메뉴 건너뛰기




Volumn 26, Issue 5, 2008, Pages 1307-1314

Bone marrow multipotent mesenchymal stromal cells do not reduce fibrosis or improve function in a rat model of severe chronic liver injury

Author keywords

Bone marrow; Fibrosis; Liver; Mesenchymal stromal cells

Indexed keywords

ALANINE AMINOTRANSFERASE; ALBUMIN; ALCOHOL; ASPARTATE AMINOTRANSFERASE; CARBON TETRACHLORIDE; COLLAGEN; PLACEBO; TECHNETIUM 99M; BIOLOGICAL MARKER; TECHNETIUM COMPLEX;

EID: 47949131075     PISSN: 10665099     EISSN: None     Source Type: Journal    
DOI: 10.1634/stemcells.2007-0941     Document Type: Article
Times cited : (146)

References (49)
  • 1
    • 0009522156 scopus 로고    scopus 로고
    • Organizational principles
    • Arias IM, Boyer JL, Chisari FV et al, eds, 4th ed. Philadelphia: Lippincott Williams & Wilkins
    • Desmet VJ. Organizational principles. In: Arias IM, Boyer JL, Chisari FV et al., eds. The liver biology and pathobiology, 4th ed. Philadelphia: Lippincott Williams & Wilkins, 2001:3-15.
    • (2001) The liver biology and pathobiology , pp. 3-15
    • Desmet, V.J.1
  • 2
    • 33644616292 scopus 로고    scopus 로고
    • Cirrhosis and its sequelae
    • Goldman L, Ausiello D, eds, 22th ed. Philadelphia: Saunders
    • Friedman SL, Schiano TD. Cirrhosis and its sequelae. In: Goldman L, Ausiello D, eds. Cecil textbook of medicine, 22th ed. Philadelphia: Saunders 2004:936-944.
    • (2004) Cecil textbook of medicine , pp. 936-944
    • Friedman, S.L.1    Schiano, T.D.2
  • 3
    • 0012119538 scopus 로고    scopus 로고
    • Pathophysiology of Liver Fibrosis
    • Arias IM, Boyer JL, Chisari FV et al, eds, 4th ed. Philadelphia: Lippincott Williams & Wilkins
    • Rojkind M, Greenwel P. Pathophysiology of Liver Fibrosis. In: Arias IM, Boyer JL, Chisari FV et al., eds. The liver biology and pathobiology, 4th ed. Philadelphia: Lippincott Williams & Wilkins, 2001:721-738.
    • (2001) The liver biology and pathobiology , pp. 721-738
    • Rojkind, M.1    Greenwel, P.2
  • 4
    • 55049127219 scopus 로고    scopus 로고
    • The World Health Report-Deaths by cause, sex and mortality stratum in World Health Organization regions. Available at, Accessed September 7, 2007
    • The World Health Report-Deaths by cause, sex and mortality stratum in World Health Organization regions. Available at http://www.who.int/en/. Accessed September 7, 2007.
  • 6
    • 33846934265 scopus 로고    scopus 로고
    • Administration of fibroblast growth factor 2 in combination with bone marrow transplantation synergistically improves carbon-tetrachloride-induced liver fibrosis in mice
    • Ishikawa T, Terai S, Urata Y et al. Administration of fibroblast growth factor 2 in combination with bone marrow transplantation synergistically improves carbon-tetrachloride-induced liver fibrosis in mice. Cell Tissue Res 2007;327:463-470.
    • (2007) Cell Tissue Res , vol.327 , pp. 463-470
    • Ishikawa, T.1    Terai, S.2    Urata, Y.3
  • 8
    • 4143114744 scopus 로고    scopus 로고
    • Systemic infusion of Flk+ mesenchymal stem cells ameliorate carbon tetrachloride-induced liver fibrosis in mice
    • Fang B, Shi M, Liao L et al. Systemic infusion of Flk+ mesenchymal stem cells ameliorate carbon tetrachloride-induced liver fibrosis in mice. Transplantation 2004;78:83-88.
    • (2004) Transplantation , vol.78 , pp. 83-88
    • Fang, B.1    Shi, M.2    Liao, L.3
  • 9
    • 33847654374 scopus 로고    scopus 로고
    • No contribution of multipotent mesenchymal stromal cells to liver regeneration in a rat model of prolonged hepatic injury
    • Popp FC, Slowik P, Eggenhofer E et al. No contribution of multipotent mesenchymal stromal cells to liver regeneration in a rat model of prolonged hepatic injury. STEM CELLS 2007;25:639-645.
    • (2007) STEM CELLS , vol.25 , pp. 639-645
    • Popp, F.C.1    Slowik, P.2    Eggenhofer, E.3
  • 10
    • 34447558272 scopus 로고    scopus 로고
    • Therapeutic potential of bone marrow-derived mesenchymal stem cells on experimental liver fibrosis
    • Abdel Aziz MT, Atta HM, Mahfouz S et al. Therapeutic potential of bone marrow-derived mesenchymal stem cells on experimental liver fibrosis. Clin Biochem 2007;40:893-899.
    • (2007) Clin Biochem , vol.40 , pp. 893-899
    • Abdel Aziz, M.T.1    Atta, H.M.2    Mahfouz, S.3
  • 11
    • 0027487229 scopus 로고
    • AIN-93 purified diets for laboratory rodents: Final report of the American Institute of Nutrition ad hoc writing committee on the reformulation of the AIN-76A rodent diet
    • Reeves PG, Nielsen FH, Fahey Jr GC. AIN-93 purified diets for laboratory rodents: final report of the American Institute of Nutrition ad hoc writing committee on the reformulation of the AIN-76A rodent diet. J Nutr 1993;123:1939-1951.
    • (1993) J Nutr , vol.123 , pp. 1939-1951
    • Reeves, P.G.1    Nielsen, F.H.2    Fahey Jr, G.C.3
  • 13
    • 0027409835 scopus 로고
    • Conventional and confocal fluorescence microscopy of collagen fibers in the heart
    • Dolber PC, Spach MS. Conventional and confocal fluorescence microscopy of collagen fibers in the heart. J Histochem Cytochem 1993;41:465-469.
    • (1993) J Histochem Cytochem , vol.41 , pp. 465-469
    • Dolber, P.C.1    Spach, M.S.2
  • 14
    • 33747713246 scopus 로고    scopus 로고
    • Minimal criteria for defining multipotent mesenchymal stromal cells. The International Society for Cellular Therapy position statement
    • Dominici M, Le Blanc K, Mueller I et al. Minimal criteria for defining multipotent mesenchymal stromal cells. The International Society for Cellular Therapy position statement. Cytotherapy 2006;8:315-317.
    • (2006) Cytotherapy , vol.8 , pp. 315-317
    • Dominici, M.1    Le Blanc, K.2    Mueller, I.3
  • 15
    • 0032146551 scopus 로고    scopus 로고
    • Mechanisms of spontaneous resolution of rat liver fibrosis. Hepatic stellate cell apoptosis and reduced hepatic expression of metalloproteinase inhibitors
    • Iredale JP, Benyon RC, Pickering J et al. Mechanisms of spontaneous resolution of rat liver fibrosis. Hepatic stellate cell apoptosis and reduced hepatic expression of metalloproteinase inhibitors. J Clin Invest 1998;102:538-549.
    • (1998) J Clin Invest , vol.102 , pp. 538-549
    • Iredale, J.P.1    Benyon, R.C.2    Pickering, J.3
  • 16
    • 2942622398 scopus 로고    scopus 로고
    • Spontaneous recovery from micronodular cirrhosis: Evidence for incomplete resolution associated with matrix cross-linking
    • Issa R, Zhou X, Constandinou CM et al. Spontaneous recovery from micronodular cirrhosis: evidence for incomplete resolution associated with matrix cross-linking. Gastroenterology 2004;126:1795-1808.
    • (2004) Gastroenterology , vol.126 , pp. 1795-1808
    • Issa, R.1    Zhou, X.2    Constandinou, C.M.3
  • 17
    • 33847363203 scopus 로고    scopus 로고
    • Models of liver fibrosis: Exploring the dynamic nature of inflammation and repair in a solid organ
    • Iredale JP. Models of liver fibrosis: exploring the dynamic nature of inflammation and repair in a solid organ. J Clin Invest 2007;117:539-548.
    • (2007) J Clin Invest , vol.117 , pp. 539-548
    • Iredale, J.P.1
  • 18
    • 33750938456 scopus 로고    scopus 로고
    • Differentiation of hematopoietic stem cells into hepatocytes in liver fibrosis in rats
    • Zhan Y, Wang Y, Wei L et al. Differentiation of hematopoietic stem cells into hepatocytes in liver fibrosis in rats. Transplant Proc 2006;38:3082-3085.
    • (2006) Transplant Proc , vol.38 , pp. 3082-3085
    • Zhan, Y.1    Wang, Y.2    Wei, L.3
  • 19
    • 0033694301 scopus 로고    scopus 로고
    • Purified hematopoietic stem cells can differentiate into hepatocytes in vivo
    • Lagasse E, Connors H, Al-Dhalimy et al. Purified hematopoietic stem cells can differentiate into hepatocytes in vivo. Nat Med 2000;6:1229-1234.
    • (2000) Nat Med , vol.6 , pp. 1229-1234
    • Lagasse, E.1    Connors, H.2    Dhalimy, A.3
  • 20
    • 0036968715 scopus 로고    scopus 로고
    • Kinetics of liver repopulation after bone marrow transplantation
    • Wang X, Montini E, Al-Dhalimy et al. Kinetics of liver repopulation after bone marrow transplantation. Am J Pathol 2002;161:565-574.
    • (2002) Am J Pathol , vol.161 , pp. 565-574
    • Wang, X.1    Montini, E.2    Dhalimy, A.3
  • 21
    • 2942749975 scopus 로고    scopus 로고
    • Hematopoietic stem cells convert into liver cells within days without fusion
    • Jang YY, Collector MI, Baylin SB et al. Hematopoietic stem cells convert into liver cells within days without fusion. Nat Cell Biol 2004;6:532-539.
    • (2004) Nat Cell Biol , vol.6 , pp. 532-539
    • Jang, Y.Y.1    Collector, M.I.2    Baylin, S.B.3
  • 22
    • 0037464574 scopus 로고    scopus 로고
    • Cell fusion is the principal source of bone-marrow-derived hepatocytes
    • Wang X, Willenbring H, Akkari Y et al. Cell fusion is the principal source of bone-marrow-derived hepatocytes. Nature 2003;422:897-901.
    • (2003) Nature , vol.422 , pp. 897-901
    • Wang, X.1    Willenbring, H.2    Akkari, Y.3
  • 23
    • 0037464545 scopus 로고    scopus 로고
    • Transplanted bone marrow regenerates liver by cell fusion
    • Vassilopoulos GP, Wang R, Russel DW et al. Transplanted bone marrow regenerates liver by cell fusion. Nature 2003;422:901-904.
    • (2003) Nature , vol.422 , pp. 901-904
    • Vassilopoulos, G.P.1    Wang, R.2    Russel, D.W.3
  • 24
    • 0242584006 scopus 로고    scopus 로고
    • Fusion of bone-marrow-derived cells with Purkinge neurons, cardiomyocytes and hepatocytes
    • Alvarez-Dolado M, Pardal R, Garcia-Verdugo JM et al. Fusion of bone-marrow-derived cells with Purkinge neurons, cardiomyocytes and hepatocytes. Nature 2003;425:968-973.
    • (2003) Nature , vol.425 , pp. 968-973
    • Alvarez-Dolado, M.1    Pardal, R.2    Garcia-Verdugo, J.M.3
  • 25
    • 85047690939 scopus 로고    scopus 로고
    • Hematopoietic myelomonocytic cells are the major source of hepatocyte fusion partners
    • Camargo FD, Finegold M, Goodell MA et al. Hematopoietic myelomonocytic cells are the major source of hepatocyte fusion partners. J Clin Invest 2004;113:1266-1270.
    • (2004) J Clin Invest , vol.113 , pp. 1266-1270
    • Camargo, F.D.1    Finegold, M.2    Goodell, M.A.3
  • 26
    • 0037183884 scopus 로고    scopus 로고
    • Little Evidence for Developmental Plasticity of Adult Hematopoietic Stem Cells
    • Wagers AJ, Sherwood RI, Christensen JL et al. Little Evidence for Developmental Plasticity of Adult Hematopoietic Stem Cells. Science 2002;297:2256-2259.
    • (2002) Science , vol.297 , pp. 2256-2259
    • Wagers, A.J.1    Sherwood, R.I.2    Christensen, J.L.3
  • 27
    • 33644509480 scopus 로고    scopus 로고
    • Hematopoietic cells as hepatocyte stem cells: A critical review of the evidence
    • Thorgeirsson SS, Grisham JW. Hematopoietic cells as hepatocyte stem cells: a critical review of the evidence. Hepatology 2006;43:2-8.
    • (2006) Hepatology , vol.43 , pp. 2-8
    • Thorgeirsson, S.S.1    Grisham, J.W.2
  • 28
    • 11144356049 scopus 로고    scopus 로고
    • Hematopoietic stem cells do not transdifferentiate into cardiac myocytes in myocardial infarction
    • Murry CE, Soonpaa MH, Reinecke H et al. Hematopoietic stem cells do not transdifferentiate into cardiac myocytes in myocardial infarction. Nature 2004;428:664-668.
    • (2004) Nature , vol.428 , pp. 664-668
    • Murry, C.E.1    Soonpaa, M.H.2    Reinecke, H.3
  • 29
    • 0033515827 scopus 로고    scopus 로고
    • Multilineage potential of adult human mesenchymal stem cells
    • Pittenger MF, Mackay AM, Beck SC et al. Multilineage potential of adult human mesenchymal stem cells. Science 1999;284:143-147.
    • (1999) Science , vol.284 , pp. 143-147
    • Pittenger, M.F.1    Mackay, A.M.2    Beck, S.C.3
  • 30
    • 33845983602 scopus 로고    scopus 로고
    • Functional neuronal differentiation of bone marrow-derived mesenchymal stem cells
    • Tropel P, Platet N, Platel JC et al. Functional neuronal differentiation of bone marrow-derived mesenchymal stem cells. STEM CELLS 2006;24:2868-2876.
    • (2006) STEM CELLS , vol.24 , pp. 2868-2876
    • Tropel, P.1    Platet, N.2    Platel, J.C.3
  • 31
    • 0033106384 scopus 로고    scopus 로고
    • Cardiomyocytes can be generated from marrow stromal cells in vitro
    • Makino S, Fukuda K, Miyoshi S et al. Cardiomyocytes can be generated from marrow stromal cells in vitro. J Clin Invest 1999;103:697-705.
    • (1999) J Clin Invest , vol.103 , pp. 697-705
    • Makino, S.1    Fukuda, K.2    Miyoshi, S.3
  • 32
    • 4644306982 scopus 로고    scopus 로고
    • Hepatic differentiation capability of rat bone marrow-derived mesenchymal stem cells and hematopoietic stem cells
    • Shu S, Wei L, Wang J et al. Hepatic differentiation capability of rat bone marrow-derived mesenchymal stem cells and hematopoietic stem cells. World J Gastroenterol 2004;10:2818-2822.
    • (2004) World J Gastroenterol , vol.10 , pp. 2818-2822
    • Shu, S.1    Wei, L.2    Wang, J.3
  • 33
    • 16244365866 scopus 로고    scopus 로고
    • Hepatocytic gene expression in cultured rat mesenchymal stem cells
    • Lange C, Bassler P, Lioznov MV et al. Hepatocytic gene expression in cultured rat mesenchymal stem cells. Transplant Proc 2005;37:276-279.
    • (2005) Transplant Proc , vol.37 , pp. 276-279
    • Lange, C.1    Bassler, P.2    Lioznov, M.V.3
  • 34
    • 23844506565 scopus 로고    scopus 로고
    • Liver-specific gene expression in mesenchymal stem cells is induced by liver cells
    • Lange C, Bassler P, Lioznov MV et al. Liver-specific gene expression in mesenchymal stem cells is induced by liver cells. World J Gastroenterol 2005;11:4497-4504.
    • (2005) World J Gastroenterol , vol.11 , pp. 4497-4504
    • Lange, C.1    Bassler, P.2    Lioznov, M.V.3
  • 35
    • 26244435756 scopus 로고    scopus 로고
    • Hepatic potential of bone marrow stromal cell: Development of in vitro co-culture and intra-portal transplantation models
    • Luk JM, Wang PP, Lee CK et al. Hepatic potential of bone marrow stromal cell: development of in vitro co-culture and intra-portal transplantation models. J Immunol Methods 2005;305:39-47.
    • (2005) J Immunol Methods , vol.305 , pp. 39-47
    • Luk, J.M.1    Wang, P.P.2    Lee, C.K.3
  • 36
    • 55049105343 scopus 로고    scopus 로고
    • Bone marrow cell transplant does not prevent or reverse murine liver cirrhosis
    • in press
    • Quintanilha LF, Mannheimer EG, Carvalho AB et al. Bone marrow cell transplant does not prevent or reverse murine liver cirrhosis. Cell Transplant 2007 (in press).
    • (2007) Cell Transplant
    • Quintanilha, L.F.1    Mannheimer, E.G.2    Carvalho, A.B.3
  • 37
    • 13744255589 scopus 로고    scopus 로고
    • Selective depletion of macrophages reveals distinct, opposing roles during liver injury and repair
    • Duffield JS, Forbes SJ, Constandinou CM et al. Selective depletion of macrophages reveals distinct, opposing roles during liver injury and repair. J Clin Invest 2005;115:56-65.
    • (2005) J Clin Invest , vol.115 , pp. 56-65
    • Duffield, J.S.1    Forbes, S.J.2    Constandinou, C.M.3
  • 38
    • 4444289142 scopus 로고    scopus 로고
    • Immune stimulation of hepatic fibrogenesis by CD8 cells and attenuation by transgenic interleukin-10 from hepatocytes
    • Safadi R, Ohta M, Alvarez CE et al. Immune stimulation of hepatic fibrogenesis by CD8 cells and attenuation by transgenic interleukin-10 from hepatocytes. Gastroenterology 2004;127:870-882.
    • (2004) Gastroenterology , vol.127 , pp. 870-882
    • Safadi, R.1    Ohta, M.2    Alvarez, C.E.3
  • 39
    • 0030885185 scopus 로고    scopus 로고
    • Strain-specific differences in mouse hepatic wound healing are mediated by divergent T helper cytokine responses
    • Shi Z, Wakil AE, Rockey DC. Strain-specific differences in mouse hepatic wound healing are mediated by divergent T helper cytokine responses. Proc Natl Acad Sci U S A 1997;94:10663-10668.
    • (1997) Proc Natl Acad Sci U S A , vol.94 , pp. 10663-10668
    • Shi, Z.1    Wakil, A.E.2    Rockey, D.C.3
  • 40
    • 38349077498 scopus 로고    scopus 로고
    • Toll-like receptors on human mesenchymal stem cells drive their migration and immunomodulating responses
    • Tomchuck SL, Zwezdaryk KJ, Coffelt SB et al. Toll-like receptors on human mesenchymal stem cells drive their migration and immunomodulating responses. STEM CELLS 2008;26:99-107.
    • (2008) STEM CELLS , vol.26 , pp. 99-107
    • Tomchuck, S.L.1    Zwezdaryk, K.J.2    Coffelt, S.B.3
  • 41
    • 0037442264 scopus 로고    scopus 로고
    • Suppression of allogeneic T-cell proliferation by human marrow stromal cells: Implications in transplantation
    • Tse WT, Pendleton JD, Beyer WM et al. Suppression of allogeneic T-cell proliferation by human marrow stromal cells: implications in transplantation. Transplantation 2003;75:389-397.
    • (2003) Transplantation , vol.75 , pp. 389-397
    • Tse, W.T.1    Pendleton, J.D.2    Beyer, W.M.3
  • 42
    • 33744913533 scopus 로고    scopus 로고
    • Mesenchymal stem cells for treatment of therapy-resistant graft-versus-host-disease
    • Ringdén O, Uzunel M, Rasmusson I et al. Mesenchymal stem cells for treatment of therapy-resistant graft-versus-host-disease. Transplantation 2006;81:1390-1397.
    • (2006) Transplantation , vol.81 , pp. 1390-1397
    • Ringdén, O.1    Uzunel, M.2    Rasmusson, I.3
  • 43
    • 33745144672 scopus 로고    scopus 로고
    • Immunomodulatory effects of mesenchymal stem cells in a rat organ transplant model
    • Inoue S, Popp FC, Koehl GE et al. Immunomodulatory effects of mesenchymal stem cells in a rat organ transplant model. Transplantation 2006;81:1589-1595.
    • (2006) Transplantation , vol.81 , pp. 1589-1595
    • Inoue, S.1    Popp, F.C.2    Koehl, G.E.3
  • 44
    • 33644931102 scopus 로고    scopus 로고
    • Failure of hepatocyte marker-expressing hematopoietic progenitor cells to efficiently convert into hepatocytes in vitro
    • Lian G, Wang C, Teng C et al. Failure of hepatocyte marker-expressing hematopoietic progenitor cells to efficiently convert into hepatocytes in vitro. Exp Hematol 2006;34:348-358.
    • (2006) Exp Hematol , vol.34 , pp. 348-358
    • Lian, G.1    Wang, C.2    Teng, C.3
  • 45
    • 34248670882 scopus 로고    scopus 로고
    • Bone marrow fails to differentiate into liver epithelium during murine development and regeneration
    • Rountree CB, Wang X, Ge S et al. Bone marrow fails to differentiate into liver epithelium during murine development and regeneration. Hepatology 2007;45:1250-1260.
    • (2007) Hepatology , vol.45 , pp. 1250-1260
    • Rountree, C.B.1    Wang, X.2    Ge, S.3
  • 46
    • 0141706428 scopus 로고    scopus 로고
    • Little evidence of bone marrow-derived hepatocytes in the replacement of injured liver
    • Kanazawa Y, Verma IM. Little evidence of bone marrow-derived hepatocytes in the replacement of injured liver. Proc Natl Acad Sci U S A 2003;100(suppl 1):11850-11853.
    • (2003) Proc Natl Acad Sci U S A , vol.100 , Issue.SUPPL. 1 , pp. 11850-11853
    • Kanazawa, Y.1    Verma, I.M.2
  • 47
    • 22144460191 scopus 로고    scopus 로고
    • Human mesenchymal stem cells xenografted directly to rat liver are differentiated into human hepatocytes without fusion
    • Sato Y, Araki H, Kato J et al. Human mesenchymal stem cells xenografted directly to rat liver are differentiated into human hepatocytes without fusion. Blood 2005;106:756-763.
    • (2005) Blood , vol.106 , pp. 756-763
    • Sato, Y.1    Araki, H.2    Kato, J.3
  • 48
    • 34047115205 scopus 로고    scopus 로고
    • Functional integration of hepatocytes derived from human mesenchymal cells into mouse livers
    • Aurich Y, Mueller LP, Aurich H et al. Functional integration of hepatocytes derived from human mesenchymal cells into mouse livers. Gut 2007;56:405-415.
    • (2007) Gut , vol.56 , pp. 405-415
    • Aurich, Y.1    Mueller, L.P.2    Aurich, H.3
  • 49
    • 38549127166 scopus 로고    scopus 로고
    • Human mesenchymal stem cells as a two-edged sword in hepatic regenerative medicine: Engraftment and hepatocyte differentiation versus profibrogenic potential
    • Bonzo LV, Ferrero I, Cravanzola C et al. Human mesenchymal stem cells as a two-edged sword in hepatic regenerative medicine: engraftment and hepatocyte differentiation versus profibrogenic potential. Gut 200;57:223-231.
    • Gut , vol.200 , Issue.57 , pp. 223-231
    • Bonzo, L.V.1    Ferrero, I.2    Cravanzola, C.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.