메뉴 건너뛰기




Volumn 299, Issue 5, 2010, Pages

Effect of ezetimibe on incretin secretion in response to the intestinal absorption of a mixed meal

Author keywords

Cholesterol absorption; Glucagon like peptide 1; Glucose dependent insulinotropic polypeptide; Lymph

Indexed keywords

CHOLESTEROL; ENSURE; EZETIMIBE; GASTRIC INHIBITORY POLYPEPTIDE; GLUCAGON LIKE PEPTIDE 1; GLUCOSE; INCRETIN; TRIACYLGLYCEROL; AZETIDINE DERIVATIVE;

EID: 78149488801     PISSN: 01931857     EISSN: 15221547     Source Type: Journal    
DOI: 10.1152/ajpgi.00294.2010     Document Type: Article
Times cited : (7)

References (51)
  • 4
    • 0021683136 scopus 로고
    • Homeostasis of mucosal cholesterol in the small intestine of the rat
    • Blumer A, Watt SM, Simmonds WJ. Homeostasis of mucosal cholesterol in the small intestine of the rat. Lipids 19: 721-727, 1984.
    • (1984) Lipids , vol.19 , pp. 721-727
    • Blumer, A.1    Watt, S.M.2    Simmonds, W.J.3
  • 5
    • 0000722187 scopus 로고
    • A cage which limits the activity of rats
    • Bollman JL. A cage which limits the activity of rats. J Lab Clin Med 33: 1348, 1948.
    • (1948) J Lab Clin Med , vol.33 , pp. 1348
    • Bollman, J.L.1
  • 6
    • 50349115008 scopus 로고
    • Techniques for the collection of lymph from the liver, small intestine, or thoracic duct of the rat
    • Bollman JL, Cain JC, Grindlay JH. Techniques for the collection of lymph from the liver, small intestine, or thoracic duct of the rat. J Lab Clin Med 33: 1349-1352, 1948.
    • (1948) J Lab Clin Med , vol.33 , pp. 1349-1352
    • Bollman, J.L.1    Cain, J.C.2    Grindlay, J.H.3
  • 7
    • 0000862285 scopus 로고
    • Studies on intestinal cholesterol absorption in the human
    • Borgstrom B. Studies on intestinal cholesterol absorption in the human. J Clin Invest 39: 809-815, 1960.
    • (1960) J Clin Invest , vol.39 , pp. 809-815
    • Borgstrom, B.1
  • 8
    • 0017184389 scopus 로고
    • A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding
    • Bradford MM. A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal Biochem 72: 248-254, 1976.
    • (1976) Anal Biochem , vol.72 , pp. 248-254
    • Bradford, M.M.1
  • 9
    • 0018193765 scopus 로고
    • Electronimmunocytochemical evidence for the K cell localization of gastric inhibitory polypeptide (GIP) in man
    • Buchan AM, Polak JM, Capella C, Solcia E, Pearse AG. Electronimmunocytochemical evidence for the K cell localization of gastric inhibitory polypeptide (GIP) in man. Histochemistry 56: 37-44, 1978.
    • (1978) Histochemistry , vol.56 , pp. 37-44
    • Buchan, A.M.1    Polak, J.M.2    Capella, C.3    Solcia, E.4    Pearse, A.G.5
  • 10
    • 0346731237 scopus 로고    scopus 로고
    • The discovery of ezetimibe: A view from outside the receptor
    • Clader JW. The discovery of ezetimibe: a view from outside the receptor. J Med Chem 47: 1-9, 2004.
    • (2004) J Med Chem , vol.47 , pp. 1-9
    • Clader, J.W.1
  • 11
    • 36849094575 scopus 로고    scopus 로고
    • Fasting and postprandial concentrations of GLP-1 in intestinal lymph and portal plasma: Evidence for selective release of GLP-1 in the lymph system
    • D'Alessio D, Lu W, Sun W, Zheng S, Yang Q, Seeley R, Woods SC, Tso P. Fasting and postprandial concentrations of GLP-1 in intestinal lymph and portal plasma: evidence for selective release of GLP-1 in the lymph system. Am J Physiol Regul Integr Comp Physiol 293: R2163-R2169, 2007.
    • (2007) Am J Physiol Regul Integr Comp Physiol , vol.293
    • D'Alessio, D.1    Lu, W.2    Sun, W.3    Zheng, S.4    Yang, Q.5    Seeley, R.6    Woods, S.C.7    Tso, P.8
  • 12
    • 0035572836 scopus 로고    scopus 로고
    • Ezetimibe, a potent cholesterol absorption inhibitor, inhibits the development of atherosclerosis in ApoE knockout mice
    • Davis HR Jr, Compton DS, Hoos L, Tetzloff G. Ezetimibe, a potent cholesterol absorption inhibitor, inhibits the development of atherosclerosis in ApoE knockout mice. Arterioscler Thromb Vasc Biol 21: 2032-2038, 2001.
    • (2001) Arterioscler Thromb Vasc Biol , vol.21 , pp. 2032-2038
    • Davis Jr., H.R.1    Compton, D.S.2    Hoos, L.3    Tetzloff, G.4
  • 13
    • 0034765624 scopus 로고    scopus 로고
    • The synergistic hypocholesterolemic activity of the potent cholesterol absorption inhibitor, ezetimibe, in combination with 3-hydroxy-3-methylglutaryl coenzyme a reductase inhibitors in dogs
    • Davis HR Jr, Pula KK, Alton KB, Burrier RE, Watkins RW. The synergistic hypocholesterolemic activity of the potent cholesterol absorption inhibitor, ezetimibe, in combination with 3-hydroxy-3-methylglutaryl coenzyme a reductase inhibitors in dogs. Metabolism 50: 1234-1241, 2001.
    • (2001) Metabolism , vol.50 , pp. 1234-1241
    • Davis Jr., H.R.1    Pula, K.K.2    Alton, K.B.3    Burrier, R.E.4    Watkins, R.W.5
  • 15
    • 15044341261 scopus 로고    scopus 로고
    • What do we know about the secretion and degradation of incretin hormones?
    • Deacon CF. What do we know about the secretion and degradation of incretin hormones? Regul Pept 128: 117-124, 2005.
    • (2005) Regul Pept , vol.128 , pp. 117-124
    • Deacon, C.F.1
  • 16
    • 0345584973 scopus 로고
    • Cholesterol synthesis in the squirrel monkey: Relative rates of synthesis in various tissues and mechanisms of control
    • Dietschy JM, Wilson JD. Cholesterol synthesis in the squirrel monkey: relative rates of synthesis in various tissues and mechanisms of control. J Clin Invest 47: 166-174, 1968.
    • (1968) J Clin Invest , vol.47 , pp. 166-174
    • Dietschy, J.M.1    Wilson, J.D.2
  • 17
    • 0037111924 scopus 로고    scopus 로고
    • Efficacy and safety of a potent new selective cholesterol absorption inhibitor, ezetimibe, in patients with primary hypercholesterolemia
    • Dujovne CA, Ettinger MP, McNeer JF, Lipka LJ, LeBeaut AP, Suresh R, Yang B, Veltri EP. Efficacy and safety of a potent new selective cholesterol absorption inhibitor, ezetimibe, in patients with primary hypercholesterolemia. Am J Cardiol 90: 1092-1097, 2002.
    • (2002) Am J Cardiol , vol.90 , pp. 1092-1097
    • Dujovne, C.A.1    Ettinger, M.P.2    McNeer, J.F.3    Lipka, L.J.4    LeBeaut, A.P.5    Suresh, R.6    Yang, B.7    Veltri, E.P.8
  • 18
    • 0015791989 scopus 로고
    • Stimulation of insulin secretion by gastric inhibitory polypeptide in man
    • Dupre J, Ross SA, Watson D, Brown JC. Stimulation of insulin secretion by gastric inhibitory polypeptide in man. J Clin Endocrinol Metab 37: 826-828, 1973.
    • (1973) J Clin Endocrinol Metab , vol.37 , pp. 826-828
    • Dupre, J.1    Ross, S.A.2    Watson, D.3    Brown, J.C.4
  • 19
    • 0018863494 scopus 로고
    • Use of a simple enzymatic assay for cholesterol analysis in human bile
    • Fromm H, Amin P, Klein H, Kupke I. Use of a simple enzymatic assay for cholesterol analysis in human bile. J Lipid Res 21: 259-261, 1980.
    • (1980) J Lipid Res , vol.21 , pp. 259-261
    • Fromm, H.1    Amin, P.2    Klein, H.3    Kupke, I.4
  • 21
    • 0021010872 scopus 로고
    • Absorption and metabolism of dietary cholesterol
    • Grundy SM. Absorption and metabolism of dietary cholesterol. Annu Rev Nutr 3: 71-96, 1983.
    • (1983) Annu Rev Nutr , vol.3 , pp. 71-96
    • Grundy, S.M.1
  • 22
    • 48849105732 scopus 로고    scopus 로고
    • Effect of protein, fat, carbohydrate and fibre on gastrointestinal peptide release in humans
    • Karhunen LJ, Juvonen KR, Huotari A, Purhonen AK, Herzig KH. Effect of protein, fat, carbohydrate and fibre on gastrointestinal peptide release in humans. Regul Pept 149: 70-78, 2008.
    • (2008) Regul Pept , vol.149 , pp. 70-78
    • Karhunen, L.J.1    Juvonen, K.R.2    Huotari, A.3    Purhonen, A.K.4    Herzig, K.H.5
  • 23
    • 0028855353 scopus 로고
    • Investigations into the actions of glucose-dependent insulinotropic polypeptide and glucagon-like peptide-1(7-36)amide on lipoprotein lipase activity in explants of rat adipose tissue
    • Knapper JM, Puddicombe SM, Morgan LM, Fletcher JM. Investigations into the actions of glucose-dependent insulinotropic polypeptide and glucagon-like peptide-1(7-36)amide on lipoprotein lipase activity in explants of rat adipose tissue. J Nutr 125: 183-188, 1995.
    • (1995) J Nutr , vol.125 , pp. 183-188
    • Knapper, J.M.1    Puddicombe, S.M.2    Morgan, L.M.3    Fletcher, J.M.4
  • 24
    • 0023638829 scopus 로고
    • Glucagon-like peptide-1 7-36: A physiological incretin in man
    • Kreymann B, Williams G, Ghatei MA, Bloom SR. Glucagon-like peptide-1 7-36: a physiological incretin in man. Lancet 2: 1300-1304, 1987.
    • (1987) Lancet , vol.2 , pp. 1300-1304
    • Kreymann, B.1    Williams, G.2    Ghatei, M.A.3    Bloom, S.R.4
  • 26
    • 36148972789 scopus 로고    scopus 로고
    • The regulation of the lymphatic secretion of glucagon-like peptide-1 (GLP-1) by intestinal absorption of fat and carbohydrate
    • Lu WJ, Yang Q, Sun W, Woods SC, D'Alessio D, Tso P. The regulation of the lymphatic secretion of glucagon-like peptide-1 (GLP-1) by intestinal absorption of fat and carbohydrate. Am J Physiol Gastrointest Liver Physiol 293: G963-G971, 2007.
    • (2007) Am J Physiol Gastrointest Liver Physiol , vol.293
    • Lu, W.J.1    Yang, Q.2    Sun, W.3    Woods, S.C.4    D'Alessio, D.5    Tso, P.6
  • 27
    • 45849136320 scopus 로고    scopus 로고
    • Using the lymph fistula rat model to study the potentiation of GIP secretion by the ingestion of fat and glucose
    • Lu WJ, Yang Q, Sun W, Woods SC, D'Alessio D, Tso P. Using the lymph fistula rat model to study the potentiation of GIP secretion by the ingestion of fat and glucose. Am J Physiol Gastrointest Liver Physiol 294: G1130-G1138, 2008.
    • (2008) Am J Physiol Gastrointest Liver Physiol , vol.294
    • Lu, W.J.1    Yang, Q.2    Sun, W.3    Woods, S.C.4    D'Alessio, D.5    Tso, P.6
  • 28
    • 0038823934 scopus 로고    scopus 로고
    • Ezetimibe for management of hypercholesterolemia
    • Mauro VF, Tuckerman CE. Ezetimibe for management of hypercholesterolemia. Ann Pharmacother 37: 839-848, 2003.
    • (2003) Ann Pharmacother , vol.37 , pp. 839-848
    • Mauro, V.F.1    Tuckerman, C.E.2
  • 29
    • 0023107555 scopus 로고
    • Insulinotropin: Glucagon-like peptide I (7-37) co-encoded in the glucagon gene is a potent stimulator of insulin release in the perfused rat pancreas
    • Mojsov S, Weir GC, Habener JF. Insulinotropin: glucagon-like peptide I (7-37) co-encoded in the glucagon gene is a potent stimulator of insulin release in the perfused rat pancreas. J Clin Invest 79: 616-619, 1987.
    • (1987) J Clin Invest , vol.79 , pp. 616-619
    • Mojsov, S.1    Weir, G.C.2    Habener, J.F.3
  • 30
    • 0025808278 scopus 로고
    • Effect of the entero-pancreatic hormones, gastric inhibitory polypeptide and glucagon-like polypeptide-1(7-36) amide, on fatty acid synthesis in explants of rat adipose tissue
    • Oben J, Morgan L, Fletcher J, Marks V. Effect of the entero-pancreatic hormones, gastric inhibitory polypeptide and glucagon-like polypeptide-1(7-36) amide, on fatty acid synthesis in explants of rat adipose tissue. J Endocrinol 130: 267-272, 1991.
    • (1991) J Endocrinol , vol.130 , pp. 267-272
    • Oben, J.1    Morgan, L.2    Fletcher, J.3    Marks, V.4
  • 31
    • 0032487931 scopus 로고    scopus 로고
    • Prevention of cardiovascular events, and death with pravastatin in patients with coronary heart disease and a broad range of initial cholesterol levels
    • The Long-Term Intervention with Pravastatin in Ischaemic Disease (LIPID) Study Group
    • Prevention of cardiovascular events, and death with pravastatin in patients with coronary heart disease and a broad range of initial cholesterol levels. The Long-Term Intervention with Pravastatin in Ischaemic Disease (LIPID) Study Group. N Engl J Med 339: 1349-1357, 1998.
    • (1998) N Engl J Med , vol.339 , pp. 1349-1357
  • 32
    • 0014747641 scopus 로고
    • Formation of cholesteryl ester-rich particulate lipid during metabolism of chylomicrons
    • Redgrave TG. Formation of cholesteryl ester-rich particulate lipid during metabolism of chylomicrons. J Clin Invest 49: 465-471, 1970.
    • (1970) J Clin Invest , vol.49 , pp. 465-471
    • Redgrave, T.G.1
  • 33
    • 33751069321 scopus 로고    scopus 로고
    • Meat hydrolysate and essential amino acid-induced glucagon-like peptide-1 secretion, in the human NCI-H716 enteroendocrine cell line, is regulated by extracellular signal-regulated kinase1/2 and p38 mitogen-activated protein kinases
    • Reimer RA. Meat hydrolysate and essential amino acid-induced glucagon-like peptide-1 secretion, in the human NCI-H716 enteroendocrine cell line, is regulated by extracellular signal-regulated kinase1/2 and p38 mitogen-activated protein kinases. J Endocrinol 191: 159-170, 2006.
    • (2006) J Endocrinol , vol.191 , pp. 159-170
    • Reimer, R.A.1
  • 34
    • 0032510318 scopus 로고    scopus 로고
    • Discovery of 1-(4-fluorophenyl)-(3R)-[3-(4-fluorophenyl)-( 3S)-hydroxypropyl]-(4S)-(4 -hydroxyphenyl)-2-azetidinone (SCH 58235): A designed, potent, orally active inhibitor of cholesterol absorption
    • Rosenblum SB, Huynh T, Afonso A, Davis HR Jr, Yumibe N, Clader JW, Burnett DA. Discovery of 1-(4-fluorophenyl)-(3R)-[3-(4-fluorophenyl)-( 3S)-hydroxypropyl]-(4S)-(4 -hydroxyphenyl)-2-azetidinone (SCH 58235): a designed, potent, orally active inhibitor of cholesterol absorption. J Med Chem 41: 973-980, 1998.
    • (1998) J Med Chem , vol.41 , pp. 973-980
    • Rosenblum, S.B.1    Huynh, T.2    Afonso, A.3    Davis Jr., H.R.4    Yumibe, N.5    Clader, J.W.6    Burnett, D.A.7
  • 37
    • 0035478113 scopus 로고    scopus 로고
    • From interaction of lipidic vehicles with intestinal epithelial cell membranes to the formation and secretion of chylomicrons
    • Shen H, Howles P, Tso P. From interaction of lipidic vehicles with intestinal epithelial cell membranes to the formation and secretion of chylomicrons. Adv Drug Deliv Rev 50, Suppl 1: S103-S125, 2001.
    • (2001) Adv Drug Deliv Rev , vol.50 , Issue.SUPPL. 1
    • Shen, H.1    Howles, P.2    Tso, P.3
  • 38
    • 0028883828 scopus 로고
    • Prevention of coronary heart disease with pravastatin in men with hypercholesterolemia
    • West of Scotland Coronary Prevention Study Group
    • Shepherd J, Cobbe SM, Ford I, Isles CG, Lorimer AR, MacFarlane PW, McKillop JH, Packard CJ. Prevention of coronary heart disease with pravastatin in men with hypercholesterolemia. West of Scotland Coronary Prevention Study Group. N Engl J Med 333: 1301-1307, 1995.
    • (1995) N Engl J Med , vol.333 , pp. 1301-1307
    • Shepherd, J.1    Cobbe, S.M.2    Ford, I.3    Isles, C.G.4    Lorimer, A.R.5    MacFarlane, P.W.6    McKillop, J.H.7    Packard, C.J.8
  • 39
    • 0034529050 scopus 로고    scopus 로고
    • How cells handle cholesterol
    • Simons K, Ikonen E. How cells handle cholesterol. Science 290: 1721-1726, 2000.
    • (2000) Science , vol.290 , pp. 1721-1726
    • Simons, K.1    Ikonen, E.2
  • 41
    • 0014481680 scopus 로고
    • Determination of blood glucose using 4-amino phenazone as oxygen acceptor
    • Trinder P. Determination of blood glucose using 4-amino phenazone as oxygen acceptor. J Clin Pathol 22: 246, 1969.
    • (1969) J Clin Pathol , vol.22 , pp. 246
    • Trinder, P.1
  • 42
    • 0034991315 scopus 로고    scopus 로고
    • Ezetimibe, a potent cholesterol absorption inhibitor, normalizes combined dyslipidemia in obese hyperinsulinemic hamsters
    • Van Heek M, Austin TM, Farley C, Cook JA, Tetzloff GG, Davis HR. Ezetimibe, a potent cholesterol absorption inhibitor, normalizes combined dyslipidemia in obese hyperinsulinemic hamsters. Diabetes 50: 1330-1335, 2001.
    • (2001) Diabetes , vol.50 , pp. 1330-1335
    • Van Heek, M.1    Austin, T.M.2    Farley, C.3    Cook, J.A.4    Tetzloff, G.G.5    Davis, H.R.6
  • 43
    • 0035831089 scopus 로고    scopus 로고
    • The cholesterol absorption inhibitor, ezetimibe, decreases diet-induced hypercholesterolemia in monkeys
    • Van Heek M, Compton DS, Davis HR. The cholesterol absorption inhibitor, ezetimibe, decreases diet-induced hypercholesterolemia in monkeys. Eur J Pharmacol 415: 79-84, 2001.
    • (2001) Eur J Pharmacol , vol.415 , pp. 79-84
    • Van Heek, M.1    Compton, D.S.2    Davis, H.R.3
  • 44
    • 0034003105 scopus 로고    scopus 로고
    • Comparison of the activity and disposition of the novel cholesterol absorption inhibitor, SCH58235, and its glucuronide, SCH60663
    • Van Heek M, Farley C, Compton DS, Hoos L, Alton KB, Sybertz EJ, Davis HR Jr. Comparison of the activity and disposition of the novel cholesterol absorption inhibitor, SCH58235, and its glucuronide, SCH60663. Br J Pharmacol 129: 1748-1754, 2000.
    • (2000) Br J Pharmacol , vol.129 , pp. 1748-1754
    • Van Heek, M.1    Farley, C.2    Compton, D.S.3    Hoos, L.4    Alton, K.B.5    Sybertz, E.J.6    Davis Jr., H.R.7
  • 45
    • 0034776367 scopus 로고    scopus 로고
    • Ezetimibe selectively inhibits intestinal cholesterol absorption in rodents in the presence and absence of exocrine pancreatic function
    • Van Heek M, Farley C, Compton DS, Hoos L, Davis HR. Ezetimibe selectively inhibits intestinal cholesterol absorption in rodents in the presence and absence of exocrine pancreatic function. Br J Pharmacol 134: 409-417, 2001.
    • (2001) Br J Pharmacol , vol.134 , pp. 409-417
    • Van Heek, M.1    Farley, C.2    Compton, D.S.3    Hoos, L.4    Davis, H.R.5
  • 46
    • 0038291655 scopus 로고    scopus 로고
    • Ezetimibe potently inhibits cholesterol absorption but does not affect acute hepatic or intestinal cholesterol synthesis in rats
    • Van Heek M, Farley C, Compton DS, Hoos LM, Smith-Torhan A, Davis HR. Ezetimibe potently inhibits cholesterol absorption but does not affect acute hepatic or intestinal cholesterol synthesis in rats. Br J Pharmacol 138: 1459-1464, 2003.
    • (2003) Br J Pharmacol , vol.138 , pp. 1459-1464
    • Van Heek, M.1    Farley, C.2    Compton, D.S.3    Hoos, L.M.4    Smith-Torhan, A.5    Davis, H.R.6
  • 47
    • 0030848734 scopus 로고    scopus 로고
    • In vivo metabolism-based discovery of a potent cholesterol absorption inhibitor, SCH58235, in the rat and rhesus monkey through the identification of the active metabolites of SCH48461
    • Van Heek M, France CF, Compton DS, McLeod RL, Yumibe NP, Alton KB, Sybertz EJ, Davis HR Jr. In vivo metabolism-based discovery of a potent cholesterol absorption inhibitor, SCH58235, in the rat and rhesus monkey through the identification of the active metabolites of SCH48461. J Pharmacol Exp Ther 283: 157-163, 1997.
    • (1997) J Pharmacol Exp Ther , vol.283 , pp. 157-163
    • Van Heek, M.1    France, C.F.2    Compton, D.S.3    McLeod, R.L.4    Yumibe, N.P.5    Alton, K.B.6    Sybertz, E.J.7    Davis Jr., H.R.8
  • 48
    • 33947380185 scopus 로고    scopus 로고
    • Regulation of intestinal cholesterol absorption
    • Wang DQ. Regulation of intestinal cholesterol absorption. Annu Rev Physiol 69: 221-248, 2007.
    • (2007) Annu Rev Physiol , vol.69 , pp. 221-248
    • Wang, D.Q.1
  • 49
  • 51
    • 0029157050 scopus 로고
    • Effects of dietary fatty acid composition on basal and hormone-stimulated hepatic lipogenesis and on circulating lipids in the rat
    • Zampelas A, Morgan LM, Furlonger N, Williams CM. Effects of dietary fatty acid composition on basal and hormone-stimulated hepatic lipogenesis and on circulating lipids in the rat. Br J Nutr 74: 381-392, 1995.
    • (1995) Br J Nutr , vol.74 , pp. 381-392
    • Zampelas, A.1    Morgan, L.M.2    Furlonger, N.3    Williams, C.M.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.