Decreased collagen types i and IV, laminin, CK-19 and α-SMA expression after bone marrow cell transplantation in rats with liver fibrosis

Histochemistry and Cell Biology

Volumn 134, Issue 5, 2010, Pages 493-502

  Carvalho, S N ^a   Lira, D C ^a   Oliveira, G P ^a   Thole, A A ^a   Stumbo, A C ^a   Caetano, C E ^a   Marques, R G ^a   Carvalho, L ^a  

^a STATE UNIVERSITY OF RIO DE JANEIRO   (Brazil)

Author keywords

Bone marrow mononuclear cells; Collagen; Extracellular matrix; Laminin; Liver fibrosis; Myofibroblasts

Indexed keywords

ALANINE AMINOTRANSFERASE; ALKALINE PHOSPHATASE; ALPHA SMOOTH MUSCLE ACTIN; ASPARTATE AMINOTRANSFERASE; COLLAGEN TYPE 1; COLLAGEN TYPE 4; CYTOKERATIN 19; LAMININ;

ALANINE AMINOTRANSFERASE BLOOD LEVEL; ALKALINE PHOSPHATASE BLOOD LEVEL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; ASPARTATE AMINOTRANSFERASE BLOOD LEVEL; BILE DUCT; BONE MARROW TRANSPLANTATION; CONTROLLED STUDY; EXTRACELLULAR MATRIX; LIVER FIBROSIS; LIVER SINUSOID; MALE; MONONUCLEAR CELL; MYOFIBROBLAST; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; TREATMENT OUTCOME;

ACTINS; ANIMALS; BIOLOGICAL MARKERS; BONE MARROW CELLS; BONE MARROW TRANSPLANTATION; CELL DIFFERENTIATION; COLLAGEN TYPE I; COLLAGEN TYPE IV; KERATIN-19; LAMININ; LIVER CIRRHOSIS, EXPERIMENTAL; LIVER FUNCTION TESTS; MALE; MONOCYTES; RATS; RATS, WISTAR;

ANIMALIA; RATTUS;

EID: 78149471151     PISSN: 09486143     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00418-010-0746-2     Document Type: Article

References (33)

1. MR Alison S Islam S Lim 2009 Stem cells in liver regeneration, fibrosis and cancer: the good, the bad and the ugly J Pathol 217 282 298 1:STN:280:DC%2BD1M%2FgtlCnsw%3D%3D 10.1002/path.2453 18991329
2. I Aurich LP Mueller H Aurich J Luetzkendorf K Tisljar MM Dollinger W Schormann J Walldorf JG Hengstler WE Fleig, et al. 2007 Functional integration of hepatocytes derived from human mesenchymal stem cells into mouse livers Gut 56 405 415 1:CAS:528:DC%2BD2sXksVCqs7w%3D 10.1136/gut.2005.090050 16928726 (Pubitemid 46579773)
3. RM Baertschiger V Serre-Beinier P Morel D Bosco M Peyrou S Clement A Sgroi A Kaelin LH Buhler C Gonelle-Gispert 2009 Fibrogenic potential of human multipotent mesenchymal stromal cells in injured liver PLoS One 4 e6657 10.1371/journal.pone.0006657 19684854
4. DA Brenner 2009 Molecular pathogenesis of liver fibrosis Trans Am Clin Climatol Assoc 120 361 368 19768189
5. T Cantz M Bleidissel M Stehling HR Scholer 2008 In vitro differentiation of reprogrammed murine somatic cells into hepatic precursor cells Biol Chem 389 889 896 1:CAS:528:DC%2BD1cXotVygt7Y%3D 10.1515/BC.2008.107 18627307
6. BQ Cao JZ Lin YS Zhong SB Huang N Lin ZF Tang R Chen P Xiang RY Xu 2007 Contribution of mononuclear bone marrow cells to carbon tetrachloride-induced liver fibrosis in rats World J Gastroenterol 13 1851 1854 1:CAS:528: DC%2BD2sXmtV2ksr0%3D 10.3748/wjg.13.6037 17465480 discussion 1854-1856 (Pubitemid 350238272)
7. AB Carvalho LF Quintanilha JV Dias BD Paredes EG Mannheimer FG Carvalho KD Asensi B Gutfilen LM Fonseca CM Resende, et al. 2008 Bone marrow multipotent mesenchymal stromal cells do not reduce fibrosis or improve function in a rat model of severe chronic liver injury Stem Cells 26 1307 1314 1:CAS:528:DC%2BD1cXnsFCgtb8%3D 10.1634/stemcells.2007-0941 18308943
8. S Carvalho E Cortez AC Stumbo A Thole C Caetano R Marques M Pelajo-Machado LC Porto L Carvalho 2008 Laminin expression during bone marrow mononuclear cell transplantation in hepatectomized rats Cell Biol Int 32 1014 1018 1:CAS:528:DC%2BD1cXptVWlur8%3D 10.1016/j.cellbi.2008.04.003 18485749
9. J Collier M Bassendine 2002 How to respond to abnormal liver function tests Clin Med 2 406 409 12448585
10. JA Fallowfield M Mizuno TJ Kendall CM Constandinou RC Benyon JS Duffield JP Iredale 2007 Scar-associated macrophages are a major source of hepatic matrix metalloproteinase-13 and facilitate the resolution of murine hepatic fibrosis J Immunol 178 5288 5295 1:CAS:528:DC%2BD2sXjslWjtLg%3D 17404313
11. SL Friedman 2008 Hepatic fibrosis-overview Toxicology 254 120 129 1:CAS:528:DC%2BD1cXhsVGhurrM 10.1016/j.tox.2008.06.013 18662740
12. EG Giannini R Testa V Savarino 2005 Liver enzyme alteration: a guide for clinicians CMAJ 172 367 379 15684121
13. Gieling RG, Burt AD, Mann DA (2008) Fibrosis and cirrhosis reversibility-molecular mechanisms. Clin Liver Dis 12:915-937, xi
14. ES Gilchrist JN Plevris 2010 Bone marrow-derived stem cells in liver repair: 10 years down the line Liver Transpl 16 118 129 10.1002/lt.21965 20104479
15. SS Glaser E Gaudio T Miller D Alvaro G Alpini 2009 Cholangiocyte proliferation and liver fibrosis Expert Rev Mol Med 11 e7 10.1017/ S1462399409000994 19239726
16. Greenbaum LE, Wells RG (2009) The role of stem cells in liver repair and fibrosis. Int J Biochem Cell Biol (Epub ahead of print)
17. C Guyot S Lepreux C Combe E Doudnikoff P Bioulac-Sage C Balabaud A Desmouliere 2006 Hepatic fibrosis and cirrhosis: the (myo)fibroblastic cell subpopulations involved Int J Biochem Cell Biol 38 135 151 1:CAS:528: DC%2BD2MXht1aqu7jN 16257564
18. MW Harty EF Papa HM Huddleston E Young S Nazareth CA Riley GA Ramm SH Gregory TF Tracy Jr 2008 Hepatic macrophages promote the neutrophil-dependent resolution of fibrosis in repairing cholestatic rat livers Surgery 143 667 678 10.1016/j.surg.2008.01.008 18436015 (Pubitemid 351626112)
19. F Heymann C Trautwein F Tacke 2009 Monocytes and macrophages as cellular targets in liver fibrosis Inflamm Allergy Drug Targets 8 307 318 1:CAS:528:DC%2BD1MXhtlWjtbzE 10.2174/187152809789352230 19534673
20. JP Iredale 2007 Models of liver fibrosis: exploring the dynamic nature of inflammation and repair in a solid organ J Clin Invest 117 539 548 1:CAS:528:DC%2BD2sXis12htr4%3D 10.1172/JCI30542 17332881 (Pubitemid 46348508)
21. R Jain S Fischer S Serra R Chetty 2010 The use of Cytokeratin 19 (CK19) immunohistochemistry in lesions of the pancreas, gastrointestinal tract, and liver Appl Immunohistochem Mol Morphol 18 9 15 1:CAS:528:DC%2BD1MXhs1WjtLrO 10.1097/PAI.0b013e3181ad36ea 19956064
22. N Kinnman C Housset 2002 Peribiliary myofibroblasts in biliary type liver fibrosis Front Biosci 7 d496 d503 1:CAS:528:DC%2BD38Xit12ru78%3D 10.2741/kinnman 11815289
23. JH Lefkowitch 2007 Hepatobiliary pathology Curr Opin Gastroenterol 23 221 231 10.1097/MOG.0b013e3280adc92e 17414836 (Pubitemid 46578070)
24. N Levicar M Pai NA Habib P Tait LR Jiao SB Marley J Davis F Dazzi C Smadja SL Jensen, et al. 2008 Long-term clinical results of autologous infusion of mobilized adult bone marrow derived CD34+ cells in patients with chronic liver disease Cell Prolif 41 Suppl 1 115 125 18181952
25. F Marra S Aleffi S Galastri A Provenzano 2009 Mononuclear cells in liver fibrosis Semin Immunopathol 31 345 358 1:CAS:528:DC%2BD1MXhtFOrsLbJ 10.1007/s00281-009-0169-0 19533130
26. E Novo LV di Bonzo S Cannito S Colombatto M Parola 2009 Hepatic myofibroblasts: a heterogeneous population of multifunctional cells in liver fibrogenesis Int J Biochem Cell Biol 41 2089 2093 1:CAS:528:DC%2BD1MXhtFyntLzK 10.1016/j.biocel.2009.03.010 19782946
27. M Parola M Pinzani 2009 Hepatic wound repair Fibrogenesis Tissue Repair 2 4 10.1186/1755-1536-2-4 19781064
28. Y Popov DY Sverdlov KR Bhaskar AK Sharma G Millonig E Patsenker S Krahenbuhl L Krahenbuhl D Schuppan 2010 Macrophage-mediated phagocytosis of apoptotic cholangiocytes contributes to reversal of experimental biliary fibrosis Am J Physiol Gastrointest Liver Physiol 298 G323 G334 1:CAS:528:DC%2BC3cXjsFGgtrg%3D 10.1152/ajpgi.00394.2009 20056896
29. HB Richter H Franke R Dargel 1998 Expression of tenascin, fibronectin, and laminin in rat liver fibrogenesis-a comparative immunohistochemical study with two models of liver injury Exp Toxicol Pathol 50 315 322 1:CAS:528:DyaK1cXmt1Cisbw%3D 9784003
30. H Rosa ER Parise 2008 Is there a place for serum laminin determination in patients with liver disease and cancer? World J Gastroenterol 14 3628 3632 1:CAS:528:DC%2BD1cXht1WlsrnM 10.3748/wjg.14.3628 18595129
31. J Rosenbloom SV Castro SA Jimenez 2010 Narrative review: fibrotic diseases: cellular and molecular mechanisms and novel therapies Ann Int Med 152 159 166 20124232
32. FP Russo MR Alison BW Bigger E Amofah A Florou F Amin G Bou-Gharios R Jeffery JP Iredale SJ Forbes 2006 The bone marrow functionally contributes to liver fibrosis Gastroenterology 130 1807 1821 10.1053/j.gastro.2006.01.036 16697743 (Pubitemid 43668827)
33. P Sancho-Bru M Najimi M Caruso K Pauwelyn T Cantz S Forbes T Roskams M Ott U Gehling E Sokal, et al. 2009 Stem and progenitor cells for liver repopulation: can we standardise the process from bench to bedside? Gut 58 594 603 1:CAS:528:DC%2BC3cXivFWltr4%3D 10.1136/gut.2008.171116 19091822