Membrane disruption and enzyme inhibition by naturally-occurring and modified chacotriose-containing Solanum steroidal glycoalkaloids

Phytochemistry

Volumn 56, Issue 6, 2001, Pages 603-610

  Roddick, James G ^a   Weissenberg, Martin ^b   Leonard, Anna L ^a  

^a UNIVERSITY OF EXETER   (United Kingdom)

^b VOLCANI CENTER   (Israel)

Author keywords

Solamarine; Chaconine; Dihydrosolasodine A glycosides; Enzyme inhibition; Glycoalkaloids; Membrane disruption; N nitroso solasodine glycosides; Solamargine; Solamum spp.; Solanaceae; Structure activity relationships

Indexed keywords

3BETA O CHACOTRIOSIDE DERIVATIVE; ACETYLCHOLINESTERASE; BETA SOLAMARIN; CHACONINE; CHACOTRIOSE; CHOLESTEROL; CHOLINESTERASE INHIBITOR; DIHYDROSOLASODINE A; ERGOSTEROL; LIPOSOME; N NITROSOSOLAMARGINE; PHOSPHATIDYLCHOLINE; SOLAMARGINE; SOLANIDINE; SOLANINE; SOLANUM ALKALOID; SOLASODINE; SOLASONINE; SOLATRIOSIDE DERIVATIVE; STIGMASTEROL; TOMATIDENOL; TROPANE DERIVATIVE; UNCLASSIFIED DRUG;

ANGIOSPERM; ANIMAL; ARTICLE; CHEMICAL MODIFICATION; CHEMICAL STRUCTURE; CHOLINESTERASE INHIBITION; CONTROLLED STUDY; DOSE RESPONSE; DRUG POTENTIATION; ERYTHROCYTE; HEMOLYSIS; HUMAN; HUMAN CELL; MEMBRANE DAMAGE; PH; PLANT; PLANT LEAF; STRUCTURE ACTIVITY RELATION; SWINE;

ACETYLCHOLINESTERASE; ANIMALS; CHOLINESTERASE INHIBITORS; ERYTHROCYTES; HUMANS; LIPOSOMES; MOLECULAR STRUCTURE; PHOSPHATIDYLCHOLINES; PLANT LEAVES; PLANT STEMS; SOLANACEAE; SOLANACEOUS ALKALOIDS; STRUCTURE-ACTIVITY RELATIONSHIP; SWINE; TROPANES;

MAMMALIA; SOLANACEAE; SOLANUM;

EID: 0035937616     PISSN: 00319422     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0031-9422(00)00420-9     Document Type: Article

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