Association with selected bacteria does not cause enterocolitis in IL-10 gene-deficient mice despite a systemic immune response

Digestive Diseases and Sciences

Volumn 50, Issue 5, 2005, Pages 905-913

  Sydora, Beate C ^a   Tavernini, Michele M ^a   Doyle, Jason S G ^b   Fedorak, Richard N ^a  

^a UNIVERSITY OF ALBERTA   (Canada)

^b Vernon Jubilee Hospital   (Canada)

Author keywords

Bacteria; Crohn's disease; Inflammatory bowel disease; Monoassociation; Tolerance

Indexed keywords

BACTERIAL ANTIGEN; CYTOKINE; INTERLEUKIN 10;

ALPHA HEMOLYTIC STREPTOCOCCUS; ANIMAL CELL; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BACTERIAL COLONIZATION; BACTERIAL STRAIN; BACTEROIDES VULGATUS; CLOSTRIDIUM SORDELLII; CONTROLLED STUDY; CYTOKINE RELEASE; ENTEROCOLITIS; GENETIC DISORDER; HISTOPATHOLOGY; IMMUNE RESPONSE; INTESTINE EPITHELIUM; INTESTINE MUCOSA PERMEABILITY; MOUSE; NONHUMAN; PRIORITY JOURNAL;

ANIMALS; BACTEROIDES; CECUM; CLOSTRIDIUM SORDELLII; COLON; ENTEROCOLITIS; GERM-FREE LIFE; INTERLEUKIN-10; MICE; MICE, KNOCKOUT; SPLEEN; VIRIDANS STREPTOCOCCI;

EID: 18844405760     PISSN: 01632116     EISSN: None     Source Type: Journal    
DOI: 10.1007/s10620-005-2663-0     Document Type: Article

References (32)

1. Casellas F, Aguade S, Soriano B, Accarino A, Molero J, Guarner L: Intestinal permeability to 99mTc-diethylenetriaminopentaacetic acid in inflammatory bowel disease. Am J Gastroenterol 81:767-770, 1986
2. Dieleman LA, Arenas A, Tonkonogy SL, et al.: Helicobacter hepaticus does not induce or potentiate colitis in interleukin-10-deficient mice. Infect Immun 68:5107-5113, 2000
3. Duchmann R, Kaiser I, Hermann E, Mayet W, Ewe K, Meyer zum Buschenfelde KH: Tolerance exists towards resident intestinal flora but is broken in active inflammatory bowel disease (IBD). Clin Exp Immunol 102:448-455, 1995
4. Duchmann R, Marker-Hermann E, Meyer zum Buschenfelde KH: Bacteria-specific T-cell clones are selective in their reactivity towards different enterobacteria or H. pylori and increased in inflammatory bowel disease. Scand J Immunol 44:71-79, 1996
5. Duchmann R, May E, Heike M, et al.: T cell specificity and cross reactivity towards enterobacteria, bacteroides, bifidobacterium, and antigens from resident intestinal flora in humans. Gut 44:812-818, 1999
6. Duchmann R, Schmitt E, Knolle P, Meyer zum Buschenfelde KH, Neurath M: Tolerance towards resident intestinal flora in mice is abrogated in experimental colitis and restored by treatment with interleukin-10 or antibodies to interleukin-12. Eur J Immunol 26:934-938, 1996
7. Fox JG, Gorelick PL, Kullberg MC, Ge Z, Dewhirst FE, Ward JM: A novel urease-negative Helicobacter species associated with colitis and typhlitis in IL-10-deficient mice. Infect Immun 67:1757-1762, 1999
8. Hollander D: The intestinal permeability barrier. A hypothesis as to its regulation and involvement in Crohn's disease. Scand J Gastroenterol 27:721-726, 1992
9. Horie Y, Chiba M, Suzuki T, et al.: Induction of major histocompatibility complex class II antigens on human colonic epithelium by interferon-gamma, tumor necrosis factor-alpha, and interleukin-2. J Gastroenterol 33:39-47, 1998
10. Kim SC, Tonkonogy SL, Balish E, and Sartor RB: Bacterial antigen specific T cell activation precedes intestinal inflammation in Enterococcus faecalis monoassociated IL-10 deficient mice. Gastroenterology 122:A-85, 2002
11. Kishi D, Takahashi I, Kai Y, et al.: Alteration of V beta usage and cytokine production of CD4+ TCR beta beta homodimer T cells by elimination of Bacteroides vulgatus prevents colitis in TCR alpha-chain-deficient mice. J Immunol 165:5891-5899, 2000
12. Landers CJ, Cohavy O, Misra R, et al.: Selected loss of tolerance evidenced by Crohn's disease-associated immune responses to auto- and microbial antigens. Gastroenterology 123:689-699, 2002
13. Macpherson A, Khoo UY, Forgacs I, Philpott-Howard J, Bjarnason I: Mucosal antibodies in inflammatory bowel disease are directed against intestinal bacteria. Gut 38:365-375, 1996
14. Madsen K, Cornish A, Soper P, et al.: Probiotic bacteria enhance murine and human intestinal epithelial barrier function. Gastroenterology 121:580-591, 2001
15. Madsen KL, Doyle JS, Jewell LD, Tavernini MM, Fedorak RN: Lactobacillus species prevents colitis in interleukin 10 gene-deficient mice. Gastroenterology 116:1107-1114, 1999
16. Madsen KL, Doyle JS, Tavernini MM, Jewell LD, Rennie RP, Fedorak RN: Antibiotic therapy attenuates colitis in interleukin 10 gene-deficient mice. Gastroenterology 118:1094-1105, 2000
17. Madsen BCL, Malfair D, Gray D, Doyle JS, Jewell LD, Fedorak RN: Interleukin-10 gene-deficient mice develop a primary intestinal permeability defect in response to enteric microflora. Inflamm Bowel Dis 5:262-270, 1999
18. Onderdonk AB, Franklin ML, Cisneros RL: Production of experimental ulcerative colitis in gnotobiotic guinea pigs with simplified microflora. Infect Immun 32:225-231, 1981
19. Peeters M, Geypens B, Claus D, et al.: Clustering of increased small intestinal permeability in families with Crohn's disease. Gastroenterology 113:802-807, 1997
20. Rath HC, Herfarth HH, Ikeda JS, et al.: Normal luminal bacteria, especially Bacteroides species, mediate chronic colitis, gastritis, and arthritis in HLA-B27/human beta2 microglobulin transgenic rats. J Clin Invest 98:945-953, 1996
21. Rath HC, Ikeda JS, Linde HJ, Scholmerich J, Wilson KH, Sartor RB: Varying cecal bacterial loads influences colitis and gastritis in HLA-B27 transgenic rats. Gastroenterology 116:310-319, 1999
22. Rath HC, Schultz M, Freitag R, et al.: Different subsets of enteric bacteria induce and perpetuate experimental colitis in rats and mice. Infect Immun 69:2277-2285, 2001
23. Ruemmele FM, Gurbindo C, Mansour AM, Marchand R, Levy E, Seidman EG: Effects of interferon gamma on growth, apoptosis, and MHC class II expression of immature rat intestinal crypt (IEC-6) cells. J Cell Physiol 176:120-126, 1998
24. Salomon P, Pizzimenti A, Panja A, Reisman A, Mayer L: The expression and regulation of class II antigens in normal and inflammatory bowel disease peripheral blood monocytes and intestinal epithelium. Autoimmunity 9:141-149, 1991
25. Sartor RB: The influence of normal microbial flora on the development of chronic mucosal inflammation. Res Immunol 148:567-576, 1997
26. Sellon RK, Tonkonogy S, Schultz M, et al.: Resident enteric bacteria are necessary for development of spontaneous colitis and immune system activation in interleukin-10-deficient mice. Infect Immun 66:5224-5231, 1998
27. Steinhart AH, Feagan BG, Wong CJ, et al.: Combined budesonide and antibiotic therapy for active Crohn's disease: A randomized controlled trial. Gastroenterology 123:33-40, 2002
28. Sutherland L, Singleton J, Sessions J, et al.: Double blind, placebo controlled trial of metronidazole in Crohn's disease. Gut 32:1071-1075, 1991
29. Sydora BC, Tavernini MM, Fedorak RN: Different bacterial strains indigenous to the intestine vary in their ability ot elicit an immune response in an intestinal inflammation. The FASEB Journal 15:A368, 2001
30. Sydora BC, Tavernini MM, Jewell LD, Wessler A, Rennie RP, Fedorak RN: Bacterial association leads to a rapid inflammatory response and persistance of bacterial immunogenicity in germ-free IL-10 gene-deficient mice. Gastroenterology 120:A521, 2001
31. Sydora BC, Tavernini MM, Wessler A, Jewell LD, Fedorak RN: Lack of interleukin-10 leads to intestinal inflammation, independent of the time at which luminal microbial colonization occurs. Inflammatory Bowel Diseases 9:87-97, 2003
32. Turunen UM, Farkkila MA, Hakala K, et al.: Long-term treatment of ulcerative colitis with ciprofloxacin: A prospective, double-blind, placebo-controlled study. Gastroenterology 115:1072-1078, 1998