Malathion-induced hepatotoxicity in rats: The effects of vitamins C and E

Food and Chemical Toxicology

Volumn 48, Issue 2, 2010, Pages 633-638

  Kalender, Suna ^a   Uzun, Fatma Gokce ^a   Durak, Dilek ^b   Demir, Filiz ^a   Kalender, Yusuf ^a  

^a GAZI UNIVERSITY   (Turkey)

^b BOZOK UNIVERSITY   (Turkey)

Author keywords

Hepatotoxicity; Histopathology; Malathion; Organophosphate insecticide; Vitamin C; Vitamin E

Indexed keywords

ALANINE AMINOTRANSFERASE; ALBUMIN; ALKALINE PHOSPHATASE; ALPHA TOCOPHEROL; ASCORBIC ACID; ASPARTATE AMINOTRANSFERASE; CHOLESTEROL; LACTATE DEHYDROGENASE; MALATHION; TRIACYLGLYCEROL; VERY LOW DENSITY LIPOPROTEIN;

ALANINE AMINOTRANSFERASE BLOOD LEVEL; ALBUMIN BLOOD LEVEL; ALKALINE PHOSPHATASE BLOOD LEVEL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ASPARTATE AMINOTRANSFERASE BLOOD LEVEL; CHOLESTEROL BLOOD LEVEL; CONTROLLED STUDY; HISTOPATHOLOGY; LACTATE DEHYDROGENASE BLOOD LEVEL; LEUKOCYTE COUNT; LIVER; LIVER TOXICITY; MALE; MICROSCOPY; NONHUMAN; PROTEIN BLOOD LEVEL; RAT; THROMBOCYTE COUNT; TRIACYLGLYCEROL BLOOD LEVEL; VITAMIN SUPPLEMENTATION; WISTAR RAT;

ADMINISTRATION, ORAL; ANIMALS; ANTIOXIDANTS; ASCORBIC ACID; BLOOD CHEMICAL ANALYSIS; BLOOD PLATELETS; DRUG THERAPY, COMBINATION; DRUG-INDUCED LIVER INJURY; HEMATOLOGIC TESTS; HEPATOCYTES; INSECTICIDES; LEUKOCYTE COUNT; LEUKOCYTES; LIVER; LIVER FUNCTION TESTS; MALATHION; MALE; RATS; RATS, WISTAR; VITAMIN E;

ANIMALIA; RATTUS; RATTUS NORVEGICUS;

EID: 74649083584     PISSN: 02786915     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.fct.2009.11.044     Document Type: Article

References (51)

1. Altuntas I., Delibas N., and Sutcu R. The effects of organophosphate insecticide methidathion on lipid peroxidation and anti-oxidant enzymes in rat erythrocytes: role of vitamins E and C. Hum. Exp. Toxicol. 21 (2002) 681-685
2. Assini F.L., Zanette K.D., Brocardo P.S., Pandolfo P., Rodrigues A.L.S., and Takahashi R.N. Behavioral effects and ChE measures after acute and repeated administration of malathion in rats. Environ. Toxicol. Pharmacol. 20 (2005) 443-449
3. Brand R.M., Charron A.R., and Brand R.E. Decreasing malathion application time for lice treatment reduces transdermal absorption. Int. J. Pharm. 301 (2005) 48-53
4. Bustos-Obregón E., and Gonzáles-Hormazabal P. Effect of a single dose of malathion on spermatogenesis in mice. Asian J. Androl. 5 (2003) 105-107
5. Büyükokuroǧlu M.E., Cemek M., Tosun M., Yürümez Y., Baş O., and Yavuz Y. Dantrolene may prevent organophosphate-induced oxidative stress and muscle injury. Pestic. Biochem. Phys. 92 (2008) 156-163
6. Celik I., and Suzek H. The hematological effects of methyl parathion in rats. J. Hazard. Mater. 153 (2008) 1117-1121
7. Celik I., Yilmaz Z., and Turkoglu V. Hematotoxic and hepatotoxic effects of dichlorvos at sublethal dosages in rats. Environ. Toxicol. 24 (2009) 128-132
8. Durak D., Uzun F.G., Kalender S., Ogutcu A., Uzunhisarcikli M., and Kalender Y. Malathion-induced oxidative stress in human erythrocytes and the protective effect of vitamins C and E in vitro. Environ. Toxicol. 24 3 (2009) 235-242
9. Edwards J.W., Lee S., Heath L.M., and Pisaniello D. Worker exposure and a risk assessment of malathion and fenthion used in the control of Mediterranean fruit fly in South Australia. Environ. Res. 103 (2007) 38-45
10. Elhalwagy M.E.A., Darwish N.S., and Zaher E.M. Prophylactic effect of green tea polyphenols against liver and kidney injury induced by fenitrothion insecticide. Pestic. Biochem. Phys. 91 (2008) 81-89
11. Elston D.M. Controversies concerning the treatment of lice and scabies. J. Am. Acad. Dermatol. 46 (2002) 794-796
12. Eraslan G., Kanbur M., and Silici S. Effect of carbaryl on some biochemical changes in rats: the ameliorative effect of bee pollen. Food Chem. Toxicol. 47 (2009) 86-91
13. Goel A., Dani V., and Dhawan D.K. Protective effects of zinc on lipid peroxidation, antioxidant enzymes and hepatic histoarchitecture in chlorpyrofos-induced toxicity. Chem. Biol. Interac. 156 (2005) 131-140
14. Gokalp O., Buyukvanli B., Cicek E., Ozer M.K., Koyu A., Altuntas I., and Koylu H. The effects of diazinon on pancreatic damage and ameliorating role of vitamin E and vitamin C. Pestic. Biochem. Phys. 81 (2005) 123-128
15. Gokcimen A., Gulle K., Demirin H., Bayram D., Kocak A., and Altuntas I. Effects of diazinon at different doses on rat liver and pancreas tissues. Pestic. Biochem. Phys. 87 (2007) 103-108
16. Handy R.D., Abd-El Samei H.A., Bayomy M.F.F., Mahran A.M., Abdeen A.M., and El-Elaimy E.A. Chronic diazinon exposure: pathologies of spleen, thymus, blood cells, and lymph nodes are modulated by dietary protein or lipid in the Mouse. Toxicology 172 (2002) 13-34
17. Hazarika A., Sarkar S.N., Hajare S., Kataria M., and Malik J.K. Influence of malathion pretreatment on the toxicity of anilofos in male rats: a biochemical interaction study. Toxicology 185 (2003) 1-8
18. IARC, 1983. Monograph on the Evaluation of Carcinogenic Risk of Chemicals to Man. Miscellaneous Pesticides, vol. 30. International Agency for Research on Cancer, Lyon France.
19. John S., Kale M., Rathore N., and Bhatnagar D. Protective effect of vitamin E in dimethoate and malathion induced oxidative stress in rat erythrocytes. J. Nutr. Biochem. 12 (2001) 500-504
20. Jurczuk M., Brzóska M.M., and Moniuszko-Jakoniuk J. Hepatic and renal concentrations of vitamins E and C in lead- and ethanol-exposed rats. An assessment of their involvement in the mechanisms of peroxidative damage. Food Chem. Toxicol. 45 (2007) 1478-1486
21. Kalender S., Kalender Y., Ates A., Yel M., Olcay E., and Candan S. Protective role of antioxidant vitamin E and catechin on idarubicin-induced cardiotoxicity in rats. Braz. J. Med. Biol. Res. 35 (2002) 1379-1387
22. Kalender S., Kalender Y., Ogutcu A., Uzunhisarcikli M., Durak D., and Acikgoz F. Endosulfan-induced cardiotoxicity and free radical metabolism in rats: the protective effect of vitamin E. Toxicology 202 (2004) 227-235
23. Kalender S., Ogutcu A., Uzunhisarcikli M., Acikgoz F., Durak D., Ulusoy Y., and Kalender Y. Diazinon-induced hepatotoxicity and protective effect of vitamin E on some biochemical indices and ultrastructural changes. Toxicology 211 (2005) 197-206
24. Kalender S., Kalender Y., Durak D., Ogutcu A., Uzunhisarcikli M., Cevrimli B.S., and Yildirim M. Methyl parathion induced nephrotoxicity in male rats and protective role of vitamins C and E. Pestic. Biochem. Phys. 88 (2007) 213-218
25. Kalender Y., Yel M., and Kalender S. Doxorubicin hepatotoxicity and hepatic free radical metabolism in rats. The effects of vitamin E and catechin. Toxicology 209 (2005) 39-45
26. Kalender Y., Uzunhisarcikli M., Ogutcu A., Acikgoz F., and Kalender S. Effects of diazinon on pseudocholinesterase activity and haematological indices in rats: the protective role of vitamin E. Environ. Toxicol. Pharmacol. 22 (2006) 46-51
27. Khan S.M., Sobti R.C., and Kataria L. Pesticide-induced alteration in mice hepato-oxidative status and protective effects of black tea extract. Clin. Chim. Acta 358 (2005) 131-138
28. Lasram M.M., Annabi A.B., Elj N., Selmi S., Kamoun A., El-Fazaa S., and Gharbi N. Metabolic disorders of acute exposure to malathion in adult Wistar rats. J. Hazard. Mater. 163 (2009) 1052-1055
29. Morowati M. Inhalation toxicity studies of thimet (phorate) in male swiss albino mouse, mus musculus: I. Hepatotoxicity. Environ. Pollut. 96 (1997) 283-288
30. Morowati M. Inhalation toxicity studies of thimet (phorate) in the male swiss albino mouse, mus musculus: II. Lung histopathology, pseudocholinesterase level and haematological studies. Environ. Pollut. 103 (1998) 309-315
31. Ncibi S., Othman M.B., Akacha A., Krifi M.N., and Zourgi L. Opuntia ficus indica extract protects against chlorpyrifos-induced damage on mice liver. Food Chem. Toxicol. 46 (2008) 797-802
32. Ogutcu A., Suludere Z., and Kalender Y. Dichlorvos-induced hepatotoxicity in rats and the protective effects of vitamins C and E. Environ. Toxicol. Pharmacol. 26 (2008) 355-361
33. Patil J.A., Patil A.J., and Govinwar S.P. Biochemical effects of various pesticides on sprayers of grape gardens. Indian J. Clin. Biochem. 18 (2003) 16-22
34. Poet T.S., Kousba A.A., Dennison S.L., and Timchalk C. Physiologically based pharmacokinetic/pharmodynamic model for the organophosporus pesticide diazinon. Neurotoxicology 25 (2004) 1013-1030
35. Rezg R., Mornagui B., El-Fazaa S., and Gharbi N. Caffeic acid attenuates malathion induced metabolic disruption in rat liver, involvement of acetylcholinesterase activity. Toxicology 250 (2008) 27-31
36. Rezg R., Mornagui B., El-Fazaa S., and Gharbi N. Biochemical evaluation of hepatic damage in subchronic exposure to malathion in rats: effect on superoxide dismutase and catalase activities using native PAGE. C. R. Biologies 331 (2008) 655-662
37. Sayi{dotless}m F. Dimethoate-induced biochemical and histopathological changes in the liver of rats. Exp. Toxicol. Pathol. 59 (2007) 237-243
38. Senger M.R., Rico E.P., Arizi M.B., Rosemberg D.B., Dias R.D., Bogo M.R., and Bonan C.D. Carbofuran and malathion inhibit nucleotide hydrolysis in zebrafish (Danio rerio) brain membranes. Toxicology 212 (2005) 107-115
39. Serbecic N., and Beutelspacher S.C. Anti-oxidative vitamins prevent lipid-peroxidation and apoptosis in corneal endothelial cells. Cell Tissue Res. 320 (2005) 465-475
40. Sodhi S., Sharma A., Brar A.P.S., and Brar R.S. Effect of α tocoferol and selenium on antioxidant status, lipid peroxidation and hepatopathy induced by malathion in chicks. Pestic. Biochem. Phys. 90 (2008) 82-86
41. Srivastava P.A., and Narain A.S. Catfish blood chemistry under environmental stress. Experimentia 41 (1985) 855-857
42. Suresh Babu N., Malik J.K., Rao G.S., Aggarwal M., and Ranganathan V. Effects of subchronic malathion exposure on the pharmacokinetic disposition of pefloxacin. Environ. Toxicol. Pharmacol. 22 (2006) 167-171
43. Traber M.G., and Atkinson J. Vitamin E, antioxidant and nothing more. Free Radic. Biol. Med. 43 (2007) 4-15
44. Uzun F.G., Kalender S., Durak D., Demir F., and Kalender Y. Malathion-induced testicular toxicity in male rats and the protective effect of vitamins C and E. Food Chem. Toxicol. 47 (2009) 1903-1908
45. Uzunhisarcikli M., Kalender Y., Dirican K., Kalender S., Ogutcu A., and Buyukkomurcu F. Acute, subacute and subchronic administration of methyl parathion-induced testicular damage in male rats and protective role of vitamins C and E. Pestic. Biochem. Phys. 87 (2007) 115-122
46. Vasough-Ghanbari S., Sayar P., Pournourmohammadi S., Aliahmadi A., Ostad S.N., and Abdollahi M. Stimulation of insulin and glucagon synthesis in rat Langerhans islets by malathion in vitro: evidence for mitochondrial interaction and involvement of suncellular non-cholinergic mechanisms. Pestic. Biochem. Phys. 89 (2007) 130-136
47. Verma R.S., Mehta A., and Srivastava N. In vivo chlorpyrifos induced oxidative stres: attenuation by antioxidant vitamins. Pestic. Biochem. Phys. 88 (2007) 191-196
48. Yavuz T., Delibas N., Yildirim B., Altuntas I., Candir O., Cora A., Karaman N., Ibrisim E., and Kutsal A. Vascular wall damage in rats induced by methidathion and ameliorating effect of vitamins E and C. Arch. Toxicol. 78 (2004) 655-659
49. Yehia M.A.H., El-Banna S.G., and Okab A.B. Diazinon toxicity affects histophysiological and biochemical parameters in rabbits. Exp. Toxicol. Pathol. 59 (2007) 215-225
50. Yousef M.I., Awad T.I., and Mohamed E.H. Deltamethrin-induced oxidative damage and biochemical alterations in rat and its attenuation by vitamin E. Toxicology 227 (2006) 240-247
51. Zaahkouk S.A.M., Helal E.G.E., Abd-Rabo T.E.I., and Rashed S.Z.A. Carbamate toxicity and protective effect of vit. A and vit. E on some biochemical aspects of male albino rats. Egypt J. Hosp. Med. 1 (2000) 60-77