Analgesic and anti-inflammatory activities of [6]-gingerol

Journal of Ethnopharmacology

Volumn 96, Issue 1-2, 2005, Pages 207-210

  Young, Haw Yaw ^a   Luo, Yen Lin ^b   Cheng, Hao Yuan ^c   Hsieh, Wen Chiuan ^c   Liao, Jung Chun ^c   Peng, Wen Huang ^c  

^a TZU HUI INSTITUTE OF TECHNOLOGY   (Taiwan)

^b 804 Kaohsiung Taiwan ROC   (Taiwan)

^c CHINA MEDICAL UNIVERSITY   (Taiwan)

Author keywords

6 Gingerol; Anti inflammation; Formalin; Writhing response

Indexed keywords

ACETIC ACID; CARRAGEENAN; FORMALDEHYDE; GINGEROL;

ANALGESIC ACTIVITY; ANIMAL EXPERIMENT; ANTIINFLAMMATORY ACTIVITY; ARTICLE; CONTROLLED STUDY; DRUG EFFECT; EDEMA; FEMALE; LICKING; MALE; MOUSE; NONHUMAN; WRITHING TEST;

ACETIC ACID; ANALGESICS; ANIMALS; ANTI-INFLAMMATORY AGENTS; CARRAGEENAN; EDEMA; FATTY ALCOHOLS; FORMALDEHYDE; GINGER; HINDLIMB; MALE; MICE; MICE, INBRED ICR; PAIN; PHYTOTHERAPY; TIME FACTORS;

EID: 9644273866     PISSN: 03788741     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jep.2004.09.009     Document Type: Article

References (21)

1. G.K. Adams, and L.M. Lichtenstein In vitro studies of antigen-induced bronchospasm: effect of antihistamine and SAS-A antagonist on response to sensitized guinea pig and human airways to antigen Journal of Immunology 122 1979 555 562
2. R.E. Alien, D.R. Blake, N.E. Nazhat, and P. Jones Superoxide radical generation by inflamed human synovium after hypoxia Lancet 2 1989 282 284
3. J.A. Austin Why patients use alternative medicine? Results of a national study The Journal of the American Medical Association 279 1998 1548 1553
4. D. Dubuisson, and S.G. Dennis The formalin test: a quantitative study of the analgesic effects of morphine meperidine, and brain stem stimulation in rats and cats Pain 4 1977 167 174
5. H. Farsam, M. Amanlou, A.R. Dehpour, and F. Jahaniani Antiinflammatory and analgesic activity of Biebersteinia multifida DC. Root [6]-gingerol Journal of Ethnopharmacology 71 2000 443 447
6. S. Hunskaar, and K. Hole The formalin test in mice: dissociation between inflammatory and non-inflammatory pain Pain 30 1987 103 114
7. M.J. Just, M.C. Recio, R.M. Giner, M.J. Cuellar, S. Manez, A.R. Bilia, and J.L. Rois Anti-inflammatory activity of unusual lupane saponins from Bupleurum fruticescens Planta Medica 64 1998 404 407
8. F. Kiuchi, S. Iwakami, M. Shibuya, F. Hanaoka, and U. Sankawa Inhibition of prostaglandin and leukotriene biosynthesis by gingerols and diarylheptanoids Chemical and Pharmaceutical Bulletin 40 1992 387 391
9. K.L. Koo, A.J. Ammit, V.H. Tran, C.C. Duke, and B.D. Roufogalis Gingerols and related analogues inhibit arachidonic acid-induced human platelet serotonin release and aggregation Thrombosis Research 103 2001 387 397
10. R. Koster, M. Anderson, and E.J. DeBeer Acetic acid analgesic screen Federation Proceedings 18 1959 418 420
11. N. Mascolo, R. Jain, S.C. Jain, and F. Capasso Ethnopharmacologic investigation of ginger (Zingiber officinale) Journal of Ethnopharmacology 27 1989 129 140
12. J.H. Rosland, A. Tjolsen, B. Maehle, and K. Hole The formalin test in mice: effect of formalin concentration Pain 42 1990 235 242
13. L.B. Schwartz, and K.F. Austen Structural and function of the chemical mediators of mast cells Progress in Allergy 34 1984 271 321
14. M. Suekawa, A. Ishige, K. Yuasa, K. Sudo, M. Aburada, and E. Hosoya Pharmacological studies on ginger. I. Pharmacological actions of pungent constitutents, (6)-gingerol and (6)-shogaol Journal of Pharmacobio-Dynamics 7 1984 836 848
15. A.G. Semb, I. Vagge, and O.D. Mjos Oxygen free radical producing leukocytes cause functional depression of isolated rat hearts: role of leukotriene Journal of Molecular Cell Cardiology 22 1990 555 563
16. M. Shibata, T. Ohkubo, H. Takahashi, and R. Inoki Modified formalin test: characteristic biphasic pain response Pain 38 1989 347 352
17. R.I. Taber, D.D. Greenhouse, J.K. Rendell, and S. Irwin Agonist and antagonist interactions of opioids on acetic acid-induced abdominal stretching in mice Journal of Pharmacology, Experimental Therapy 169 1969 29 37
18. A. Tjolsen, O.G. Berge, S. Hunskaar, J.H. Rosland, and K. Hole The formalin test: an evaluation of the method Pain 51 1992 5 17
19. G. Weissmann, J.E. Smolen, and H.M. Korchak Release of inflammatory mediators from stimulated neutrophils New England Journal of Medicine 303 1980 27 34
20. H.Y. Young, and G.L. Chen Analytical and stability of ginger preparations Journal of Food, Drug Analysis 10 2002 149 153
21. M. Zimmermann Ethical guidelines for investigations of experimental pain in conscious animals Pain 16 1983 109 110