Arsenic (+3 oxidation state) methyltransferase genotype affects steady-state distribution and clearance of arsenic in arsenate-treated mice

Toxicology and Applied Pharmacology

Volumn 249, Issue 3, 2010, Pages 217-223

  Hughes, Michael F ^a   Edwards, Brenda C ^a   Herbin Davis, Karen M ^a   Saunders, Jesse ^b   Styblo, Miroslav ^b   Thomas, David J ^a  

^a U S ENVIRONMENTAL PROTECTION AGENCY   (United States)

^b IL   (United States)

Author keywords

Arsenic; Arsenic (+3 oxidation state) methyltransferase; Gene knockout; Methylation; Mouse

Indexed keywords

ARSENIC; ARSENIC METHYLTRANSFERASE; METHYLTRANSFERASE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BLADDER; BODY BURDEN; C57BL 6 MOUSE; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; DRUG CLEARANCE; DRUG DISTRIBUTION; FEMALE; GENOTYPE; KIDNEY; KNOCKOUT MOUSE; LIVER; METABOLITE; METHYLATION; MOUSE; NONHUMAN; SPECIES DIFFERENCE; STEADY STATE; TOXICOKINETICS; WILD TYPE;

ANIMALS; ARSENATES; ARSENIC; DOSE-RESPONSE RELATIONSHIP, DRUG; FEMALE; GENOTYPE; KIDNEY; LIVER; METHYLTRANSFERASES; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; URINARY BLADDER;

MUS;

EID: 78149406437     PISSN: 0041008X     EISSN: 10960333     Source Type: Journal    
DOI: 10.1016/j.taap.2010.09.017     Document Type: Article

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