Selective degradation of aggregate-prone CryAB mutants by HSPB1 is mediated by ubiquitin-proteasome pathways

Journal of Molecular and Cellular Cardiology

Volumn 49, Issue 6, 2010, Pages 918-930

  Zhang, Huali ^a   Rajasekaran, Namakkal S ^a   Orosz, Andras ^a   Xiao, Xianzhong ^b   Rechsteiner, Martin ^a   Benjamin, Ivor J ^a  

^a UNIVERSITY OF UTAH SCHOOL OF MEDICINE   (United States)

^b CENTRAL SOUTH UNIVERSITY   (China)

Author keywords

Aggregate; CryAB; Degradation; HSPB1; Macroautophagy; Proteasome; Solubility; Stability

Indexed keywords

ALANINE; ALPHA CRYSTALLIN; ARGININE; GLYCINE; HEAT SHOCK PROTEIN 27; MUTANT PROTEIN; POLYUBIQUITIN; PROTEASOME; PROTEASOME INHIBITOR; THREONINE; UBIQUITIN;

ANIMAL CELL; ARTICLE; CONJUGATION; CONTROLLED STUDY; EMBRYO; GENE OVEREXPRESSION; HEART MUSCLE CELL; NONHUMAN; PRIORITY JOURNAL; PROTEIN AGGREGATION; PROTEIN DEGRADATION; PROTEIN PROTEIN INTERACTION; PROTEIN STABILITY; PROTEIN STRUCTURE; RAT; SIGNAL TRANSDUCTION;

ALPHA-CRYSTALLIN B CHAIN; AMINO ACID SEQUENCE; ANIMALS; AUTOPHAGY; CYTOPLASM; DOWN-REGULATION; GENE KNOCKDOWN TECHNIQUES; HSP27 HEAT-SHOCK PROTEINS; HUMANS; MICE; MOLECULAR SEQUENCE DATA; MUTANT PROTEINS; MYOCYTES, CARDIAC; POLYUBIQUITIN; PROTEASOME ENDOPEPTIDASE COMPLEX; PROTEIN PROCESSING, POST-TRANSLATIONAL; PROTEIN STRUCTURE, QUATERNARY; RATS; SIGNAL TRANSDUCTION; SOLUBILITY; SUBCELLULAR FRACTIONS; UBIQUITIN;

RATTUS;

EID: 78149416783     PISSN: 00222828     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.yjmcc.2010.09.004     Document Type: Article

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