Evaluation of dense polylactic acid/beta-tricalcium phosphate scaffolds for bone tissue engineering

Journal of Biomedical Materials Research - Part A

Volumn 95, Issue 3 A, 2010, Pages 717-726

  Yanoso Scholl, Laura ^a,b   Jacobson, Justin A ^b   Bradica, Gino ^c   Lerner, Amy L ^a,b   O'Keefe, Regis J ^b   Schwarz, Edward M ^b   Zuscik, Michael J ^b   Awad, Hani A ^a,b  

^a University of Rochester   (United States)

^b UNIVERSITY OF ROCHESTER MEDICAL CENTER   (United States)

^c Kensey Nash Corporation   (United States)

Author keywords

Biomechanics; Bone; Micro computed tomography; Polylactic acid; Tricalcium phosphate

Indexed keywords

BONE TISSUE ENGINEERING; BURST RELEASE; CORTICAL BONE; DELIVERY VEHICLE; GROWTH FACTOR; IN-VITRO; IN-VIVO; INTERCONNECTED POROSITY; LOAD BEARING; MECHANICAL STRENGTH; MICRO-STRUCTURAL; MICROCOMPUTED TOMOGRAPHY; MINERAL PARTICLES; POLY LACTIC ACID; POROUS POLYMERS; REFLECTING SURFACE; RETENTION EFFICIENCIES; SEPARATION TECHNIQUES; SURFACE POROSITY; TISSUE IN-GROWTH; TORSIONAL STRENGTH; TRI-CALCIUM PHOSPHATES; VESSEL FORMATION; VOLUME EXPANSION; VOLUMETRIC POROSITY;

ACIDS; BEARINGS (MACHINE PARTS); BIOLOGICAL MATERIALS; BIOMATERIALS; BIOMECHANICS; BONE; COATINGS; COMPRESSIVE STRENGTH; COMPUTERIZED TOMOGRAPHY; GROWTH KINETICS; INNOVATION; MECHANICAL PROPERTIES; PEPTIDES; PHASE SEPARATION; POROSITY; STRESSES; TISSUE ENGINEERING;

SCAFFOLDS;

CALCIUM PHOSPHATE; POLYLACTIC ACID; RECOMBINANT BONE MORPHOGENETIC PROTEIN 2; RECOMBINANT VASCULOTROPIN;

ANGIOGENESIS; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BONE DEVELOPMENT; BONE TISSUE; DRUG RELEASE; IN VITRO STUDY; IN VIVO STUDY; MECHANICAL TORSION; MOUSE; NONHUMAN; PHASE SEPARATION; POROSITY; QUADRICEPS FEMORIS MUSCLE; SCANNING ELECTRON MICROSCOPY; SURFACE PROPERTY; TISSUE ENGINEERING;

ANIMALS; BIOCOMPATIBLE MATERIALS; BONE AND BONES; BONE MORPHOGENETIC PROTEIN 2; CALCIUM PHOSPHATES; COMPRESSIVE STRENGTH; IMPLANTS, EXPERIMENTAL; LACTIC ACID; MATERIALS TESTING; MICE; MICE, INBRED C57BL; NEOVASCULARIZATION, PHYSIOLOGIC; OSTEOGENESIS; POLYMERS; POROSITY; RECOMBINANT PROTEINS; STRESS, MECHANICAL; SURFACE PROPERTIES; TISSUE ENGINEERING; TISSUE SCAFFOLDS; VASCULAR ENDOTHELIAL GROWTH FACTOR A;

EID: 78249270409     PISSN: 15493296     EISSN: 15524965     Source Type: Journal    
DOI: 10.1002/jbm.a.32868     Document Type: Article

References (29)

1. Akkus O, Rimnac CM,. Fracture resistance of gamma radiation sterilized cortical bone allografts. J Orthop Res 2001; 19: 927 -934.
2. Reddi AH,. Morphogenesis and tissue engineering of bone and cartilage: Inductive signals, stem cells, and biomimetic biomaterials. Tissue Eng 2000; 6: 351 -359.
3. Hutmacher DW,. Scaffolds in tissue engineering bone and cartilage. Biomaterials 2000; 21: 2529 -2543.
4. Suuronen R, Kallela I, Lindqvist C,. Bioabsorbable plates and screws: Current state of the art in facial fracture repair. J Craniomaxillofac Trauma 2000; 6: 19 -275.
5. Montjovent MO, Mathieu L, Schmoekel H, Mark S, Bourban PE, Zambelli PY, Laurent-Applegate LA, Pioletti DP,. Repair of critical size defects in the rat cranium using ceramic-reinforced PLA scaffolds obtained by supercritical gas foaming. J Biomed Mater Res A 2007; 83: 41 -51.
6. Namikawa T, Terai H, Suzuki E, Hoshino M, Toyoda H, Nakamura H, Miyamoto S, Takahashi N, Ninomiya T, Takaoka K,. Experimental spinal fusion with recombinant human bone morphogenetic protein-2 delivered by a synthetic polymer and beta-tricalcium phosphate in a rabbit model. Spine (Phila Pa 1976) 2005; 30: 1717 -1722.
7. Lin AS, Barrows TH, Cartmell SH, Guldberg RE,. Microarchitectural and mechanical characterization of oriented porous polymer scaffolds. Biomaterials 2003; 24: 481 -489.
8. Brodt MD, Ellis CB, Silva MJ,. Growing C57Bl/6 mice increase whole bone mechanical properties by increasing geometric and material properties. J Bone Miner Res 1999; 14: 2159 -2166.
9. Patel HJ, Su SH, Patterson C, Nguyen KT,. A combined strategy to reduce restenosis for vascular tissue engineering applications. Biotechnol Prog 2006; 22: 38 -44.
10. Guldberg RE, Ballock RT, Boyan BD, Duvall CL, Lin AS, Nagaraja S, Oest M, Phillips J, Porter BD, Robertson G, Taylor WR,. Analyzing bone, blood vessels, and biomaterials with microcomputed tomography. IEEE Eng Med Biol Mag 2003; 22: 77 -83.
11. Charles-Harris M, del Valle S, Hentges E, Bleuet P, Lacroix D, Planell JA,. Mechanical and structural characterisation of completely degradable polylactic acid/calcium phosphate glass scaffolds. Biomaterials 2007; 28: 4429 -4438.
12. Zhang R, Ma PX,. Poly(alpha-hydroxyl acids)/hydroxyapatite porous composites for bone-tissue engineering. I. Preparation and morphology. J Biomed Mater Res A 1999; 44: 446 -455.
13. Lee KC, Maxwell A, Lanyon LE,. Validation of a technique for studying functional adaptation of the mouse ulna in response to mechanical loading. Bone 2002; 31: 407 -412.
14. Murakami N, Saito N, Takahashi J, Ota H, Horiuchi H, Nawata M, Okada T, Nozaki K, Takaoka K,. Repair of a proximal femoral bone defect in dogs using a porous surfaced prosthesis in combination with recombinant BMP-2 and a synthetic polymer carrier. Biomaterials 2003; 24: 2153 -2159.
15. Keselowsky BG, Collard DM, Garcia AJ,. Surface chemistry modulates focal adhesion composition and signaling through changes in integrin binding. Biomaterials 2004; 25: 5947 -5954.
16. Schrier JA, DeLuca PP,. Recombinant human bone morphogenetic protein-2 binding and incorporation in PLGA microsphere delivery systems. Pharm Dev Technol 1999; 4: 611 -621.
17. Polson A,. Some Aspects of Diffusion in Solution and a Definition of a Colloidal Particle. J Phys Colloid Chem 1950; 54: 649 -652.
18. Helm GA, Sheehan JM, Sheehan JP, Jane JA Jr, diPierro CG, Simmons NE, Gillies GT, Kallmes DF, Sweeney TM,. Utilization of type I collagen gel, demineralized bone matrix, and bone morphogenetic protein-2 to enhance autologous bone lumbar spinal fusion. J Neurosurg 1997; 86: 93 -100.
19. Hedberg EL, Tang A, Crowther RS, Carney DH, Mikos AG,. Controlled release of an osteogenic peptide from injectable biodegradable polymeric composites. J Control Release 2002; 84: 137 -150.
20. Burdick JA, Frankel D, Dernell WS, Anseth KS,. An initial investigation of photocurable three-dimensional lactic acid based scaffolds in a critical-sized cranial defect. Biomaterials 2003; 24: 1613 -1620.
21. Arifin DY, Lee LY, Wang CH,. Mathematical modeling and simulation of drug release from microspheres: Implications to drug delivery systems. Adv Drug Deliv Rev 2006; 58: 1274 -1325.
22. Baker RW, Lonsdale HK,. Controlled release: Mechanisms and rates. In:, Tanquarry AC, Lacey RE, editors. Controlled Release of Biologically Active Agents. New York, NY: Plenum Press; 1974. p 15 -71.
23. Saito N, Okada T, Horiuchi H, Murakami N, Takahashi J, Nawata M, Ota H, Nozaki K, Takaoka K,. A biodegradable polymer as a cytokine delivery system for inducing bone formation. Nat Biotechnol 2001; 19: 332 -335.
24. Liang G, Yang Y, Oh S, Ong JL, Zheng C, Ran J, Yin G, Zhou D,. Ectopic osteoinduction and early degradation of recombinant human bone morphogenetic protein-2-loaded porous beta-tricalcium phosphate in mice. Biomaterials 2005; 26: 4265 -4271.
25. Schliephake H, Weich HA, Schulz J, Gruber R,. In vitro characterization of a slow release system of polylactic acid and rhBMP2. J Biomed Mater Res A 2007; 83: 455 -462.
26. Aspenberg P, Jeppsson C, Wang JS, Bostrom M,. Transforming growth factor beta and bone morphogenetic protein 2 for bone ingrowth: a comparison using bone chambers in rats. Bone 1996; 19: 499 -503.
27. Pike DB, Cai S, Pomraning KR, Firpo MA, Fisher RJ, Shu XZ, Prestwich GD, Peattie RA,. Heparin-regulated release of growth factors in vitro and angiogenic response in vivo to implanted hyaluronan hydrogels containing VEGF and bFGF. Biomaterials 2006; 27: 5242 -5251.
28. Huang YC, Kaigler D, Rice KG, Krebsbach PH, Mooney DJ,. Combined angiogenic and osteogenic factor delivery enhances bone marrow stromal cell-driven bone regeneration. J Bone Miner Res 2005; 20: 848 -857.
29. Kempen DH, Lu L, Heijink A, Hefferan TE, Creemers LB, Maran A, Yaszemski MJ, Dhert WJ,. Effect of local sequential VEGF and BMP-2 delivery on ectopic and orthotopic bone regeneration. Biomaterials 2009; 30: 2816 -2825.