Dietary phytosterol inhibits the growth and metastasis of MDA-MB-231 human breast cancer cells grown in SCID mice

Anticancer Research

Volumn 20, Issue 2 A, 2000, Pages 821-824

  Awad, A B ^a   Downie, A ^a   Fink, C S ^a   Kim, U ^b  

^a UNIVERSITY AT BUFFALO   (United States)

^b VA WESTERN NEW YORK HEALTHCARE SYSTEM   (United States)

Author keywords

sitosterol; MDA MB 231 cells; Metastasis; Tumor growth

Indexed keywords

CAMPESTEROL; CHOLESTEROL; CHOLIC ACID; PHYTOSTEROL; SITOSTEROL;

ANIMAL EXPERIMENT; ARTICLE; BREAST CANCER; CHOLESTEROL BLOOD LEVEL; DIET THERAPY; FEMALE; FOOD INTAKE; GROWTH INHIBITION; HUMAN; HUMAN CELL; METASTASIS; MOUSE; NONHUMAN; PRIORITY JOURNAL; SCID MOUSE; TUMOR GROWTH; TUMOR VOLUME; TUMOR XENOGRAFT;

ANIMALS; BODY WEIGHT; BREAST NEOPLASMS; CELL DIVISION; CHOLESTEROL; CHOLIC ACID; DIETARY SUPPLEMENTS; FEMALE; HUMANS; MICE; MICE, SCID; NEOPLASM METASTASIS; PHYTOSTEROLS; STEROLS; TRANSPLANTATION, HETEROLOGOUS;

EID: 0034093809     PISSN: 02507005     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (18)

1. Awad AB, Chen Y-C, Fink CS and Hennessey T: ß-Sitosterol inhibits HT-29 human colon cancer cell growth and alters membrane lipids. Anticancer Res 16: 2797-2904, 1996.
2. von Holtz RL, Fink CS and Awad AB: ß-Sitosterol activates the sphingomyelin cycle and induces apoptosis in LNCaP human prostate cancer cells. Nutr Cancer 32: 8-12, 1998.
3. Rao AV and Janezic SA: The role of dietary phytosterols in colon carcinogenesis. Nutr Cancer 18: 43-52, 1992.
4. Downie A, Fink CS and Awad AB: Effect of phytosterols on MDA-MB-231 human breast cancer cell growth. FASEB J: A433-3, 1999.
5. Reichet RFB, Cohen B I, Fazzini EP, Sarwal AN and Takahashi M: Protective effects of plant sterols against chemically induced colon tumors in rats. Cancer Res 40: 403-405, 1980.
6. Gould G, Jones R, LeRoy G, Wissler R and Taylor C: Absorbability of ß-sitosterol in humans. Metabolism 18: 652-662, 1969.
7. Messina M and Barnes S: The role of soy products in reducing risk of cancer. J Natl. Cancer Inst 83: 541-546, 1991.
8. Awad AB, von Holtz RL, Cone JP, Fink CS and Chen Y-C: ß-Sitosterol inhibits the growth of HT-29 human colon cancer cells by activating the sphingomyelin cycle. Anticancer Res 18: 471-479, 1998.
9. Awad AB, Gan Y and Fink CS: ß-Sitosterol activates protein phosphatase 2A and phosphopase D in LNCaP cells. Anticancer Res 18: 4829-4830, 1998.
10. Awad AB, Sri Hartati M and Fink CS: Phytosterol feeding induces alteration in testosterone metabolism in rat tissues. J Nutr Biochem 9: 712-717, 1998.
11. Reeves PG, Rossow KL and Lindlaug J: Development and testing of the AIN-93 purified diets for rodents: Results on growth, kidney calcification and bone mineralization in rats and mice. J Nutr 123: 1923-1931, 1993.
12. Cesano A, Visonneau S, Scimeca JA, Kritchevsky D and Sanloli D: Opposite effects of linoleic acid and conjugated linoleic acid on human prostatic cancer in SCID mice. Anticancer Res 18: 833-838, 1998.
13. Awad AB, Garcia MD and Fink CS: Effect of dietary phytosterols on rat tissue lipids. Nutr Cancer 29: 212-216, 1997.
14. Awad AB, Tagle-Hernandez AY, Fink CS and Mendel SL: Effect of dietary phytosterols on cell proliferation and protein kinase C activity in rat colonic mucosa. Nutr Cancer 27: 210-215, 1997.
15. Janezic SA and Rao AV: Dose-dependent effect of dietary phytosterols on epithelial cell proliferation of the murine colon. Food Chem Toxicol 30: 611-616, 1992.
16. Lipkin MK, Uehara K, Winawer S, Sanchez A et al: Seventh-Day Adventist vegetarians have a quiescent proliferative activity in colonic mucosa. Cancer Lett 26: 139-144, 1985.
17. Bouic PJD, Etsebeth S, Liebenberg RW, Albrecht CF, Pegel K and Van Jaarsveld PP: Beta-sitosterol and Beta-sitosterol glucoside stimulate human peripheral blood lymphocyte proliferation: Simplifications for their use as an immunomodulatory vitamin combination. Int J Immunopharmac 18: 693-700, 1996.
18. Awad AB, Chan KC, Downie AC and Fink CS: Peanuts as a source of ß-sitosterol, a sterol with anticancer properties. Nut Cancer, in press.