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Volumn 36, Issue 4, 2010, Pages 241-247

Modulation of signal transduction in cancer cells by phytosterols

Author keywords

Apoptosis; Cancer chemoprevention; Ceramide; Liver X receptor; Phytosterols

Indexed keywords

ANTINEOPLASTIC AGENT; CAMPESTEROL; CASPASE; CERAMIDE; LIVER X RECEPTOR; PHYTOSTEROL; SITOSTEROL; SPHINGOMYELIN; STIGMASTEROL;

EID: 78149476478     PISSN: 09516433     EISSN: 18728081     Source Type: Journal    
DOI: 10.1002/biof.97     Document Type: Article
Times cited : (55)

References (71)
  • 1
    • 79955066647 scopus 로고    scopus 로고
    • Herbal Medicine: A Cancer Chemopreventive and Therapeutic Perspective
    • (Arora, R., ed.), Jaypee Brothers Medical Publishers, New Delhi, India.
    • Arora, R. (2010Herbal drugs for oncology. Current status and future directions in cancer chemoprevention. In Herbal Medicine: A Cancer Chemopreventive and Therapeutic Perspective. (Arora, R., ed.). pp. 3-41, Jaypee Brothers Medical Publishers, New Delhi, India.
    • (2010) Herbal drugs for oncology. Current status and future directions in cancer chemoprevention , pp. 3-41
    • Arora, R.1
  • 2
    • 78149475040 scopus 로고    scopus 로고
    • American Institute for Cancer Research/World Cancer Research Fund (, Food, nutrition, physical activity and the prevention of cancer: a global perspective. Available at: Accessed on 12 April 2010.
    • American Institute for Cancer Research/World Cancer Research Fund (2007Food, nutrition, physical activity and the prevention of cancer: a global perspective. Available at: Accessed on 12 April 2010.
    • (2007)
  • 3
    • 78149481108 scopus 로고    scopus 로고
    • National Cancer Institute (, Cancer control and population science. Available at: Accessed on 18 January 2010.
    • National Cancer Institute (2006Cancer control and population science. Available at: Accessed on 18 January 2010.
    • (2006)
  • 4
    • 0142166328 scopus 로고    scopus 로고
    • Cancer chemoprevention with dietary phytochemicals
    • Surh, Y.-J. (2003Cancer chemoprevention with dietary phytochemicals. Nat. Rev. Cancer 3, 768-780.
    • (2003) Nat. Rev. Cancer , vol.3 , pp. 768-780
    • Surh, Y.1
  • 5
    • 78149488593 scopus 로고    scopus 로고
    • National Cancer Institute (, Cancer Trends Progress Report. Available at: Accessed on 26 January 2010.
    • National Cancer Institute (2007Cancer Trends Progress Report. Available at: Accessed on 26 January 2010.
    • (2007)
  • 6
    • 78149485992 scopus 로고    scopus 로고
    • -Plant compounds continue to challenge science. The American Institute for Cancer Research. Available at: Accessed on 12 April 2010.
    • Welden, G. and Prince, J. (2006Plant compounds continue to challenge science. The American Institute for Cancer Research. Available at: Accessed on 12 April 2010.
    • (2006)
    • Welden, G.1    Prince, J.2
  • 7
    • 34250890634 scopus 로고    scopus 로고
    • Phytosterols as anticancer compounds
    • Bradford, P. G. and Awad, A. B. (2007Phytosterols as anticancer compounds. Mol. Nutr. Food Res. 51, 161-170.
    • (2007) Mol. Nutr. Food Res. , vol.51 , pp. 161-170
    • Bradford, P.G.1    Awad, A.B.2
  • 9
    • 1642504912 scopus 로고    scopus 로고
    • Plant sterol biosynthesis: identification of two distinct families of sterol 4α-methyloxidases
    • Darnet, S. and Rahier, A. (2004Plant sterol biosynthesis: identification of two distinct families of sterol 4α-methyloxidases. Biochem. J. 378, 889-898.
    • (2004) Biochem. J. , vol.378 , pp. 889-898
    • Darnet, S.1    Rahier, A.2
  • 10
    • 0034657215 scopus 로고    scopus 로고
    • Plant sterols: biosynthesis, biological function and their importance to human nutrition
    • Piironen, V., Lindsay, D. G., Miettinen, T. A., Toivo, J., and Lampi, A. M. (2000Plant sterols: biosynthesis, biological function and their importance to human nutrition. J. Sci. Food Agric. 80, 939-966.
    • (2000) J. Sci. Food Agric. , vol.80 , pp. 939-966
    • Piironen, V.1    Lindsay, D.G.2    Miettinen, T.A.3    Toivo, J.4    Lampi, A.M.5
  • 11
    • 78149473863 scopus 로고    scopus 로고
    • Food Chemicals Codex
    • Food Chemicals Codex (, Committee on Food Chemicals Codex, eds.), The National Academic Press, Washington DC.
    • Food Chemicals Codex (2004Vegetable oil phytosterol esters. In: Food Chemicals Codex. (Committee on Food Chemicals Codex, eds.). pp. 492-494, The National Academic Press, Washington DC.
    • (2004) Vegetable oil phytosterol esters , pp. 492-494
  • 12
    • 0032720785 scopus 로고    scopus 로고
    • The cholesterol-lowering action of plant stanol esters
    • Nguyen, T. T. (1999The cholesterol-lowering action of plant stanol esters. J. Nutr. 129, 2109-2112.
    • (1999) J. Nutr. , vol.129 , pp. 2109-2112
    • Nguyen, T.T.1
  • 13
    • 78149472032 scopus 로고    scopus 로고
    • Plant sterols and related lipids: structure, occurrence, biochemistry and analysis. Available at: Accessed on 12 April 2010.
    • Christie, W. W. (2008Plant sterols and related lipids: structure, occurrence, biochemistry and analysis. Available at: Accessed on 12 April 2010.
    • (2008)
    • Christie, W.W.1
  • 15
    • 78149481457 scopus 로고    scopus 로고
    • -Phytosterols. Available at: Accessed on 12 April 2010.
    • Higdon, J., Drake, V. J., and Jones, P. (2008Phytosterols. Available at: Accessed on 12 April 2010.
    • (2008)
    • Higdon, J.1    Drake, V.J.2    Jones, P.3
  • 16
    • 85008634299 scopus 로고    scopus 로고
    • Nutrition and Cancer Prevention
    • -Awad, A. B. and, Bradford, P. G. eds.), CRC Taylor and Francis, Boca Raton, FL, USA.
    • Trautwein, E. A. and Duchateau, G. (2006Phytosterols: sources and metabolism, In: Nutrition and Cancer Prevention. (Awad, A. B. and Bradford, P. G. eds.). pp. 223-249, CRC Taylor and Francis, Boca Raton, FL, USA.
    • (2006) Phytosterols: sources and metabolism , pp. 223-249
    • Trautwein, E.A.1    Duchateau, G.2
  • 17
    • 0033936879 scopus 로고    scopus 로고
    • Peanuts as a source of β-sitosterol, a sterol with anticancer properties
    • Awad, A. B., Chan, K. C., Downie, A. C., and Fink, C. S. (2000Peanuts as a source of β-sitosterol, a sterol with anticancer properties. Nutr. Cancer 36, 238-241.
    • (2000) Nutr. Cancer , vol.36 , pp. 238-241
    • Awad, A.B.1    Chan, K.C.2    Downie, A.C.3    Fink, C.S.4
  • 18
    • 67649983234 scopus 로고    scopus 로고
    • Position of the American Dietetic Association: vegetarian diets
    • American Dietetic Association (
    • American Dietetic Association (2009Position of the American Dietetic Association: vegetarian diets. J. Am. Diet. Assoc. 109, 1266-1282.
    • (2009) J. Am. Diet. Assoc. , vol.109 , pp. 1266-1282
  • 19
    • 65549115509 scopus 로고    scopus 로고
    • Health effects of vegan diets
    • Craig, W. J. (2009Health effects of vegan diets. Am. J. Clin. Nutr. 89, 1627S-1633S.
    • (2009) Am. J. Clin. Nutr. , vol.89
    • Craig, W.J.1
  • 20
    • 65549100580 scopus 로고    scopus 로고
    • Vegetarian diets: what do we know of their effects on common chronic diseases?
    • Fraser, G. E. (2009Vegetarian diets: what do we know of their effects on common chronic diseases? Am. J. Clin. Nutr. 89, 1607S-1612S.
    • (2009) Am. J. Clin. Nutr. , vol.89
    • Fraser, G.E.1
  • 21
    • 0032865975 scopus 로고    scopus 로고
    • Associations between diet and cancer, ischemic heart disease, and all-cause mortality in non-Hispanic white California Seventh-day Adventists
    • Fraser, G. E. (1999Associations between diet and cancer, ischemic heart disease, and all-cause mortality in non-Hispanic white California Seventh-day Adventists. Am. J. Clin. Nutr. 70, 532S-538S.
    • (1999) Am. J. Clin. Nutr. , vol.70
    • Fraser, G.E.1
  • 22
    • 65549090982 scopus 로고    scopus 로고
    • Mortality in British vegetarians: results from the European Prospective Investigation into Cancer and Nutrition (EPIC-Oxford)
    • Key, T. J., Appleby, P. N., Spencer, E. A., Travis, R. C., Roddam, A. W., and Allen, N. E. (2009Mortality in British vegetarians: results from the European Prospective Investigation into Cancer and Nutrition (EPIC-OxfordAm. J. Clin. Nutr. 89, 1620S-1626S.
    • (2009) Am. J. Clin. Nutr. , vol.89
    • Key, T.J.1    Appleby, P.N.2    Spencer, E.A.3    Travis, R.C.4    Roddam, A.W.5    Allen, N.E.6
  • 23
    • 38349130506 scopus 로고    scopus 로고
    • A very-low-fat vegan diet increases intake of protective dietary factors and decreases intake of pathogenic dietary factors
    • Dewell, A., Weidner, G., Sumner, M. D., Chi, C. S., and Ornish, D. (2008A very-low-fat vegan diet increases intake of protective dietary factors and decreases intake of pathogenic dietary factors. J. Am. Diet. Assoc. 108, 347-346.
    • (2008) J. Am. Diet. Assoc. , vol.108 , pp. 347-346
    • Dewell, A.1    Weidner, G.2    Sumner, M.D.3    Chi, C.S.4    Ornish, D.5
  • 25
    • 0018872473 scopus 로고
    • Protective effect of plant sterols against chemically-induced colon tumors in rats
    • Raicht, R. F., Cohen, B. I., Fazzini, E., Sarwal, A., and Takehashi, M. (1980Protective effect of plant sterols against chemically-induced colon tumors in rats. Cancer Res. 40, 403-405.
    • (1980) Cancer Res. , vol.40 , pp. 403-405
    • Raicht, R.F.1    Cohen, B.I.2    Fazzini, E.3    Sarwal, A.4    Takehashi, M.5
  • 26
    • 0020065827 scopus 로고
    • The kinetics of the protective effect of β-sitosterol against MNU-induced colon neoplasia
    • Deschner, E. E., Cohen, B. I., and Raicht, R. F. (1982The kinetics of the protective effect of β-sitosterol against MNU-induced colon neoplasia. J. Cancer Res. Clin. Oncol. 103, 49-54.
    • (1982) J. Cancer Res. Clin. Oncol. , vol.103 , pp. 49-54
    • Deschner, E.E.1    Cohen, B.I.2    Raicht, R.F.3
  • 27
    • 1842335728 scopus 로고    scopus 로고
    • Effect of dietary phytosterols on cell proliferation and protein kinase C activity in rat colonic mucosa
    • Awad, A. B., Tagle-Hernandez, A. Y., Fink, C. S., and Mendel, S. L. (1997Effect of dietary phytosterols on cell proliferation and protein kinase C activity in rat colonic mucosa. Nutr. Cancer 27, 210-215.
    • (1997) Nutr. Cancer , vol.27 , pp. 210-215
    • Awad, A.B.1    Tagle-Hernandez, A.Y.2    Fink, C.S.3    Mendel, S.L.4
  • 28
    • 0034093809 scopus 로고    scopus 로고
    • Dietary phytosterol inhibits the growth and metastasis of MDA-MB-231 human breast cancer cells grown in SCID mice
    • Awad, A. B., Downie, A., Fink, C. F., and Kim, U. (2000). Dietary phytosterol inhibits the growth and metastasis of MDA-MB-231 human breast cancer cells grown in SCID mice. Anticancer Res. 20, 821-824.
    • (2000) Anticancer Res. , vol.20 , pp. 821-824
    • Awad, A.B.1    Downie, A.2    Fink, C.F.3    Kim, U.4
  • 29
    • 0035680055 scopus 로고    scopus 로고
    • In vitro and in vivo (SCID miceeffect of phytosterols on the growth and dissemination of human prostate cancer PC-3 cells
    • Awad, A. B., Fink, C. S., Williams, H., and Kim, U. (2001In vitro and in vivo (SCID miceeffect of phytosterols on the growth and dissemination of human prostate cancer PC-3 cells. Eur. J. Cancer Prev. 10, 507-513.
    • (2001) Eur. J. Cancer Prev. , vol.10 , pp. 507-513
    • Awad, A.B.1    Fink, C.S.2    Williams, H.3    Kim, U.4
  • 30
    • 38549152194 scopus 로고    scopus 로고
    • Principles of bioactive lipid signalling: lessons from sphingolipids
    • Hannun, Y. A. and Obeid, L. M. (2008Principles of bioactive lipid signalling: lessons from sphingolipids. Nat. Rev. Mol. Cell Biol. 9, 139-150.
    • (2008) Nat. Rev. Mol. Cell Biol. , vol.9 , pp. 139-150
    • Hannun, Y.A.1    Obeid, L.M.2
  • 31
    • 33646146401 scopus 로고    scopus 로고
    • Alkaline sphingomyelinase: an old enzyme with novel implications
    • Duan, R. D. (2006Alkaline sphingomyelinase: an old enzyme with novel implications. Biochim. Biophys. Acta 1761, 281-291.
    • (2006) Biochim. Biophys. Acta , vol.1761 , pp. 281-291
    • Duan, R.D.1
  • 32
    • 0031023763 scopus 로고    scopus 로고
    • Alkaline sphingomyelinase activity is decreased in human colorectal carcinoma
    • Hertevig, E., Nilsson, L., Nyberg, R. D., and Duan, R. D. (1997Alkaline sphingomyelinase activity is decreased in human colorectal carcinoma. Cancer 79, 448-453.
    • (1997) Cancer , vol.79 , pp. 448-453
    • Hertevig, E.1    Nilsson, L.2    Nyberg, R.D.3    Duan, R.D.4
  • 33
    • 4344656249 scopus 로고    scopus 로고
    • Identification of one exon deletion of intestinal alkaline sphingomyelinase in colon cancer HT-29 cells and a differentiation-related expression of the wild-type enzyme in Caco-2 cells
    • Wu, J., Cheng, Y., Nilsson, A., and Duan, R. D. (2004Identification of one exon deletion of intestinal alkaline sphingomyelinase in colon cancer HT-29 cells and a differentiation-related expression of the wild-type enzyme in Caco-2 cells. Carcinogenesis 25, 1327-1333.
    • (2004) Carcinogenesis , vol.25 , pp. 1327-1333
    • Wu, J.1    Cheng, Y.2    Nilsson, A.3    Duan, R.D.4
  • 34
    • 0036303786 scopus 로고    scopus 로고
    • The therapeutic potential of modulating the ceramide/sphingomyelin pathway
    • Kolesnick, R. (2002The therapeutic potential of modulating the ceramide/sphingomyelin pathway. J. Clin. Invest. 110, 3-8.
    • (2002) J. Clin. Invest. , vol.110 , pp. 3-8
    • Kolesnick, R.1
  • 36
    • 0029966199 scopus 로고    scopus 로고
    • Beta-sitosterol inhibits HT-29 human colon cancer cell growth and alters membrane lipids
    • Awad, A. B., Chen, Y. C., Fink, C. S., and Hennessey, T. (1996Beta-sitosterol inhibits HT-29 human colon cancer cell growth and alters membrane lipids. Anticancer Res. 16, 2797-2804.
    • (1996) Anticancer Res. , vol.16 , pp. 2797-2804
    • Awad, A.B.1    Chen, Y.C.2    Fink, C.S.3    Hennessey, T.4
  • 37
    • 0031742610 scopus 로고    scopus 로고
    • Beta-sitosterol activates the sphingomyelin cycle and induces apoptosis in LNCaP human prostate cancer cells
    • von Holtz, R. L., Fink, C. S., and Awad, A. B. (1998Beta-sitosterol activates the sphingomyelin cycle and induces apoptosis in LNCaP human prostate cancer cells. Nutr. Cancer 32, 8-12.
    • (1998) Nutr. Cancer , vol.32 , pp. 8-12
    • von Holtz, R.L.1    Fink, C.S.2    Awad, A.B.3
  • 38
    • 48649098935 scopus 로고    scopus 로고
    • Beta-sitosterol enhances tamoxifen effectiveness on breast cancer cells by affecting ceramide metabolism
    • Awad, A. B., Barta, S. L., Fink, C. S., and Bradford, P. G. (2008Beta-sitosterol enhances tamoxifen effectiveness on breast cancer cells by affecting ceramide metabolism. Mol. Nutr. Food Res. 51, 171-177.
    • (2008) Mol. Nutr. Food Res. , vol.51 , pp. 171-177
    • Awad, A.B.1    Barta, S.L.2    Fink, C.S.3    Bradford, P.G.4
  • 39
    • 37349114118 scopus 로고    scopus 로고
    • Nuclear receptors: decoding metabolic disease
    • Sonoda, J., Pei, L., and Evans, R. M. (2008Nuclear receptors: decoding metabolic disease. FEBS Lett. 582, 2-9.
    • (2008) FEBS Lett. , vol.582 , pp. 2-9
    • Sonoda, J.1    Pei, L.2    Evans, R.M.3
  • 41
    • 0037385266 scopus 로고    scopus 로고
    • LXRs: new therapeutic targets in atherosclerosis?
    • Joseph, S. B. and Tontonoz, P. (2003LXRs: new therapeutic targets in atherosclerosis? Curr. Opin. Pharmacol. 3, 192-197.
    • (2003) Curr. Opin. Pharmacol. , vol.3 , pp. 192-197
    • Joseph, S.B.1    Tontonoz, P.2
  • 43
    • 34548675597 scopus 로고    scopus 로고
    • Modulation of the liver X receptor signaling as novel therapy for prostate cancer
    • Chuu, C.-P., Kokontis, J. M., Hiipakka, R. A., and Liao, S. (2007Modulation of the liver X receptor signaling as novel therapy for prostate cancer. J. Biomed. Sci. 14, 543-553.
    • (2007) J. Biomed. Sci. , vol.14 , pp. 543-553
    • Chuu, C.1    Kokontis, J.M.2    Hiipakka, R.A.3    Liao, S.4
  • 45
    • 64349083106 scopus 로고    scopus 로고
    • The oxysterol receptor LXR inhibits proliferation of human breast cancer cells
    • Vedin, L.-L., Lewandowski, S. A., Parini, P., Gustafsson, J.-A., and Steffensen, K. R. (2009The oxysterol receptor LXR inhibits proliferation of human breast cancer cells. Carcinogenesis 30, 575-579.
    • (2009) Carcinogenesis , vol.30 , pp. 575-579
    • Vedin, L.1    Lewandowski, S.A.2    Parini, P.3    Gustafsson, J.4    Steffensen, K.R.5
  • 48
    • 70350724704 scopus 로고    scopus 로고
    • Editorial: liver X receptor α (LXRαas a therapeutic target in chronic lymphocytic leukemia (CLL)
    • Christopherson, K. W. and Lamday, A. (2009Editorial: liver X receptor α (LXRαas a therapeutic target in chronic lymphocytic leukemia (CLL). J. Leukoc. Biol. 86, 1019-1021.
    • (2009) J. Leukoc. Biol. , vol.86 , pp. 1019-1021
    • Christopherson, K.W.1    Lamday, A.2
  • 50
    • 42949178186 scopus 로고    scopus 로고
    • Peroxisome proliferator-activated receptors and liver X receptors in epidermal biology
    • Schmuth, M., Jiang, Y. J., Dubrac, S., Elias, P. M., and Feingold, K. R. (2008Peroxisome proliferator-activated receptors and liver X receptors in epidermal biology. J. Lipid Res. 49, 499-509.
    • (2008) J. Lipid Res. , vol.49 , pp. 499-509
    • Schmuth, M.1    Jiang, Y.J.2    Dubrac, S.3    Elias, P.M.4    Feingold, K.R.5
  • 51
    • 33947367803 scopus 로고    scopus 로고
    • Activation of liver X receptors and retinoid X receptors induces growth arrest and apoptosis in insulin-secreting cells
    • Wente, W., Brenner, M. B., Zitzer, H., Gromada, J., and Efanov, A. M. (2007Activation of liver X receptors and retinoid X receptors induces growth arrest and apoptosis in insulin-secreting cells. Endocrinology 148, 1843-1849.
    • (2007) Endocrinology , vol.148 , pp. 1843-1849
    • Wente, W.1    Brenner, M.B.2    Zitzer, H.3    Gromada, J.4    Efanov, A.M.5
  • 52
    • 34249682775 scopus 로고    scopus 로고
    • Chronic activation of liver X receptor induces β-cell apoptosis through hyperactivation of lipogenesis
    • Choe, S. K., Choi, A. H., Lee, J.-W., Kim, K. H. Chung, J.-J., Park, J., Lee, K.-M., Park, K.-G., Lee, I.-K., and Kim, J. B. (2007Chronic activation of liver X receptor induces β-cell apoptosis through hyperactivation of lipogenesis. Diabetes 56, 1534-1543.
    • (2007) Diabetes , vol.56 , pp. 1534-1543
    • Choe, S.K.1    Choi, A.H.2    Lee, J.3    Kim, K.H.4    Chung, J.5    Park, J.6    Lee, K.7    Park, K.8    Lee, I.9    Kim, J.B.10
  • 53
    • 0036325649 scopus 로고    scopus 로고
    • Increased intestinal ABC1 expression contributes to the decrease in cholesterol absorption after plant sterol consumption
    • Plat, J. and Messink, R. P. (2002Increased intestinal ABC1 expression contributes to the decrease in cholesterol absorption after plant sterol consumption. FASEB J. 16, 1248-1253.
    • (2002) FASEB J. , vol.16 , pp. 1248-1253
    • Plat, J.1    Messink, R.P.2
  • 54
    • 0141481039 scopus 로고    scopus 로고
    • Induction of intestinal ATP-binding cassette transporters by a phytosterol-derived liver X receptor agonists
    • Kaneko, E., Matsuda, M., Yamada, Y., Tachibana, Y., Shimomura, I., and Makishima, M. (2003Induction of intestinal ATP-binding cassette transporters by a phytosterol-derived liver X receptor agonists. J. Biol. Chem. 278, 36091-36098.
    • (2003) J. Biol. Chem. , vol.278 , pp. 36091-36098
    • Kaneko, E.1    Matsuda, M.2    Yamada, Y.3    Tachibana, Y.4    Shimomura, I.5    Makishima, M.6
  • 55
    • 0037166261 scopus 로고    scopus 로고
    • Regulation of the ATP-binding cassette sterol transporters ABCG5 and ABCG8 by the liver X receptors α and β
    • Repa, J. J., Berge, K. E., Pomajzl, C., Richardson, J. A., Hobbs, H., and Mangelsdorf, D. J. (2002Regulation of the ATP-binding cassette sterol transporters ABCG5 and ABCG8 by the liver X receptors α and β. J. Biol. Chem. 277, 18793-18800.
    • (2002) J. Biol. Chem. , vol.277 , pp. 18793-18800
    • Repa, J.J.1    Berge, K.E.2    Pomajzl, C.3    Richardson, J.A.4    Hobbs, H.5    Mangelsdorf, D.J.6
  • 56
    • 60949112151 scopus 로고    scopus 로고
    • New insights into the molecular actions of plant sterols and stanols in cholesterol metabolism
    • Calpe-Berdiel, L., Escola-Gil, J. C., and Blanco-Vaca, F. (2009New insights into the molecular actions of plant sterols and stanols in cholesterol metabolism. Atherosclerosis 203, 18-31.
    • (2009) Atherosclerosis , vol.203 , pp. 18-31
    • Calpe-Berdiel, L.1    Escola-Gil, J.C.2    Blanco-Vaca, F.3
  • 57
    • 27444436469 scopus 로고    scopus 로고
    • Plant sterols and stanols: effects on mixed micellar composition and LXR (target geneactivation
    • Plat, J., Nichols, J. A., and Mensink, R. P. (2005Plant sterols and stanols: effects on mixed micellar composition and LXR (target geneactivation. J. Lipid Res. 46, 2468-2476.
    • (2005) J. Lipid Res. , vol.46 , pp. 2468-2476
    • Plat, J.1    Nichols, J.A.2    Mensink, R.P.3
  • 58
    • 0013199471 scopus 로고    scopus 로고
    • cholesterol and bile acid metabolism are impaired in mice lacking the nuclear oxysterol receptor LXRα
    • Peet, D. J., Turley, S. D., Ma, W., Janowski, B. A., Lobaccaro, J.-M. A., Hammer, R. E., and Mangelsdorf, D. J. (1998cholesterol and bile acid metabolism are impaired in mice lacking the nuclear oxysterol receptor LXRα. Cell 93, 693-704.
    • (1998) Cell , vol.93 , pp. 693-704
    • Peet, D.J.1    Turley, S.D.2    Ma, W.3    Janowski, B.A.4    Lobaccaro, J.A.5    Hammer, R.E.6    Mangelsdorf, D.J.7
  • 60
    • 0035665346 scopus 로고    scopus 로고
    • Oxidized plant sterols in human serum and lipid infusions as measured by combined gas-liquid chromatography-mass spectrometry
    • Plat, J., Brzezinka, H., Lutjohann, D., Mensink, R. P., and von Bergmann, K. (2001Oxidized plant sterols in human serum and lipid infusions as measured by combined gas-liquid chromatography-mass spectrometry. J. Lipid Res. 42, 2030-2038.
    • (2001) J. Lipid Res. , vol.42 , pp. 2030-2038
    • Plat, J.1    Brzezinka, H.2    Lutjohann, D.3    Mensink, R.P.4    von Bergmann, K.5
  • 62
    • 26044448563 scopus 로고    scopus 로고
    • Qualitative and quantitative comparison of the cytotoxic and apoptotic potential of phytosterol oxidation products with their corresponding cholesterol oxidation products
    • Ryan, E., Chopra, J., McCarthy, F., Maguire, A. R., and O'Brien, N. M. (2005Qualitative and quantitative comparison of the cytotoxic and apoptotic potential of phytosterol oxidation products with their corresponding cholesterol oxidation products. Br. J. Nutr. 94, 433-451.
    • (2005) Br. J. Nutr. , vol.94 , pp. 433-451
    • Ryan, E.1    Chopra, J.2    McCarthy, F.3    Maguire, A.R.4    O'Brien, N.M.5
  • 63
    • 3042710723 scopus 로고    scopus 로고
    • Induction of Bax and activation of caspases during β-sitosterol-mediated apoptosis in human colon cancer cells
    • Choi, Y. H., Kong, K. R., Kim, Y. A., Jung, K.-O., Kil, J. H., Rhee, S. H., and Park K. Y. (2003Induction of Bax and activation of caspases during β-sitosterol-mediated apoptosis in human colon cancer cells. Int. J. Oncol. 23, 1657-1662.
    • (2003) Int. J. Oncol. , vol.23 , pp. 1657-1662
    • Choi, Y.H.1    Kong, K.R.2    Kim, Y.A.3    Jung, K.4    Kil, J.H.5    Rhee, S.H.6    Park, K.Y.7
  • 64
    • 34250213261 scopus 로고    scopus 로고
    • β-Sitosterol-induced apoptosis is mediated by the activation of ERK and the downregulation of Akt in MCA-102 murine fibrosarcoma cells
    • Moon, D.-O., Lee, K.-J., Choi, Y. H., and Kim, G.-Y. (2007β-Sitosterol-induced apoptosis is mediated by the activation of ERK and the downregulation of Akt in MCA-102 murine fibrosarcoma cells. Int. Immunopharmacol. 7, 1044-1053.
    • (2007) Int. Immunopharmacol. , vol.7 , pp. 1044-1053
    • Moon, D.1    Lee, K.2    Choi, Y.H.3    Kim, G.4
  • 65
    • 0035728953 scopus 로고    scopus 로고
    • Phytosterols reduce in vitro metastatic ability of MDA-MB-231 human breast cancer cells
    • Awad, A. B., Williams, H., and Fink, C. S. (2001Phytosterols reduce in vitro metastatic ability of MDA-MB-231 human breast cancer cells. Nutr. Cancer 40, 157-164.
    • (2001) Nutr. Cancer , vol.40 , pp. 157-164
    • Awad, A.B.1    Williams, H.2    Fink, C.S.3
  • 67
    • 35148820279 scopus 로고    scopus 로고
    • Beta-sitosterol activates Fas-mediated apoptosis in breast cancer cells
    • Awad, A. B., Chinnam, M., Fink, C. S., and Bradford, P. G. (2007Beta-sitosterol activates Fas-mediated apoptosis in breast cancer cells. Phytomedicine 14, 747-754.
    • (2007) Phytomedicine , vol.14 , pp. 747-754
    • Awad, A.B.1    Chinnam, M.2    Fink, C.S.3    Bradford, P.G.4
  • 68
    • 67649233313 scopus 로고    scopus 로고
    • β-Sitosterol inhibits cell growth and induces apoptosis in SGC-7901 human stomach cancer cells
    • Zhao, T., Chang, S. K. C., Qu, G., Li, T., and Cui, H. (2009β-Sitosterol inhibits cell growth and induces apoptosis in SGC-7901 human stomach cancer cells. J. Agric. Food Chem. 57, 5211-5218.
    • (2009) J. Agric. Food Chem. , vol.57 , pp. 5211-5218
    • Zhao, T.1    Chang, S.K.C.2    Qu, G.3    Li, T.4    Cui, H.5
  • 69
    • 34447115675 scopus 로고    scopus 로고
    • β-Sitosterol induces anti-proliferation and apoptosis in human leukemic U937 cells through activation of caspase-3 and induction of Bax/Bcl-2 ratio
    • Park, C., Moon, D.-O., Rhu, C.-H., Choi, B. T., Lee, W. H., Kim, G.-Y., and Choi, Y. H. (2007β-Sitosterol induces anti-proliferation and apoptosis in human leukemic U937 cells through activation of caspase-3 and induction of Bax/Bcl-2 ratio. Biol. Pharm. Bull. 30, 1317-1323.
    • (2007) Biol. Pharm. Bull. , vol.30 , pp. 1317-1323
    • Park, C.1    Moon, D.2    Rhu, C.3    Choi, B.T.4    Lee, W.H.5    Kim, G.6    Choi, Y.H.7
  • 70
    • 67649344133 scopus 로고    scopus 로고
    • Cytotoxic and apoptotic effects of single and mixed oxides of beta-sitosterol on HepG2 cells
    • Koschutnig, K., Heikkinen, S., Kemmo, S., Lampi, A.-M., Piironen, V., and Wagner, K.-H. (2009Cytotoxic and apoptotic effects of single and mixed oxides of beta-sitosterol on HepG2 cells. Toxicol. In Vitro 23, 755-762.
    • (2009) Toxicol. In Vitro , vol.23 , pp. 755-762
    • Koschutnig, K.1    Heikkinen, S.2    Kemmo, S.3    Lampi, A.4    Piironen, V.5    Wagner, K.6
  • 71
    • 26844463336 scopus 로고    scopus 로고
    • β-Sitosterol stimulates ceramide metabolism in differentiated Caco2 cells
    • Awad, A. B., Fink, C. S., Trautwein, E. A., and Ntanios, F. Y. (2005β-Sitosterol stimulates ceramide metabolism in differentiated Caco2 cells. J. Nutr. Biochem. 16, 650-655.
    • (2005) J. Nutr. Biochem. , vol.16 , pp. 650-655
    • Awad, A.B.1    Fink, C.S.2    Trautwein, E.A.3    Ntanios, F.Y.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.