003 43 218-227
    • (2003) J Chem Inf Comput Sci , vol.43 , pp. 218-227
    • Feher, M.1    Schmidt, J.M.2
  • 5
    • 34547265045 scopus 로고    scopus 로고
    • Properties and architecture of natural products revisited
    • Grabowski K, Schneider G. Properties and architecture of natural products revisited. Curr Chem Biol 2007 1 115-127
    • (2007) Curr Chem Biol , vol.1 , pp. 115-127
    • Grabowski, K.1    Schneider, G.2
  • 6
    • 52649134945 scopus 로고    scopus 로고
    • Scaffold diversity of natural products: Inspiration for combinatorial library design
    • Grabowski K, Baringhaus K H., Schneider G. Scaffold diversity of natural products: inspiration for combinatorial library design. Nat Prod Rep 2008 25 892-904
    • (2008) Nat Prod Rep , vol.25 , pp. 892-904
    • Grabowski, K.1    Baringhaus, K.H.2    Schneider, G.3
  • 7
    • 49149098057 scopus 로고    scopus 로고
    • In the pipeline. Derek Lowe is looking for a little more variety among his reactions
    • Lowe D. In the pipeline. Derek Lowe is looking for a little more variety among his reactions. Chem World 2008 5 18
    • (2008) Chem World , vol.5 , pp. 18
    • Lowe, D.1
  • 8
    • 68849101000 scopus 로고    scopus 로고
    • Animal-derived pharmaceutical proteins
    • Redwan el-RM.
    • Redwan el-RM. Animal-derived pharmaceutical proteins. J Immunoassay Immunochem 2009 30 262-290
    • (2009) J Immunoassay Immunochem , vol.30 , pp. 262-290
  • 9
    • 70350364533 scopus 로고    scopus 로고
    • Chamavioline antiedematous, but not a constituent of Matricaria recutita
    • Oehler C, Bensdorf K, Gust R, Imming P. Chamavioline antiedematous, but not a constituent of Matricaria recutita. Phytochem Lett 2009 2 171-175
    • (2009) Phytochem Lett , vol.2 , pp. 171-175
    • Oehler, C.1    Bensdorf, K.2    Gust, R.3    Imming, P.4
  • 10
    • 33749234216 scopus 로고    scopus 로고
    • Drugs, their targets and the nature and number of drug targets
    • Imming P, Sinning C, Meyer A. Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov 2006 5 821-834
    • (2006) Nat Rev Drug Discov , vol.5 , pp. 821-834
    • Imming, P.1    Sinning, C.2    Meyer, A.3
  • 11
    • 78649319192 scopus 로고
    • Dame Agatha's poisonous pharmacopoeia. A chronological list of Agatha Christie stories which involved poison
    • Gwilt P G., Gwilt J R. Dame Agatha's poisonous pharmacopoeia. A chronological list of Agatha Christie stories which involved poison. Pharmacol J 1978 221 572-573
    • (1978) Pharmacol J , vol.221 , pp. 572-573
    • Gwilt, P.G.1    Gwilt, J.R.2
  • 12
    • 4544381198 scopus 로고    scopus 로고
    • Biochemical mechanisms of drug action: What does it take for success?
    • Swinney D C. Biochemical mechanisms of drug action: what does it take for success? Nat Rev Drug Discov 2004 3 801-808
    • (2004) Nat Rev Drug Discov , vol.3 , pp. 801-808
    • Swinney, D.C.1
  • 13
    • 58449131873 scopus 로고    scopus 로고
    • The role of binding kinetics in therapeutically useful drug action
    • Swinney D C. The role of binding kinetics in therapeutically useful drug action. Curr Opin Drug Discov Devel 2009 12 31-39
    • (2009) Curr Opin Drug Discov Devel , vol.12 , pp. 31-39
    • Swinney, D.C.1
  • 14
    • 66249144426 scopus 로고    scopus 로고
    • The structure and function of G-protein-coupled receptors
    • Rosenbaum D M., Rasmussen S G., Kobilka B K. The structure and function of G-protein-coupled receptors. Nature 2009 459 356-363
    • (2009) Nature , vol.459 , pp. 356-363
    • Rosenbaum, D.M.1    Rasmussen, S.G.2    Kobilka, B.K.3
  • 15
    • 0037102346 scopus 로고    scopus 로고
    • Signal transduction: Positive feedback from coffee
    • Vaugeois J M. Signal transduction: positive feedback from coffee. Nature 2002 418 734-736
    • (2002) Nature , vol.418 , pp. 734-736
    • Vaugeois, J.M.1
  • 16
    • 16244394010 scopus 로고    scopus 로고
    • How receptor mosaics decode transmitter signals. Possible relevance of cooperativity
    • Agnati L F., Fuxe K, Ferré S. How receptor mosaics decode transmitter signals. Possible relevance of cooperativity. Trends Biochem Sci 2005 30 188-193
    • (2005) Trends Biochem Sci , vol.30 , pp. 188-193
    • Agnati, L.F.1    Fuxe, K.2    Ferré, S.3
  • 20
    • 3242794178 scopus 로고    scopus 로고
    • From magic bullets to designed multiple ligands
    • Morphy R, Kay C, Rankovic Z. From magic bullets to designed multiple ligands. Drug Discov Today 2004 9 641-651
    • (2004) Drug Discov Today , vol.9 , pp. 641-651
    • Morphy, R.1    Kay, C.2    Rankovic, Z.3
  • 21
    • 33644858616 scopus 로고    scopus 로고
    • Selective optimization of side activities: The SOSA approach
    • Wermuth C G. Selective optimization of side activities: the SOSA approach. Drug Discov Today 2006 11 160-164
    • (2006) Drug Discov Today , vol.11 , pp. 160-164
    • Wermuth, C.G.1
  • 22
    • 33845903833 scopus 로고    scopus 로고
    • Drugs for bad bugs: Confronting the challenges of antibacterial discovery
    • Payne D J., Gwynn M N., Holmes D J., Pompliano D L. Drugs for bad bugs: confronting the challenges of antibacterial discovery. Nat Rev Drug Discov 2007 6 29-40
    • (2007) Nat Rev Drug Discov , vol.6 , pp. 29-40
    • Payne, D.J.1    Gwynn, M.N.2    Holmes, D.J.3    Pompliano, D.L.4
  • 23
    • 0005323951 scopus 로고    scopus 로고
    • Molecular drug targets
    • Drews J, Ryser St. Molecular drug targets. Nat Biotechnol 1997 15 1350
    • (1997) Nat Biotechnol , vol.15 , pp. 1350
    • Drews, J.1    Ryser, S.2
  • 25
    • 0038458880 scopus 로고    scopus 로고
    • Prioritizing the human genome: Knowledge management for drug discovery
    • Golden J B. Prioritizing the human genome: Knowledge management for drug discovery. Curr Opin Drug Discov Devel 2003 6 310-316
    • (2003) Curr Opin Drug Discov Devel , vol.6 , pp. 310-316
    • Golden, J.B.1
  • 26
    • 0037323955 scopus 로고    scopus 로고
    • Towards a tractable genome: Knowledge management in drug discovery
    • Golden J. Towards a tractable genome: knowledge management in drug discovery. Curr Drug Discov 2003 3 17-20 (Pubitemid 36231317)
    • (2003) Current Drug Discovery , Issue.FEB. , pp. 17-20
    • Golden, J.1
  • 31
    • 0016913421 scopus 로고
    • Crystal and molecular structure of compactin, a new antifungal metabolite from Penicillium brevicompactum
    • Brown A G., Smale T C., King T J., Hasenkamp R, Thompson R H. Crystal and molecular structure of compactin, a new antifungal metabolite from Penicillium brevicompactum. J Chem Soc [Perkin I] 1976 1165-1170
    • (1976) J Chem Soc [Perkin I] , pp. 1165-1170
    • Brown, A.G.1    Smale, T.C.2    King, T.J.3    Hasenkamp, R.4    Thompson, R.H.5
  • 32
    • 68049107130 scopus 로고    scopus 로고
    • Physiological, morphological and kinetic aspects of lovastatin biosynthesis by Aspergillus terreus
    • Bizukojc M, Ledakowicz S. Physiological, morphological and kinetic aspects of lovastatin biosynthesis by Aspergillus terreus. Biotechnol J 2009 4 647-664
    • (2009) Biotechnol J , vol.4 , pp. 647-664
    • Bizukojc, M.1    Ledakowicz, S.2
  • 34
    • 34548213103 scopus 로고    scopus 로고
    • A common mechanism of cellular death induced by bactericidal antibiotics
    • Kohanski M A., Dwyer D J., Hayete B, Lawrence C A., Collins J J. A common mechanism of cellular death induced by bactericidal antibiotics. Cell 2007 130 797-810
    • (2007) Cell , vol.130 , pp. 797-810
    • Kohanski, M.A.1    Dwyer, D.J.2    Hayete, B.3    Lawrence, C.A.4    Collins, J.J.5
  • 35
    • 44949134801 scopus 로고    scopus 로고
    • The impact of natural products upon modern drug discovery
    • Ganesan A. The impact of natural products upon modern drug discovery. Curr Opin Chem Biol 2008 12 306-317
    • (2008) Curr Opin Chem Biol , vol.12 , pp. 306-317
    • Ganesan, A.1
  • 36
    • 0037252194 scopus 로고    scopus 로고
    • Chemistry after the rule of five
    • Lipinski C A. Chemistry after the rule of five. Drug Discov Today 2003 8 12-16
    • (2003) Drug Discov Today , vol.8 , pp. 12-16
    • Lipinski, C.A.1
  • 37
    • 0015353307 scopus 로고
    • Perspectives in nonsteroidal anti-inflammatory agents
    • Shen T Y. Perspectives in nonsteroidal anti-inflammatory agents. Angew Chem Int Ed Engl 1972 11 460-472
    • (1972) Angew Chem Int Ed Engl , vol.11 , pp. 460-472
    • Shen, T.Y.1
  • 38
    • 0026513328 scopus 로고
    • The propionic acids: A personal perspective
    • Adams S S. The propionic acids: a personal perspective. J Clin Pharmacol 1992 32 317-323
    • (1992) J Clin Pharmacol , vol.32 , pp. 317-323
    • Adams, S.S.1
  • 39
    • 68849110176 scopus 로고    scopus 로고
    • From nature to drug discovery: The indole scaffold as a 'privileged structure'
    • de Sá Alves F R., Barreiro E J., Fraga C A. From nature to drug discovery: the indole scaffold as a 'privileged structure'. Mini Rev Med Chem 2009 9 782-793
    • (2009) Mini Rev Med Chem , vol.9 , pp. 782-793
    • De Sá Alves, F.R.1    Barreiro, E.J.2    Fraga, C.A.3
  • 40
    • 57349172322 scopus 로고    scopus 로고
    • Peptidomimetics
    • Wu Y D., Gellman S. Peptidomimetics. Acc Chem Res 2008 41 1231-1232
    • (2008) Acc Chem Res , vol.41 , pp. 1231-1232
    • Wu, Y.D.1    Gellman, S.2
  • 42
    • 36049051459 scopus 로고    scopus 로고
    • Back to basics: How natural products can provide the basis for new therapeutics
    • Deorukhar A, Krishnan S, Sethi G, Aggarwal B B. Back to basics: how natural products can provide the basis for new therapeutics. Expert Opin Investig Drugs 2007 16 1753-1773
    • (2007) Expert Opin Investig Drugs , vol.16 , pp. 1753-1773
    • Deorukhar, A.1    Krishnan, S.2    Sethi, G.3    Aggarwal, B.B.4
  • 43
    • 0037449586 scopus 로고    scopus 로고
    • What are the right targets for psychopharmacology?
    • Hyman S E., Fenton W S. What are the right targets for psychopharmacology? Science 2003 299 350-351
    • (2003) Science , vol.299 , pp. 350-351
    • Hyman, S.E.1    Fenton, W.S.2
  • 44
    • 33746052403 scopus 로고    scopus 로고
    • Next-generation therapeutics: Turning the current 'innovation gap' into an 'innovation leap'
    • Barry III C E., Matter A. Next-generation therapeutics: Turning the current 'innovation gap' into an 'innovation leap'. Curr Opin Chem Biol 2006 10 291-293
    • (2006) Curr Opin Chem Biol , vol.10 , pp. 291-293
    • Barry Iii, C.E.1    Matter, A.2
  • 47
    • 0031028432 scopus 로고    scopus 로고
    • Natural products in drug discovery and development
    • Cragg G M., Newman D J., Snader K M. Natural products in drug discovery and development. J Nat Prod 1997 60 52-60
    • (1997) J Nat Prod , vol.60 , pp. 52-60
    • Cragg, G.M.1    Newman, D.J.2    Snader, K.M.3
  • 48
    • 0042844744 scopus 로고    scopus 로고
    • Natural products as sources of new drugs over the period 19812002
    • Newman D J., Cragg G M., Snader K M. Natural products as sources of new drugs over the period 19812002. J Nat Prod 2003 66 1022-1037
    • (2003) J Nat Prod , vol.66 , pp. 1022-1037
    • Newman, D.J.1    Cragg, G.M.2    Snader, K.M.3
  • 49
    • 36348987143 scopus 로고    scopus 로고
    • The value of natural products to future pharmaceutical discovery
    • Baker D D., Chu M, Oza U, Rajgarhia V. The value of natural products to future pharmaceutical discovery. Nat Prod Rep 2007 24 1225-1244
    • (2007) Nat Prod Rep , vol.24 , pp. 1225-1244
    • Baker, D.D.1    Chu, M.2    Oza, U.3    Rajgarhia, V.4
  • 50
    • 44249098800 scopus 로고    scopus 로고
    • Natural products to drugs: Natural product-derived compounds in clinical trials
    • Butler M S. Natural products to drugs: natural product-derived compounds in clinical trials. Nat Prod Rep 2008 25 475-516
    • (2008) Nat Prod Rep , vol.25 , pp. 475-516
    • Butler, M.S.1
  • 51
    • 0043026937 scopus 로고    scopus 로고
    • Proopiomelanocortin, a polypeptide precursor with multiple functions: From physiology to pathological conditions
    • Raffin-Sanson M L., de Keyzer Y, Bertagna X. Proopiomelanocortin, a polypeptide precursor with multiple functions: from physiology to pathological conditions. Eur J Endocrinol 2003 149 79-90
    • (2003) Eur J Endocrinol , vol.149 , pp. 79-90
    • Raffin-Sanson, M.L.1    De Keyzer, Y.2    Bertagna, X.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.