Speciation of arsenic in exfoliated urinary bladder epithelial cells from individuals exposed to arsenic in drinking water

Environmental Health Perspectives

Volumn 116, Issue 12, 2008, Pages 1656-1660

  Hernández Zavala, Araceli ^a   Valenzuela, Olga L ^b   Matoušek, Tamáš ^c   Drobná, Zuzana ^d   Dědina, Jiří ^c   Garcia Vargas, Gonzalo G ^e   Thomas, David J ^f   Del Razo, Luz M ^b   Stýblo, Miroslav ^a,d  

^a UNIVERSITY OF NORTH CAROLINA SCHOOL OF MEDICINE   (United States)

^b DEPARTAMENTO DE FÍSICA   (Mexico)

^c INSTITUTE OF ANALYTICAL CHEMISTRY   (Czech Republic)

^d IL   (United States)

^e UNIVERSIDAD JUÁREZ DEL ESTADO DE DURANGO   (Mexico)

^f U S ENVIRONMENTAL PROTECTION AGENCY   (United States)

Author keywords

Arsenic species; Drinking water; Exfoliated human urinary bladder epithelial cells

Indexed keywords

ARSENIC; DRINKING WATER;

ADOLESCENT; ADULT; ANALYTIC METHOD; ARTICLE; ATOMIC ABSORPTION SPECTROMETRY; BLADDER CANCER; BLADDER EPITHELIUM; CALIBRATION; CELL ISOLATION; CONTROLLED STUDY; ENVIRONMENTAL EXPOSURE; EPITHELIUM CELL; FEMALE; HUMAN; HUMAN CELL; MALE; METABOLITE; PRIORITY JOURNAL; RISK ASSESSMENT; URINALYSIS; UROGENITAL TRACT DISEASE; BLADDER; CHEMISTRY; CLASSIFICATION; CYTOLOGY; ISOLATION AND PURIFICATION; MIDDLE AGED; WATER POLLUTANT; WATER SUPPLY;

ADOLESCENT; ADULT; ARSENIC; EPITHELIAL CELLS; FEMALE; HUMANS; MALE; MIDDLE AGED; SPECTROPHOTOMETRY, ATOMIC; URINARY BLADDER; WATER POLLUTANTS, CHEMICAL; WATER SUPPLY;

EID: 58149356736     PISSN: 00916765     EISSN: 15529924     Source Type: Journal    
DOI: 10.1289/ehp.11503     Document Type: Article

References (42)

1. Aposhian HV, Gurzau ES, Le XC, Gurzau A, Healy SM, Lu X, et al. 2000. Occurrence of monomethylarsonous acid in urine of humans exposed to inorganic arsenic. Chem Res Toxicol 13:693-697.
2. ATSDR. 2007. Toxicological Profile for Arsenic. Atlanta, GA:Agency for Toxic Substances and Disease Registry. Available: http://www.atsdr.cdc.gov/toxprofiles/tp2.html [accessed 22 October 2008].
3. Biggs ML, Kalman DA, Moore LE, Hopenhayn-Rich C, Smith MT, Smith AH. 1997. Relationship of urinary arsenic to intake estimates and a biomarker of effect, bladder cell micronuclei. Mutat Res 386:185-195.
4. Born M, Pahner I, Ahnert-Hilger G, Jöns T. 2003. The maintenance of the permeability barrier of bladder facet cells requires a continuous fusion of discoid vesicles with the apical plasma membrane. Eur J Cell Biol 82:343-350.
5. Chen YC, Guo YL, Su HJ, Hsueh YM, Smith TJ, Ryan LM, et al. 2003. Arsenic methylation and skin cancer risk in south-western Taiwan. J Occup Environ Med 45:241-248.
6. Cullen WR, McBridge BC, Reglinski J. 1984. The reaction of methylarsenicals with thiols: some biological implications. J Inorg Biochem 21:179-194.
7. Del Razo LM, García-Vargas GG, Vargas, Albores A, Gonsebatt ME, Montero R, et al. 1997. Altered profile of urinary arsenic metabolites in adults with chronic arsenicism. A pilot study. Arch Toxicol 71:211-217.
8. Del Razo LM, Styblo M, Cullen WR, Thomas DJ. 2001. Determination of trivalent methylated arsenicals in biological matrices. Toxicol Appl Pharmacol 174:282-293.
9. Devesa V, Del Razo LM, Adair B, Drobná Z, Waters SB, Hughes MF, et al. 2004. Comprehensive analysis of arsenic metabolites by pH-specific hydride generation atomic absorption spectrometry. J Anal At Spectrom 19:1460-1467.
10. Dörrenhaus A, Müller JI, Golka K, Jedrusik P, Schulze H, Füllmann W. 2000. Cultures of exfoliated epithelial cells from different locations of the human urinary tract and the renal tubular system. Arch Toxicol 74:618-626.
11. Drobná Z, Jaspers I, Thomas DJ, Styblo M. 2003. Differential activation of AP-1 in human bladder epithelial cells by inorganic and methylated arsenicals. FASEB J 17:67-69.
12. Drobná Z, Waters SB, Devesa V, Harmon AW, Thomas DJ, Styblo M. 2005. Metabolism and toxicity of arsenic in human urothelial cells expressing rat arsenic (+3 oxidation state)-methyltransferase. Toxicol Appl Pharmacol 207:147-159.
13. Drobná Z, Xing W, Thomas DJ, Stýblo M. 2006. shRNA silencing of AS3MT expression minimizes arsenic methylation capacity of HepG2 cells. Chem Res Toxicol 19:894-898.
14. Hernández-Zavala A, Matoušek T, Drobná Z, Adair BM, Dědina J, Thomas DJ, et al. 2008. Speciation of arsenic in biological matrices by automated hydride generation-cryotrapping-atomic absorption spectrometry with multiple microflame quartz tube atomizer (multiatomizer). J Anal At Spectrom 23:342-351.
15. Herz F, Deitch D, Adler SA, Brijlall D. 1993. Short-term culture of exfoliated cells from the urine of patients with bladder tumors. Urol Res 21:23-26.
16. Hicks RM, Ketterer B, Warren RC. 1974. The ultrastructure and chemistry of the luminal plasma membrane of the mammalian urinary bladder: a structure with low permeability to water and ions. Philos Trans R Soc Lond B Biol Sci 268:23-38.
17. Irgolic KJ. 1994. Determination of total arsenic and arsenic compounds in drinking water. In: Arsenic Exposure and Health. (Chappel WR, Abernathy CO, Cothern CR, eds). Science and Technology Letters, Middlesex, England:Northwood, 51-60.
18. Kala SV, Neely MW, Kala G, Prater CI, Atwood DW, Rice JS, et al. 2000. The MRP2/cMOAT transporter and arsenic-glutathione complex formation are required for biliary excretion of arsenic. J Biol Chem 275: 33404-33408.
19. Le XC, Ma M, Cullen WR, Aposhian HV, Lu X, Zheng B. 2000. Determination of monomethylarsonous acid, a key arsenic methylation intermediate, in human urine. Environ Health Perspect 108:1015-1018.
20. Lin S, Shi Q, Nix FB, Styblo M, Beck MA, Herbin-Davis KM, et al. 2002. A novel S-adenosyl-L-methionine: arsenic(III) methyltransferase from rat liver cytosol. J Biol Chem 277:10795-10803.
21. Liu J, Chen H, Miller DS, Saavedra JE, Keefer LK, Johnson DR, et al. 2001. Overexpression of glutathione S-transferase II and multidrug resistance transport proteins is associated with acquired tolerance to inorganic arsenic. Mol Pharmacol 60:302-309.
22. Liu Z, Styblo M, Rosen BP. 2006. Methylarsonous acid transport by aquaglyceroporins. Environ Health Perspect 114:527-531.
23. Mandal BK, Ogra Y, Suzuki KT. 2001. Identification of dimethyl-arsinous and monomethylarsonous acids in human urine of the arsenic-affected areas in West Bengal, India. Chem Res Toxicol 14:371-378.
24. Mass MJ, Tennant A, Roop BC, Cullen WR, Styblo M, Thomas DJ, et al. 2001. Methylated trivalent arsenic species are genotoxic. Chem Res Toxicol 14:355-361.
25. Matoušek T, Dědina J, Selecká A. 2002. A multiple microflame quartz tube atomizer-further development towards the ideal hydride atomizer for atomic absorption spectrometry. Spectrochim Acta Part B 57:451-462.
26. Matoušek T, Hernández-Zavala A, Svoboda M, Langerová L, Adair BM, Drobná Z, et al. 2008. Oxidation state specific generation of arsines from methylated arsenicals based on L-cysteine treatment in buffered media for speciation analysis by hydride generation-automated cryotrapping-gas chromatography-atomic absorption spectrometry with the multiatomizer. Spetrochim Acta Part B 63:396-406.
27. Moore LE, Smith AH, Hopenhayn-Rich C, Biggs ML, Kalman DA, Smith MT. 1997. Micronuclei in exfoliated bladder cells among individuals chronically exposed to arsenic in drinking water. Cancer Epidemiol Biomarkers Prev 6:31-36.
28. Murray EB, Edwards JW. 1999. Differential induction of micronuclei in peripheral lymphocytes and exfoliated urothelial cells of workers exposed to 4,4′-methylenebis-(2-chloroaniline) (MOCA) and bitumen fumes. Mutat Res 446:175-180.
29. Naranmandura H, Ibata K, Suzuki KT. 2007. Toxicity of dimethyl-monothioarsinic acid toward human epidermoid carcinoma A431 cells. Chem Res Toxicol. 20:1120-1125.
30. Ozen H. 1999. Bladder cancer. Curr Opin Oncol 11:207-212.
31. Paul DS, Harmon AW, Devesa V, Thomas DJ, Styblo M. 2007. Molecular mechanisms of diabetogenic effects of arsenic: Inhibition of insulin signaling by arsenite and methylarsonous acid. Environ Health Perspect 115:734-742.
32. Petrick JS, Jagadish B, Mash EA, Aposhian HV. 2001. Monomethylarsonous acid (MMAIII) and arsenite: LD50 in hamsters and in vitro inhibition of pyruvate dehydrogenase. Chem Res Toxicol 14:651-656.
33. Raml R, Rumpler A, Goessler W, Vahter M, Li L, Ochi T, et al. 2007. Thio-dimethylarsinate is a common metabolite in urine samples from arsenic-exposed women in Bangladesh. Toxicol Appl Pharmacol 222:374-380.
34. Steele W, Allegrucci C, Singh R, Lucas E, Priddle E, Denning C, et al. 2005. Human embryonic stem cell methyl cycle enzyme expression: modelling epigenetic programming in assisted reproduction? Rep Biomed 10:755-766.
35. Styblo M, Drobná Z, Jaspers I, Lin S, Thomas DJ. 2002. The role of biomethylation in toxicity and carcinogenicity of arsenic. A research update. Environ Health Perspect 110(suppl 5):767-771.
36. Thomas DJ, Li J, Waters SB, Xing W, Adair BM, Drobná Z, et al. 2007. Arsenic (+3 oxidation state) methyltransferase and methylation of arsenicals. Exp Biol Med 232:3-13.
37. Thomas DJ, Styblo M, Shan L. 2001. Cellular metabolism and systemic toxicity of arsenic. Toxicol Appl Pharmacol 176:127-144.
38. Vahter M. 1999. Variation in human metabolism of arsenic. In: Arsenic Exposure and Health Effects (Chappell WR, Abernathy CO, Calderon RL, eds). Oxford, UK:Elsevier, 367-379.
39. Valenzuela OL, Borja-Aburto VH, Garcia-Vargas GG, Cruz-Gonzalez MB, García-Montalvo EA, Calderon-Aranda ES, et al. 2005. Urinary trivalent methylated arsenic species in a population chronically exposed to inorganic arsenic. Environ Health Perspect 113:250-254.
40. Valenzuela OL, Germolec DR, Borja-Aburto VH, Contreras-Ruiz J, García-Vargas GG, Del Razo LM. 2007. Chronic arsenic exposure increases TGFalpha concentration in bladder urothelial cells of Mexican populations environmentally exposed to inorganic arsenic. Toxicol Appl Pharmacol 222:264-270.
41. Warner ML, Moore LE, Smith MT, Kalman DA, Fanning E, Smith AH. 1994. Increased micronuclei in exfoliated bladder cells of individuals who chronically ingest arsenic-contaminated water in Nevada. Cancer Epidemiol Biomarkers Prev 3:583-590.
42. Yu RC, Hsu KH, Chen CJ, Froines JR. 2000. Arsenic methylation capacity and skin cancer. Cancer Epidemiol Biomarkers Prev 9:1259-1262.