Truncation of αB-crystallin by the myopathy-causing Q151X mutation significantly destabilizes the protein leading to aggregate formation in transfected cells

Journal of Biological Chemistry

Volumn 283, Issue 16, 2008, Pages 10500-10512

  Hayes, Victoria H ^a   Devlin, Glyn ^b   Quinlan, Roy A ^a  

^a DURHAM UNIVERSITY   (United Kingdom)

^b UNIVERSITY OF CAMBRIDGE   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

AGGLOMERATION; OLIGOMERIZATION; PLANTS (BOTANY); PORT TERMINALS;

AGGREGATE FORMATIONS; CATASTROPHIC LOSSES; CELL EXTRACTS; CHAPERONE ACTIVITIES; CRYSTALLIN; INSOLUBLE FRACTIONS; MAJOR FACTORS; TERMINAL DOMAINS; TRANSFECTED CELLS; WILD TYPES;

AGGREGATES;

ALANINE; ALPHA CRYSTALLIN; CITRATE SYNTHASE; DESMIN; GLUTAMIC ACID; INSULIN; LYSINE; CHAPERONE;

ARTICLE; CELL STRAIN MCF 7; CIRCULAR DICHROISM; CONTROLLED STUDY; GENE MUTATION; HUMAN; HUMAN CELL; HYDROPHOBICITY; MYOPATHY; NUCLEOTIDE SEQUENCE; OLIGOMERIZATION; PATHOGENESIS; PRIORITY JOURNAL; PROTEIN AGGREGATION; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN PROTEIN INTERACTION; PROTEIN PURIFICATION; PROTEIN SECONDARY STRUCTURE; PROTEIN STABILITY; THERMOSTABILITY; BIOLOGICAL MODEL; CHEMISTRY; CYTOPLASM; FLUORESCENCE MICROSCOPY; GENETIC TRANSFECTION; GENETICS; METABOLISM; MUSCLE DISEASE; MUTATION; PROTEIN BINDING; PROTEIN DENATURATION; PROTEIN RENATURATION; PROTEIN TERTIARY STRUCTURE; TUMOR CELL LINE;

ALPHA-CRYSTALLIN B CHAIN; CELL LINE, TUMOR; CYTOPLASM; HUMANS; MICROSCOPY, FLUORESCENCE; MODELS, BIOLOGICAL; MOLECULAR CHAPERONES; MUSCULAR DISEASES; MUTATION; PROTEIN BINDING; PROTEIN DENATURATION; PROTEIN RENATURATION; PROTEIN STRUCTURE, TERTIARY; TRANSFECTION;

EID: 44849103123     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M706453200     Document Type: Article

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