Effect of combined administration of ginger (Zingiber officinale Roscoe) and atorvastatin on the liver of rats

Phytomedicine

Volumn 17, Issue 14, 2010, Pages 1076-1081

  Heeba, Gehan H ^a   Abd Elghany, Manal I ^b  

^a Minia University   (Egypt)

^b Minia University   (Egypt)

Author keywords

Antioxidant; Ginger extract; Hepatotoxicity; Malondialdehyde; Nitric oxide; Statins

Indexed keywords

ALPHA TOCOPHEROL; AMINOTRANSFERASE; ATORVASTATIN; CATALASE; CHOLESTEROL; GINGER EXTRACT; MALONALDEHYDE; NITRIC OXIDE; SUPEROXIDE DISMUTASE;

AMINOTRANSFERASE BLOOD LEVEL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CHOLESTEROL BLOOD LEVEL; CONTROLLED STUDY; DRUG DOSE COMPARISON; DRUG EFFECT; HISTOPATHOLOGY; INJURY SEVERITY; LIVER INJURY; LIVER TOXICITY; MALE; NONHUMAN; PRIORITY JOURNAL; RAT; TREATMENT DURATION;

ANIMALS; ANTI-INFLAMMATORY AGENTS; ANTICHOLESTEREMIC AGENTS; ANTIOXIDANTS; CATALASE; CHOLESTEROL; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG SYNERGISM; DRUG THERAPY, COMBINATION; DRUG-INDUCED LIVER INJURY; GINGER; HEPTANOIC ACIDS; LIVER; MALE; MALONDIALDEHYDE; NITRIC OXIDE; PHYTOTHERAPY; PLANT EXTRACTS; PYRROLES; RANDOM ALLOCATION; RATS; RATS, WISTAR; RHIZOME; SUPEROXIDE DISMUTASE; TRANSAMINASES; VITAMIN E;

RATTUS; ZINGIBER OFFICINALE;

EID: 78149410567     PISSN: 09447113     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.phymed.2010.04.007     Document Type: Article

References (38)

1. Ahmed R.S., Seth V., Banerjee B.D. Influence of dietary ginger (Zingiber officinales Rosc) on the antioxidant defense system in rat: comparison with ascorbic acid. Indian J. Exp. Biol. 2000, 38:604-606.
2. Ahmed R.S., Suke S.G., Seth V., Chakraborti A., Tripathi A.K., Banerjee B.D. Protective effects of dietary ginger (Zingiber officinales Rosc.) on lindane-induced oxidative stress in rats. Phytother. Res. 2008, 22:902-906.
3. Ajith T.A., Hema U., Aswathy M.S. Zingiber officinale Roscoe prevents acetaminophen-induced acute hepatotoxicity by enhancing hepatic antioxidant status. Food Chem. Toxicol. 2007, 45:2267-2272.
4. Bhandari U., kanojia R., Pillai K.K. Effect of ethanolic extract of Zingiber officinale on dyslipidaemia in diabetic rats. J. Ethnopharmacol. 2005, 97:227-230.
5. Black D.M. A general assessment of the safety of HMG CoA reductase inhibitors (statins). Curr. Atheroscler. Rep. 2002, 4:34-41.
6. Chang W.S., Chang Y.H., Lu F.J., Chiang H.C. Inhibitory effects of phenolic on xanthine oxidase. Anticancer Res. 1994, 14:501-506.
7. Clarke A.T., Mills P.R. Brief clinical observation: atorvastatin associated liver disease. Dig. Liver Dis. 2006, 38:772-777.
8. El-Sharaky A.S., Newairy A.A., Kamel M.A., Eweda S.M. Protective effect of ginger extract against bromobenzene-induced hepatotoxicity in male rats. Food Chem. Toxicol. 2009, 47:1584-1590.
9. Fuhrman B., Rosenblat M., Hayek T., Coleman R., Aviram M. Ginger extract consumption reduces plasma cholesterol, inhibits LDL oxidation and attenuates development of atherosclerosis in atherosclerotic, apolipoprotein E-deficient mice. J. Nutr. 2000, 130:1124-1131.
10. Giri J., Devi T.K.S., Meerarani S. Effect of ginger on serum cholesterol levels. Indian J. Nutr. Dietet. 1984, 21:433-437.
11. Habib S.H.M., Makpol S., Hamid N.A., Das S., Zurinah W., Ngah W., Yusof Y.A.M. Ginger extract (Zingiber officinale) has anti-cancer and anti-inflammatory effects on ethionine-induced hepatoma rats. Clinics 2008, 63:807-813.
12. Halliwell B. Antioxidants and human disease: a general introduction. Nutr. Rev. 1997, 55:S44-S49.
13. Horsman Y., Desager J.P., Harvengt C. Biochemical changes and morphological alterations of the liver in guinea-pigs after administration of simvastatin. Pharmacol. Toxicol. 1990, 67:336-339.
14. Ippoushi K., Azuma K., Ito H., Horie H., Higashio H. [6]-Gingerol inhibits nitric oxide synthesis in activated J774.1 mouse macrophages and prevents peroxynitrite-induced oxidation and nitration reactions. Life Sci. 2003, 73:3427-3437.
15. Kalender S., Uzun F.G., Durak D., Demir F., Kalender Y. Malathion-induced hepatotoxicity in rats: the effects of vitamins C and E. Food Chem. Toxicol. 2010, 48:633-638.
16. Lowry O.H., Rosenbrough M.S., Farr A.L., Randall R.J. Protein measurement with the folin phenol reagent. J. Biol. Chem. 1951, 193:265-267.
17. MacDonald J.S., Gerson R.J., Kornbrust D.J., Kloss M.W., Prahalada S., Berry P.H. Preclinical evaluation of lovastatin. Am. J. Card. 1988, 62:16J-27J.
18. Mallikarjuna K., Sahitya C.P., Sathyavelu R.K., Rajendra W. Ethanol toxicity: rehabilitation of hepatic antioxidant defense system with dietary ginger. Fitoterapia 2008, 79:174-178.
19. Masuda Y., Kikuzaki H., Hisamoto M., Nakatani N. Antioxidant properties of gingerol related compounds from ginger. Biofactors 2004, 21:293-296.
20. Mihara M., Uchiyama M. Determination of malonaldehyde precursor in tissue by thiobarbituric acid test. Anal. Biochem. 1978, 86:271-278.
21. Nakad A., Bataille L., Hamoir V., Sempoux C., Horsmans Y. Atorvastatin-induced acute hepatitis with absence of cross-toxicity with simvastatin. Lancet 1999, 353:1763-1764.
22. Parra J.L., Reddy K.R. Hepatotoxicity of hypolipidemic drugs. Clin. Liver Dis. 2003, 7:415-433.
23. Pelli N., Setti M. Atorvastatin as a trigger of autoimmune hepatitis. J. Hepatol. 2004, 40:716.
24. Perger L., Kohler M., Fattinger K., Flury R., Meier P.J., Pauli-Magnus C. Fatal liver failure with atorvastatin. J. Hepatol. 2003, 39:1095-1097.
25. Ridruejo E., Mando O.G. Acute cholestatic hepatitis after reinitiating treatment with atorvastatin. J. Hepatol. 2002, 37:165-166.
26. Sastry H., Moudgal R.P., Mohan J., Tyagi J.S., Rao G.S. Spectrophotometric determination of serum nitrite and nitrate by copper-cadmium alloy. Anal. Biochem. 2002, 306:79-82.
27. Sharma I., Gusain D., Dixit V.P. Hypolipidemic and antiatherosclerotic effect of Zingiber officinale in cholesterol fed rabbits. Phytother. Res. 1996, 10:517-518.
28. Shukla Y., Singh M. Cancer preventive properties of ginger: a brief review. Food Chem. Toxicol. 2007, 45:683-690.
29. Srinivasan K., Sambaiah K. The effect of spices on cholesterol 7 alpha-hydroxylase activity and on serum and hepatic cholesterol levels in the rat. Int. J. Vitam. Nutr. Res. 1991, 61:364-369.
30. Stoilova I., Krastanov A., Stoyanova A., Denev P., Gargova S. Antioxidant activity of ginger extract (Zingiber officinale). Food Chem. 2007, 102:764-770.
31. Traber M.G., Atkinson J. Vitamin E, antioxidant and nothing more. Free Radic. Biol. Med. 2007, 43:4-15.
32. Thomson M., Al-Qattan K.K., Al-Sawan S.M., Alnaqeeb M.A., Khan I., Ali M. The use of ginger (Zingiber officinale Rosc.) as a potential anti-inflammatory and antithrombotic agent. Prostaglandins Leukot. Essent. Fatty Acids 2002, 67:475-478.
33. Veillard N.R., Mach F. Statins: the new aspirin?. Cell Mol. Life Sci. 2002, 59:1771-1786.
34. Wagner H., Ulrich-Merzenich G. Synergy research: approaching a new generation of phytopharmaceuticals. Phytomedicine 2009, 16:97-110.
35. Wainwright C.L. Statins: is there no end to their usefulness?. Cardiovas. Res. 2005, 65:296-298.
36. Waters D.D. Safety of high-dose atorvastatin therapy. Am. J. Card. 2005, 96:69F-75F.
37. Yemitan O.K., Izegbu M.C. Protective Effects of Zingiber officinale (Zingiberaceae) against carbon tetrachloride and acetaminophen-induced hepatotoxicity in rats. Phytother. Res. 2006, 20:997-1002.
38. Young H.Y., Luo Y.L., Cheng H.Y., Hsieh W.C., Liao J.C., Peng W.H. Analgesic and anti-inflammatory activities of [6]-gingerol. J. Ethnopharmacol. 2005, 96:207-210.