Chorismate synthase: An attractive target for drug development against orphan diseases

Current Drug Targets

Volumn 8, Issue 3, 2007, Pages 437-444

  Dias, Marcio V B ^a   Ely, Fernanda ^b   Palma, Mário S ^a   de Azevedo Jr , Walter F ^b   Basso, Luiz A ^b   Santos, Diógenes S ^b  

^a SÃO PAULO STATE UNIVERSITY UNESP   (Brazil)

^b PONTIFICAL CATHOLIC UNIVERSITY OF RIO GRANDE DO SUL   (Brazil)

Author keywords

Chorismate synthase; Flavin dependent enzymes; Infectious disease; Neglected disease; Shikimate pathway

Indexed keywords

6 FLUOROSHIKIMIC ACID; ANTIFUNGAL AGENT; ANTIINFECTIVE AGENT; ANTIPARASITIC AGENT; BACTERIAL ENZYME; BENZOFURAN 3[2H] ONE; CHORISMATE SYNTHASE; CHORISMATE SYNTHASE INHIBITOR; ENZYME INHIBITOR; FUNGAL ENZYME; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE; SHIKIMIC ACID; SHIKIMIC ACID DERIVATIVE; UNCLASSIFIED DRUG;

BACTERIAL INFECTION; BACTERIAL STRAIN; CATALYSIS; CRYSTAL STRUCTURE; CRYSTALLIZATION; DRUG DESIGN; DRUG RESEARCH; DRUG SYNTHESIS; DRUG TARGETING; ENZYME ACTIVE SITE; ENZYME ACTIVITY; ENZYME ANALYSIS; ENZYME INHIBITION; ENZYME ISOLATION; ENZYME KINETICS; ENZYME LOCALIZATION; ENZYME MECHANISM; ENZYME STRUCTURE; FUNGAL STRAIN; GENETIC CODE; MINIMUM INHIBITORY CONCENTRATION; NONHUMAN; PHYLOGENY; PROTEIN SECONDARY STRUCTURE; REVIEW; SITE DIRECTED MUTAGENESIS; STRUCTURE ANALYSIS;

ANIMALS; DRUG DELIVERY SYSTEMS; ENZYME INHIBITORS; HUMANS; ORPHAN DRUG PRODUCTION; PHOSPHORUS-OXYGEN LYASES; RARE DISEASES;

EID: 33847723314     PISSN: 13894501     EISSN: None     Source Type: Journal    
DOI: 10.2174/138945007780058924     Document Type: Review

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