Rapid Neurofibrillary Tangle Formation after Localized Gene Transfer of Mutated Tau

American Journal of Pathology

Volumn 164, Issue 1, 2004, Pages 347-353

  Klein, Ronald L ^a   Lin, Wen Lang ^b   Dickson, Dennis W ^b   Lewis, Jada ^c   Hutton, Michael ^c   Duff, Karen ^f   Meyer, Edwin M ^d   King, Michael A ^d,e  

^a LOUISIANA STATE UNIVERSITY HEALTH SCIENCES CENTER   (United States)

^b MAYO CLINIC   (United States)

^c MAYO GRADUATE SCHOOL   (United States)

^d UNIVERSITY OF FLORIDA COLLEGE OF MEDICINE   (United States)

^e VETERANS AFFAIRS MEDICAL CENTER   (United States)

^f NATHAN S KLINE INSTITUTE FOR PSYCHIATRIC RESEARCH   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMYLOID; TAU PROTEIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN INJURY; CONTROLLED STUDY; DISEASE ASSOCIATION; ELECTRON MICROSCOPY; FOREBRAIN; FRONTOTEMPORAL DEMENTIA; GENE LOCATION; GENE MUTATION; GENE TRANSFER; GENETIC TRANSFECTION; HIPPOCAMPUS; IMMUNOREACTIVITY; MALE; MICROSCOPY; NERVE DEGENERATION; NEUROFIBRILLARY TANGLE; NEUROPIL; NONHUMAN; PARKINSONISM; PRIORITY JOURNAL; RAT; ANIMAL; BRAIN; DISEASE MODEL; GENETICS; HUMAN; IMMUNOHISTOCHEMISTRY; METABOLISM; MUTATION; PATHOLOGY; SENILE PLAQUE; SPRAGUE DAWLEY RAT; TAUOPATHY; ULTRASTRUCTURE; WESTERN BLOTTING;

ANIMALS; BLOTTING, WESTERN; BRAIN; DISEASE MODELS, ANIMAL; HUMANS; IMMUNOHISTOCHEMISTRY; MALE; MICROSCOPY, ELECTRON; MUTATION; NEUROFIBRILLARY TANGLES; RATS; RATS, SPRAGUE-DAWLEY; SENILE PLAQUES; TAU PROTEINS; TAUOPATHIES; TRANSFECTION;

EID: 1542784350     PISSN: 00029440     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0002-9440(10)63124-0     Document Type: Article

References (25)

1. Hutton M, Lendon CL, Rizzu P, Baker M, Froelich S, Houlden H, Pickering-Brown S, Chakraverty S, Isaacs A, Grover A, Hackett J, Adamson J, Lincoln S, Dickson D, Davies P, Petersen RC, Stevens M, de Graaff E, Wauters E, van Baren J, Hillebrand M, Joosse M, Kwon JM, Nowotny P, Che LK, Norton J, Morris JC, Reed LA, Trojanowski J, Basun H, Lannfelt L, Neystat M, Fahn S, Dark F, Tannenberg T, Dodd PR, Hayward N, Kwok JBJ, Schofield PR, Andreadis A, Snowden J, Craufurd D, Neary D, Owen F, Oostra BA, Hardy J, Goate A, Swieten JV, Mann D, Lynch T, Heutink P: Association of missense and 5′-splice-site mutations in tau with the inherited dementia FTDP-17. Nature 1998, 393:702-705
2. Spillantini MG, Bird TD, Ghetti B: Frontotemporal dementia and parkinsonism linked to chromosome 17: a new group of tauopathies. Brain Pathol 1998, 8:387-402
3. Binder LI, Frankfurter A, Rebhun LI: The distribution of tau in the mammalian central nervous system. J Cell Biol 1984, 101:1371-1378
4. Stamer K, Vogel R, Thies E, Mandelkow E, Mandelkow EM: Tau blocks traffic of organelles, neurofilaments, and APP vesicles in neurons and enhances oxidative stress. J Cell Biol 2002, 156:1051-1063
5. Bancher C, Brunner C, Lassmann H, Budka H, Jellinger K, Wiche G, Seitelberger F, Grundke-Iqbal I, Iqbal K, Wisniewski HM: Accumulation of abnormally phosphorylated tau precedes the formation of neurofibrillary tangles in Alzheimer's disease. Brain Res 1989, 477: 90-99
6. Buee L, Bussiere T, Buee-Scherrer V, Delacourte A: Tau protein isoforms, phosphorylation and role in neurodegenerative disorders. Brain Res Brain Res Rev 2000, 33:95-130
7. van Slegtenhorst M, Lewis J, Hutton M: The molecular genetics of the tauopathies. Exp Gerontol 2000, 35:461-471
8. Braak E, Braak H, Mandelkow EM: A sequence of cytoskeleton changes related to the formation of neurofibrillary tangles and neuropil threads. Acta Neuropathol (Berl) 1994, 87:554-567
9. Weaver CL, Espinoza M, Kress Y, Davies P: Conformational change as one of the earliest alterations of tau in Alzheimer's disease. Neurobiol Aging 2000, 21:719-727
10. Alonso AC, Grundke-Iqbal I, Iqbal K: Alzheimer's disease hyperphosphorylated tau sequesters normal tau into tangles of filaments and disassembles microtubules. Nat Med 1996, 2:783-787
11. Kowall NW, Kosik KS: Axonal disruption and aberrant localization of tau protein characterize the neuropil pathology of Alzheimer's disease. Ann Neurol 1987, 22:639-643
12. Lewis J, McGowan E, Rockwood J, Melrose H, Nacharaju P, Van Slegtenhorst M, Gwinn-Hardy K, Paul Murphy M, Baker M, Yu X, Duff K, Hardy J, Corral A, Lin WL, Yen SH, Dickson DW, Davies P, Hutton M: Neurofibrillary tangles, amyotrophy and progressive motor disturbance in mice expressing mutant (P301L) tau protein. Nat Genet 2000, 25:402-405
13. Götz J, Chen F, Barmettler R, Nitsch RM: Tau filament formation in transgenic mice expression P301L tau. J Biol Chem 2001, 5:529-534
14. Lin WL, Lewis J, Yen SH, Hutton M, Dickson DW: Filamentous tau in oligodendrocytes and astrocytes of transgenic mice expressing the human tau isoform with the P301L mutation. Am J Pathol 2003, 162:213-218
15. Klein RL, King MA, Hamby ME, Meyer EM: Dopaminergic cell loss induced by human A30P alpha-synuclein gene transfer to the rat substantia nigra. Hum Gene Ther 2002, 13:605-612
16. Holcomb L, Gordon MN, McGowan E, Yu X, Benkovic S, Jantzen P, Wright K, Saad I, Mueller R, Morgan D, Sanders S, Zehr C, O'Campo K, Hardy J, Prada CM, Eckman C, Younkin S, Hsiao K, Duff K: Accelerated Alzheimer-type phenotype in transgenic mice carrying both mutant amyloid precursor protein and presenilin 1 transgenes. Nat Med 1998, 4:97-100
17. Niwa H, Yamamura K, Miyazaki J: Efficient selection for high-expression transfectants with a novel eukaryotic vector. Gene 1991, 108: 193-199
18. Loeb JE, Cordier WS, Harris ME, Weitzman MD, Hope TJ: Enhanced expression of transgenes from adeno-associated virus vectors with the woodchuck hepatitis virus posttranscriptional regulatory element: implications for gene therapy. Hum Gene Ther 1999, 10:2295-2305
19. Klein RL, Hamby ME, Gong Y, Hirko AC, Wang S, Hughes JA, King MA, Meyer EM: Dose and promoter effects of adeno-associated viral vector for GFP expression in the rat brain. Exp Neurol 2002, 176: 66-74
20. Chou YC, Luttge WG, Sumners C: Characterization of glucocorticoid type II receptors in neuronal and glial cultures from rat brain. J Neuroendocrinol 1990, 2:29-38
21. Zolotukhin S, Byrne BJ, Mason E, Zolotukhin I, Potter M, Chesnut K, Summerford C, Samulski RJ, Muzyczka N: Recombinant adeno-associated virus purification using novel methods improves infectious titer and yield. Gene Therapy 1999, 6:973-985
22. Grimm D, Kern A, Rittner K, Kleinschmidt JA: Novel tools for production and purification of recombinant adeno-associated virus vectors. Hum Gene Ther 1998, 9:2745-2760
23. Paxinos G, Watson C: The Rat Brain in Stereotaxic Coordinates. San Diego, Academic Press, 1998
24. Paxinos G, Franklin KBJ: The Mouse Brain in Stereotaxic Coordinates. San Diego, Academic Press, 2001
25. Dickson DW: The pathogenesis of senile plaques. J Neuropathol Exp Neurol 1997, 56:321-339