Quantifying human susceptibility to contact sensitization; Risk assessments now and in the future

Contact Dermatitis

Volumn 63, Issue 5, 2010, Pages 237-247

  Friedmann, Peter S ^a   Pickard, Christopher ^a  

^a UNIVERSITY HOSPITAL SOUTHAMPTON NHS FOUNDATION TRUST   (United Kingdom)

Author keywords

contact sensitization; DNCB; epidermal barrier; quantitative risk assessment; review; stratum corneum

Indexed keywords

1 CHLORO 2,4 DINITROBENZENE; CYTOCHROME P450; DODECYL SULFATE SODIUM; MERCURY; MONOBENZONE; NEOMYCIN; NICKEL SULFATE; PENICILLIN G; PENICILLIN V; PHENYLENEDIAMINE;

AGE; ANTIGEN PRESENTING CELL; ARTICLE; ATOPIC DERMATITIS; CONTACT ALLERGY; CONTACT SENSITIZATION; DISEASE PREDISPOSITION; GENE MUTATION; HUMAN; LOCAL LYMPH NODE ASSAY; RACE; RISK ASSESSMENT; SEX; SKIN PERMEABILITY; STRATUM CORNEUM; X LINKED ICHTHYOSIS;

ANIMAL TESTING ALTERNATIVES; COSMETICS; DERMATITIS, ALLERGIC CONTACT; DISEASE SUSCEPTIBILITY; EUROPE; FORECASTING; HUMANS; MODELS, THEORETICAL; RISK ASSESSMENT; RISK FACTORS; SKIN;

EID: 78349241789     PISSN: 01051873     EISSN: 16000536     Source Type: Journal    
DOI: 10.1111/j.1600-0536.2010.01801.x     Document Type: Article

References (45)

1. Api A M, Basketter D A, Cadby P A et al., Dermal sensitization quantitative risk assessment (QRA) for fragrance ingredients. Regul Toxicol Pharmacol 2008: 52: 3-23.
2. Kern P S, Gerberick G F, Ryan C A, Kimber I, Aptula A, Basketter D A., Local lymph node data for the evaluation of skin sensitization alternatives: a second compilation. Dermatitis 2010: 21: 8-32.
3. Gerberick G F, Ryan C A, Kern P S, Schlatter H, Dearman R J, Kimber I, Patlewicz G Y, Basketter D A., Compilation of historical local lymph node data for evaluation of skin sensitization alternative methods. Dermatitis 2005: 16: 157-202.
4. Dearman R J, Wright Z M, Basketter D A, Ryan C A, Gerberick G F, Kimber I., The suitability of hexyl cinnamic aldehyde as a calibrant for the murine local lymph node assay. Contact Dermatitis 2001: 44: 357-361.
5. Basketter D A, Cadby P., Reproducible prediction of contact allergenic potency using the local lymph node assay. Contact Dermatitis 2004: 50: 15-17.
6. Basketter D A, Clapp C, Jefferies D, Safford B, Ryan C A, Gerberick F, Dearman R J, Kimber I., Predictive identification of human skin sensitization thresholds. Contact Dermatitis 2005: 53: 260-267.
7. Gerberick G F, Robinson M K, Felter S P, White I R, Basketter D A., Understanding fragrance allergy using an exposure-based risk assessment approach. Contact Dermatitis 2001: 45: 333-340.
8. Basketter D A., Skin sensitization: strategies for the assessment and management of risk. Br J Dermatol 2008: 159: 267-273.
9. Demerjian M, Hachem J P, Tschachler E et al., Acute modulations in permeability barrier function regulate epidermal cornification: role of caspase-14 and the protease-activated receptor type 2. Am J Pathol 2008: 172: 86-97.
10. Hachem J P, Houben E, Crumrine D et al., Serine protease signaling of epidermal permeability barrier homeostasis. J Invest Dermatol 2006: 126: 2074-2086.
11. Grabbe S, Steinert M, Mahnke K, Schwartz A, Luger T A, Schwarz T., Dissection of antigenic and irritative effects of epicutaneously applied haptens in mice. Evidence that not the antigenic component but nonspecific proinflammatory effects of haptens determine the concentration-dependent elicitation of allergic contact dermatitis. J Clin Invest 1996: 98: 1158-1164.
12. Smith H R, Holloway D, Armstrong D K, Basketter D A, McFadden J P., Irritant thresholds in subjects with colophony allergy. Contact Dermatitis 2000: 42: 95-97.
13. Smith H R, Armstrong D K, Holloway D, Whittam L, Basketter D A, McFadden J P., Skin irritation thresholds in hairdressers: implications for the development of hand dermatitis. Br J Dermatol 2002: 146: 849-852.
14. Jowsey I R, Clapp C J, Safford B, Gibbons B T, Basketter D A., The impact of vehicle on the relative potency of skin-sensitizing chemicals in the local lymph node assay. Cutaneous Ocul Toxicol 2008: 27: 67-75.
15. Kligman A M., The identification of contact allergens by human assay. II. Factors influencing the induction and measurement of allergic contact dermatitis. J Invest Dermatol 1966: 47: 375-392.
16. Marzulli F N, Maibach H I., Effects of vehicles and elicitation concentration in contact dermatitis testing. I. Experimental contact sensitization in humans. Contact Dermatitis 1976: 2: 325-329.
17. Basketter D A, Gerberick G F, Kimber I., Skin sensitisation, vehicle effects and the local lymph node assay. Food Chem Toxicol 2001: 39: 621-627.
18. McLelland J, Shuster S, Matthews J N., 'Irritants' increase the response to an allergen in allergic contact dermatitis. Arch Dermatol 1991: 127: 1016-1019.
19. Coulter E M, Jenkinson C, Wu Y et al., Activation of T-cells from allergic patients and volunteers by p-phenylenediamine and Bandrowski's base. J Invest Dermatol 2008: 128: 897-905.
20. Friedmann P S., The relationships between exposure dose and response in induction and elicitation of contact hypersensitivity in humans. Br J Dermatol 2007: 157: 1093-1102.
21. Friedmann P S., Graded continuity, or all or none-studies of the human immune response. Clin Exp Dermatol 1991: 16: 79-84.
22. Moss C, Friedmann P S, Shuster S, Simpson J M., Susceptibility and amplification of sensitivity in contact dermatitis. Clin Exp Immunol 1985: 61: 232-241.
23. Basketter D A, Jefferies D, Safford B J et al., The impact of exposure variables on the induction of skin sensitization. Contact Dermatitis 2006: 55: 178-185.
24. Paramasivan P, Lai C, Pickard C, Ardern-Jones M R, Healy E, Friedmann P S., Repeated low-dose skin exposure is an effective sensitising stimulus: a factor to be taken into account in predicting sensitisation risk. Br J Dermatol 2010: 162: 594-597.
25. Pickard C, Smith A M, Cooper H, Strickland I, Jackson J, Healy E, Friedmann P S., Investigation of mechanisms underlying the T-cell response to the hapten 2,4-dinitrochlorobenzene. J Invest Dermatol 2007: 127: 630-637.
26. Friedmann P S., Thresholds, dose-response relationships and dose metrics in allergic contact dermatitis. Br J Dermatol 2008: 159: 1381-1382.
27. Johansen J D, Andersen K E, Svedman C, et al., Chloroatranol, an extremely potent allergen hidden in perfumes: a dose-response elicitation study. Contact Dermatitis 2003: 49: 180-184.
28. Zachariae C, Lerbaek A, McNamee P M, Gray J E, Wooder M, Menne T., An evaluation of dose/unit area and time as key factors influencing the elicitation capacity of methylchloroisothiazolinone/methylisothiazolinone (MCI/MI) in MCI/MI-allergic patients. Contact Dermatitis 2006: 55: 160-166.
29. Robinson M K., Population differences in acute skin irritation responses. Race, sex, age, sensitive skin and repeat subject comparisons. Contact Dermatitis 2002: 46: 86-93.
30. Cassimos C, Kanakoudi-Tsakalidis F, Spyroglou K, Ladianos M, Tzaphi R., Skin sensitization to 2, 4 dinitrochlorobenzene (DNCB) in the first months of life. J Clin Lab Immunol 1980: 3: 111-113.
31. Girard J P, Paychere M, Cuevas M, Fernandes B., Cell-mediated immunity in an ageing population. Clin Exp Immunol 1977: 27: 85-91.
32. Robinson M K., Population differences in skin structure and physiology and the susceptibility to irritant and allergic contact dermatitis: implications for skin safety testing and risk assessment. Contact Dermatitis 1999: 41: 65-79.
33. Agius E, Lacy K E, Vukmanovic-Stejic M, et al., Decreased TNF-alpha synthesis by macrophages restricts cutaneous immunosurveillance by memory CD4+ T cells during aging. J Exp Med 2009: 206: 1929-1940.
34. Kalogeromitros D, Katsarou A, Armenaka M, Rigopoulos D, Zapanti M, Stratigos I., Influence of the menstrual cycle on skin-prick test reactions to histamine, morphine and allergen. Clin Exp Allergy 1995: 25: 461-466.
35. Rees J L, Friedmann P S, Matthews J N S., Sex differences in susceptibility to development of contact hypersensitivity to dinitrochlorobenzene. Br J Dermatol 1989: 120: 371-374.
36. Morrissey K, Xue W, Cooper K, Baron E., Age and gender effects on contact sensitization and photoimmune suppression in young and middle-aged adults. Photodermatol Photoimmunol Photomed 2008: 24: 46-48.
37. Palmer C N, Irvine A D, Terron-Kwiatkowski A, et al., Common loss-of-function variants of the epidermal barrier protein filaggrin are a major predisposing factor for atopic dermatitis. Nat Genet 2006: 38: 441-446.
38. Rees J, Friedmann P S, Matthews J N., Contact sensitivity to dinitrochlorobenzene is impaired in atopic subjects. Controversy revisited. Arch Dermatol 1990: 126: 1173-1175.
39. Newell L, Polak M, Pickard C, Owen C, Holloway J, Healy E, Ardern-Jones M R, Friedmann P S., Impaired allergic contact dermatitis response to DNCB in atopic dermatitis (AD) is enhanced by filaggrin loss of function variants. J Invest Dermatol 2009: 129: S8-S8.
40. Elias P M, Williams M L, Holleran W M, Jiang Y J, Schmuth M., Pathogenesis of permeability barrier abnormalities in the ichthyoses: inherited disorders of lipid metabolism. J Lipid Res 2008: 49: 697-714.
41. De Jongh C M, Jakasa I, Verberk M M, Kezic S., Variation in barrier impairment and inflammation of human skin as determined by sodium lauryl sulphate penetration rate. Br J Dermatol 2006: 154: 651-657.
42. Grubauer G, Elias P M, Feingold K R., Transepidermal water loss: the signal for recovery of barrier structure and function. J Lipid Res 1989: 30: 323-333.
43. Menon G K, Feingold K R, Elias P M., Lamellar body secretory response to barrier disruption. J Invest Dermatol 1992: 98: 279-289.
44. Pickard C, Louafi F, McGuiré C et al., The cutaneous biochemical redox barrier: a component of the innate immune defences against sensitisation by highly reactive environmental xenobiotics. J Immunol 2009: 183: 7576-7584.
45. Zachariae C, Rastogi S, Devantier C, Menné T, Johansen J D., Methyldibromo glutaronitrile: clinical experience and exposure-based risk assessment. Contact Dermatitis 2003: 48: 150-154.